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01.02.2011 | Invited Update

Change in glucose metabolism measured by 18F-FDG PET/CT as a predictor of histopathologic response to neoadjuvant treatment in rectal cancer

verfasst von: Luca Guerra, Rita Niespolo, Giuseppe Di Pisa, Davide Ippolito, Elena De Ponti, Sara Terrevazzi, Giorgio Bovo, Sandro Sironi, Gianstefano Gardani, Cristina Messa

Erschienen in: Abdominal Radiology | Ausgabe 1/2011

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Abstract

Purpose

In order to analyze the changes of glucose metabolism by maximum standardized uptake value (SUVmax) of 18F-FDG PET/CT in patients with rectal cancer submitted to neoadjuvant radiochemotherapy (nRCT) and to correlate SUV changes with tumor regression grade (TRG).

Methods and material

Three sequential 18F-FDG PET/CT studies were performed in 31 patients with rectal cancer at the following time point: before starting the treatment (PET/CT1), during the treatment (PET/CT2), and after completion of neoadjuvant treatment (PET/CT3). The SUVmax values of the rectal lesion in the PET/CT1 (SUV1), PET/CT2 (SUV2), and PET/CT3 (SUV3) were obtained; deltaSUV1 [(SUV1 − SUV2)/SUV1] and deltaSUV2 [(SUV1 − SUV3)/SUV1] were also calculated. Metabolic parameters were compared to TRG.

Results

Significant differences in pathologic responder and non-responder patients were found only for SUV2 (6.4 ± 2.9 in responder and 10.7 ± 4.8 in non-responder patients, respectively; P = 0.006) and SUV3 (3.6 ± 1.4 in responder and 6.6 ± 2.1 in non-responder patients, respectively; P = 0.0009). The best predictor for TRG response was SUV3 (threshold of 4.4) with sensitivity, specificity, accuracy, negative predictive value, and positive predictive value of 77.3%, 88.9%, 80.7%, 61.5%, and 94.4%, respectively.

Conclusion

18F-FDG PET/CT is a reliable and accurate technique to assess the response to nRCT in rectal cancer. In our population, the absolute value of SUVmax after treatment was the best predictor of pathological response.

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Titel: Change in glucose metabolism measured by 18F-FDG PET/CT as a predictor of histopathologic response to neoadjuvant treatment in rectal cancer
verfasst von: Luca Guerra
Rita Niespolo
Giuseppe Di Pisa
Davide Ippolito
Elena De Ponti
Sara Terrevazzi
Giorgio Bovo
Sandro Sironi
Gianstefano Gardani
Cristina Messa
Publikationsdatum: 01.02.2011
Verlag: Springer-Verlag
Erschienen in: Abdominal Radiology / Ausgabe 1/2011
Print ISSN: 2366-004X
Elektronische ISSN: 2366-0058
DOI: https://doi.org/10.1007/s00261-009-9594-8

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Change in glucose metabolism measured by 18F-FDG PET/CT as a predictor of histopathologic response to neoadjuvant treatment in rectal cancer

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Purpose

Methods and material

Results

Conclusion

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