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Annals of Nuclear Medicine
Erschienen in: Annals of Nuclear Medicine 10/2015

01.12.2015 | Original Article

18F-FPRGD2 PET/CT imaging of musculoskeletal disorders

verfasst von: Nadia Withofs, Edith Charlier, Paolo Simoni, Victoria Alvarez-Miezentseva, Frédéric Mievis, Fabrice Giacomelli, Christine Mella, Sanjiv S. Gambhir, Olivier Malaise, Dominique de Seny, Michel Malaise, Roland Hustinx

Erschienen in: Annals of Nuclear Medicine | Ausgabe 10/2015

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Abstract

Objective

This work reports on musculoskeletal uptake of 18F-FPRGD2, targeting the integrin αvβ3, in patients who had undergone 18F-FPRGD2 positron emission tomography combined with computed tomography (PET/CT) for oncologic purposes.

Methods

Whole-body 18F-FPRGD2 PET/CT images of 62 cancer patients were retrospectively reviewed to detect foci of musculoskeletal 18F-FPRGD2 uptake. For 37 patients, a FDG PET/CT performed in clinical settings was available. In each joint with an abnormal uptake, the maximum standardized uptake value (SUVmax) was estimated.

Results

A total of 260 musculoskeletal foci of 18F-FPRGD2 uptake were detected. Most common sites of uptake were joints and discs (n = 160; 61.5 %), entheses (osteotendinous and osteoligamentous junctions; n = 55; 21.2 %) and recent fractures (n = 18; 6.9 %). In addition, 27 (10.4 %) miscellaneous foci were detected. Out of the 146 lesions for which a FDG PET was available, 63 % showed both 18F-FPRGD2 and FDG uptake, 33.6 % did not show FDG avidity and 3.4 % showed only FDG uptake. The uptake intensity of the 92 lesions positive with 18F-FPRGD2 and FDG was similar with both radiopharmaceuticals, but the target-to-background (blood pool or muscle) ratios were significantly higher with 18F-FPRGD2 than with FDG (p < 0.0001).

Conclusion

The 18F-FPRGD2 uptake in joints, spine degenerative diseases and tendons was highly prevalent in our population. Up to one-third of 18F-FPRGD2 foci showed no FDG uptake suggesting that 18F-FPRGD2 signal may not be related to inflammatory angiogenesis only.
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Metadaten
Titel
18F-FPRGD2 PET/CT imaging of musculoskeletal disorders
verfasst von
Nadia Withofs
Edith Charlier
Paolo Simoni
Victoria Alvarez-Miezentseva
Frédéric Mievis
Fabrice Giacomelli
Christine Mella
Sanjiv S. Gambhir
Olivier Malaise
Dominique de Seny
Michel Malaise
Roland Hustinx
Publikationsdatum
01.12.2015
Verlag
Springer Japan
Erschienen in
Annals of Nuclear Medicine / Ausgabe 10/2015
Print ISSN: 0914-7187
Elektronische ISSN: 1864-6433
DOI
https://doi.org/10.1007/s12149-015-1011-5

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