nach oben

Journal of Neuro-Oncology

Erschienen in:

02.01.2019 | Topic Review

5-aminolevulinic acid induced protoporphyrin IX (ALA-PpIX) fluorescence guidance in meningioma surgery

verfasst von: Pablo A. Valdes, Matthias Millesi, Georg Widhalm, David W. Roberts

Erschienen in: Journal of Neuro-Oncology | Ausgabe 3/2019

Einloggen, um Zugang zu erhalten

Abstract

Introduction

5-aminolevulinic acid induced protoporphyrin IX (5-ALA-PpIX) fluorescence guidance has emerged as a valuable surgical adjunct for resection of intracranial tumors.

Methods

Here we present a focused review on 5-ALA-PpIX fluorescence guidance for meningiomas.

Results

We discuss the clinical studies and specific applications to date as well as the two main intraoperative fluorescence technologies applied to meningiomas.

Conclusions

The use of 5-ALA-PpIX in meningiomas holds promising potential so neurosurgeons can improve surgical outcomes for patients with meningiomas as well as be pioneers in developing improved fluorescence imaging technologies.

Kajimoto Y, Kuroiwa T, Miyatake S, Ichioka T, Miyashita M, Tanaka H, Tsuji M (2007) Use of 5-aminolevulinic acid in fluorescence-guided resection of meningioma with high risk of recurrence. Case report. J Neurosurg 106(6):1070–1074. https://doi.org/10.3171/jns.2007.106.6.1070 CrossRefPubMed

Motekallemi A, Jeltema HR, Metzemaekers JD, van Dam GM, Crane LM, Groen RJ (2015) The current status of 5-ALA fluorescence-guided resection of intracranial meningiomas-a critical review. Neurosurg Rev 38(4):619–628. https://doi.org/10.1007/s10143-015-0615-5 CrossRefPubMedPubMedCentral

Valdes PA, Bekelis K, Harris BT, Wilson BC, Leblond F, Kim A, Simmons NE, Erkmen K, Paulsen KD, Roberts DW (2014) 5-Aminolevulinic acid-induced protoporphyrin IX fluorescence in meningioma: qualitative and quantitative measurements in vivo. Neurosurg 10 Suppl 1:74–82; discussion 82 – 73. https://doi.org/10.1227/NEU.0000000000000117

Simpson D (1957) The recurrence of intracranial meningiomas after surgical treatment. J Neurol Neurosurg Psychiatry 20(1):22–39CrossRefPubMedPubMedCentral

Stummer W, Pichlmeier U, Meinel T, Wiestler OD, Zanella F, Reulen HJ (2006) Fluorescence-guided surgery with 5-aminolevulinic acid for resection of malignant glioma: a randomised controlled multicentre phase III trial. Lancet Oncol 7(5):392–401. https://doi.org/10.1016/S1470-2045(06)70665-9 CrossRefPubMed

Bekelis K, Valdes PA, Erkmen K, Leblond F, Kim A, Wilson BC, Harris BT, Paulsen KD, Roberts DW (2011) Quantitative and qualitative 5-aminolevulinic acid-induced protoporphyrin IX fluorescence in skull base meningiomas. Neurosurg Focus 30(5):E8. https://doi.org/10.3171/2011.2.FOCUS1112 CrossRefPubMedPubMedCentral

Chae MP, Song SW, Park SH, Park CK (2012) Experience with 5-aminolevulinic Acid in fluorescence-guided resection of a deep sylvian meningioma. J Korean Neurosurg Soc 52(6):558–560. https://doi.org/10.3340/jkns.2012.52.6.558 CrossRefPubMedPubMedCentral

Coluccia D, Fandino J, Fujioka M, Cordovi S, Muroi C, Landolt H (2010) Intraoperative 5-aminolevulinic-acid-induced fluorescence in meningiomas. Acta Neurochir 152(10):1711–1719. https://doi.org/10.1007/s00701-010-0708-4 CrossRefPubMed

Millesi M, Kiesel B, Mischkulnig M, Martinez-Moreno M, Wohrer A, Wolfsberger S, Knosp E, Widhalm G (2016) Analysis of the surgical benefits of 5-ALA-induced fluorescence in intracranial meningiomas: experience in 204 meningiomas. J Neurosurg 125(6):1408–1419. https://doi.org/10.3171/2015.12.JNS151513 CrossRefPubMed

10.

Bradley RS, Thorniley MS (2006) A review of attenuation correction techniques for tissue fluorescence. J R Soc Interface 3(6):1–13. https://doi.org/10.1098/rsif.2005.0066 CrossRefPubMed

11.

Valdes PA, Jacobs VL, Paulsen KD, Roberts DW, Leblond F (2011) In vivo fluorescence detection in surgery: a review of principles, methods, and applications. Curr Med Imaging Rev 8(3):211–232

12.

Valdes PA, Leblond F, Kim A, Harris BT, Wilson BC, Fan X, Tosteson TD, Hartov A, Ji S, Erkmen K, Simmons NE, Paulsen KD, Roberts DW (2011) Quantitative fluorescence in intracranial tumor: implications for ALA-induced PpIX as an intraoperative biomarker. J Neurosurg 115(1):11–17. https://doi.org/10.3171/2011.2.JNS101451 CrossRefPubMedPubMedCentral

13.

Hadjipanayis CG, Widhalm G, Stummer W (2015) What is the Surgical Benefit of Utilizing 5-Aminolevulinic Acid for Fluorescence-Guided Surgery of Malignant Gliomas? Neurosurgery 77(5):663–673. https://doi.org/10.1227/NEU.0000000000000929 CrossRefPubMed

14.

Pogue BW, Gibbs-Strauss S, Valdes PA, Samkoe K, Roberts DW, Paulsen KD (2010) Review of neurosurgical fluorescence imaging methodologies. IEEE J Sel Top Quantum Electron 16(3):493–505. https://doi.org/10.1109/JSTQE.2009.2034541 CrossRefPubMedPubMedCentral

15.

Stummer W, Stepp H, Moller G, Ehrhardt A, Leonhard M, Reulen HJ (1998) Technical principles for protoporphyrin-IX-fluorescence guided microsurgical resection of malignant glioma tissue. Acta Neurochir 140(10):995–1000CrossRefPubMed

16.

Stummer W, Novotny A, Stepp H, Goetz C, Bise K, Reulen HJ (2000) Fluorescence-guided resection of glioblastoma multiforme by using 5-aminolevulinic acid-induced porphyrins: a prospective study in 52 consecutive patients. J Neurosurg 93(6):1003–1013. https://doi.org/10.3171/jns.2000.93.6.1003 CrossRefPubMed

17.

Stummer W, Pichlmeier U, Meinel T, Wiestler OD, Zanella F, Reulen HJ, Group AL-GS (2006) Fluorescence-guided surgery with 5-aminolevulinic acid for resection of malignant glioma: a randomised controlled multicentre phase III trial. Lancet Oncol 7(5):392–401. https://doi.org/10.1016/S1470-2045(06)70665-9 CrossRefPubMed

18.

Stummer W, Reulen HJ, Novotny A, Stepp H, Tonn JC (2003) Fluorescence-guided resections of malignant gliomas—an overview. Acta Neurochir Suppl 88:9–12

19.

Stummer W, Stocker S, Wagner S, Stepp H, Fritsch C, Goetz C, Goetz AE, Kiefmann R, Reulen HJ (1998) Intraoperative detection of malignant gliomas by 5-aminolevulinic acid-induced porphyrin fluorescence. Neurosurgery 42(3):518–525 (discussion 525–516)CrossRefPubMed

20.

Roberts DW, Valdes PA, Harris BT, Fontaine KM, Hartov A, Fan X, Ji S, Lollis SS, Pogue BW, Leblond F, Tosteson TD, Wilson BC, Paulsen KD (2011) Coregistered fluorescence-enhanced tumor resection of malignant glioma: relationships between delta-aminolevulinic acid-induced protoporphyrin IX fluorescence, magnetic resonance imaging enhancement, and neuropathological parameters. Clinical article. J Neurosurg 114(3):595–603. https://doi.org/10.3171/2010.2.JNS091322 CrossRefPubMed

21.

Valdes PA, Angelo JP, Choi HS, Gioux S (2017) qF-SSOP: real-time optical property corrected fluroescence imaging. Biomed Opt Express 8(8):3597–3605. https://doi.org/10.1364/BOE.8.003597 CrossRefPubMedPubMedCentral

22.

Valdes PA, Jacobs V, Harris BT, Wilson BC, Leblond F, Paulsen KD, Roberts DW (2015) Quantitative fluorescence using 5-aminolevulinic acid-induced protoporphyrin IX biomarker as a surgical adjunct in low-grade glioma surgery. J Neurosurg 123(3):771–780. https://doi.org/10.3171/2014.12.JNS14391 CrossRefPubMedPubMedCentral

23.

Valdes PA, Roberts DW, Lu FK, Golby A (2016) Optical technologies for intraoperative neurosurgical guidance. Neurosurg Focus 40(3):E8. https://doi.org/10.3171/2015.12.FOCUS15550 CrossRefPubMedPubMedCentral

24.

Valdes PA, Leblond F, Jacobs VL, Wilson BC, Paulsen KD, Roberts DW (2012) Quantitative, spectrally-resolved intraoperative fluorescence imaging. Sci Rep 2:798. https://doi.org/10.1038/srep00798 CrossRefPubMedPubMedCentral

25.

Kim A, Khurana M, Moriyama Y, Wilson BC (2010) Quantification of in vivo fluorescence decoupled from the effects of tissue optical properties using fiber-optic spectroscopy measurements. J Biomed Opt 15(6):067006. https://doi.org/10.1117/1.3523616 CrossRefPubMedPubMedCentral

26.

Valdes PA, Kim A, Leblond F, Conde OM, Harris BT, Paulsen KD, Wilson BC, Roberts DW (2011) Combined fluorescence and reflectance spectroscopy for in vivo quantification of cancer biomarkers in low- and high-grade glioma surgery. J Biomed Opt 16(11):116007. https://doi.org/10.1117/1.3646916 CrossRefPubMedPubMedCentral

27.

Bravo JJ, Olson JD, Davis SC, Roberts DW, Paulsen KD, Kanick SC (2017) Hyperspectral data processing improves PpIX contrast during fluorescence guided surgery of human brain tumors. Sci Rep 7(1):9455. https://doi.org/10.1038/s41598-017-09727-8 CrossRefPubMedPubMedCentral

28.

Morofuji Y, Matsuo T, Hayashi Y, Suyama K, Nagata I (2008) Usefulness of intraoperative photodynamic diagnosis using 5-aminolevulinic acid for meningiomas with cranial invasion: technical case report. Neurosurgery 62 (3 Suppl 1):102–103 (discussion 103–104). https://doi.org/10.1227/01.neu.0000317378.22820.4600006123-200803001-00012 CrossRefPubMed

29.

Cornelius JF, Slotty PJ, Stoffels G, Galldiks N, Langen KJ, Steiger HJ (2013) 5-Aminolevulinic acid and (18)F-FET-PET as metabolic imaging tools for surgery of a recurrent skull base meningioma. J Neurol Surg Part B Skull Base 74(4):211–216. https://doi.org/10.1055/s-0033-1342918 CrossRef

30.

Scheichel F, Ungersboeck K, Kitzwoegerer M, Marhold F (2017) Fluorescence-guided resection of extracranial soft tissue tumour infiltration in atypical meningioma. Acta Neurochir 159(6):1027–1031. https://doi.org/10.1007/s00701-017-3166-4 CrossRefPubMed

31.

Wilbers E, Hargus G, Wolfer J, Stummer W (2014) Usefulness of 5-ALA (Gliolan(R))-derived PPX fluorescence for demonstrating the extent of infiltration in atypical meningiomas. Acta Neurochir 156(10):1853–1854. https://doi.org/10.1007/s00701-014-2148-z CrossRefPubMed

32.

Cornelius JF, Slotty PJ, Kamp MA, Schneiderhan TM, Steiger HJ, El-Khatib M (2014) Impact of 5-aminolevulinic acid fluorescence-guided surgery on the extent of resection of meningiomas–with special regard to high-grade tumors. Photodiagn Photodyn Ther 11(4):481–490. https://doi.org/10.1016/j.pdpdt.2014.07.008 CrossRef

33.

Bekelis K, Valdés PA, Erkmen K, Leblond F, Kim A, Wilson BC, Harris BT, Paulsen KD, Roberts DW (2011) Quantitative and qualitative ALA-induced PpIX fluorescence in skull base meningiomas. Neurosurg Focus

34.

Whitson WJ, Valdes PA, Harris BT, Paulsen KD, Roberts DW (2011) Confocal microscopy for the histological fluorescence pattern of a recurrent atypical meningioma: case report. Neurosurgery 68(6):E1768–E1772. https://doi.org/10.1227/NEU.0b013e318217163c (discussion E1772–E1763)CrossRefPubMed

35.

Eljamel MS (2009) Which intracranial lesions would be suitable for 5-aminolevulenic acid-induced fluorescence-guided identification, localization, or resection? A prospective study of 114 consecutive intracranial lesions. Clin Neurosurg 56:93–97PubMed

36.

Marbacher S, Klinger E, Schwyzer L, Fischer I, Nevzati E, Diepers M, Roelcke U, Fathi AR, Coluccia D, Fandino J (2014) Use of fluorescence to guide resection or biopsy of primary brain tumors and brain metastases. Neurosurg Focus 36(2):E10. https://doi.org/10.3171/2013.12.FOCUS13464 CrossRefPubMed

37.

Potapov AA, Goryaynov SA, Okhlopkov VA, Shishkina LV, Loschenov VB, Savelieva TA, Golbin DA, Chumakova AP, Goldberg MF, Varyukhina MD, Spallone A (2016) Laser biospectroscopy and 5-ALA fluorescence navigation as a helpful tool in the meningioma resection. Neurosurg Rev 39(3):437–447. https://doi.org/10.1007/s10143-015-0697-0 CrossRefPubMed

38.

Della Puppa A, Rustemi O, Gioffre G, Troncon I, Lombardi G, Rolma G, Sergi M, Munari M, Cecchin D, Gardiman MP, Scienza R (2014) Predictive value of intraoperative 5-aminolevulinic acid-induced fluorescence for detecting bone invasion in meningioma surgery. J Neurosurg 120(4):840–845. https://doi.org/10.3171/2013.12.JNS131642 CrossRefPubMed

39.

Borovich B, Doron Y (1986) Recurrence of intracranial meningiomas: the role played by regional multicentricity. J Neurosurg 64(1):58–63CrossRefPubMed

40.

Muroi C, Fandino J, Coluccia D, Berkmann S, Fathi AR, Landolt H (2013) 5-Aminolevulinic acid fluorescence-guided surgery for spinal meningioma. World neurosurgery 80(1–2):223–e1. https://doi.org/10.1016/j.wneu.2012.12.017 CrossRefPubMed

41.

Eicker SO, Floeth FW, Kamp M, Steiger HJ, Hanggi D (2013) The impact of fluorescence guidance on spinal intradural tumour surgery. European spine journal: official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical. Spine Res Soc 22(6):1394–1401. https://doi.org/10.1007/s00586-013-2657-0 CrossRef

Titel: 5-aminolevulinic acid induced protoporphyrin IX (ALA-PpIX) fluorescence guidance in meningioma surgery
verfasst von: Pablo A. Valdes
Matthias Millesi
Georg Widhalm
David W. Roberts
Publikationsdatum: 02.01.2019
Verlag: Springer US
Erschienen in: Journal of Neuro-Oncology / Ausgabe 3/2019
Print ISSN: 0167-594X
Elektronische ISSN: 1573-7373
DOI: https://doi.org/10.1007/s11060-018-03079-7

Leitlinien kompakt für die Neurologie

Mit medbee Pocketcards sicher entscheiden.

^{Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag}

Kostenlos registrieren

Neu im Fachgebiet Neurologie

Schützt Olivenöl vor dem Tod durch Demenz?

10.05.2024 Morbus Alzheimer Nachrichten

Konsumieren Menschen täglich 7 Gramm Olivenöl, ist ihr Risiko, an einer Demenz zu sterben, um mehr als ein Vierten reduziert – und dies weitgehend unabhängig von ihrer sonstigen Ernährung. Dafür sprechen Auswertungen zweier großer US-Studien.

Bluttest erkennt Parkinson schon zehn Jahre vor der Diagnose

10.05.2024 Parkinson-Krankheit Nachrichten

Ein Bluttest kann abnorm aggregiertes Alpha-Synuclein bei einigen Menschen schon zehn Jahre vor Beginn der motorischen Parkinsonsymptome nachweisen. Mit einem solchen Test lassen sich möglicherweise Prodromalstadien erfassen und die Betroffenen früher behandeln.

Darf man die Behandlung eines Neonazis ablehnen?

08.05.2024 Gesellschaft Nachrichten

In einer Leseranfrage in der Zeitschrift Journal of the American Academy of Dermatology möchte ein anonymer Dermatologe bzw. eine anonyme Dermatologin wissen, ob er oder sie einen Patienten behandeln muss, der eine rassistische Tätowierung trägt.

Wartezeit nicht kürzer, aber Arbeit flexibler

Psychotherapie Medizin aktuell

Fünf Jahren nach der Neugestaltung der Psychotherapie-Richtlinie wurden jetzt die Effekte der vorgenommenen Änderungen ausgewertet. Das Hauptziel der Novellierung war eine kürzere Wartezeit auf Therapieplätze. Dieses Ziel wurde nicht erreicht, es gab jedoch positive Auswirkungen auf andere Bereiche.

Update Neurologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Klimawandel und Gesundheit: Was Sie in der Hausarztpraxis wissen müssen und tun können

Springer Medizin

Abstract

Introduction

Methods

Results

Conclusions

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 3/2019

Effects of 5-ALA dose on resection of glioblastoma

Established and emerging uses of 5-ALA in the brain: an overview

The role of 5-aminolevulinic acid in spinal tumor surgery: a review

Use of optical fluorescence agents during surgery for pituitary adenomas: current state of the field

Is 5-ALA fluorescence of cerebral metastases a prognostic factor for local recurrence and overall survival?