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Journal of Neuro-Oncology

Journal of Neuro-Oncology OnlineFirst articles

09.12.2018 | Laboratory Investigation

Tropomyosin Tpm 2.1 loss induces glioblastoma spreading in soft brain-like environments

The diffusely infiltrating nature of glioma brain tumour cells precludes successful surgical excision of all malignant cells and thus contributes to the poor survival rate for patients diagnosed with a glioblastoma (GBM) [ 1 ]. Neural tissue is one …

09.12.2018 | Clinical Study

Comprehensive genetic alteration profiling in primary and recurrent glioblastoma

Glioblastoma (GBM) is highly heterogeneous [ 1 – 4 ] and it is unclear how genomic alterations (GA) contribute to this phenotype. Two common models propose that tumor heterogeneity arises and therapeutic resistance develops via the cancer stem cell …

07.12.2018 | Clinical Study

Radiographic assessment of contrast enhancement and T2/FLAIR mismatch sign in lower grade gliomas: correlation with molecular groups

Imaging plays an essential role in the management of lower-grade gliomas (LGG). Indeed, magnetic resonance imaging (MRI) represents the first-line modality in the diagnosis of these tumors, and in the assessment of response to treatment. Recent …

07.12.2018 | Clinical Study

Etiology and prognosis of acute respiratory failure in patients with primary malignant brain tumors admitted to the intensive care unit

Acute respiratory failure (ARF) is the main cause for intensive care unit (ICU) admission of cancer patients [ 1 , 2 ]. In these patients, acute infectious pneumonia is the leading cause of ARF, ranging from scarce infiltrates to life-threatening …

07.12.2018 | Laboratory Investigation

Impact of ANXA5 polymorphisms on glioma risk and patient prognosis

Glioma is one of the common primary brain tumors in the central nervous system (CNS) and a high fatal disease, accounting for almost 80% of brain malignancies [ 1 ]. In 2015, 101,6000 new cases of brain and CNS tumor were diagnosed in China, with a …

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