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Journal of Neuro-Oncology OnlineFirst articles

19.02.2019 | Clinical Study

Impact on survival of early tumor growth between surgery and radiotherapy in patients with de novo glioblastoma

Glioblastoma remains the most aggressive primary brain tumor in adults with an incidence rate ranging from 2.0 to 5.0/100,000 population and varying among regions of the world [ 1 – 3 ]. Median overall survival (OS) ranges from 14 to 18 months with …

18.02.2019 | Clinical Study Open Access

Withdrawal of antiepileptic drugs in patients with low grade and anaplastic glioma after long-term seizure freedom: a prospective observational study

Low grade gliomas are a group of primary brain tumors supposedly developing from supportive tissue cells, such as oligodendrocytes and astrocytes, or neural stem cells. In the presence of microvascular proliferation and necrosis, these tumors are …

15.02.2019 | Clinical Study

High-dose radiation therapy is needed for intracranial control and long-term survival in patients with non-seminomatous germ cell tumor brain metastases

Although most patients with advanced non-seminomatous germ cell tumors (NSGCT) can achieve long-term survival, patients with NSGCT and brain metastases (BM) have been considered to have poor prognosis [ 1 , 2 ]. Due to the rarity of developing BM …

15.02.2019 | Clinical Study

A multicenter phase II study of temozolomide plus disulfiram and copper for recurrent temozolomide-resistant glioblastoma

Glioblastoma (GBM, World Health Organization/WHO grade IV) is one of the most devastating cancers with median overall survival (OS) of approximately 16 months even after best contemporary multi-modality treatment of surgery, radiation therapy …

11.02.2019 | Clinical Study

Neuro-radiological characteristics of adult diffuse grade II and III insular gliomas classified according to WHO 2016

Diffuse gliomas are the most frequent and aggressive primary brain tumors in adults. Molecular understanding of gliomagenesis was first improved with the identification of the 1p/19q codeletion that is associated with an oligodendroglial phenotype …

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