Erschienen in:
11.01.2016 | Case Report
A Case of Chronic Lymphocytic Leukaemia Occurring During Treatment of Chronic Myeloid Leukaemia
Erschienen in:
Indian Journal of Hematology and Blood Transfusion
|
Sonderheft 1/2016
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Excerpt
Chronic myeloid leukaemia (CML) and chronic lymphocytic leukaemia (CLL) are the most common types of leukaemia in elderly. The characteristic of CML is Philadelphia chromosome, became of translocation of chromosome 9 and 22 and fusion of bcr-abl gene. Result of fusion bcr-abl gene is activation tyrosin-kinase and uncontrolled proliferation of myeloid cells [
1]. CLL characteristics are low proliferative activity and accumulation of monoclonal B lymphocytes in bone marrow, lymph nodes and other organs which are resistant to apoptosis. Simultaneous occurrence of CML and CLL is extremely rare. We report here a case of patient in whom CLL developed during the treatment of CML with imatinib mesilate. …