Background
Methods
Study design
Mammographic density measurement
Visual estimation of percentage density
Cumulus
Quantra™
Volpara™
Densitas™
Statistical methods
Results
Study 1 | Study 2 | PROCAS | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Control subjects | Case subjects | Control subjects | Case subjects | (n = 57902) | ||||||||
(n = 1098) | (n = 366) | (n = 1014) | (n = 338) | |||||||||
Number | Percent | Number | Percent | P value | Number | Percent | Number | Percent | P value | Number | Percent | |
Age at consent (years) | ||||||||||||
< 50 | 117 | 10.7 | 40 | 10.9 | 50 | 4.9 | 17 | 5.0 | 7173 | 12.4 | ||
50–54 | 316 | 28.8 | 104 | 28.4 | 203 | 20.0 | 66 | 19.5 | 16962 | 29.3 | ||
55–59 | 157 | 14.3 | 53 | 14.5 | 179 | 17.7 | 61 | 18.0 | 11046 | 19.1 | ||
60–64 | 237 | 21.6 | 79 | 21.6 | 315 | 31.1 | 105 | 31.1 | 11223 | 19.4 | ||
65–69 | 197 | 17.9 | 66 | 18.0 | 210 | 20.7 | 70 | 20.7 | 8552 | 14.8 | ||
70+ | 74 | 6.7 | 24 | 6.6 | 1.000 | 57 | 5.6 | 19 | 5.6 | 1.000 | 2946 | 5.1 |
Median (IQR) | 58 | 51–64 | 58 | 51–64 | 0.988 | 61 | 55–65 | 61 | 55–65 | 0.965 | 57 | 51–63 |
Menopausal status | ||||||||||||
Perimenopausal | 170 | 15.5 | 57 | 15.6 | 145 | 14.3 | 49 | 14.5 | 10760 | 18.6 | ||
Postmenopausal | 747 | 68.0 | 248 | 67.8 | 769 | 75.8 | 256 | 75.7 | 37201 | 64.2 | ||
Premenopausal | 136 | 12.4 | 46 | 12.6 | 67 | 6.6 | 22 | 6.5 | 6869 | 11.9 | ||
Unknown | 45 | 4.1 | 15 | 4.1 | 1.000 | 33 | 3.3 | 11 | 3.3 | 1.000 | 3072 | 5.3 |
HRT use | ||||||||||||
Never | 699 | 63.7 | 250 | 68.3 | 518 | 51.1 | 177 | 52.4 | 36505 | 63.0 | ||
Previous | 342 | 31.1 | 93 | 25.4 | 379 | 37.4 | 122 | 36.1 | 16438 | 28.4 | ||
Current | 56 | 5.1 | 19 | 5.2 | 110 | 10.8 | 37 | 10.9 | 4421 | 7.6 | ||
Unknown | 1 | 0.1 | 4 | 1.1 | 0.302a | 7 | 0.7 | 2 | 0.6 | 0.972 | 538 | 0.9 |
BMI (kg/m2) | ||||||||||||
< 25 | 345 | 31.4 | 112 | 30.6 | 334 | 32.9 | 108 | 32.0 | 20774 | 35.8 | ||
25–29 | 353 | 32.1 | 122 | 33.3 | 346 | 34.1 | 118 | 34.9 | 18969 | 32.8 | ||
≥ 30 | 327 | 29.8 | 105 | 28.7 | 272 | 26.8 | 88 | 26.0 | 14256 | 24.6 | ||
Unknown | 73 | 6.6 | 27 | 7.4 | 0.918 | 62 | 6.1 | 24 | 7.1 | 0.904 | 3933 | 6.8 |
Median (IQR) | 27.2 | 24.0–31.2 | 27.8 | 24.0–30.8 | 0.581 | 26.6 | 23.9–30.5 | 26.6 | 23.9–30.5 | 0.517 | 26.4 | 23.6–30.3 |
Ethnic origin | ||||||||||||
White | 1038 | 94.5 | 334 | 91.3 | 924 | 91.1 | 304 | 89.9 | 52689 | 91.0 | ||
Other/unknown | 50 | 4.6 | 32 | 8.7 | 0.003 | 90 | 8.9 | 34 | 10.1 | 0.511 | 5213 | 9.0 |
Year of mammogram | ||||||||||||
2009 | 22 | 2.0 | 0 | 0.0 | 2372 | 4.1 | ||||||
2010 | 607 | 55.3 | 43 | 11.7 | 196 | 19.3 | 70 | 20.7 | 14761 | 25.5 | ||
2011 | 396 | 36.1 | 130 | 35.5 | 553 | 54.5 | 177 | 52.4 | 18350 | 31.7 | ||
2012 | 70 | 6.4 | 129 | 35.2 | 264 | 26.0 | 86 | 25.4 | 14214 | 24.5 | ||
2013 | 3 | 0.3 | 30 | 8.2 | 1 | 0.1 | 3 | 0.9 | 3499 | 6.0 | ||
2014 | 0 | 0.0 | 33 | 9.0 | 0 | 0.0 | 2 | 0.6 | 3804 | 6.6 | ||
2015 | 0 | 0.0 | 1 | 0.3 | < 0.001b | 0.769c | 900 | 1.6 | ||||
Initial Tyrer-Cuzick (10-year %) | ||||||||||||
Median (IQR) | 2.72 | 2.18 – 3.52 | 2.95 | 2.29–3.90 | 0.003 | 2.63 | 2.10–3.47 | 2.91 | 2.25–4.02 | < 0.001 | 2.67 | 2.12–3.47 |
Family history | ||||||||||||
None | 803 | 73.1 | 249 | 68.0 | 754 | 74.4 | 229 | 67.8 | 42367 | 73.2 | ||
FDR only | 104 | 9.5 | 42 | 11.5 | 107 | 10.6 | 47 | 13.0 | 5749 | 9.9 | ||
SDR only | 147 | 13.4 | 51 | 13.9 | 126 | 12.4 | 42 | 12.4 | 7998 | 13.8 | ||
FDR and SDR | 44 | 4.0 | 24 | 6.6 | 0.112 | 27 | 2.7 | 20 | 5.9 | 0.008 | 1788 | 3.1 |
Current alcohol use | ||||||||||||
No | 283 | 25.8 | 89 | 24.3 | 273 | 26.9 | 93 | 27.5 | 15815 | 27.3 | ||
Yes | 797 | 72.6 | 269 | 73.5 | 726 | 71.6 | 241 | 71.3 | 41130 | 71.0 | ||
Unknown | 18 | 1.6 | 8 | 2.2 | 0.697 | 15 | 1.5 | 4 | 1.2 | 0.908 | 957 | 1.7 |
Any children | ||||||||||||
No | 128 | 11.7 | 43 | 11.7 | 98 | 9.7 | 45 | 13.3 | 7384 | 12.7 | ||
Yes | 970 | 88.3 | 323 | 88.3 | 915 | 90.2 | 290 | 85.8 | 50411 | 87.1 | ||
Unknown | 0.963 | 1 | 0.1 | 3 | 0.9 | 0.023d | 107 | 0.2 | ||||
Prior biopsy of breast | ||||||||||||
No | 910 | 82.9 | 284 | 77.6 | 837 | 82.5 | 252 | 74.6 | 47359 | 81.8 | ||
Yes | 159 | 14.5 | 65 | 17.8 | 153 | 15.1 | 76 | 22.5 | 8911 | 15.4 | ||
Unknown | 29 | 2.6 | 17 | 4.6 | 0.041 | 24 | 2.4 | 10 | 3.0 | 0.005 | 1632 | 2.8 |
Study 1: screen-detected cancers
Subset with data for all methodsb | ||||||||
---|---|---|---|---|---|---|---|---|
Univariate | Adjustedc | Univariate | Adjustedc | |||||
OR | 95% CI | OR | 95% CI | OR | 95% CI | OR | 95% CI | |
Study 1 | ||||||||
1.00 | (referent) | 1.00 | (referent) | 1.00 | (referent) | 1.00 | (referent) | |
VAS (%) |
4.45
|
(2.77–7.15)
|
4.37
|
(2.72–7.03)
|
5.61
|
(3.29–9.56)
|
5.44
|
(3.18–9.29)
|
Volpara gland volume (cm3) |
2.13
|
(1.40–3.24)
|
2.09
|
(1.37–3.18)
|
2.00
|
(1.24–3.21)
|
1.97
|
(1.22–3.18)
|
Volpara breast density (%) |
2.44
|
(1.57–3.80)
|
2.42
|
(1.56–3.78)
|
2.38
|
(1.45–3.91)
|
2.41
|
(1.46–3.97)
|
Cumulus dense area (cm2) |
2.11
|
(1.32–3.38)
|
2.15
|
(1.34–3.45)
|
2.08
|
(1.28–3.27)
|
2.12
|
(1.30–3.45)
|
Cumulus breast density (%) |
2.09
|
(1.29–3.40)
|
2.12
|
(1.30–3.45)
|
2.20
|
(1.32–3.64)
|
2.23
|
(1.34–3.71)
|
Quantra gland volume (cm3) | 0.86 | (0.58–1.30) | 0.83 | (0.55–1.25) | 0.72 | (0.45–1.15) | 0.71 | (0.44–1.13) |
Quantra breast density (%) | 1.05 | (0.70–1.59) | 1.02 | (0.67–1.54) | 1.11 | (0.70–1.77) | 1.08 | (0.68–1.72) |
Densitas dense area (cm2) | 1.44 | (0.96–2.16) | 1.41 | (0.93–2.12) |
1.62
|
(1.01–2.59)
|
1.61
|
(1.00–2.58)
|
Densitas breast density (%) |
2.30
|
(1.50–3.52)
|
2.17
|
(1.41–3.33)
|
2.19
|
(1.35–3.56)
|
2.10
|
(1.29–3.41)
|
Study 2 | ||||||||
1.00 | (referent) | 1.00 | (referent) | 1.00 | (referent) | 1.00 | (referent) | |
VAS (%) |
4.54
|
(2.86–7.22)
|
4.48
|
(2.79–7.18)
|
4.41
|
(2.76–7.06)
|
4.36
|
(2.70–7.04)
|
Volpara gland volume (cm3) |
2.72
|
(1.79–4.14)
|
2.66
|
(1.74–4.08)
|
2.71
|
(1.77–4.14)
|
2.65
|
(1.72–4.09)
|
Volpara breast density (%) |
2.78
|
(1.74–4.44)
|
2.87
|
(1.77–4.64)
|
2.61
|
(1.62–4.19)
|
2.71
|
(1.67–4.39)
|
Quantra gland volume (cm3) | 1.36 | (0.90–2.06) | 1.28 | (0.84–1.95) | 1.32 | (0.87–2.01) | 1.24 | (0.80–1.90) |
Quantra breast density (%) | 1.32 | (0.86–2.03) | 1.32 | (0.85–2.05) | 1.30 | (0.84–2.00) | 1.32 | (0.85–2.05) |
Densitas dense area (cm2) |
2.34
|
(1.56–3.52)
|
2.23
|
(1.48–3.38)
|
2.29
|
(1.50–3.50)
|
2.14
|
(1.40–3.29)
|
Densitas breast density (%) |
2.45
|
(1.57–3.82)
|
2.34
|
(1.50–3.68)
|
2.44
|
(1.56–3.80)
|
2.34
|
(1.49–3.66)
|
Subset with data for all methodsb | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Controls | Cases | Univariate | Adjusteda | Controls | Cases | Univariate | Adjusteda | |||||||||
N
| Percent |
N
| Percent | OR | 95% CI | OR | 95% CI |
N
| Percent |
N
| Percent | OR | 95% CI | OR | 95% CI | |
Study 1 | ||||||||||||||||
VAS (mean) - Boyd categories (combining > 50–75% and > 75%) | ||||||||||||||||
≥ 0–10% | 208 | (18.9) | 29 | (9.1) | 1.00 | (referent) | 1.00 | (referent) | 176 | (21.1) | 25 | (8.3) | 1.00 | (referent) | 1.00 | (referent) |
> 10–25% | 436 | (39.7) | 115 | (35.9) |
2.17
|
(1.37–3.42)
|
2.16
|
(1.37–3.40)
| 331 | (39.7) | 111 | (36.9) |
2.67
|
(1.63–4.38)
|
2.65
|
(1.62–4.34)
|
> 25–50% | 379 | (34.5) | 133 | (41.6) |
3.25
|
(2.05–5.18)
|
3.20
|
(2.01–5.09)
| 277 | (33.3) | 125 | (41.5) |
3.95
|
(2.38–6.54)
|
3.84
|
(2.31–6.36)
|
> 50% | 75 | (6.8) | 43 | (13.4) |
6.92
|
(3.74–12.79)
|
6.73
|
(3.64–12.45)
| 49 | (5.9) | 40 | (13.3) |
8.30
|
(4.28–16.07)
|
8.02
|
(4.13–15.56)
|
Volpara Density Grades 4th Edition | ||||||||||||||||
1 (<4.5) | 496 | (45.2) | 124 | (34.0) | 1.00 | (referent) | 1.00 | (referent) | 400 | (48.0) | 108 | (35.9) | 1.00 | (referent) | 1.00 | (referent) |
2 (4.5–<7.5) | 339 | (30.9) | 131 | (35.9) |
1.78
|
(1.31–2.41)
|
1.74
|
(1.29–2.37)
| 258 | (31.0) | 113 | (37.5) |
1.90
|
(1.35–2.66)
|
1.88
|
(1.34–2.63)
|
3 (7.5–<15.5) | 229 | (20.9) | 85 | (23.3) |
1.85
|
(1.29–2.64)
|
1.86
|
(1.30–2.68)
| 153 | (18.4) | 64 | (21.3) |
1.92
|
(1.28–2.90)
|
1.94
|
(1.29–2.94)
|
4 (15.5+) | 34 | (3.1) | 25 | (6.8) |
4.18
|
(2.24–7.77)
|
4.07
|
(2.18–7.60)
| 22 | (2.6) | 16 | (5.3) |
3.73
|
(1.80–7.75)
|
3.58
|
(1.72–7.44)
|
Volpara Density Grades 5th Edition | ||||||||||||||||
1 (< 3.5) | 274 | (25.0) | 62 | (17.0) | 1.00 | (referent) | 1.00 | (referent) | 216 | (25.9) | 50 | (16.6) | 1.00 | (referent) | 1.00 | (referent) |
2 (3.5–<7.5) | 561 | (51.1) | 193 | (52.9) |
1.68
|
(1.20–2.34)
|
1.68
|
(1.20–2.35)
| 442 | (53.1) | 171 | (56.8) |
1.88
|
(1.29–2.73)
|
1.89
|
(1.30–2.75)
|
3 (7.5–<15.5) | 229 | (20.9) | 85 | (23.3) |
2.00
|
(1.32–3.02)
|
2.04
|
(1.34–3.09)
| 153 | (18.4) | 64 | (21.3) |
2.22
|
(1.38–3.57)
|
2.27
|
(1.41–3.66)
|
4 (15.5+) | 34 | (3.1) | 25 | (6.8) |
4.44
|
(2.31–8.54)
|
4.39
|
(2.28–8.48)
| 22 | (2.6) | 16 | (5.3) |
4.26
|
(1.98–9.17)
|
4.14
|
(1.92–8.95)
|
Quantized density (BIRADS) | ||||||||||||||||
1 | 54 | (4.9) | 27 | (7.4) | 1.00 | (referent) | 1.00 | (referent) | 47 | (5.6) | 21 | (7.0) | 1.00 | (referent) | 1.00 | (referent) |
2 | 682 | (62.2) | 220 | (60.3) | 0.63 | (0.39–1.02) |
0.61
|
(0.38–0.99)
| 530 | (63.6) | 193 | (64.1) | 0.85 | (0.50–1.44) | 0.80 | (0.47–1.37) |
3 | 317 | (28.9) | 102 | (27.9) | 0.63 | (0.37–1.05) |
0.58
|
(0.34–0.99)
| 226 | (27.1) | 75 | (24.9) | 0.77 | (0.43–1.38) | 0.71 | (0.39–1.28) |
4 | 44 | (4.0) | 16 | (4.4) | 0.71 | (0.33–1.52) | 0.62 | (0.29–1.33) | 30 | (3.6) | 12 | (4.0) | 0.92 | (0.39–2.17) | 0.79 | (0.33–1.88) |
Densitas: BIRADS 4 | ||||||||||||||||
0–24 | 387 | (37.4) | 105 | (35.2) | 1.00 | (referent) | 1.00 | (referent) | 326 | (39.1) | 94 | (31.2) | 1.00 | (referent) | 1.00 | (referent) |
25–50 | 599 | (57.8) | 219 | (60.8) |
1.53
|
(1.15–2.04)
|
1.48
|
(1.11–1.98)
| 470 | (56.4) | 186 | (61.8) |
1.53
|
(1.12–2.08)
|
1.48
|
(1.09–2.03)
|
51+ | 50 | (4.8) | 36 | (10.0) |
3.46
|
(2.04–5.87)
|
3.21
|
(1.88–5.47)
| 35 | (4.2) | 21 | (7.0) |
2.47
|
(1.34–4.55)
|
2.33
|
(1.26–4.30)
|
Densitas: BIRADS 5 | ||||||||||||||||
A | 194 | (18.7) | 46 | (12.8) | 1.00 | (referent) | 1.00 | (referent) | 171 | (20.5) | 37 | (12.3) | 1.00 | (referent) | 1.00 | (referent) |
B | 552 | (53.3) | 191 | (53.1) |
1.58
|
(1.08–2.30)
|
1.50
|
(1.03–2.19)
| 446 | (53.5) | 174 | (57.8) |
1.97
|
(1.29–2.99)
|
1.87
|
(1.23–2.85)
|
C | 278 | (26.8) | 117 | (32.5) |
2.01
|
(1.33–3.04)
|
1.92
|
(1.27–2.91)
| 206 | (24.7) | 85 | (28.2) |
2.12
|
(1.34–3.37)
|
2.03
|
(1.28–3.23)
|
D | 12 | (1.2) | 6 | (1.7) | 2.79 | (0.94–8.24) | 2.50 | (0.84–7.48) | 8 | (1.0) | 5 | (1.7) |
3.71
|
(1.09–12.66)
|
3.30
|
(0.95–11.42)
|
Study 2 | ||||||||||||||||
VAS (mean) - Boyd categories (combining >50–75% and >75%) | ||||||||||||||||
≥ 0–10% | 193 | (19.0) | 34 | (10.1) | 1.00 | (referent) | 1.00 | (referent) | 180 | (18.7) | 32 | (9.7) | 1.00 | (referent) | 1.00 | (referent) |
> 10–25% | 401 | (39.5) | 103 | (30.5) |
1.61
|
(1.05–2.49)
|
1.55
|
(1.00–2.40)
| 383 | (39.8) | 100 | (30.4) |
1.61
|
(1.03–2.50)
| 1.55 | (0.99–2.42) |
> 25–50% | 356 | (35.1) | 154 | (45.6) |
2.92
|
(1.89–4.52)
|
2.87
|
(1.85–4.46)
| 329 | (34.2) | 152 | (46.2) |
3.02
|
(1.94–4.71)
|
2.97
|
(1.90–4.67)
|
> 50% | 64 | (6.3) | 45 | (13.3) |
5.52
|
(3.08–9.91)
|
5.45
|
(3.00–9.89)
| 60 | (6.2) | 45 | (13.7) |
5.65
|
(3.12–10.23)
|
5.63
|
(3.07–10.3)
|
Volpara Density Grades 4th Edition | ||||||||||||||||
1 (< 4.5) | 474 | (46.7) | 126 | (37.3) | 1.00 | (referent) | 1.00 | (referent) | 447 | (46.5) | 123 | (37.4) | 1.00 | (referent) | 1.00 | (referent) |
2 (4.5– < 7.5) | 336 | (33.1) | 120 | (35.5) |
1.45
|
(1.07–1.96)
|
1.44
|
(1.06–1.95)
| 315 | (32.7) | 118 | (35.9) |
1.44
|
(1.06–1.95)
|
1.43
|
(1.05–1.95)
|
3 (7.5– < 15.5) | 167 | (16.5) | 73 | (21.6) |
1.96
|
(1.34–2.87)
|
2.08
|
(1.40–3.08)
| 156 | (16.2) | 69 | (21.0) |
1.81
|
(1.23–2.67)
|
1.92
|
(1.29–2.86)
|
4 (15.5+) | 37 | (3.6) | 19 | (5.6) |
2.47
|
(1.30–4.70)
|
2.61
|
(1.34–5.10)
| 34 | (3.5) | 19 | (5.8) |
2.56
|
(1.33–4.91)
|
2.73
|
(1.38–5.38)
|
Volpara Density Grades 5th Edition | ||||||||||||||||
1 (<3.5) | 205 | (20.2) | 47 | (13.9) | 1.00 | (referent) | 1.00 | (referent) | 195 | (20.3) | 47 | (14.3) | 1.00 | (referent) | 1.00 | (referent) |
2 (3.5–<7.5) | 570 | (56.2) | 189 | (55.9) |
1.55
|
(1.07–2.24)
|
1.53
|
(1.06–2.23)
| 533 | (55.4) | 184 | (55.9) |
1.51
|
(1.04–2.19)
|
1.51
|
(1.04–2.21)
|
3 (7.5–<15.5) | 193 | (19.0) | 78 | (23.1) |
2.09
|
(1.33–3.28)
|
2.16
|
(1.36–3.43)
| 181 | (18.8) | 74 | (22.5) |
1.92
|
(1.22–3.04)
|
1.99
|
(1.25–3.17)
|
4 (15.5+) | 46 | (4.5) | 24 | (7.1) |
2.92
|
(1.53–5.58)
|
3.00
|
(1.54–5.86)
| 43 | (4.5) | 24 | (7.3) |
2.82
|
(1.47–5.40)
|
2.91
|
(1.48–5.72)
|
Quantized density (BIRADS) | ||||||||||||||||
1 | 32 | (3.2) | 12 | (3.6) | 1.00 | (referent) | 1.00 | (referent) | 32 | (3.3) | 12 | (3.6) | 1.00 | (referent) | 1.00 | (referent) |
2 | 654 | (64.5) | 197 | (58.5) | 0.81 | (0.39–1.70) | 0.87 | (0.42–1.82) | 616 | (64.0) | 192 | (58.4) | 0.82 | (0.39–1.71) | 0.88 | (0.42–1.83) |
3 | 287 | (28.3) | 108 | (32.0) | 1.05 | (0.49–2.27) | 1.12 | (0.52–2.41) | 267 | (27.8) | 105 | (31.9) | 1.04 | (0.48–2.23) | 1.11 | (0.52–2.39) |
4 | 40 | (3.9) | 20 | (5.9) | 1.51 | (0.59–3.88) | 1.54 | (0.59–4.01) | 37 | (3.8) | 20 | (6.1) | 1.50 | (0.58–3.87) | 1.54 | (0.59–4.02) |
Densitas: BIRADS 4 | ||||||||||||||||
0–24 | 354 | (36.1) | 95 | (28.7) | 1.00 | (referent) | 1.00 | (referent) | 345 | (35.9) | 95 | (28.9) | 1.00 | (referent) | 1.00 | (referent) |
25–50 | 586 | (59.8) | 208 | (62.8) |
1.37
|
(1.02–1.83)
|
1.34
|
(1.00–1.80)
| 568 | (59.0) | 207 | (62.9) |
1.37
|
(1.02–1.83)
|
1.34
|
(1.00–1.80)
|
51+ | 40 | (4.1) | 28 | (8.5) |
2.94
|
(1.65–5.24)
|
2.83
|
(1.55–5.16)
| 39 | (4.1) | 27 | (8.2) |
2.86
|
(1.60–5.11)
|
2.76
|
(1.51–5.05)
|
Densitas: BIRADS 5 | ||||||||||||||||
A | 96 | (9.8) | 25 | (7.6) | 1.00 | (referent) | 1.00 | (referent) | 94 | (9.8) | 25 | (7.6) | 1.00 | (referent) | 1.00 | (referent) |
B | 574 | (58.6) | 185 | (57.9) | 1.25 | (0.77–2.01) | 1.20 | (0.74–1.94) | 558 | (58.0) | 185 | (56.2) | 1.25 | (0.77–2.01) | 1.20 | (0.74–1.94) |
C | 294 | (30.0) | 110 | (33.2) | 1.47 | (0.88–2.45) | 1.46 | (0.87–2.45) | 284 | (29.5) | 108 | (32.8) | 1.46 | (0.88–2.44) | 1.45 | (0.87–2.44) |
D | 16 | (1.6) | 11 | (3.3) |
2.90
|
(1.14–7.42)
| 2.59 | (0.99–6.78) | 16 | (1.7) | 11 | (3.3) |
2.90
|
(1.13–7.41)
| 2.58 | (0.99–6.76) |
Study 1 | Study 2 | |||||
---|---|---|---|---|---|---|
mCa | 95% CI | mCb | 95% CI | |||
VAS (%) | 0.651 | 0.611 | 0.691 | 0.647 | 0.607 | 0.688 |
Volpara breast density (%) | 0.571 | 0.528 | 0.618 | 0.575 | 0.534 | 0.615 |
Volpara gland volume (cm3) | 0.553 | 0.513 | 0.591 | 0.586 | 0.546 | 0.627 |
Quantra breast density (%) | 0.510 | 0.469 | 0.552 | 0.543 | 0.504 | 0.584 |
Quantra gland volume (cm3) | 0.487 | 0.447 | 0.528 | 0.531 | 0.490 | 0.574 |
Densitas breast density (%) | 0.571 | 0.526 | 0.612 | 0.587 | 0.548 | 0.628 |
Densitas dense area (cm2) | 0.535 | 0.496 | 0.574 | 0.577 | 0.537 | 0.616 |
Cumulus breast density (%) | 0.582 | 0.541 | 0.623 | - | - | - |
Cumulus dense area (cm2) | 0.558 | 0.516 | 0.599 | - | - | - |