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Erschienen in: Journal of Nephrology 5/2016

01.10.2016 | Position Papers and Guidelines

A Delphi consensus panel on nutritional therapy in chronic kidney disease

verfasst von: Vincenzo Bellizzi, Stefano Bianchi, Piergiorgio Bolasco, Giuliano Brunori, Adamasco Cupisti, Giovanni Gambaro, Loreto Gesualdo, Pasquale Polito, Domenico Santoro, Antonio Santoro

Erschienen in: Journal of Nephrology | Ausgabe 5/2016

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Abstract

The conservative management of chronic kidney disease (CKD) includes nutritional therapy (NT) with the aim to reduce the intake of proteins, phosphorus, organic acids, sodium, and potassium, while ensuring adequate caloric intake. While there is evidence that NT may help to prevent and control metabolic alterations in CKD, the criteria for implementing a low-protein regimen in CKD are still debated. There is no final consensus on the composition of the diet, nor indications for specific patient settings or different stages of CKD. Also when and how to start dietary manipulation of different nutrients in CKD is not well defined. A group of Italian nephrologists participated, under the auspices of the Italian Society of Nephrology, in a Delphi exercise to explore the consensus on some open questions regarding the nutritional treatment in CKD in Italy, generating a consensus opinion for 23 statements on: (1) general principles of NT; (2) indications for and initiation of NT; (3) role of protein-free products; (4) NT safety; (5) integrated management of NT. This Delphi exercise shows that there is broad consensus regarding NT in CKD across a wide range of management areas. These clinician-led consensus statements provide a framework for appropriate guidance on NT in patients with CKD, and are intended as a guide in decision-making whenever possible.
Literatur
1.
Zurück zum Zitat Brenner BM, Lawler EV, Mackenzie HS (1996) The hyperfiltration theory: a paradigm shift in nephrology. Kidney Int 49(6):1774–1777PubMedCrossRef Brenner BM, Lawler EV, Mackenzie HS (1996) The hyperfiltration theory: a paradigm shift in nephrology. Kidney Int 49(6):1774–1777PubMedCrossRef
4.
Zurück zum Zitat Stevens PE, Levin A, Kidney Disease: Improving Global Outcomes Chronic Kidney Disease Guideline Development Work Group M (2013) Evaluation and management of chronic kidney disease: synopsis of the kidney disease: improving global outcomes 2012 clinical practice guideline. Ann Intern Med 158(11):825–830. doi:10.7326/0003-4819-158-11-201306040-00007 PubMedCrossRef Stevens PE, Levin A, Kidney Disease: Improving Global Outcomes Chronic Kidney Disease Guideline Development Work Group M (2013) Evaluation and management of chronic kidney disease: synopsis of the kidney disease: improving global outcomes 2012 clinical practice guideline. Ann Intern Med 158(11):825–830. doi:10.​7326/​0003-4819-158-11-201306040-00007 PubMedCrossRef
5.
Zurück zum Zitat Cianciaruso B, Italian Society of N (2003) Conservative therapy Guidelines for chronic renal failure. G Ital Nefrol 20(Suppl 24):S48–S60PubMed Cianciaruso B, Italian Society of N (2003) Conservative therapy Guidelines for chronic renal failure. G Ital Nefrol 20(Suppl 24):S48–S60PubMed
6.
Zurück zum Zitat Aparicio M, Bellizzi V, Chauveau P, Cupisti A, Ecder T, Fouque D, Garneata L, Lin S, Mitch WE, Teplan V, Zakar G, Yu X (2012) Keto acid therapy in predialysis chronic kidney disease patients: final consensus. J Ren Nutr 22(2 Suppl):S22–S24. doi:10.1053/j.jrn.2011.09.006 PubMedCrossRef Aparicio M, Bellizzi V, Chauveau P, Cupisti A, Ecder T, Fouque D, Garneata L, Lin S, Mitch WE, Teplan V, Zakar G, Yu X (2012) Keto acid therapy in predialysis chronic kidney disease patients: final consensus. J Ren Nutr 22(2 Suppl):S22–S24. doi:10.​1053/​j.​jrn.​2011.​09.​006 PubMedCrossRef
9.
Zurück zum Zitat Hasson F, Keeney S, McKenna H (2000) Research guidelines for the Delphi survey technique. J Adv Nurs 32(4):1008–1015PubMed Hasson F, Keeney S, McKenna H (2000) Research guidelines for the Delphi survey technique. J Adv Nurs 32(4):1008–1015PubMed
10.
Zurück zum Zitat Dalkey N, Helmer O (1963) Delphi technique: characteristics and sequence model to the use of experts. Manage Sci 9:458–467CrossRef Dalkey N, Helmer O (1963) Delphi technique: characteristics and sequence model to the use of experts. Manage Sci 9:458–467CrossRef
11.
Zurück zum Zitat Lynn MR, Layman EL, Englebardt SP (1998) Nursing administration research priorities. A national Delphi study. J Nurs Adm 28(5):7–11PubMedCrossRef Lynn MR, Layman EL, Englebardt SP (1998) Nursing administration research priorities. A national Delphi study. J Nurs Adm 28(5):7–11PubMedCrossRef
12.
Zurück zum Zitat McKenna HP (1994) The Delphi technique: a worthwhile research approach for nursing? J Adv Nurs 19(6):1221–1225PubMedCrossRef McKenna HP (1994) The Delphi technique: a worthwhile research approach for nursing? J Adv Nurs 19(6):1221–1225PubMedCrossRef
13.
Zurück zum Zitat Evans C (1997) The use of consensus methods and expert panels in pharmacoeconomic studies. Practical applications and methodological shortcomings. Pharmacoeconomics 12(2 Pt 1):121–129PubMedCrossRef Evans C (1997) The use of consensus methods and expert panels in pharmacoeconomic studies. Practical applications and methodological shortcomings. Pharmacoeconomics 12(2 Pt 1):121–129PubMedCrossRef
15.
Zurück zum Zitat Murphy MK, Black NA, Lamping DL, McKee CM, Sanderson CF, Askham J, Marteau T (1998) Consensus development methods, and their use in clinical guideline development. Health Technol Assess 2(3):1–88 (i–iv) Murphy MK, Black NA, Lamping DL, McKee CM, Sanderson CF, Askham J, Marteau T (1998) Consensus development methods, and their use in clinical guideline development. Health Technol Assess 2(3):1–88 (i–iv)
16.
18.
Zurück zum Zitat Girolomoni G, Altomare G, Ayala F, Berardesca E, Calzavara Pinton P, Chimenti S, Martini P, Peserico A, Puglisi Guerra A, Vena GA, Delphi working g (2015) Differential management of mild-to-severe psoriasis with biologic drugs: An Italian Delphi consensus expert panel. J Dermatolog Treat 26(2):128–133. doi:10.3109/09546634.2014.907466 PubMedCrossRef Girolomoni G, Altomare G, Ayala F, Berardesca E, Calzavara Pinton P, Chimenti S, Martini P, Peserico A, Puglisi Guerra A, Vena GA, Delphi working g (2015) Differential management of mild-to-severe psoriasis with biologic drugs: An Italian Delphi consensus expert panel. J Dermatolog Treat 26(2):128–133. doi:10.​3109/​09546634.​2014.​907466 PubMedCrossRef
19.
Zurück zum Zitat National Kidney Foundation (2002) K/DOQI clinical practice guidelines for chronic kidney disease: evaluation, classification and stratification (2002). Guideline 9. Association of level of GFR with nutritional status. Am J Kidney Dis 39(suppl 1):S145–S163 National Kidney Foundation (2002) K/DOQI clinical practice guidelines for chronic kidney disease: evaluation, classification and stratification (2002). Guideline 9. Association of level of GFR with nutritional status. Am J Kidney Dis 39(suppl 1):S145–S163
21.
Zurück zum Zitat Johnson DW, Atai E, Chan M, Phoon RK, Scott C, Toussaint ND, Turner GL, Usherwood T, Wiggins KJ, Kha C (2013) KHA-CARI guideline: early chronic kidney disease: detection, prevention and management. Nephrology (Carlton) 18(5):340–350. doi:10.1111/nep.12052 CrossRef Johnson DW, Atai E, Chan M, Phoon RK, Scott C, Toussaint ND, Turner GL, Usherwood T, Wiggins KJ, Kha C (2013) KHA-CARI guideline: early chronic kidney disease: detection, prevention and management. Nephrology (Carlton) 18(5):340–350. doi:10.​1111/​nep.​12052 CrossRef
23.
25.
Zurück zum Zitat Aparicio M, Bellizzi V, Chauveau P, Cupisti A, Ecder T, Fouque D, Garneata L, Lin S, Mitch W, Teplan V, Yu X, Zakar G (2013) Do ketoanalogues still have a role in delaying dialysis initiation in CKD predialysis patients? Semin Dial 26(6):714–719. doi:10.1111/sdi.12132 PubMedCrossRef Aparicio M, Bellizzi V, Chauveau P, Cupisti A, Ecder T, Fouque D, Garneata L, Lin S, Mitch W, Teplan V, Yu X, Zakar G (2013) Do ketoanalogues still have a role in delaying dialysis initiation in CKD predialysis patients? Semin Dial 26(6):714–719. doi:10.​1111/​sdi.​12132 PubMedCrossRef
27.
Zurück zum Zitat Bellizzi V, Chiodini P, Cupisti A, Viola BF, Pezzotta M, De Nicola L, Minutolo R, Barsotti G, Piccoli GB, Di Iorio B (2015) Very low-protein diet plus ketoacids in chronic kidney disease and risk of death during end-stage renal disease: a historical cohort controlled study. Nephrol Dial Transplant 30(1):71–77. doi:10.1093/ndt/gfu251 PubMedCrossRef Bellizzi V, Chiodini P, Cupisti A, Viola BF, Pezzotta M, De Nicola L, Minutolo R, Barsotti G, Piccoli GB, Di Iorio B (2015) Very low-protein diet plus ketoacids in chronic kidney disease and risk of death during end-stage renal disease: a historical cohort controlled study. Nephrol Dial Transplant 30(1):71–77. doi:10.​1093/​ndt/​gfu251 PubMedCrossRef
28.
Zurück zum Zitat Levey AS, Adler S, Caggiula AW, England BK, Greene T, Hunsicker LG, Kusek JW, Rogers NL, Teschan PE (1996) Effects of dietary protein restriction on the progression of advanced renal disease in the Modification of Diet in Renal Disease Study. Am J Kidney Dis 27(5):652–663PubMedCrossRef Levey AS, Adler S, Caggiula AW, England BK, Greene T, Hunsicker LG, Kusek JW, Rogers NL, Teschan PE (1996) Effects of dietary protein restriction on the progression of advanced renal disease in the Modification of Diet in Renal Disease Study. Am J Kidney Dis 27(5):652–663PubMedCrossRef
29.
Zurück zum Zitat Barsotti G, Morelli E, Cupisti A, Bertoncini P, Giovannetti S (1991) A special, supplemented ‘vegan’ diet for nephrotic patients. Am J Nephrol 11(5):380–385PubMedCrossRef Barsotti G, Morelli E, Cupisti A, Bertoncini P, Giovannetti S (1991) A special, supplemented ‘vegan’ diet for nephrotic patients. Am J Nephrol 11(5):380–385PubMedCrossRef
31.
Zurück zum Zitat Kaysen GA, Gambertoglio J, Jimenez I, Jones H, Hutchison FN (1986) Effect of dietary protein intake on albumin homeostasis in nephrotic patients. Kidney Int 29(2):572–577PubMedCrossRef Kaysen GA, Gambertoglio J, Jimenez I, Jones H, Hutchison FN (1986) Effect of dietary protein intake on albumin homeostasis in nephrotic patients. Kidney Int 29(2):572–577PubMedCrossRef
33.
Zurück zum Zitat Castellino P, Cataliotti A (2002) Changes of protein kinetics in nephrotic patients. Curr Opin Clin Nutr Metab Care 5(1):51–54PubMedCrossRef Castellino P, Cataliotti A (2002) Changes of protein kinetics in nephrotic patients. Curr Opin Clin Nutr Metab Care 5(1):51–54PubMedCrossRef
35.
Zurück zum Zitat Ash S, Campbell KL, MacLaughlin H, McCoy E, Chan M, Anderson K, Corke K (2006) Evidence based practice guidelines for the nutritional management of chronic kidney disease. Nutrition Dietitics 63(Suppl 2):S35–S45 Ash S, Campbell KL, MacLaughlin H, McCoy E, Chan M, Anderson K, Corke K (2006) Evidence based practice guidelines for the nutritional management of chronic kidney disease. Nutrition Dietitics 63(Suppl 2):S35–S45
37.
Zurück zum Zitat Fouque D, Vennegoor M, ter Wee P, Wanner C, Basci A, Canaud B, Haage P, Konner K, Kooman J, Martin-Malo A, Pedrini L, Pizzarelli F, Tattersall J, Tordoir J, Vanholder R (2007) EBPG guideline on nutrition. Nephrol Dial Transplant 22(Suppl 2):ii45–87. doi:10.1093/ndt/gfm020 PubMed Fouque D, Vennegoor M, ter Wee P, Wanner C, Basci A, Canaud B, Haage P, Konner K, Kooman J, Martin-Malo A, Pedrini L, Pizzarelli F, Tattersall J, Tordoir J, Vanholder R (2007) EBPG guideline on nutrition. Nephrol Dial Transplant 22(Suppl 2):ii45–87. doi:10.​1093/​ndt/​gfm020 PubMed
38.
39.
Zurück zum Zitat Wesson DE, Simoni J (2010) Acid retention during kidney failure induces endothelin and aldosterone production which lead to progressive GFR decline, a situation ameliorated by alkali diet. Kidney Int 78(11):1128–1135. doi:10.1038/ki.2010.348 PubMedCrossRef Wesson DE, Simoni J (2010) Acid retention during kidney failure induces endothelin and aldosterone production which lead to progressive GFR decline, a situation ameliorated by alkali diet. Kidney Int 78(11):1128–1135. doi:10.​1038/​ki.​2010.​348 PubMedCrossRef
40.
Zurück zum Zitat Williams B, Hattersley J, Layward E, Walls J (1991) Metabolic acidosis and skeletal muscle adaptation to low protein diets in chronic uremia. Kidney Int 40(4):779–786PubMedCrossRef Williams B, Hattersley J, Layward E, Walls J (1991) Metabolic acidosis and skeletal muscle adaptation to low protein diets in chronic uremia. Kidney Int 40(4):779–786PubMedCrossRef
41.
Zurück zum Zitat Banerjee T, Crews DC, Wesson DE, Tilea A, Saran R, Rios Burrows N, Williams DE, Powe NR, Centers for Disease C, Prevention Chronic Kidney Disease Surveillance T (2014) Dietary acid load and chronic kidney disease among adults in the United States. BMC Nephrol 15:137. doi:10.1186/1471-2369-15-137 PubMedPubMedCentralCrossRef Banerjee T, Crews DC, Wesson DE, Tilea A, Saran R, Rios Burrows N, Williams DE, Powe NR, Centers for Disease C, Prevention Chronic Kidney Disease Surveillance T (2014) Dietary acid load and chronic kidney disease among adults in the United States. BMC Nephrol 15:137. doi:10.​1186/​1471-2369-15-137 PubMedPubMedCentralCrossRef
42.
Zurück zum Zitat Kiisk L, Kaarma H, Ots-Rosenberg M (2012) Impact of anthropometric measurements in clinical practice. Coll Antropol 36(4):1325–1333PubMed Kiisk L, Kaarma H, Ots-Rosenberg M (2012) Impact of anthropometric measurements in clinical practice. Coll Antropol 36(4):1325–1333PubMed
43.
Zurück zum Zitat National Institute of Health and Clinical Excellence (NICE) (2008) CG73 Chronic kidney disease: early identification and management of chronic kidney disease in adults in primary and secondary care. NICE guideline 73. https://www.nice.org.uk/guidance/cg73. Accessed 9 June 2016 National Institute of Health and Clinical Excellence (NICE) (2008) CG73 Chronic kidney disease: early identification and management of chronic kidney disease in adults in primary and secondary care. NICE guideline 73. https://​www.​nice.​org.​uk/​guidance/​cg73. Accessed 9 June 2016
44.
Zurück zum Zitat Srivastava N, Singh RG, Alok K, Singh S (2014) Variation of body fat percentage with special reference to diet modification in patients with chronic kidney disease: a longitudinal study. Saudi J Kidney Dis Transpl 25(4):793–800PubMedCrossRef Srivastava N, Singh RG, Alok K, Singh S (2014) Variation of body fat percentage with special reference to diet modification in patients with chronic kidney disease: a longitudinal study. Saudi J Kidney Dis Transpl 25(4):793–800PubMedCrossRef
46.
47.
Zurück zum Zitat Hecking E, Bragg-Gresham JL, Rayner HC, Pisoni RL, Andreucci VE, Combe C, Greenwood R, McCullough K, Feldman HI, Young EW, Held PJ, Port FK (2004) Haemodialysis prescription, adherence and nutritional indicators in five European countries: results from the Dialysis Outcomes and Practice Patterns Study (DOPPS). Nephrol Dial Transplant 19(1):100–107PubMedCrossRef Hecking E, Bragg-Gresham JL, Rayner HC, Pisoni RL, Andreucci VE, Combe C, Greenwood R, McCullough K, Feldman HI, Young EW, Held PJ, Port FK (2004) Haemodialysis prescription, adherence and nutritional indicators in five European countries: results from the Dialysis Outcomes and Practice Patterns Study (DOPPS). Nephrol Dial Transplant 19(1):100–107PubMedCrossRef
48.
Zurück zum Zitat Bellizzi V, Di Iorio BR, Brunori G, De Nicola L, Minutolo R, Conte G, Cianciaruso B, Scalfi L (2010) Assessment of nutritional practice in Italian chronic kidney disease clinics: a questionnaire-based survey. J Ren Nutr 20(2):82–90. doi:10.1053/j.jrn.2009.05.001 PubMedCrossRef Bellizzi V, Di Iorio BR, Brunori G, De Nicola L, Minutolo R, Conte G, Cianciaruso B, Scalfi L (2010) Assessment of nutritional practice in Italian chronic kidney disease clinics: a questionnaire-based survey. J Ren Nutr 20(2):82–90. doi:10.​1053/​j.​jrn.​2009.​05.​001 PubMedCrossRef
50.
Zurück zum Zitat Brown AK, O’Connor PJ, Roberts TE, Wakefield RJ, Karim Z, Emery P (2005) Recommendations for musculoskeletal ultrasonography by rheumatologists: setting global standards for best practice by expert consensus. Arthritis Rheum 53(1):83–92. doi:10.1002/art.20926 PubMedCrossRef Brown AK, O’Connor PJ, Roberts TE, Wakefield RJ, Karim Z, Emery P (2005) Recommendations for musculoskeletal ultrasonography by rheumatologists: setting global standards for best practice by expert consensus. Arthritis Rheum 53(1):83–92. doi:10.​1002/​art.​20926 PubMedCrossRef
51.
Zurück zum Zitat Iagnocco A, Porta F, Cuomo G, Delle Sedie A, Filippucci E, Grassi W, Sakellariou G, Epis O, Adinolfi A, Ceccarelli F, De Lucia O, Di Geso L, Di Sabatino V, Gabba A, Gattamelata A, Gutierrez M, Massaro L, Massarotti M, Perricone C, Picerno V, Ravagnani V, Riente L, Scioscia C, Naredo E, Filippou G, Musculoskeletal Ultrasound Study Group of the Italian Society of R (2014) The Italian MSUS Study Group recommendations for the format and content of the report and documentation in musculoskeletal ultrasonography in rheumatology. Rheumatology (Oxford) 53(2):367–373. doi:10.1093/rheumatology/ket356 CrossRef Iagnocco A, Porta F, Cuomo G, Delle Sedie A, Filippucci E, Grassi W, Sakellariou G, Epis O, Adinolfi A, Ceccarelli F, De Lucia O, Di Geso L, Di Sabatino V, Gabba A, Gattamelata A, Gutierrez M, Massaro L, Massarotti M, Perricone C, Picerno V, Ravagnani V, Riente L, Scioscia C, Naredo E, Filippou G, Musculoskeletal Ultrasound Study Group of the Italian Society of R (2014) The Italian MSUS Study Group recommendations for the format and content of the report and documentation in musculoskeletal ultrasonography in rheumatology. Rheumatology (Oxford) 53(2):367–373. doi:10.​1093/​rheumatology/​ket356 CrossRef
53.
Zurück zum Zitat Mahler DA, Selecky PA, Harrod CG, Benditt JO, Carrieri-Kohlman V, Curtis JR, Manning HL, Mularski RA, Varkey B, Campbell M, Carter ER, Chiong JR, Ely EW, Hansen-Flaschen J, O’Donnell DE, Waller A (2010) American College of Chest Physicians consensus statement on the management of dyspnea in patients with advanced lung or heart disease. Chest 137(3):674–691. doi:10.1378/chest.09-1543 PubMedCrossRef Mahler DA, Selecky PA, Harrod CG, Benditt JO, Carrieri-Kohlman V, Curtis JR, Manning HL, Mularski RA, Varkey B, Campbell M, Carter ER, Chiong JR, Ely EW, Hansen-Flaschen J, O’Donnell DE, Waller A (2010) American College of Chest Physicians consensus statement on the management of dyspnea in patients with advanced lung or heart disease. Chest 137(3):674–691. doi:10.​1378/​chest.​09-1543 PubMedCrossRef
54.
Zurück zum Zitat Italian Association of Hospital Gastroenterologists and Endoscopists, Italian Association for the Study of the Pancreas Buscarini et al (2014) Italian consensus guidelines for the diagnostic work-up and follow-up of cystic pancreatic neoplasms. Dig Liver Dis 46(6):479–493. doi:10.1016/j.dld.2013.12.019 PubMedCrossRef Italian Association of Hospital Gastroenterologists and Endoscopists, Italian Association for the Study of the Pancreas Buscarini et al (2014) Italian consensus guidelines for the diagnostic work-up and follow-up of cystic pancreatic neoplasms. Dig Liver Dis 46(6):479–493. doi:10.​1016/​j.​dld.​2013.​12.​019 PubMedCrossRef
55.
Zurück zum Zitat Cupisti A, Bottai A, Bellizzi V, Brunori G, Cianciaruso B, De Nicola L, Oldrizzi L, Quintaliani G, Santoro D, Di Iorio BR (2015) Characteristics of patients with chronic kidney disease referred to a nephrology outpatient clinic: results of Nefrodata study. G Ital Nefrol 32(2):36 Cupisti A, Bottai A, Bellizzi V, Brunori G, Cianciaruso B, De Nicola L, Oldrizzi L, Quintaliani G, Santoro D, Di Iorio BR (2015) Characteristics of patients with chronic kidney disease referred to a nephrology outpatient clinic: results of Nefrodata study. G Ital Nefrol 32(2):36
Metadaten
Titel
A Delphi consensus panel on nutritional therapy in chronic kidney disease
verfasst von
Vincenzo Bellizzi
Stefano Bianchi
Piergiorgio Bolasco
Giuliano Brunori
Adamasco Cupisti
Giovanni Gambaro
Loreto Gesualdo
Pasquale Polito
Domenico Santoro
Antonio Santoro
Publikationsdatum
01.10.2016
Verlag
Springer International Publishing
Erschienen in
Journal of Nephrology / Ausgabe 5/2016
Print ISSN: 1121-8428
Elektronische ISSN: 1724-6059
DOI
https://doi.org/10.1007/s40620-016-0323-4

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