Erschienen in:
12.04.2021 | Case Report
A fatal wound complication following sequential anti-angiogenesis, immune checkpoint inhibition and ultra-hypofractionated radiotherapy
verfasst von:
Miha Orazem, Cédric Draulans, Mathieu Spaas, Eric Van Cutsem, Marina Debecker, Gert De Meerleer, Sabine Tejpar, Jeroen Dekervel, Karin Haustermans
Erschienen in:
Clinical Journal of Gastroenterology
|
Ausgabe 4/2021
Einloggen, um Zugang zu erhalten
Abstract
Purpose
Multimodality treatments combining radiotherapy, immune therapy and/or targeted therapy are under heavy investigation. Promising data from clinical trials are emerging, nevertheless unexpected interactions and adverse events should not be overlooked.
Case presentation
Here we present a case study of a patient with metastatic colon adenocarcinoma treated sequentially with a chemotherapy/targeted therapy combination, immune checkpoint inhibitors and ultra-hypofractionated radiotherapy. After radiation treatment, the patient developed extensive posterior abdominal wall wounds coinciding with regression of the irradiated metastatic tumour mass and marked elevation of the inflammation parameters.
Conclusion
This case represents an unusual fatal wound complication after palliative ultra-hypofractionated radiotherapy. Further research into synergistic effects of sequential radiotherapy and anti-angiogenesis therapy may provide an advantage in anticipating severe sequelae.