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Cancer Immunology, Immunotherapy

Erschienen in:

01.12.2009 | Original Article

A genetic variant of immunoglobulin γ2 is strongly associated with immunity to mucin 1 in patients with breast cancer

verfasst von: Janardan P. Pandey, Paul J. Nietert, Kersti Klaamas, Oleg Kurtenkov

Erschienen in: Cancer Immunology, Immunotherapy | Ausgabe 12/2009

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Abstract

High levels of antibodies to mucin 1 (MUC1), a membrane-bound glycoprotein that is overexpressed in adenocarcinomas, are associated with good prognosis in patients with breast cancer. The aim of the present investigation was to determine whether GM and KM allotypes—genetic markers of IgG heavy chains and κ-type light chains, respectively—contribute to the magnitude of natural antibody responsiveness to MUC1 in patients with breast cancer. A total of 153 Caucasian subjects with breast cancer were allotyped for several GM and KM markers. These subjects were also characterized for IgG and IgM antibodies to MUC1. Anti-MUC1 IgG antibody levels in subjects who were carriers of the immunoglobulin γ2 allele GM 23 were significantly higher than in those who were noncarriers (P = 0.003). These results could potentially divide the population into high or low responders to MUC1, which has important implications for MUC1-based immunotherapeutic interventions in breast cancer.

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Titel: A genetic variant of immunoglobulin γ2 is strongly associated with immunity to mucin 1 in patients with breast cancer
verfasst von: Janardan P. Pandey
Paul J. Nietert
Kersti Klaamas
Oleg Kurtenkov
Publikationsdatum: 01.12.2009
Verlag: Springer-Verlag
Erschienen in: Cancer Immunology, Immunotherapy / Ausgabe 12/2009
Print ISSN: 0340-7004
Elektronische ISSN: 1432-0851
DOI: https://doi.org/10.1007/s00262-009-0709-4

Springer Medizin

A genetic variant of immunoglobulin γ2 is strongly associated with immunity to mucin 1 in patients with breast cancer

Abstract

Neu im Fachgebiet Onkologie

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Springer Medizin

Abstract

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