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01.05.2015 | Original Article

A myocardial perfusion imaging system using a multifocal collimator for detecting coronary artery disease: validation with invasive coronary angiography

verfasst von: Yutaka Ogino, Yoriko Horiguchi, Tomohiro Ueda, Tomofumi Shiomori, Masahiko Kanna, Tomoko Kawaminami, Naoki Iinuma, Yuta Sudo, Yukiko Morita

Erschienen in: Annals of Nuclear Medicine | Ausgabe 4/2015

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Abstract

Objective

Myocardial perfusion imaging (MPI) systems using a multifocal collimator can reduce scan time substantially compared with conventional MPI systems. In this study, we evaluated the diagnostic accuracy of multifocal collimator SPECT/CT in coronary artery disease (CAD) detection by comparing it with coronary artery angiography (CAG).

Methods

We retrospectively analyzed 50 consecutive patients who had undergone CAG and stress ²⁰¹Tl MPI multifocal collimator SPECT/CT within a 3-month period. A summed difference score (SDS) was calculated for each vascular territory from the MPI images. On CAG, a stenotic coronary artery was defined as one with luminal narrowing of ≥75 % with quantitative coronary angiography software.

Results

We analyzed the diagnostic accuracy of coronary artery stenosis detection using the definition that a coronary artery territory was ischemic when the SDS per vessel was ≥2. We generated receiver operating characteristic (ROC) curves to evaluate the usefulness of SDS per vascular territory to find coronary artery stenoses. The area under the ROC curve was 0.86 and cut-off value was 2. Sensitivity, specificity, positive predictive value, negative predictive value, and accuracy to detect stenoses were 85, 83, 66, 94 and 84 %, respectively.

Conclusions

We confirmed the high accuracy of imaging with multifocal collimator SPECT/CT for detection of angiographically significant CAD.

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Titel: A myocardial perfusion imaging system using a multifocal collimator for detecting coronary artery disease: validation with invasive coronary angiography
verfasst von: Yutaka Ogino
Yoriko Horiguchi
Tomohiro Ueda
Tomofumi Shiomori
Masahiko Kanna
Tomoko Kawaminami
Naoki Iinuma
Yuta Sudo
Yukiko Morita
Publikationsdatum: 01.05.2015
Verlag: Springer Japan
Erschienen in: Annals of Nuclear Medicine / Ausgabe 4/2015
Print ISSN: 0914-7187
Elektronische ISSN: 1864-6433
DOI: https://doi.org/10.1007/s12149-015-0955-9

Springer Medizin

Abstract

Objective

Methods

Results

Conclusions

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