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01.10.2017 | Note

A new biphenyl ether derivative produced by Indonesian ascidian-derived Penicillium albobiverticillium

verfasst von: Deiske A. Sumilat, Hiroyuki Yamazaki, Kotaro Endo, Henki Rotinsulu, Defny S. Wewengkang, Kazuyo Ukai, Michio Namikoshi

Erschienen in: Journal of Natural Medicines | Ausgabe 4/2017

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Abstract

A new biphenyl ether derivative, 2-hydroxy-6-(2′-hydroxy-3′-hydroxymethyl-5-methylphenoxy)-benzoic acid (1), was isolated together with the known benzophenone derivative, monodictyphenone (2), from a culture broth of Indonesian ascidian-derived Penicillium albobiverticillium TPU1432 by solvent extraction, ODS column chromatography, and preparative HPLC (ODS). The structure of 1 was elucidated based on NMR experiments. Compound 2 exhibited moderate inhibitory activities against protein tyrosine phosphatase (PTP) 1B, T cell PTP (TCPTP), and CD45 tyrosine phosphatase (CD45), whereas compound 1 modestly inhibited CD45 activity.

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Titel: A new biphenyl ether derivative produced by Indonesian ascidian-derived Penicillium albobiverticillium
verfasst von: Deiske A. Sumilat
Hiroyuki Yamazaki
Kotaro Endo
Henki Rotinsulu
Defny S. Wewengkang
Kazuyo Ukai
Michio Namikoshi
Publikationsdatum: 01.10.2017
Verlag: Springer Singapore
Erschienen in: Journal of Natural Medicines / Ausgabe 4/2017
Print ISSN: 1340-3443
Elektronische ISSN: 1861-0293
DOI: https://doi.org/10.1007/s11418-017-1094-5

Die Highlights vom Kongress des American College of Cardiology 2024

Springer Medizin

A new biphenyl ether derivative produced by Indonesian ascidian-derived Penicillium albobiverticillium

Abstract

Die Highlights vom Kongress des American College of Cardiology 2024

Springer Medizin

Abstract

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