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01.01.2006 | Original Paper

A new indole alkaloid, 7-hydroxyspeciociliatine, from the fruits of Malaysian Mitragyna speciosa and its opioid agonistic activity

verfasst von: Mariko Kitajima, Kaori Misawa, Noriyuki Kogure, Ikram M. Said, Syunji Horie, Yoshio Hatori, Toshihiko Murayama, Hiromitsu Takayama

Erschienen in: Journal of Natural Medicines | Ausgabe 1/2006

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Abstract

A new indole alkaloid, 7-hydroxyspeciociliatine (1), was isolated from the fruits of Malaysian Mitragyna speciosa Korth., together with 11 known indole and oxindole alkaloids (3–13). The structure of the new compound was determined by spectroscopic analysis and chemical conversion. The opioid agonistic activity of the new alkaloid was investigated in guinea-pig ileum experiments. The compound was found to have a weak stimulatory effect on μ-opioid receptors.

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Titel: A new indole alkaloid, 7-hydroxyspeciociliatine, from the fruits of Malaysian Mitragyna speciosa and its opioid agonistic activity
verfasst von: Mariko Kitajima
Kaori Misawa
Noriyuki Kogure
Ikram M. Said
Syunji Horie
Yoshio Hatori
Toshihiko Murayama
Hiromitsu Takayama
Publikationsdatum: 01.01.2006
Verlag: Springer-Verlag
Erschienen in: Journal of Natural Medicines / Ausgabe 1/2006
Print ISSN: 1340-3443
Elektronische ISSN: 1861-0293
DOI: https://doi.org/10.1007/s11418-005-0001-7

Springer Medizin

Abstract

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