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Erschienen in:
01.06.2013 | Colorectal Cancer
A New Policy Regarding Ovarian Resection in Young Women Treated for Peritoneal Carcinomatosis
Erschienen in: Annals of Surgical Oncology | Ausgabe 6/2013
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Objective
To appreciate if the ovaries can be preserved in selected young women with peritoneal carcinomatosis (PC).
Background
The traditional rule is to resect the ovaries systematically when PC is found at surgery.
Methods
A new policy was developed to preserve the ovaries when they were macroscopically normal in young women with PC of different origin who expressed a strong desire for future pregnancy.
Results
A total of 106 women younger than age 41 years underwent complete cytoreductive surgery plus hyperthermic intraperitoneal chemotherapy. At least one ovary was preserved in 29 % of them (and in 44 % of those who strongly wished future pregnancy). Among resected “normal” ovaries, 17 % were involved by tumor at the final pathologic examination. Among the resected “suspicious” ovaries, 38 % were involved. Among the 29 preserved ovaries (in 21 women), after a median follow-up of 32 months, 4 (14 %) developed ovarian recurrence, in 3 of them associated with other metastases. Two women became pregnant. In five women with partially normal ovary, egg harvesting and cryopreservation was performed.
Conclusions
This new policy allowed ovarian preservation in 44 % of the young women wishing childbearing and allowed two births. Recurrence in the preserved ovary was 14 % with our criteria of selection. This policy is promising but can be further improved.