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01.07.2010 | Original paper

A prospective study of one-carbon metabolism biomarkers and risk of renal cell carcinoma

verfasst von: Todd M. Gibson, Stephanie J. Weinstein, Susan T. Mayne, Ruth M. Pfeiffer, Jacob Selhub, Philip R. Taylor, Jarmo Virtamo, Demetrius Albanes, Rachael Stolzenberg-Solomon

Erschienen in: Cancer Causes & Control | Ausgabe 7/2010

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Abstract

Objective

Previous studies have found associations between one-carbon metabolism factors and risk of several cancers, but little is known regarding renal cell carcinoma (RCC). We conducted a nested case–control study within the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study, a prospective study of Finnish male smokers aged 50–69 at baseline.

Methods

Prediagnostic folate, vitamin B₆, vitamin B₁₂, cysteine, riboflavin, and homocysteine concentrations were measured in fasting serum from 224 incident RCC cases and 224 controls (matched on age and date of serum collection). Conditional logistic regression was used to calculate odds ratios (ORs) and 95% confidence intervals (CIs), adjusted for potential confounders.

Results

Serum folate tended to be inversely associated with RCC, compared to the first quartile, the odds ratios (95% CI) for subsequent quartiles were 0.62 (0.35–1.08), 0.52 (0.29–0.93), and 0.67 (0.37–1.20) (P-trend = 0.19). When modeled as a threshold effect, subjects in the lowest serum folate quartile (≤6.64 nmol/l), which corresponds to deficient folate status, had a significant increased RCC risk (OR = 1.68, 95% CI 1.06–2.65) compared to those with higher serum folate. The other one-carbon metabolism biomarkers were not associated with RCC.

Conclusions

This study in male smokers suggests that deficient folate status may increase risk of RCC, but confirmation is needed in other epidemiologic studies that include women and non-smokers.

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Titel: A prospective study of one-carbon metabolism biomarkers and risk of renal cell carcinoma
verfasst von: Todd M. Gibson
Stephanie J. Weinstein
Susan T. Mayne
Ruth M. Pfeiffer
Jacob Selhub
Philip R. Taylor
Jarmo Virtamo
Demetrius Albanes
Rachael Stolzenberg-Solomon
Publikationsdatum: 01.07.2010
Verlag: Springer Netherlands
Erschienen in: Cancer Causes & Control / Ausgabe 7/2010
Print ISSN: 0957-5243
Elektronische ISSN: 1573-7225
DOI: https://doi.org/10.1007/s10552-010-9534-5

Springer Medizin

A prospective study of one-carbon metabolism biomarkers and risk of renal cell carcinoma