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European Journal of Nuclear Medicine and Molecular Imaging

Erschienen in:

23.12.2021 | Original Article

A pure nanoICG-based homogeneous lipiodol formulation: toward precise surgical navigation of primary liver cancer after long-term transcatheter arterial embolization

verfasst von: Yang Zhang, Hongwei Cheng, Hu Chen, Peiyao Xu, En Ren, Yonghe Jiang, Dengfeng Li, Xing Gao, Yating Zheng, Pan He, Huirong Lin, Biaoqi Chen, Gan Lin, Aizheng Chen, Chengchao Chu, Jingsong Mao, Gang Liu

Erschienen in: European Journal of Nuclear Medicine and Molecular Imaging | Ausgabe 8/2022

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Abstract

Purpose

To surmount the critical issues of indocyanine green (ICG), and thus achieving a precise surgical navigation of primary liver cancer after long-term transcatheter arterial embolization.

Methods

In this study, a facile and green pure-nanomedicine formulation technology is developed to construct carrier-free indocyanine green nanoparticles (nanoICG), and which subsequently dispersed into lipiodol via a super-stable homogeneous lipiodol formulation technology (SHIFT nanoICG) for transcatheter arterial embolization combined near-infrared fluorescence-guided precise hepatectomy.

Results

SHIFT nanoICG integrates excellent anti-photobleaching capacity, great optical imaging property, and specific tumoral deposition to recognize tumor regions, featuring entire-process enduring fluorescent-guided precise hepatectomy, especially in resection of the indiscoverable satellite lesions (0.6 mm × 0.4 mm) in rabbit bearing VX2 orthotopic hepatocellular carcinoma models.

Conclusion

Such a simple and effective strategy provides a promising avenue to address the clinical issue of clinical hepatectomy and has excellent potential for a translational pipeline.

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Titel: A pure nanoICG-based homogeneous lipiodol formulation: toward precise surgical navigation of primary liver cancer after long-term transcatheter arterial embolization
verfasst von: Yang Zhang
Hongwei Cheng
Hu Chen
Peiyao Xu
En Ren
Yonghe Jiang
Dengfeng Li
Xing Gao
Yating Zheng
Pan He
Huirong Lin
Biaoqi Chen
Gan Lin
Aizheng Chen
Chengchao Chu
Jingsong Mao
Gang Liu
Publikationsdatum: 23.12.2021
Verlag: Springer Berlin Heidelberg
Erschienen in: European Journal of Nuclear Medicine and Molecular Imaging / Ausgabe 8/2022
Print ISSN: 1619-7070
Elektronische ISSN: 1619-7089
DOI: https://doi.org/10.1007/s00259-021-05654-z

Springer Medizin

Abstract

Purpose

Methods

Results

Conclusion

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