A Randomized Study of Minimally Invasive Percutaneous Nephrolithotomy (MPCNL) with the aid of a patented suctioning sheath in the treatment of renal calculus complicated by pyonephrosis by one surgery
verfasst von:
Jianrong Huang, Leming Song, Donghua Xie, Monong Li, Xiaolin Deng, Min Hu, Zuofeng Peng, Tairong Liu, Chuance Du, Lei Yao, Shengfeng Liu, Shulin Guo, Jiuqing Zhong
Calculus pyonephrosis is difficult to manage. The aim of this study is to explore the value of a patented suctioning sheath assisted minimally invasive percutaneous nephrolithotomy (MPCNL) in the treatment of calculus pyonephrosis.
Methods
One hundred and eighty two patients with calculus pyonephrosis were randomizely divided into observation group (n = 91) and control group (n = 91). The control group was treated with MPCNL traditionally using peel-away sheath while the observation group was treated with MPCNL using the patented suctioning sheath.
Results
All the patients in the observation group underwent one stage surgical treatment, 14 patients in the control group underwent first-stage surgery with the rest of the group underwent one stage surgery. The complication rate was 12.1% in the observation group, significantly lower than the rate in the control group which was 51.6%; One surgery stone clearance in the observation group was 96.7% while it was 73.6% in the control group; operative time in the observation group was (54.5 ± 14.5) min, compared to (70.2 ± 11.7) min in the control group; the bleeding amount in the observation group was (126.4 ± 47.2) ml, compared to (321.6 ± 82.5) ml in the control group; the hospitalization duration for the observation group was (6.4 ± 2.3) days, compared to (10.6 ± 3.7) days in the control group. Comparison of the above indicators, the observation group was better than the control group with significant difference (p < 0.001 each).
Conclusions
Minimally invasive percutaneous nephrolithotomy with the aid of the patented suctioning sheath in the treatment of calculus pyonephrosis in one surgery is economic, practical, and warrants clinical promotion.
Trial registration
This study was registered with Chinese Clinical Trial Registry on May 18, 2016 (retrospective registration) with a trial registration number of ChiCTR-IOR-16008490.
Abkürzungen
BUN
Blood urea nitrogen
CT
Computed tomography
CVA
Costovertebral angle
IVU
Intravenous urography
KUB
Kidneys, ureters, and bladder x-ray
MPa
Megapascal
MPCNL
Minimally invasive percutaneous nephrolithotomy
PaCO2
Partial pressure of carbon dioxide in arterial blood
PCNL
Percutaneous nephrolithotomy
Scr
Serum creatinine (Scr)
WBC
White blood cell
Background
Currently MPCNL has become one of the most important means in the treatment of upper urinary calculi. However, inappropriate infusion or poor drainage both can lead to significantly increased renal pelvic pressure, resulting in renal damage at various degrees, liquid reflux or extravasation, infection spread, urosepsis, or infectious shock. Patients undergo surgeries for complicated stones with pyonephrosis are more liable to worsening infection and urosepsis [1]. We designed a patented system with suctioning ability to facilitate minimally invasive PCNL (MPCNL). This patented system was found to be safe and highly efficient in managing renal stones in the previous study [2‐4]. However, we did not know the success and complication rates of our MPCNLs in treating renal calculus complicated by pyonephrosis by one surgery. In this study, we performed one-stage MPCNLs using a self-designed and patented suctioning lithotripsy sheath [4] (thereafter referred to as the patent sheath, see Fig. 1) in treating renal and upper ureteral calculi complicated by pyonephrosis in 91 cases to clear stone by one surgery, avoided two stage surgeries including first-stage percutaneous nephrostomy and second-stage stone lithotripsy. We thus reported the outcome as below.
Fig. 1
Patented suctioning lithotripsy sheath
×
Methods
Patients
From March 2011 to April 2013 one hundred eighty two patients with calculus pyonephrosis were admitted and treated at Ganzhou Hospital of Nanchang University, China. Among them 110 were males while 72 were females. The age ranged from 21 to 82 years old with a mean age at 44.1 ± 3.7 years old. There were 98 cases with left renal calculus while 84 cases with right renal calculus. Calculus dimension ranged from 8.8 to 22.5 cm2 with a mean dimension at 15.1 ± 6.5 cm2. All patients had costovertebral angle (CVA) tenderness by physical exam. Urinalysis revealed white blood cell (WBC) ++ ~ +++. Seventy four patients were found to have Temperature ≥ 37.8 °C. The stone diseases were diagnosed by B ultrasonography, KUB (Kidneys, ureters, and bladder x-ray), or intravenous urography (IVU). Computed tomography (CT) scan was performed for each patient to confirm. Patients with systemic coagulopathy were ruled out from the study. These enrolled patients were randomized into either control group(n = 91) or observation group(n = 91) in a ratio of 1:1 according to the random number table. As shown in Table 1, comparisons of the two groups on sex, age, stone location, and course of disease revealed no significant difference (P > 0.05 each).
Table 1
General clinical data comparison(n = 91 each, \( \overline{x} \) ±s)
Variable
Observation group
Control group
P value
Age (year)
43.5 ± 2.9
44.1 ± 3.2
>0.05
Sex
Male: Female
53:38
51:40
>0.05
BMI(kg/cm2)
21.6 ± 5.7
22.5 ± 1.1
>0.05
Stone size(mm)
16.7 ± 5.8
15.1 ± 6.3
>0.05
Stone location
>0.05
Renal pelvis and upper segment of ureter
27 (29.7%)
29 (31.9%)
Upper renal calyx
25 (27.5%)
21 (23.1%)
Mid renal calyx
9 (9.9%)
7 (7.7%)
Lower renal calyx
30 (33.0%)
34 (37.4%)
Renal insufficiency (n,%)
8 (8.8%)
11 (12.1%)
>0.05
H/o ESWL (n,%)
15 (14.3%)
17 (12.8%)
>0.05
H/o surgery to remove stone (n,%)
13 (14.3%)
14 (15.4%)
>0.05
Comorbidities
>0.05
Hypertension
7 (7.7%)
6 (6.6%)
Diabetes mellitus
4 (4.4%)
6 (6.6%)
Heart disease
5 (5.5%)
3 (3.3%)
Stone composition
>0.05
Calcium oxalate
44 (48.4%)
43 (47.3%)
Calcium phosphate
11 (12.1%)
15 (16.5%)
Cystine
2 (2.2%)
1 (1.1%)
Struvite
19 (20.9%)
17 (18.7%)
Uric acid
7 (7.7%)
5 (5.5%)
Mixed
8 (8.8%)
10 (11.0%)
Hydronephrosis
>0.05
Mild
13 (14.3%)
17 (18.7%)
Moderate
47 (51.6%)
49 (53.8%)
Severe
31 (34.1%)
25 (27.5%)
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Surgical procedure
Surgery was performed under general anesthesia for all 182 patients, all the surgeries were performed by one surgeon. Patients in the observation group underwent patented sheath assisted MPCNL. Patients in the control group were treated using traditional MPCNL without the assistance of the patented sheath but peel-away sheath. Patients in both groups were administered antibiotic pre and post surgery. The patient was first placed in a lithotomy position. A 5 F ureteral catheter was then inserted retrogradely into the renal pelvis through cystoscopy or ureteroscopy, and continuous infusion of saline was used to produce artificial hydronephrosis. After this, a Foley catheter was inserted; the patient was then changed to the prone position. Ultrasonography-guided percutaneous punctures were made with an 18-gauge coaxial needle into the targeted calyx. The puncture point was in the 11th intercostal space or the 12 th subcostal margin, between the posterior axillary line and scapula line. The puncture was judged successful if there was urine overflow or if it touched a stone. Zebra guidewire was inserted and fixed. The puncture needle was then taken out. After a 0.5–0.7 cm skin incision, the dilation of the percutaneous tract was performed serially over the guidewire with a fascial dilator from 8 F to 16 F. A 16 F patented sheath was then placed at the percutaneous access port and was connected to a vacuum aspiration machine. The pressure was maintained at 0.01–0.02 MPa. Subsequently, a small diameter nephroscope was inserted through the sheath. Initially, pus or purulent bolts were sucked out using the vacuum suctioning device (See Fig. 2). A holmium laser was then used to break the stones, and a vacuum suctioning device was used to clear gravel through the patented sheath until complete clearance. We then inspected renal pelvis and each renal calyx carefully. After finding that all stones were cleared, we indwelled a 6 F ureteral stent and a 16 F nephrostomy tube which will be removed 4–5 days after surgery. Occurrence of renal pelvic perforation was investigated at the end of the procedure via nephrostogram.
Fig. 2
Endoscopic view of renal calculus complicated by pyonephrosis
×
For any patient in the two groups with the following intraoperative occurrences, the surgery was converted to a simple nephrostomy: (1) body temperature lower than 36 °C or higher than 38 °C; (2) heart rate higher than 90 beats per minute; (3) respiratory rate greater than 20 breaths per minute or PaCO2 less than 32 mmHg [5]; (4) excessive bleeding;(5) suctioning channel was blocked due to thick pus.
Observation index
Perioperatively, vital signs were closely monitored. Also, the complete blood count, serum electrolytes, BUN/creatinine, and calcitonin were checked. Patients were evaluated on postoperative day 30 by KUB assess stone-free status. For patients with radiolucent or residual stones, CT scan was performed. Successful stone clearance was defined as no residual stone or residual stone size < 4 mm. Patients in the two groups were compared for operation time, bleeding amount, stone clearance rate, complication rate, and average days of hospitalization.
Statistical analysis
We used Excel for data input. SPSSll.5 statistical software package was used for data analysis. The measurement data were represented as mean ± standard deviation (\( \overline{x} \) ±s) and analyzed using t test. Count data was analyzed using χ2 test. P < 0.05, with statistically significant difference.
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Results
All patients in the observation group were treated with patented sheath assisted MPCNL successfully by one surgery without major complication including surrounding organ injury, pleural effusion, or major bleeding. There were 75 cases stones were cleared through one percutaneous tract, 15 cases stones was cleared through two percutaneous tracts, and two cases stones were cleared through three percutaneous tracts. There were ten cases with temperature ≥ 38.5 °C on postoperative day 2. There was one case in this group with complication of renal pelvic perforation. For the patients in the control group, 14 cases underwent first-stage percutaneous nephrostomy due to the difficulty in doing lithotripsy in the first surgery, while the rest of this group underwent one stage MPCNL. There were 15 cases with bleeding ≥ 800 ml and were transfused. There were 25 cases with temperature ≥ 38.5 °C on postoperative day 2. There were seven cases in this group with complication of renal pelvic perforation. In the observation group each index is better than the control group with significant difference (P < 0.001 each, see Table 2). Body temperatures returned to normal for those patients with postoperative fever after strengthening anti-infection treatment without the occurrence of sepsis or pyemia. After a follow up of 3 months, serum creatinine (Scr) and blood urea nitrogen (BUN) in 74 cases that had elevated preoperative Scr and BUN preoperatively were reduced to varying degrees (See Table 2 and Fig. 3).
Table 2
Operative outcome comparison between two groups(\( \overline{x} \) ±s)
Variables
Observation group
Control group
P value
Operation time (min)
54.5 ± 14.5
70.2 ± 11.7
<0.001
Bleeding amount (ml)
126.4 ± 47.2
321.6 ± 82.5
<0.001
Stone-free rates
96.7% (88)
73.6% (67)
<0.001
Incidence of complication
Fever ≥ 38.5 °C
10
25
<0.001
Bleeding amount ≥ 800 ml
0
15
<0.001
Renal pelvic perforation
1
7
<0.001
Days for hospitalization
6.4 ± 2.3
10.6 ± 3.7
<0.001
Fig. 3
Left: Preoperative KUB for a patient with staghorn renal calculus complicated by pyonephrosis; Middle: Preoperative IVU for a patient with staghorn renal calculus complicated by pyonephrosis; Right: Post-MPCNL KUB for a patient with staghorn renal calculus complicated by pyonephrosis, with the aid of the patented suctioning sheath
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Discussion
Upper ureter or renal stones often were treated with MPCNL and most patients can achieve the purpose of cure. Due to the pressure limit of renal parenchymal reflux is 30 mmHg [6], when the MPCNL is performed under high pressure perfusion it is easy to cause the intrapelvic pressure over 30 mmHg, and the operation manipulation, the integrity of the pelvic wall epithelium could be injured and thereafter leads to direct exposure of venous and lymphatic system followed by renal parenchyma reflux [7]; When the stones and infection occur at the same time, tissue edema and congestion are more likely to cause pelvic fluid absorption. A large amount of short-term liquid absorption can cause the perfusion fluid syndrome, and when the bacteria and its toxin reflux into the blood, complications like bacteremia, sepsis, or postoperative fever occur [8]. MPCNL surgery complication is related to the amount of liquid absorption. It is a positive correlation between the integrity of the epithelial cells, renal pelvic pressure, and the operation time [6, 9]. Performing MPCNL through irrigation can cause stones shift. When the collection system is connected to the renal abscess pus, due to the blurring of vision, it is not easy to find the pelvic outlet so the surgeon is often forced to abandon stone lithotripsy in which circumstance usually a percutaneous nephrostomy is performed as a first-stage surgery. In the current study, incidence rate of surgical complications in the control group was 51.6%% with 14 cases needing two staged operation. Therefore, how to improve success rate of surgery and reduce postoperative complications for calculus pyonephrosis is always a challenge in the field of Urology [10].
According to a previous report, when the intra-pelvic pressure is below 20 mmHg, it is feasible to use the EMS LithoClast master for one-phase PCNL of the relatively symptomatically stable patients with calculous pyonephrosis. Nevertheless, this surgical procedure has always carried high risks and its advantages and disadvantages should be validated by further studies of larger sample sizes [11, 12]. Patented sheath connected during surgery remains 0.01–0.02 MPa negative pressure suction to keep renal pelvis in a negative pressure state, so that the discharge of perfusion fluid and pus went smoothly, avoided lavage, bacteria, toxins reflux and spread to surrounding tissues, reduced fever infection complications after surgery. In the current study, only 10 patients in the observation group were found to have temperature ≥ 38.5 °C, significantly lower than those in the control group; Negative pressure adsorption can remove the effect of blood clots and floc, the vision can be more clear. With negative pressure “adsorption” effect on the gravel, small stones and pus hidden in the calyces can be automatically removed by suction. Due to a big discharge cavity of the sheath which is not easy to be blocked, there is no need of lithotomy forceps or stone basket, without the need for repeated importing a ureteroscope to flush, either. We are thus able to improve the efficacy of lithotripsy and stone clearance, shorten operation time, and reduce the operation complications such as bleeding [3]. In this study, all patients in the observation group were successfully treated with the MPCNL by one surgery with a stone clearance rate of 96.7%. There were no adjacent organ injury and major bleeding, compared with the control group, with significant difference. With improved success rate of surgery and reduced rate of complication, the hospitalization time was shortened and the cost of hospitalization was reduced. Of course, surgeons may have been more aggressive using the patented sheath and less aggressive with the peel-away sheath due to the aims of this study, therefore getting higher stone-free rates in patients in the observation arm. Other limitation of this study is that we did not measure intrarenal pelvic pressure for every patient during the surgery, even though we have had previous research data revealing that the patented sheath could reduce intrarenal pressure.
Conclusion
In summary, through analysis and comparison the observation group was better than the control group reflected by multiple clinical indexes. Managing calculus pyonephrosis using patented sheath assisted MPCNL is safe, economic with fewer complications.
Acknowledgements
Not applicable.
Funding
Major Scientific Fund from Science and Technology Department of Jiangxi Province to L.M.S.
Availability of data and materials
All the data supporting our findings is contained within the manuscript, any missing details will be shared upon request.
Authors’ contributions
DX, ML, and XD were involved in analysis and interpretation of data, and drafting the report; JH, LS, DX, MH, ZP, TL, CD, LY, SL, SG and JZ were involved in data acquisition; LS, JH, DX, and ML were involved in conception and design; All authors read and approved the final manuscript.
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Competing interests
Dr. Leming Song is the owner of the patent.
Consent for publication
Written informed consent was obtained from every patient for publication of this research report and any accompanying images.
Ethics approval and consent to participate
The study was performed with the approval of ethics committee at the Affiliated Ganzhou City People’s Hospital of Nanchang University, China, in compliance with the Helsinki Declaration. Written informed consent was obtained from every patient for participation in this study prior to undergoing treatment.
Statement
We have adhered to CONSORT methodology for this study.
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Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
A Randomized Study of Minimally Invasive Percutaneous Nephrolithotomy (MPCNL) with the aid of a patented suctioning sheath in the treatment of renal calculus complicated by pyonephrosis by one surgery
verfasst von
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