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Calcified Tissue International

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01.12.2015 | Original Research

A Root-Based Combination Supplement Containing Pueraria lobata and Rehmannia glutinosa and Exercise Preserve Bone Mass in Ovariectomized Rats Fed a High-Fat Diet

verfasst von: Hyang Mok Ok, Meron Regu Gebreamanuel, Sang A. Oh, Hyejin Jeon, Won Jun Lee, Oran Kwon

Erschienen in: Calcified Tissue International | Ausgabe 6/2015

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Abstract

The aim of this study was to evaluate the effects of a supplement containing Pueraria lobata/Rehmannia glutinosa (PR) root extracts on bone turnover in ovariectomized (OVX) rats (a model for postmenopausal osteoporosis). Female Sprague–Dawley rats (8 weeks old) were randomized into eight groups: sham-operated rats with low-fat control diet + vehicle, OVX rats with low-fat control diet + vehicle, OVX rats with high-fat diet (HFD) + vehicle, OVX rats with HFD + vehicle + exercise, OVX rats with HFD + PR (400 mg/kg body weight/day p.o.), OVX rats with HFD + PR + exercise, OVX rats with HFD + 17β-estradiol (0.5 mg/kg body weight/day p.o.), OVX rats with HFD + 17β-estradiol + exercise. Bone microarchitecture, bone turnover markers (e.g., plasma alkaline phosphatase and osteocalcin), expressions of osteogenic and resorptive gene markers in the bone were measured. Eight weeks of PR and/or aerobic exercise improved cortical microarchitecture of the femur and decreased markers of bone turnover and expression of skeletal osteoclastogenic genes in the femur. PR supplementation combined with exercise preserved bone loss induced by estrogen deficiency and should be investigated further as an alternative to hormone replacement therapy for preventing osteoporosis in postmenopausal women.

Deal C (2009) Potential new drug targets for osteoporosis. Nat Clin Pract Rheumatol 5:20–27CrossRefPubMed

Ray NF, Chan JK, Thamer M, Melton LJ 3rd (1997) Medical expenditures for the treatment of osteoporotic fractures in the United States in 1995: report from the National Osteoporosis Foundation. J Bone Miner Res 12:24–35CrossRefPubMed

Geusens P, Dinant G (2007) Integrating a gender dimension into osteoporosis and fracture risk research. Gend Med 4(Suppl B):S147–S161CrossRefPubMed

Kanis JA, Johnell O, Oden A, Jonsson B, De Laet C, Dawson A (2000) Risk of hip fracture according to the World Health Organization criteria for osteopenia and osteoporosis. Bone 27:585–590CrossRefPubMed

Zhao LJ, Jiang H, Papasian CJ, Maulik D, Drees B, Hamilton J, Deng HW (2008) Correlation of obesity and osteoporosis: effect of fat mass on the determination of osteoporosis. J Bone Miner Res 23:17–29PubMedCentralCrossRefPubMed

Lacey JV Jr, Mink PJ, Lubin JH, Sherman ME, Troisi R, Hartge P, Schatzkin A, Schairer C (2002) Menopausal hormone replacement therapy and risk of ovarian cancer. JAMA 288:334–341CrossRefPubMed

Beral V, Million Women Study C (2003) Breast cancer and hormone-replacement therapy in the Million Women Study. Lancet 362:419–427CrossRef

Fitzpatrick LA (1999) Selective estrogen receptor modulators and phytoestrogens: new therapies for the postmenopausal women. Mayo Clin Proc 74:601–607CrossRefPubMed

Oh KO, Kim SW, Kim JY, Ko SY, Kim HM, Baek JH, Ryoo HM, Kim JK (2003) Effect of Rehmannia glutinosa Libosch extracts on bone metabolism. Clin Chim Acta 334:185–195CrossRefPubMed

10.

Shiguemoto GE, Rossi EA, Baldissera V, Gouveia CH, de Valdez Vargas GM, de Andrade Perez SE (2007) Isoflavone-supplemented soy yoghurt associated with resistive physical exercise increase bone mineral density of ovariectomized rats. Maturitas 57:261–270CrossRefPubMed

11.

Wu J, Wang X, Chiba H, Higuchi M, Nakatani T, Ezaki O, Cui H, Yamada K, Ishimi Y (2004) Combined intervention of soy isoflavone and moderate exercise prevents body fat elevation and bone loss in ovariectomized mice. Metab Clin Exp 53:942–948CrossRefPubMed

12.

Evans EM, Racette SB, Van Pelt RE, Peterson LR, Villareal DT (2007) Effects of soy protein isolate and moderate exercise on bone turnover and bone mineral density in postmenopausal women. Menopause 14:481–488PubMedCentralCrossRefPubMed

13.

Nakajima D, Kim CS, Oh TW, Yang CY, Naka T, Igawa S, Ohta F (2001) Suppressive effects of genistein dosage and resistance exercise on bone loss in ovariectomized rats. J Physiol Anthropol Appl Human Sci 20:285–291CrossRefPubMed

14.

Trivedi R, Kumar A, Gupta V, Kumar S, Nagar GK, Romero JR, Dwivedi AK, Chattopadhyay N (2009) Effects of Egb 761 on bone mineral density, bone microstructure, and osteoblast function: possible roles of quercetin and kaempferol. Mol Cell Endocrinol 302:86–91CrossRefPubMed

15.

Delmas PD, Schlemmer A, Gineyts E, Riis B, Christiansen C (1991) Urinary excretion of pyridinoline crosslinks correlates with bone turnover measured on iliac crest biopsy in patients with vertebral osteoporosis. J Bone Miner Res 6:639–644CrossRefPubMed

16.

Alves-Rodrigues A, Shao A (2004) The science behind lutein. Toxicol Lett 150:57–83CrossRefPubMed

17.

Simonet WS, Lacey DL, Dunstan CR, Kelley M, Chang MS, Luthy R, Nguyen HQ, Wooden S, Bennett L, Boone T, Shimamoto G, DeRose M, Elliott R, Colombero A, Tan HL, Trail G, Sullivan J, Davy E, Bucay N, Renshaw-Gegg L, Hughes TM, Hill D, Pattison W, Campbell P, Sander S, Van G, Tarpley J, Derby P, Lee R, Boyle WJ (1997) Osteoprotegerin: a novel secreted protein involved in the regulation of bone density. Cell 89:309–319CrossRefPubMed

18.

Kalu DN (1991) The ovariectomized rat model of postmenopausal bone loss. Bone Miner 15:175–191CrossRefPubMed

19.

Brzezinski A, Debi A (1999) Phytoestrogens: the “natural” selective estrogen receptor modulators? Eur J Obstet Gynecol Reprod Biol 85:47–51CrossRefPubMed

20.

Sharan K, Siddiqui JA, Swarnkar G, Maurya R, Chattopadhyay N (2009) Role of phytochemicals in the prevention of menopausal bone loss: evidence from in vitro and in vivo, human interventional and pharma-cokinetic studies. Curr Med Chem 16:1138–1157CrossRefPubMed

21.

Chiechi LM, Lobascio A, Grillo A, Valerio T (1999) Phytoestrogen-containing food and prevention of postmenopausal osteoporosis and cardiovascular diseases. Miner Ginecol 51:343–348

22.

Cherdshewasart W, Subtang S, Dahlan W (2007) Major isoflavonoid contents of the phytoestrogen rich-herb Pueraria mirifica in comparison with Pueraria lobata. J Pharm Biomed Anal 43:428–434CrossRefPubMed

23.

Michihara S, Tanaka T, Uzawa Y, Moriyama T, Kawamura Y (2012) Puerarin exerted anti-osteoporotic action independent of estrogen receptor-mediated pathway. J Nutr Sci Vitaminol 58:202–209CrossRefPubMed

24.

Mody N, Parhami F, Sarafian TA, Demer LL (2001) Oxidative stress modulates osteoblastic differentiation of vascular and bone cells. Free Radic Biol Med 31:509–519CrossRefPubMed

25.

Seibel MJ (2005) Biochemical markers of bone turnover: part I: biochemistry and variability. Clin Biochem 26:97–122

26.

Devareddy L, Khalil DA, Smith BJ, Lucas EA, Soung do Y, Marlow DD, Arjmandi BH (2006) Soy moderately improves microstructural properties without affecting bone mass in an ovariectomized rat model of osteoporosis. Bone 38:686–693CrossRefPubMed

27.

Laib A, Beuf O, Issever A, Newitt DC, Majumdar S (2001) Direct measures of trabecular bone architecture from MR images. Adv Exp Med Biol 496:37–46CrossRefPubMed

28.

Ding M, Odgaard A, Hvid I (2003) Changes in the three-dimensional microstructure of human tibial cancellous bone in early osteoarthritis. J Bone Joint Surg 85:906–912

29.

Hahn M, Vogel M, Pompesius-Kempa M, Delling G (1992) Trabecular bone pattern factor—a new parameter for simple quantification of bone microarchitecture. Bone 13:327–330CrossRefPubMed

30.

Chaffai S, Peyrin F, Nuzzo S, Porcher R, Berger G, Laugier P (2002) Ultrasonic characterization of human cancellous bone using transmission and backscatter measurements: relationships to density and microstructure. Bone 30:229–237CrossRefPubMed

31.

Boyce BF, Xing LP (2008) Functions of RANKL/RANK/OPG in bone modeling and remodeling. Arch Biochem Biophys 473:139–146PubMedCentralCrossRefPubMed

32.

Kobayashi Y, Udagawa N, Takahashi N (2009) Action of RANKL and OPG for Osteoclastogenesis. Crit Rev Eukar Gene 19:61–72CrossRef

33.

Teitelbaum SL (2000) Bone resorption by osteoclasts. Science 289:1504–1508CrossRefPubMed

34.

Udomsuk L, Chatuphonprasert W, Monthakantirat O, Churikhit Y, Jarukamjorn K (2012) Impact of Pueraria candollei var. mirifica and its potent phytoestrogen miroestrol on expression of bone-specific genes in ovariectomized mice. Fitoterapia 83:1687–1692CrossRefPubMed

35.

Delmas PD, Eastell R, Garnero P, Seibel MJ, Stepan J, Committee of Scientific Advisors of the International Osteoporosis Foundation (2000) The use of biochemical markers of bone turnover in osteoporosis. Osteoporos Int 11(Suppl 6):S2–S17CrossRefPubMed

36.

Khedgikar V, Gautam J, Kushwaha P, Kumar A, Nagar GK, Dixit P, Chillara R, Voruganti S, Singh SP, Uddin W, Jain GK, Singh D, Maurya R, Chattopadhyay N, Trivedi R (2012) A standardized phytopreparation from an Indian medicinal plant (Dalbergia sissoo) has antiresorptive and bone-forming effects on a postmenopausal osteoporosis model of rat. Menopause 19:1336–1346PubMed

37.

Liu HY, Liu MC, Wang MF, Chen WH, Tsai CY, Wu KH, Lin CT, Shieh YH, Zeng R, Deng WP (2013) Potential osteoporosis recovery by deep sea water through bone regeneration in SAMP8 mice. Evid Based Complement Altern Med 2013:161976

Titel: A Root-Based Combination Supplement Containing Pueraria lobata and Rehmannia glutinosa and Exercise Preserve Bone Mass in Ovariectomized Rats Fed a High-Fat Diet
verfasst von: Hyang Mok Ok
Meron Regu Gebreamanuel
Sang A. Oh
Hyejin Jeon
Won Jun Lee
Oran Kwon
Publikationsdatum: 01.12.2015
Verlag: Springer US
Erschienen in: Calcified Tissue International / Ausgabe 6/2015
Print ISSN: 0171-967X
Elektronische ISSN: 1432-0827
DOI: https://doi.org/10.1007/s00223-015-0057-7

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A Root-Based Combination Supplement Containing Pueraria lobata and Rehmannia glutinosa and Exercise Preserve Bone Mass in Ovariectomized Rats Fed a High-Fat Diet

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