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01.08.2010 | Review Article

A systematic review of salivary gland hypofunction and xerostomia induced by cancer therapies: management strategies and economic impact

verfasst von: S. B. Jensen, A. M. L. Pedersen, A. Vissink, E. Andersen, C. G. Brown, A. N. Davies, J. Dutilh, J. S. Fulton, L. Jankovic, N. N. F. Lopes, A. L. S. Mello, L. V. Muniz, C. A. Murdoch-Kinch, R. G. Nair, J. J. Napeñas, A. Nogueira-Rodrigues, D. Saunders, B. Stirling, I. von Bültzingslöwen, D. S. Weikel, L. S. Elting, F. K. L. Spijkervet, M. T. Brennan, Salivary Gland Hypofunction/Xerostomia Section, Oral Care Study Group, Multinational Association of Supportive Care in Cancer (MASCC)/International Society of Oral Oncology (ISOO)

Erschienen in: Supportive Care in Cancer | Ausgabe 8/2010

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Abstract

Purpose

This systematic review aimed to assess the literature for management strategies and economic impact of salivary gland hypofunction and xerostomia induced by cancer therapies and to determine the quality of evidence-based management recommendations.

Methods

The electronic databases of MEDLINE/PubMed and EMBASE were searched for articles published in English since the 1989 NIH Development Consensus Conference on the Oral Complications of Cancer Therapies until 2008 inclusive. For each article, two independent reviewers extracted information regarding study design, study population, interventions, outcome measures, results, and conclusions.

Results

Seventy-two interventional studies met the inclusion criteria. In addition, 49 intensity-modulated radiation therapy (IMRT) studies were included as a management strategy aiming for less salivary gland damage. Management guideline recommendations were drawn up for IMRT, amifostine, muscarinic agonist stimulation, oral mucosal lubricants, acupuncture, and submandibular gland transfer.

Conclusions

There is evidence that salivary gland hypofunction and xerostomia induced by cancer therapies can be prevented or symptoms be minimized to some degree, depending on the type of cancer treatment. Management guideline recommendations are provided for IMRT, amifostine, muscarinic agonist stimulation, oral mucosal lubricants, acupuncture, and submandibular gland transfer. Fields of sparse literature identified included effects of gustatory and masticatory stimulation, specific oral mucosal lubricant formulas, submandibular gland transfer, acupuncture, hyperbaric oxygen treatment, management strategies in pediatric cancer populations, and the economic consequences of salivary gland hypofunction and xerostomia.

Jensen SB, Pedersen AML, Vissink A, Andersen E, Brown CG, Davies AN, Dutilh J, Fulton JS, Jankovic L, Lopes NNF, Mello ALS, Muniz LV, Murdoch-Kinch CA, Nair RG, Napeñas JJ, Nogueira-Rodrigues A, Saunders D, Stirling B, von Bültzingslöwen I, Weikel DS, Elting LS, Spijkervet FKL, Brennan MT (2010) A systematic review of salivary gland hypofunction and xerostomia induced by cancer therapies: prevalence, severity and impact on quality of life. Support Care Cancer doi:10.1007/s00520-010-0827-8

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Titel: A systematic review of salivary gland hypofunction and xerostomia induced by cancer therapies: management strategies and economic impact
verfasst von: S. B. Jensen
A. M. L. Pedersen
A. Vissink
E. Andersen
C. G. Brown
A. N. Davies
J. Dutilh
J. S. Fulton
L. Jankovic
N. N. F. Lopes
A. L. S. Mello
L. V. Muniz
C. A. Murdoch-Kinch
R. G. Nair
J. J. Napeñas
A. Nogueira-Rodrigues
D. Saunders
B. Stirling
I. von Bültzingslöwen
D. S. Weikel
L. S. Elting
F. K. L. Spijkervet
M. T. Brennan
Salivary Gland Hypofunction/Xerostomia Section
Oral Care Study Group
Multinational Association of Supportive Care in Cancer (MASCC)/International Society of Oral Oncology (ISOO)
Publikationsdatum: 01.08.2010
Verlag: Springer-Verlag
Erschienen in: Supportive Care in Cancer / Ausgabe 8/2010
Print ISSN: 0941-4355
Elektronische ISSN: 1433-7339
DOI: https://doi.org/10.1007/s00520-010-0837-6

Springer Medizin

A systematic review of salivary gland hypofunction and xerostomia induced by cancer therapies: management strategies and economic impact

Abstract

Purpose

Methods

Results

Conclusions

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Alectinib verbessert krankheitsfreies Überleben bei ALK-positivem NSCLC

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Update Onkologie

Springer Medizin

Abstract

Purpose

Methods

Results

Conclusions

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