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24.09.2019 | Original Article – Cancer Research | Ausgabe 11/2019

Journal of Cancer Research and Clinical Oncology 11/2019

A three-platelet mRNA set: MAX, MTURN and HLA-B as biomarker for lung cancer

Journal of Cancer Research and Clinical Oncology > Ausgabe 11/2019
Lele Liu, Xingguo Song, Xinyi Li, Linlin Xue, Shanshan Ding, Limin Niu, Li Xie, Xianrang Song
Wichtige Hinweise

Electronic supplementary material

The online version of this article (https://​doi.​org/​10.​1007/​s00432-019-03032-9) contains supplementary material, which is available to authorized users.
Lele Liu and Xingguo Song contributed equally to this work.

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During the development of tumors, tumors “educate” platelets causing changes in their mRNAs expression profiles and phenotypes, thereby, tumor-educated platelet (TEP) mRNA profile has the potential to diagnose lung cancer. The current study aimed to examine whether TEPs might be a potential biomarker for lung cancer diagnostics.


Platelet precipitation was obtained by low-speed centrifugation and subjected to Trizol for total RNA extraction. Platelet MAX, MTURN, and HLA-B mRNA were selected by microarray, validated by qPCR, and analyzed combined with related clinical factors.


Our results showed that a three-platelet mRNA set: MAX, MTURN, and HLA-B was significantly up-regulated in lung cancer patients as well as in early-stage lung cancer patients compared with those from healthy donors, the area under the curve (AUC) was 0.734, 0.787, respectively, among which platelet MTURN mRNA processed a dramatically high diagnostic efficiency in female patients with lung cancer, its AUC for female was 0.825. More importantly, the three-platelet mRNA set: MAX, MTURN, and HLA-B was associated with chemotherapeutic effect, low mRNA expression of this three-platelet set was correlated with “favorable” first chemotherapy response.


A three-platelet mRNA set: MAX, MTURN and HLA-B enables blood-based lung cancer diagnosis and chemotherapy response prediction.

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Supplementary material 1 Platelet quality control. Platelet purity was detected by wright-giemsa dye under a microscope (a), white arrow indicated the red blood cells, and activation state (b) of the platelet was detected by flow cytometry (TIFF 25418 kb)
Supplementary material 2 Platelet UQCRH mRNA expression as biomarker for lung cancer. a Platelet UQCRH mRNA was elevated in lung cancer significantly. LC, patients with lung cancer; HD, healthy donors. b Low mRNA expression of UQCRH was correlated with favorable first chemotherapy response. PR, partial response. *P < 0.05. (TIFF 5418 kb)
Supplementary material 3 (DOCX 31 kb)
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