Ausgabe 4/2016
Inhalt (10 Artikel)
Immunotherapies in Alzheimer’s disease: Too much, too little, too late or off-target?
Isabelle St-Amour, Francesca Cicchetti, Frédéric Calon
Mitochondria-associated membranes as hubs for neurodegeneration
Michiel Krols, Gert van Isterdael, Bob Asselbergh, Anna Kremer, Saskia Lippens, Vincent Timmerman, Sophie Janssens
Phosphorylation of the amyloid β-peptide at Ser26 stabilizes oligomeric assembly and increases neurotoxicity
Sathish Kumar, Oliver Wirths, Kathrin Stüber, Patrick Wunderlich, Philipp Koch, Sandra Theil, Nasrollah Rezaei-Ghaleh, Markus Zweckstetter, Thomas A. Bayer, Oliver Brüstle, Dietmar R. Thal, Jochen Walter
Axonal transport and secretion of fibrillar forms of α-synuclein, Aβ42 peptide and HTTExon 1
Michel Brahic, Luc Bousset, Gregor Bieri, Ronald Melki, Aaron D. Gitler
Heterotypic seeding of Tau fibrillization by pre-aggregated Abeta provides potent seeds for prion-like seeding and propagation of Tau-pathology in vivo
Bruno Vasconcelos, Ilie-Cosmin Stancu, Arjan Buist, Matthew Bird, Peng Wang, Alexandre Vanoosthuyse, Kristof Van Kolen, An Verheyen, Pascal Kienlen-Campard, Jean-Noël Octave, Peter Baatsen, Diederik Moechars, Ilse Dewachter
Updated TDP-43 in Alzheimer’s disease staging scheme
Keith A. Josephs, Melissa E. Murray, Jennifer L. Whitwell, Nirubol Tosakulwong, Stephen D. Weigand, Leonard Petrucelli, Amanda M. Liesinger, Ronald C. Petersen, Joseph E. Parisi, Dennis W. Dickson
Monomethylated and unmethylated FUS exhibit increased binding to Transportin and distinguish FTLD-FUS from ALS-FUS
Marc Suárez-Calvet, Manuela Neumann, Thomas Arzberger, Claudia Abou-Ajram, Eva Funk, Hannelore Hartmann, Dieter Edbauer, Elisabeth Kremmer, Christoph Göbl, Moritz Resch, Benjamin Bourgeois, Tobias Madl, Stefan Reber, Daniel Jutzi, Marc-David Ruepp, Ian R. A. Mackenzie, Olaf Ansorge, Dorothee Dormann, Christian Haass
Pur-alpha regulates cytoplasmic stress granule dynamics and ameliorates FUS toxicity
J. Gavin Daigle, Karthik Krishnamurthy, Nandini Ramesh, Ian Casci, John Monaghan, Kevin McAvoy, Earl W. Godfrey, Dianne C. Daniel, Edward M. Johnson, Zachary Monahan, Frank Shewmaker, Piera Pasinelli, Udai Bhan Pandey
Neuronal ceroid lipofuscinosis with DNAJC5/CSPα mutation has PPT1 pathology and exhibit aberrant protein palmitoylation
Michael X. Henderson, Gregory S. Wirak, Yong-quan Zhang, Feng Dai, Stephen D. Ginsberg, Natalia Dolzhanskaya, John F. Staropoli, Peter C. G. Nijssen, TuKiet T. Lam, Amy F. Roth, Nicholas G. Davis, Glyn Dawson, Milen Velinov, Sreeganga S. Chandra
Human spinal autografts of olfactory epithelial stem cells recapitulate donor site histology, maintaining proliferative and differentiation capacity many years after transplantation
Kevin S. Chen, Jeremy C. McIntyre, Andrew P. Lieberman, Jeffrey R. Martens, Parag G. Patil