Ausgabe 1/2024
Inhalt (76 Artikel)
G2C4 targeting antisense oligonucleotides potently mitigate TDP-43 dysfunction in human C9orf72 ALS/FTD induced pluripotent stem cell derived neurons
Jeffrey D. Rothstein, Victoria Baskerville, Sampath Rapuri, Emma Mehlhop, Paymaan Jafar-Nejad, Frank Rigo, Frank Bennett, Sarah Mizielinska, Adrian Isaacs, Alyssa N. Coyne
A new subtype of diffuse midline glioma, H3 K27 and BRAF/FGFR1 co-altered: a clinico-radiological and histomolecular characterisation
Lucie Auffret, Yassine Ajlil, Arnault Tauziède-Espariat, Thomas Kergrohen, Chloé Puiseux, Laurent Riffaud, Pascale Blouin, Anne-Isabelle Bertozzi, Pierre Leblond, Klas Blomgren, Sébastien Froelich, Alberto Picca, Mehdi Touat, Marc Sanson, Kévin Beccaria, Thomas Blauwblomme, Volodia Dangouloff-Ros, Nathalie Boddaert, Pascale Varlet, Marie-Anne Debily, Jacques Grill, David Castel
“De novo replication repair deficient glioblastoma, IDH-wildtype” is a distinct glioblastoma subtype in adults that may benefit from immune checkpoint blockade
Sara Hadad, Rohit Gupta, Nancy Ann Oberheim Bush, Jennie W. Taylor, Javier E. Villanueva-Meyer, Jacob S. Young, Jasper Wu, Ajay Ravindranathan, Yalan Zhang, Gayathri Warrier, Lucie McCoy, Anny Shai, Melike Pekmezci, Arie Perry, Andrew W. Bollen, Joanna J. Phillips, Steve E. Braunstein, David R. Raleigh, Philip Theodosopoulos, Manish K. Aghi, Edward F. Chang, Shawn L. Hervey-Jumper, Joseph F. Costello, John de Groot, Nicholas A. Butowski, Jennifer L. Clarke, Susan M. Chang, Mitchel S. Berger, Annette M. Molinaro, David A. Solomon
Loss of TDP-43 splicing repression occurs early in the aging population and is associated with Alzheimer’s disease neuropathologic changes and cognitive decline
Koping Chang, Jonathan P. Ling, Javier Redding-Ochoa, Yang An, Ling Li, Stephanie A. Dean, Thomas G. Blanchard, Tatiana Pylyukh, Alexander Barrett, Katherine E. Irwin, Abhay Moghekar, Susan M. Resnick, Philip C. Wong, Juan C. Troncoso
Optimal blood tau species for the detection of Alzheimer’s disease neuropathology: an immunoprecipitation mass spectrometry and autopsy study
Laia Montoliu-Gaya, Michael L. Alosco, Eukyung Yhang, Yorghos Tripodis, Daniel Sconzo, Madeline Ally, Lana Grötschel, Nicholas J. Ashton, Juan Lantero-Rodriguez, Mathias Sauer, Bárbara Gomes, Johanna Nilsson, Gunnar Brinkmalm, Michael A. Sugarman, Hugo J. Aparicio, Brett Martin, Joseph N. Palmisano, Eric G. Steinberg, Irene Simkin, Katherine W. Turk, Andrew E. Budson, Rhoda Au, Lindsay Farrer, Gyungah R. Jun, Neil W. Kowall, Robert A. Stern, Lee E. Goldstein, Wei Qiao Qiu, Jesse Mez, Bertrand Russell Huber, Victor E. Alvarez, Ann C. McKee, Henrik Zetterberg, Johan Gobom, Thor D. Stein, Kaj Blennow
Disruption of MAM integrity in mutant FUS oligodendroglial progenitors from hiPSCs
Yingli Zhu, Thibaut Burg, Katrien Neyrinck, Tim Vervliet, Fatemeharefeh Nami, Ellen Vervoort, Karan Ahuja, Maria Livia Sassano, Yoke Chin Chai, Arun Kumar Tharkeshwar, Jonathan De Smedt, Haibo Hu, Geert Bultynck, Patrizia Agostinis, Johannes V. Swinnen, Ludo Van Den Bosch, Rodrigo Furtado Madeiro da Costa, Catherine Verfaillie
p-tau Ser356 is associated with Alzheimer’s disease pathology and is lowered in brain slice cultures using the NUAK inhibitor WZ4003
Lewis W. Taylor, Elizabeth M. Simzer, Claire Pimblett, Oscar T. T. Lacey-Solymar, Robert I. McGeachan, Soraya Meftah, Jamie L. Rose, Maxwell P. Spires-Jones, Kristján Holt, James H. Catterson, Henner Koch, Imran Liaquat, Jonathan H. Clarke, John Skidmore, Colin Smith, Sam A. Booker, Paul M. Brennan, Tara L. Spires-Jones, Claire S. Durrant
Cortical matrix remodeling as a hallmark of relapsing–remitting neuroinflammation in MR elastography and quantitative MRI
Rafaela V. Silva, Anna S. Morr, Helge Herthum, Stefan P. Koch, Susanne Mueller, Clara S. Batzdorf, Gergely Bertalan, Tom Meyer, Heiko Tzschätzsch, Anja A. Kühl, Philipp Boehm-Sturm, Jürgen Braun, Michael Scheel, Friedemann Paul, Carmen Infante-Duarte, Ingolf Sack
Cryptic splicing of stathmin-2 and UNC13A mRNAs is a pathological hallmark of TDP-43-associated Alzheimer’s disease
Ana Rita Agra Almeida Quadros, Zhaozhi Li, Xue Wang, I. Sandra Ndayambaje, Sandeep Aryal, Nandini Ramesh, Matthew Nolan, Rojashree Jayakumar, Yi Han, Hannah Stillman, Corey Aguilar, Hayden J. Wheeler, Theresa Connors, Jone Lopez-Erauskin, Michael W. Baughn, Ze’ev Melamed, Melinda S. Beccari, Laura Olmedo Martínez, Michael Canori, Chao-Zong Lee, Laura Moran, Isabelle Draper, Alan S. Kopin, Derek H. Oakley, Dennis W. Dickson, Don W. Cleveland, Bradley T. Hyman, Sudeshna Das, Nilüfer Ertekin-Taner, Clotilde Lagier-Tourenne
New evidence suggests SARS-CoV-2 neuroinvasion along the nervus terminalis rather than the olfactory pathway
Christopher S. von Bartheld, Rafal Butowt
Improved prognostic stratification of patients with isocitrate dehydrogenase-mutant astrocytoma
Michael Weller, Jörg Felsberg, Bettina Hentschel, Dorothee Gramatzki, Nadezhda Kubon, Marietta Wolter, Matthias Reusche, Patrick Roth, Dietmar Krex, Ulrich Herrlinger, Manfred Westphal, Joerg C. Tonn, Luca Regli, Claude-Alain Maurage, Andreas von Deimling, Torsten Pietsch, Emilie Le Rhun, Guido Reifenberger
CSF p-tau205: a biomarker of tau pathology in Alzheimer’s disease
Juan Lantero-Rodriguez, Laia Montoliu-Gaya, Andrea L. Benedet, Agathe Vrillon, Julien Dumurgier, Emmanuel Cognat, Wagner S. Brum, Nesrine Rahmouni, Jenna Stevenson, Stijn Servaes, Joseph Therriault, Bruno Becker, Gunnar Brinkmalm, Anniina Snellman, Hanna Huber, Hlin Kvartsberg, Nicholas J. Ashton, Henrik Zetterberg, Claire Paquet, Pedro Rosa-Neto, Kaj Blennow
Novel lissencephaly-associated NDEL1 variant reveals distinct roles of NDE1 and NDEL1 in nucleokinesis and human cortical malformations
Meng-Han Tsai, Hao-Chen Ke, Wan-Cian Lin, Fang-Shin Nian, Chia-Wei Huang, Haw-Yuan Cheng, Chi-Sin Hsu, Tiziana Granata, Chien-Hui Chang, Barbara Castellotti, Shin-Yi Lin, Fabio M. Doniselli, Cheng-Ju Lu, Silvana Franceschetti, Francesca Ragona, Pei-Shan Hou, Laura Canafoglia, Chien-Yi Tung, Mei-Hsuan Lee, Won-Jing Wang, Jin-Wu Tsai
Distinct tau and alpha-synuclein molecular signatures in Alzheimer’s disease with and without Lewy bodies and Parkinson’s disease with dementia
Bram L. van der Gaag, Natasja A. C. Deshayes, John J. P. Breve, John G. J. M. Bol, Allert J. Jonker, Jeroen J. M. Hoozemans, Jean-Philippe Courade, Wilma D. J. van de Berg
Complement and MHC patterns can provide the diagnostic framework for inflammatory neuromuscular diseases
Christopher Nelke, Simone Schmid, Felix Kleefeld, Christina B. Schroeter, Hans-Hilmar Goebel, Sarah Hoffmann, Corinna Preuße, Heike Kölbel, Sven G. Meuth, Tobias Ruck, Werner Stenzel
Pituitary neuroendocrine tumors with PIT1/SF1 co-expression show distinct clinicopathological and molecular features
Matthias Dottermusch, Alice Ryba, Franz L. Ricklefs, Jörg Flitsch, Simone Schmid, Markus Glatzel, Wolfgang Saeger, Julia E. Neumann, Ulrich Schüller
Large-scale validation of skin prion seeding activity as a biomarker for diagnosis of prion diseases
Weiguanliu Zhang, Christina D. Orrú, Aaron Foutz, Mingxuan Ding, Jue Yuan, Syed Zahid Ali Shah, Jing Zhang, Keisi Kotobelli, Maria Gerasimenko, Tricia Gilliland, Wei Chen, Michelle Tang, Mark Cohen, Jiri Safar, Bin Xu, Dao-Jun Hong, Li Cui, Andrew G. Hughson, Lawrence B. Schonberger, Curtis Tatsuoka, Shu G. Chen, Justin J. Greenlee, Zerui Wang, Brian S. Appleby, Byron Caughey, Wen-Quan Zou
Performance of a seed amplification assay for misfolded alpha-synuclein in cerebrospinal fluid and brain tissue in relation to Lewy body disease stage and pathology burden
Giuseppe Mario Bentivenga, Angela Mammana, Simone Baiardi, Marcello Rossi, Alice Ticca, Franco Magliocchetti, Andrea Mastrangelo, Anna Poleggi, Anna Ladogana, Sabina Capellari, Piero Parchi
Multi-level profiling unravels mitochondrial dysfunction in myotonic dystrophy type 2
Felix Kleefeld, Rita Horvath, Iago Pinal-Fernandez, Andrew L. Mammen, Maria Casal-Dominguez, Denisa Hathazi, Sarah Melchert, Katrin Hahn, Albert Sickmann, Claudia Muselmann-Genschow, Andreas Hentschel, Corinna Preuße, Andreas Roos, Benedikt Schoser, Werner Stenzel
A familial missense variant in the Alzheimer’s disease gene SORL1 impairs its maturation and endosomal sorting
Elnaz Fazeli, Daniel D. Child, Stephanie A. Bucks, Miki Stovarsky, Gabrielle Edwards, Shannon E. Rose, Chang-En Yu, Caitlin Latimer, Yu Kitago, Thomas Bird, Suman Jayadev, Olav M. Andersen, Jessica E. Young
Temporal change of DNA methylation subclasses between matched newly diagnosed and recurrent glioblastoma
Richard Drexler, Robin Khatri, Ulrich Schüller, Alicia Eckhardt, Alice Ryba, Thomas Sauvigny, Lasse Dührsen, Malte Mohme, Tammo Ricklefs, Helena Bode, Fabian Hausmann, Tobias B. Huber, Stefan Bonn, Hannah Voß, Julia E. Neumann, Dana Silverbush, Volker Hovestadt, Mario L. Suvà, Katrin Lamszus, Jens Gempt, Manfred Westphal, Dieter H. Heiland, Sonja Hänzelmann, Franz L. Ricklefs
Transcriptomic and epigenetic dissection of spinal ependymoma (SP-EPN) identifies clinically relevant subtypes enriched for tumors with and without NF2 mutation
Sina Neyazi, Erika Yamazawa, Karoline Hack, Shota Tanaka, Genta Nagae, Catena Kresbach, Takayoshi Umeda, Alicia Eckhardt, Kenji Tatsuno, Lara Pohl, Taijun Hana, Michael Bockmayr, Phyo Kim, Mario M. Dorostkar, Toshihiro Takami, Denise Obrecht, Keisuke Takai, Abigail K. Suwala, Takashi Komori, Shweta Godbole, Annika K. Wefers, Ryohei Otani, Julia E. Neumann, Fumi Higuchi, Leonille Schweizer, Yuta Nakanishi, Camelia-Maria Monoranu, Hirokazu Takami, Lara Engertsberger, Keisuke Yamada, Viktoria Ruf, Masashi Nomura, Theresa Mohme, Akitake Mukasa, Jochen Herms, Shunsaku Takayanagi, Martin Mynarek, Reiko Matsuura, Katrin Lamszus, Kazuhiko Ishii, Lan Kluwe, Hideaki Imai, Andreas von Deimling, Tsukasa Koike, Martin Benesch, Yoshihiro Kushihara, Matija Snuderl, Shohei Nambu, Stephan Frank, Takaki Omura, Christian Hagel, Kazuha Kugasawa, Viktor F. Mautner, Koichi Ichimura, Stefan Rutkowski, Hiroyuki Aburatani, Nobuhito Saito, Ulrich Schüller
Clinically relevant molecular hallmarks of PFA ependymomas display intratumoral heterogeneity and correlate with tumor morphology
Swenja Gödicke, Catena Kresbach, Max Ehlert, Denise Obrecht, Lea Altendorf, Karoline Hack, Katja von Hoff, Helena Carén, Viktoria Melcher, Kornelius Kerl, Bernhard Englinger, Mariella Filbin, Kristian W. Pajtler, Johannes Gojo, Torsten Pietsch, Stefan Rutkowski, Ulrich Schüller
Molecular characteristics and improved survival prediction in a cohort of 2023 ependymomas
Lara C. Pohl, Maximilian Leitheiser, Denise Obrecht, Leonille Schweizer, Annika K. Wefers, Alicia Eckhardt, Mark Raffeld, Dominik Sturm, Kristian W. Pajtler, Stefan Rutkowski, Kohei Fukuoka, Koichi Ichimura, Michael Bockmayr, Ulrich Schüller
Head-to-head comparison of [18F]-Flortaucipir, [18F]-MK-6240 and [18F]-PI-2620 postmortem binding across the spectrum of neurodegenerative diseases
Cinthya Aguero, Maeva Dhaynaut, Ana C. Amaral, S.-H. Moon, Ramesh Neelamegam, Margaret Scapellato, Carlos Carazo-Casas, Sunny Kumar, Georges El Fakhri, Keith Johnson, Matthew P. Frosch, Marc D. Normandin, Teresa Gómez-Isla
Mitochondrial damage and impaired mitophagy contribute to disease progression in SCA6
Tsz Chui Sophia Leung, Eviatar Fields, Namrata Rana, Ru Yi Louisa Shen, Alexandra E. Bernstein, Anna A. Cook, Daniel E. Phillips, Alanna J. Watt
Similar brain proteomic signatures in Alzheimer’s disease and epilepsy
Dominique Leitner, Geoffrey Pires, Tomas Kavanagh, Evgeny Kanshin, Manor Askenazi, Beatrix Ueberheide, Orrin Devinsky, Thomas Wisniewski, Eleanor Drummond
Neuroinflammatory disease signatures in SPG11-related hereditary spastic paraplegia patients
Laura Krumm, Tatyana Pozner, Naime Zagha, Roland Coras, Philipp Arnold, Thanos Tsaktanis, Kathryn Scherpelz, Marie Y. Davis, Johanna Kaindl, Iris Stolzer, Patrick Süß, Mukhran Khundadze, Christian A. Hübner, Markus J. Riemenschneider, Jonathan Baets, Claudia Günther, Suman Jayadev, Veit Rothhammer, Florian Krach, Jürgen Winkler, Beate Winner, Martin Regensburger
Cryptic exon inclusion is a molecular signature of LATE-NC in aging brains
Mingee Chung, E. Kathleen Carter, Austin M. Veire, Eric B. Dammer, Jianjun Chang, Duc M. Duong, Nisha Raj, Gary J. Bassell, Jonathan D. Glass, Tania F. Gendron, Peter T. Nelson, Allan I. Levey, Nicholas T. Seyfried, Zachary T. McEachin
Scientific commentary on: “Phosphorylated tau in the retina correlates with tau pathology in the brain in Alzheimer’s disease and primary tauopathies”
Frederike C. Oertel, Daniel Casillas, Yann Cobigo, Shivany Condor Montes, Hilary W. Heuer, Makenna Chapman, Alexandra Beaudry-Richard, Henriette Reinsberg, Ahmed Abdelhak, Christian Cordano, Bradley F. Boeve, Bradford C. Dickerson, Murray Grossman, Edward Huey, David J. Irwin, Irene Litvan, Alexander Pantelyat, M. Carmela Tartaglia, Lawren Vandevrede, Adam Boxer, Ari J. Green
New insights into neuropathology and pathogenesis of autoimmune glial fibrillary acidic protein meningoencephalomyelitis
Yong Guo, Verena Endmayr, Anastasia Zekeridou, Andrew McKeon, Frank Leypoldt, Katharina Hess, Alicja Kalinowska-Lyszczarz, Andrea Klang, Akos Pakozdy, Elisabeth Höftberger, Simon Hametner, Carmen Haider, Désirée De Simoni, Sönke Peters, Ellen Gelpi, Christoph Röcken, Stefan Oberndorfer, Hans Lassmann, Claudia F. Lucchinetti, Romana Höftberger
Transmembrane protein 97 is a potential synaptic amyloid beta receptor in human Alzheimer’s disease
Martí Colom-Cadena, Jamie Toombs, Elizabeth Simzer, Kristjan Holt, Robert McGeachan, Jane Tulloch, Rosemary J. Jackson, James H. Catterson, Maxwell P. Spires-Jones, Jamie Rose, Lora Waybright, Anthony O. Caggiano, Declan King, Francesco Gobbo, Caitlin Davies, Monique Hooley, Sophie Dunnett, Robert Tempelaar, Soraya Meftah, Makis Tzioras, Mary E. Hamby, Nicholas J. Izzo, Susan M. Catalano, Claire S. Durrant, Colin Smith, Owen Dando, Tara L. Spires-Jones
“RYR1 and the cerebellum”: scientific commentary on “Defective Cerebellar Ryanodine Receptor Type 1 and Endoplasmic Reticulum Calcium ‘Leak’ in Tremor Pathophysiology”
Heinz Jungbluth, Dennis T. Famili, Rick C. Helmich, Stefano Previtali, Nicol C. Voermans
Pineal parenchymal tumors of intermediate differentiation: in need of a stringent definition to avoid confusion. Scientific commentary on ‘Genetical and epigenetical profiling identifies two subgroups of pineal parenchymal tumors of intermediate differentiation (PPTID) with distinct molecular, histological and clinical characteristics’
Alexandre Vasiljevic
Reply: pineal parenchymal tumors of intermediate differentiation: in need of a stringent definition to avoid confusion
Ramin Rahmanzade, Felix Sahm
Macrophages and endothelial cells in the neurovascular unit
Jan Wenzel, Markus Schwaninger
The niche matters: origin, function and fate of CNS-associated macrophages during health and disease
Adrià Dalmau Gasull, Martina Glavan, Sai K. Reddy Samawar, Kishan Kapupara, Joe Kelk, Marina Rubio, Stefano Fumagalli, Lydia Sorokin, Denis Vivien, Marco Prinz
Endothelial cells and macrophages as allies in the healthy and diseased brain
Adam Denes, Cathrin E. Hansen, Uemit Oezorhan, Sara Figuerola, Helga E. de Vries, Lydia Sorokin, Anna M. Planas, Britta Engelhardt, Markus Schwaninger
The contribution of β-amyloid, Tau and α-synuclein to blood–brain barrier damage in neurodegenerative disorders
Ying-Chieh Wu, Tizibt Ashine Bogale, Jari Koistinaho, Marina Pizzi, Taisia Rolova, Arianna Bellucci
Regional AT-8 reactive tau species correlate with intracellular Aβ levels in cases of low AD neuropathologic change
Nauman Malik, Mohi-Uddin Miah, Alessandro Galgani, Kirsty McAleese, Lauren Walker, Fiona E. LeBeau, Johannes Attems, Tiago F. Outeiro, Alan Thomas, David J. Koss
PP2A and GSK3 act as modifiers of FUS-ALS by modulating mitochondrial transport
Paraskevi Tziortzouda, Jolien Steyaert, Wendy Scheveneels, Adria Sicart, Katarina Stoklund Dittlau, Adriana Margarida Barbosa Correia, Thibaut Burg, Arun Pal, Andreas Hermann, Philip Van Damme, Thomas G. Moens, Ludo Van Den Bosch
Aggressive human MenG C meningiomas have a molecular counterpart in canines
Akdes S. Harmanci, Beth Boudreau, Sean Lau, Shervin Hosseingholi Nouri, Jacob J. Mandel, Hsiang-Chih Lu, Arif O. Harmanci, Tiemo J. Klisch, Jonathan M. Levine, Akash J. Patel
Canine meningiomas are comprised of 3 DNA methylation groups that resemble the molecular characteristics of human meningiomas
Naomi Zakimi, Christina N. Mazcko, Christine Toedebusch, Gregory Tawa, Kevin Woolard, Amy K. LeBlanc, Peter J. Dickinson, David R. Raleigh
MET receptor serves as a promising target in melanoma brain metastases
Torben Redmer, Elisa Schumann, Kristin Peters, Martin E. Weidemeier, Stephan Nowak, Henry W. S. Schroeder, Anna Vidal, Helena Radbruch, Annika Lehmann, Susanne Kreuzer-Redmer, Karsten Jürchott, Josefine Radke
Cortical-sparing chronic traumatic encephalopathy (CSCTE): a distinct subtype of CTE
Abigail Alexander, Victor E. Alvarez, Bertrand R. Huber, Michael L. Alosco, Jesse Mez, Yorghos Tripodis, Raymond Nicks, Douglas I. Katz, Brigid Dwyer, Daniel H. Daneshvar, Brett Martin, Joseph Palmisano, Lee E. Goldstein, John F. Crary, Christopher Nowinski, Robert C. Cantu, Neil W. Kowall, Robert A. Stern, Ivana Delalle, Ann C. McKee, Thor D. Stein
Myofiber-type-dependent ‘boulder’ or ‘multitudinous pebble’ formations across distinct amylopectinoses
Sharmistha Mitra, Baozhi Chen, John M. Shelton, Silvia Nitschke, Jun Wu, Lindsay Covington, Mathew Dear, Tori Lynn, Mayank Verma, Felix Nitschke, Yasuhiro Fuseya, Kazuhiro Iwai, Bret M. Evers, Berge A. Minassian
Disruption of the blood–brain barrier is correlated with spike endocytosis by ACE2 + endothelia in the CNS microvasculature in fatal COVID-19. Scientific commentary on "Detection of blood–brain barrier disruption in brains of patients with COVID-19, but no evidence of brain penetration by SARS-CoV-2”
Cynthia Magro, Esmerina Tili, Gerard Nuovo
Astroglial calcium signaling and homeostasis in tuberous sclerosis complex
Alessia Romagnolo, Giulia Dematteis, Mirte Scheper, Mark J. Luinenburg, Angelika Mühlebner, Wim Van Hecke, Marcello Manfredi, Veronica De Giorgis, Simone Reano, Nicoletta Filigheddu, Valeria Bortolotto, Laura Tapella, Jasper J. Anink, Liesbeth François, Stefanie Dedeurwaerdere, James D. Mills, Armando A. Genazzani, Dmitry Lim, Eleonora Aronica
Methylation class oligosarcoma, IDH-mutant could exhibit astrocytoma-like molecular features
Lingyu Liu, Yuqing Liu, Jing Chen, Tao Jiang, Xing Liu, Ke-Nan Zhang
RNA aptamer reveals nuclear TDP-43 pathology is an early aggregation event that coincides with STMN-2 cryptic splicing and precedes clinical manifestation in ALS
Holly Spence, Fergal M. Waldron, Rebecca S. Saleeb, Anna-Leigh Brown, Olivia M. Rifai, Martina Gilodi, Fiona Read, Kristine Roberts, Gillian Milne, Debbie Wilkinson, Judi O’Shaughnessy, Annalisa Pastore, Pietro Fratta, Neil Shneider, Gian Gaetano Tartaglia, Elsa Zacco, Mathew H. Horrocks, Jenna M. Gregory
The prevalence and topography of spinal cord demyelination in multiple sclerosis: a retrospective study
Alex D. Waldman, Cecilia Catania, Marco Pisa, Mark Jenkinson, Michael J. Lenardo, Gabriele C. DeLuca
Comprehensive proteomics of CSF, plasma, and urine identify DDC and other biomarkers of early Parkinson’s disease
Jarod Rutledge, Benoit Lehallier, Pardis Zarifkar, Patricia Moran Losada, Marian Shahid-Besanti, Dan Western, Priyanka Gorijala, Sephira Ryman, Maya Yutsis, Gayle K. Deutsch, Elizabeth Mormino, Alexandra Trelle, Anthony D. Wagner, Geoffrey A. Kerchner, Lu Tian, Carlos Cruchaga, Victor W. Henderson, Thomas J. Montine, Per Borghammer, Tony Wyss-Coray, Kathleen L. Poston
Alteration of LARGE1 abundance in patients and a mouse model of 5q-associated spinal muscular atrophy
Andreas Roos, Linda-Isabell Schmitt, Christina Hansmann, Stefanie Hezel, Schahin Salmanian, Andreas Hentschel, Nancy Meyer, Adela Della Marina, Heike Kölbel, Christoph Kleinschnitz, Ulrike Schara-Schmidt, Markus Leo, Tim Hagenacker
Role of GBA variants in Lewy body disease neuropathology
Ronald L. Walton, Shunsuke Koga, Alexandra I. Beasley, Launia J. White, Teresa Griesacker, Melissa E. Murray, Koji Kasanuki, Xu Hou, Fabienne C. Fiesel, Wolfdieter Springer, Ryan J. Uitti, Julie A. Fields, Hugo Botha, Vijay K. Ramanan, Kejal Kantarci, Val J. Lowe, Clifford R. Jack, Nilufer Ertekin-Taner, Rodolfo Savica, Jonathan Graff-Radford, Ronald C. Petersen, Joseph E. Parisi, R. Ross Reichard, Neill R. Graff-Radford, Tanis J. Ferman, Bradley F. Boeve, Zbigniew K. Wszolek, Dennis W. Dickson, Owen A. Ross, Michael G. Heckman
MSUT2 regulates tau spreading via adenosinergic signaling mediated ASAP1 pathway in neurons
Hong Xu, Qi Qiu, Peng Hu, Kevt’her Hoxha, Elliot Jang, Mia O’Reilly, Christopher Kim, Zhuohao He, Nicholas Marotta, Lakshmi Changolkar, Bin Zhang, Hao Wu, Gerard D. Schellenberg, Brian Kraemer, Kelvin C. Luk, Edward B. Lee, John Q. Trojanowski, Kurt R. Brunden, Virginia M.-Y. Lee
Neuronal STING activation in amyotrophic lateral sclerosis and frontotemporal dementia
Christine Marques, Aaron Held, Katherine Dorfman, Joon Sung, Catherine Song, Amey S. Kavuturu, Corey Aguilar, Tommaso Russo, Derek H. Oakley, Mark W. Albers, Bradley T. Hyman, Leonard Petrucelli, Clotilde Lagier-Tourenne, Brian J. Wainger
Gene transcript fusions are associated with clinical outcomes and molecular groups of meningiomas
Naomi Zakimi, Minh P. Nguyen, David R. Raleigh
Disentangling and quantifying the relative cognitive impact of concurrent mixed neurodegenerative pathologies
Carolina Maldonado-Díaz, Satomi Hiya, Raquel T. Yokoda, Kurt Farrell, Gabriel A. Marx, Justin Kauffman, Elena V. Daoud, Mitzi M. Gonzales, Alicia S. Parker, Leyla Canbeldek, Lakshmi Shree Kulumani Mahadevan, John F. Crary, Charles L. White III, Jamie M. Walker, Timothy E. Richardson
Correction: Abeta targets of the biosimilar antibodies of Bapineuzumab, Crenezumab, Solanezumab in comparison to an antibody against N-truncted Abeta in sporadic Alzheimer disease cases and mouse models
Yvonne Bouter, Jose Socrates Lopez Noguerola, Petra Tucholla, Gabriela A. N. Crespi, Michael W. Parker, Jens Wiltfang, Luke A. Miles, Thomas A. Bayer
A muscarinic receptor antagonist reverses multiple indices of diabetic peripheral neuropathy: preclinical and clinical studies using oxybutynin
Carolina M. Casselini, Henri K. Parson, Katie E. Frizzi, Alex Marquez, Darrell R. Smith, Lucie Guernsey, Rakesh Nemmani, Alireza Tayarani, Corinne G. Jolivalt, Jessica Weaver, Paul Fernyhough, Aaron I. Vinik, Nigel A. Calcutt
TMEM106B coding variant is protective and deletion detrimental in a mouse model of tauopathy
George A. Edwards III, Caleb A. Wood, Yang He, Quynh Nguyen, Peter J. Kim, Ruben Gomez-Gutierrez, Kyung-Won Park, Yong Xu, Cody Zurhellen, Ismael Al-Ramahi, Joanna L. Jankowsky
Loss of TMEM106B exacerbates Tau pathology and neurodegeneration in PS19 mice
Tuancheng Feng, Huan Du, Cha Yang, Ya Wang, Fenghua Hu
Correction to: MET receptor serves as a promising target in melanoma brain metastases
Torben Redmer, Elisa Schumann, Kristin Peters, Martin E. Weidemeier, Stephan Nowak, Henry W. S. Schroeder, Anna Vidal, Helena Radbruch, Annika Lehmann, Susanne Kreuzer-Redmer, Karsten Jürchott, Josefine Radke
Microglial phagolysosome dysfunction and altered neural communication amplify phenotypic severity in Prader-Willi Syndrome with larger deletion
Felipe Correa-da-Silva, Jenny Carter, Xin-Yuan Wang, Rui Sun, Ekta Pathak, José Manuel Monroy Kuhn, Sonja C. Schriever, Clarissa M. Maya-Monteiro, Han Jiao, Martin J. Kalsbeek, Pedro M. M. Moraes-Vieira, Johan J. P. Gille, Margje Sinnema, Constance T. R. M. Stumpel, Leopold M. G. Curfs, Dirk Jan Stenvers, Paul T. Pfluger, Dominik Lutter, Alberto M. Pereira, Andries Kalsbeek, Eric Fliers, Dick F. Swaab, Lawrence Wilkinson, Yuanqing Gao, Chun-Xia Yi
Landscape of brain myeloid cell transcriptome along the spatiotemporal progression of Alzheimer’s disease reveals distinct sequential responses to Aβ and tau
Astrid Wachter, Maya E. Woodbury, Sylvia Lombardo, Aicha Abdourahman, Carolin Wuest, Emily McGlame, Timothy Pastika, Joseph Tamm, Nandini Romanul, Kiran Yanamandra, Rachel Bennett, Gen Lin, Taekyung Kwon, Fan Liao, Corinna Klein, Yelena Grinberg, Methasit Jaisa-aad, Huan Li, Matthew. P. Frosch, Markus P. Kummer, Sudeshna Das, Tammy Dellovade, Eric H. Karran, Xavier Langlois, Janina S. Ried, Alberto Serrano-Pozo, Robert V. Talanian, Knut Biber, Bradley T. Hyman
Characterization of monoamine oxidase-B (MAO-B) as a biomarker of reactive astrogliosis in Alzheimer’s disease and related dementias
Methasit Jaisa-aad, Clara Muñoz-Castro, Molly A. Healey, Bradley T. Hyman, Alberto Serrano-Pozo
Altered TFEB subcellular localization in nigral neurons of subjects with incidental, sporadic and GBA-related Lewy body diseases
Tim E. Moors, Martino L. Morella, Cesc Bertran-Cobo, Hanneke Geut, Vinod Udayar, Evelien Timmermans-Huisman, Angela M. T. Ingrassia, John J. P. Brevé, John G. J. M. Bol, Vincenzo Bonifati, Ravi Jagasia, Wilma D. J. van de Berg
Metabologenomic characterization uncovers a clinically aggressive IDH mutant glioma subtype
Farshad Nassiri, Andrew Ajisebutu, Vikas Patil, Yasin Mamatjan, Jeff Liu, Justin Z. Wang, Mathew R. Voisin, Romina Nejad, Sheila Mansouri, Shirin Karimi, Ankur Chakravarthy, Eric Chen, Daniel D. De Carvalho, Kenneth Aldape, Gelareh Zadeh
Regulated cell death and its role in Alzheimer’s disease and amyotrophic lateral sclerosis
Dietmar Rudolf Thal, Klara Gawor, Sebastiaan Moonen
Rare genetic variation in fibronectin 1 (FN1) protects against APOEε4 in Alzheimer’s disease
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