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Archives of Virology
Erschienen in: Archives of Virology 9/2009

01.09.2009 | Brief Report

Activation of extracellular signal-regulated kinase in MDBK cells infected with bovine viral diarrhea virus

verfasst von: Daisuke Yamane, Muhammad Atif Zahoor, Yassir Mahgoub Mohamed, Walid Azab, Kentaro Kato, Yukinobu Tohya, Hiroomi Akashi

Erschienen in: Archives of Virology | Ausgabe 9/2009

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Abstract

Our efforts to identify the cellular signaling cascades triggered by bovine viral diarrhea virus (BVDV) infection in MDBK cells revealed marked activation of extracellular signal-regulated kinase 1/2 (ERK). Enhanced phosphorylation of ERK was detected following infection with cytopathogenic (cp) BVDV, but not with noncytopathogenic BVDV. It appears that cp BVDV-induced ERK phosphorylation is caused by oxidative stress, because ERK phosphorylation was inducible by treatment with hydrogen peroxide or serum deprivation and was attenuated by addition of antioxidants. These results indicate that BVDV infection influences the ERK signaling pathway via oxidative stress, depending on the biotype.
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Metadaten
Titel
Activation of extracellular signal-regulated kinase in MDBK cells infected with bovine viral diarrhea virus
verfasst von
Daisuke Yamane
Muhammad Atif Zahoor
Yassir Mahgoub Mohamed
Walid Azab
Kentaro Kato
Yukinobu Tohya
Hiroomi Akashi
Publikationsdatum
01.09.2009
Verlag
Springer Vienna
Erschienen in
Archives of Virology / Ausgabe 9/2009
Print ISSN: 0304-8608
Elektronische ISSN: 1432-8798
DOI
https://doi.org/10.1007/s00705-009-0453-2

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