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Drugs & Aging
Erschienen in: Drugs & Aging 7/2007

01.07.2007 | Therapy In Practice

Acute Exacerbations of Chronic Bronchitis in Elderly Patients

Pathogenesis, Diagnosis and Management

verfasst von: Don Hayes Jr, Dr Keith C. Meyer

Erschienen in: Drugs & Aging | Ausgabe 7/2007

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Abstract

Chronic bronchitis (CB) is a disorder that is characterised by chronic mucus production. This disorder is called chronic obstructive pulmonary disease (COPD) when airflow obstruction is present. The majority of patients with COPD, which often goes undiagnosed or inadequately treated in the elderly, have symptoms consistent with CB. The clinical course of CB is usually punctuated by periodic acute exacerbations linked to infections caused by viral and typical or atypical bacterial pathogens. Acute exacerbations of chronic bronchitis (AECB) often lead to a decline in lung function and poor quality of life in association with increased risk of mortality and a significant economic impact on the healthcare system and society because of the direct costs of hospitalisations. In elderly individuals with COPD, co-morbidities play a vital role as determinants of health status and prognosis. Failure to eradicate infecting pathogens contributes to persistence of infection and inflammation that requires repeated courses of therapy and hospitalisation. Stratifying patients with AECB according to symptoms, degree of pulmonary function impairment and risk factors for poor outcome can help clinicians choose empirical antimicrobial chemotherapy regimens that are most likely to result in treatment success. Failure to cover likely pathogens associated with episodes of AECB can lead to lengthy hospital admissions and significant declines in functional status for elderly patients. Fluoroquinolones may provide the best therapeutic option for elderly patients with COPD who have complicated underlying CB but who are sufficiently stable to be treated in the outpatient setting. Optimised treatment for stable outpatients with CB may diminish the frequency of AECB, and effective antimicrobial therapy for AECB episodes can significantly diminish healthcare costs and maintain quality of life in the elderly patient.
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Metadaten
Titel
Acute Exacerbations of Chronic Bronchitis in Elderly Patients
Pathogenesis, Diagnosis and Management
verfasst von
Don Hayes Jr
Dr Keith C. Meyer
Publikationsdatum
01.07.2007
Verlag
Springer International Publishing
Erschienen in
Drugs & Aging / Ausgabe 7/2007
Print ISSN: 1170-229X
Elektronische ISSN: 1179-1969
DOI
https://doi.org/10.2165/00002512-200724070-00004

Weitere Artikel der Ausgabe 7/2007

Drugs & Aging 7/2007 Zur Ausgabe

Original Research Article

Characterisation of Patients with Postmenopausal Osteoporosis in French Primary Healthcare

Current Opinion

Clinical Perspectives on Bone Quality in Osteoporosis

Review Article

Sustained-Release Ophthalmic Drug Delivery Systems for Treatment of Macular Disorders

Review Article

Glucosamine and Chondroitin Sulfate as Therapeutic Agents for Knee and Hip Osteoarthritis

Therapy In Practice

Epidemiology and Management of Apathy in Patients with Alzheimer’s Disease

Leading Article

Neuroprotective Effects of Free Radical Scavengers in Stroke

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