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01.12.2008 | Case Report

Additional acquisition of t(1;21)(p32;q22) in a patient relapsing with acute myelogenous leukemia with NUP98-HOXA9

verfasst von: Takatoshi Aoki, Toshihiro Miyamoto, Shuro Yoshida, Asataro Yamamoto, Takuji Yamauchi, Goichi Yoshimoto, Yasuo Mori, Kenjiro Kamezaki, Hiromi Iwasaki, Katsuto Takenaka, Naoki Harada, Koji Nagafuji, Takanori Teshima, Koichi Akashi

Erschienen in: International Journal of Hematology | Ausgabe 5/2008

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Abstract

We report a 29-year-old Japanese male with acute myelogenous leukemia (AML)-M4 with a cryptic t(7;11)(p15;p15), in which a chimeric NUP98-HOXA9 fusion was detected by polymerase chain reaction analysis and a chromosomal analysis showed 46,XY. The patient received intensive chemotherapy and underwent autologous stem cell transplantation, and remission was confirmed by the disappearance of NUP98-HOXA9. However, 6 months after transplantation, the patient relapsed; NUP98-HOXA9 was detected again and karyotypic analysis revealed 46,XY, t(1;21)(p32;q22). Fluorescent in situ hybridization (FISH) analysis using an AML1-ETO translocation dual probe, showed that the 21q22 breakpoint involved AML1 locus. A retrospective FISH analysis showed that t(1;21) was absent at onset. This is the first reported case with AML who had a cryptic t(7;11)(p15;p15), and additionally acquired t(1;21)(p32;q22) at relapse.

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Titel: Additional acquisition of t(1;21)(p32;q22) in a patient relapsing with acute myelogenous leukemia with NUP98-HOXA9
verfasst von: Takatoshi Aoki
Toshihiro Miyamoto
Shuro Yoshida
Asataro Yamamoto
Takuji Yamauchi
Goichi Yoshimoto
Yasuo Mori
Kenjiro Kamezaki
Hiromi Iwasaki
Katsuto Takenaka
Naoki Harada
Koji Nagafuji
Takanori Teshima
Koichi Akashi
Publikationsdatum: 01.12.2008
Verlag: Springer Japan
Erschienen in: International Journal of Hematology / Ausgabe 5/2008
Print ISSN: 0925-5710
Elektronische ISSN: 1865-3774
DOI: https://doi.org/10.1007/s12185-008-0198-9

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Additional acquisition of t(1;21)(p32;q22) in a patient relapsing with acute myelogenous leukemia with NUP98-HOXA9

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