Background
Methods
Study design
Patients
Therapy and follow-Up treatment
Microbiological analysis
Statistical analysis
Results
Variables | test | control | P (U test) | |
---|---|---|---|---|
n | 23 | 23 | ||
Age | (years) | 50.6 ± 5.8 | 50.9 ± 6.9 | |
Males | (n) | 11 | 13 | |
Females | (n) | 12 | 10 | |
Smoker | (n) | 8 | 8 | |
PD | (mm) | 3.3 ± 0.4 | 3.3 ± 0.3 | 0.965 |
AL | (mm) | 3.5 ± 0.2 | 3.4 ± 0.3 | 0.947 |
BOP | (%) | 16.5 ± 4 | 16.7 ± 5.5 | 0.724 |
API | (%) | 18.3 ± 8.2 | 21.7 ± 5.6 | 0.094 |
SBI | (%) | 18.7 ± 6.5 | 18.1 ± 5.6 | 0.869 |
N test group = 23 N control group = 23 | Baseline | 3 months | 6 months | Difference t0-t3 | Difference t0-t6 |
---|---|---|---|---|---|
BoP (%) | |||||
Test Control | 17.0 (13.0, 19.0) *** 16.0 (13.0, 19.0) *** | 6.0 (4.0, 9.0) *** †† 9.0 (5.0, 12.0) *** | 12.0 (9.0, 14.0) *** 11.0 (8.0, 17.0) *** | 10.0 (8.0, 12.0) *** † 9.0 (6.0, 11.0) *** | 5.0 (3.0, 8.0) *** 4.0 (2.0, 7.0) *** |
Test Control | 16.5 ± 4.0 16.7 ± 5.5 | 6.2 ± 3.0 8.7 ± 3.7 | 11.5 ± 4.9 13.0 ± 6.7 | 10.3 ± 3.1 8.0 ± 4.0 | 5.0 ± 4.0 3.7 ± 5.6 |
SBI (%) | |||||
Test group Control group | 18.0 (14.0, 23.0) *** 16.0 (14.0, 21.0) *** | 12.0 (8.0, 15.0) *** 11.0 (7.0, 15.0) *** | 13.0 (11.0, 18.0) *** 13.0 (11.0, 15.0) *** | 7.0 (4.0, 11.0) *** 8.0 (4.0, 12.0) *** | 4.0 (0.0, 8.0) ** 4.0 (3.0, 8.0) ** |
Test Control | 18.7 ± 6.5 18.1 ± 5.6 | 11.8 ± 4.4 10.3 ± 4.3 | 13.4 ± 5.2 13.4 ± 3.8 | 6.8 ± 5.2 7.8 ± 5.4 | 5.2 ± 5.7 4.7 ± 5.9 |
Mean PD (mm) | |||||
Test Control | 3.3 (3.1, 3.6) *** 3.2 (3.1, 3.5) *** | 2.1 (2.0, 2.2) *** †† 2.2 (2.0, 2.5) *** | 2.2 (2.0, 2.3) *** †† 2.3 (2.1, 2.5) *** | 1.2 (0.8, 1.2) *** † 1.0 (0.9, 1.5) *** | 1.1 (0.8, 1.2) *** 1.0 (0.8, 1.5) *** |
Test Control | 3.3 ± 0.4 3.3 ± 0.3 | 2.1 ± 0.3 2.3 ± 0.2 | 2.2 ± 0.2 2.3 ± 0.3 | 1.2 ± 0.3 1.0 ± 0.3 | 1.1 ± 0.3 1.0 ± 0.3 |
Mean AL (mm) | |||||
Test group Control group | 3.5 (3.3, 3.7) *** 3.5 (3.3, 3.7) *** | 2.5 (2.4, 2.6) *** †† 2.8 (2.5, 2.9) *** | 2.6 (2.5, 2.7) *** †† 2.8 (2.7, 3.0) *** | 0.9 (0.8, 1.1) *** ††† 0.7 (0.6, 0.8) *** | 0.9 (0.7, 1.0) *** ††† 0.6 (0.5, 0.7) *** |
Test Control | 3.5 ± 0.2 3.4 ± 0.3 | 2.5 ± 0.3 2.7 ± 0.3 | 2.6 ± 0.2 2.8 ± 0.3 | 1.0 ± 0.3 0.7 ± 0.2 | 0.9 ± 0.2 0.6 ± 0.2 |
Sites PD > 5 mm (n) | |||||
Test Control | 18.0 (13.0,27.0) 19.0 (9.0, 25.0) | 0.0 (0.0, 2.0) 1.0 (0.0, 5.0) | 0.0 (0.0, 2.0) 2.0 (0.0, 6.0) | 17.0 (13.0, 26.0) 17.0 (8.0, 22.0) | 18.0 (13.0, 25.0) 16.0 (7.0, 22.0) |
Test Control | 18.7 ± 10.3 19.4 ± 13.0 | 1.1 ± 1.7 2.7 ± 3.3 | 1.3 ± 2.2 3.4 ± 4.2 | 17.6 ± 9.2 16.7 ± 10.2 | 17.4 ± 8.7 16.0 ± 9.9 |
Mean sites PD > 5 mm (n) | |||||
Test Control | 5.3 (5.0, 5.5) 5.3 (5.0, 5.5) | 3.0 (2.8, 3.3) 3,0 (2.8, 3.3) | 3.0 (2.8, 3.5) 3.0 (2.8, 3.3) | 2.5 (2.3, 2.5) 2.3 (2.0, 2.5) | 2.3 (2.0, 2.5) 2.3 (2.0, 2.3) |
Test Control | 5.3 ± 0.4 5.3 ± 0.4 | 3.0 ± 0.4 3.0 ± 0.3 | 3.1 ± 0.4 3.1 ± 0.3 | 2.3 ± 0.2 2.3 ± 0.3 | 2.2 ± 0.3 2.2 ± 0.4 |
Sites AL > 5 mm (n) | |||||
Test Control | 21.0 (14.0, 31.0) 21.0 (12.0, 27.0) | 2.0 (0.0, 3.0) 2.0 (0.0, 6.0) | 1.0 (0.0, 3.0) 3.0 (0.0, 8.0) | 21.0 (14.0, 27.0) 16.0 (12.0, 24.0) | 21.0 (14.0, 27.0) 16.0 (9.0, 23.0) |
Test Control | 21.3 ± 11.5 22.3 ± 14.7 | 2.1 ± 3.3 3.4 ± 4.2 | 2.4 ± 3.7 4.3 ± 4.4 | 19.2 ± 9.5 18.9 ± 11.7 | 18.9 ± 9.1 18.0 ± 11.7 |
Mean sites AL > 5 mm (n) | |||||
Test Control | 4.0 (4.0, 4.3) 4.0 (4.0, 4.3) | 2.8 (2.8, 3.0) 3.0 (2.8, 3.0) | 3.0 (3.0, 3.0) 3.0 (3.0, 3.3) | 1.3 (1.3, 1.5) 1.3 (1.0, 1.5) | 1.0 (1.0, 1.3) 1.0 (0.8, 1.3) |
Test Control | 4.2 ± 0.3 4.1 ± 0.2 | 2.9 ± 0.2 2.9 ± 0.3 | 3.1 ± 0.2 3.1 ± 0.2 | 1.3 ± 0.2 1.2 ± 0.3 | 1.1 ± 0.3 1.0 ± 0.2 |
Species | Cat. | Baseline | 3 months | 6 months | Sig. Δt0-t3 inter | Sig. Δt0-t6 inter | Sig. Δt0-t3 intra | Sig. Δt0-t6 intra | |||
---|---|---|---|---|---|---|---|---|---|---|---|
test | control | test | control | test | control | ||||||
N = 23 |
N = 23 |
N = 23 |
N = 23 |
N = 23 |
N = 23 | ||||||
A. act.
| 0-1 | 82.6 | 91.3 | 87 | 91.3 | 82.6 | 91.3 |
p = 0.156 |
p = 0.221 | pt = 0.625 | pt = 0.375 |
2 | 4.3 | 0 | 0 | 4.3 | 0 | 4.3 | |||||
3 4 | 13.0 0 | 0 8.7 | 4.3 8.7 | 0 4.3 | 8.7 8.7 | 0 4.3 | pc = xxx | pc = xxx | |||
P. ging.
| 0-1 | 60.8 | 43.5 | 73.9 | 60.9 | 52.1 | 39.1 |
p = 0.693 |
p = 0.849 | pt = 0.289 | pt = 0.687 |
2 | 4.3 | 0 | 4.3 | 13.0 | 0 | 0 | |||||
3 4 | 0 34.8 | 8.7 47.8 | 8.7 13.0 | 4.3 21.7 | 17.4 30.4 | 17.4 43.5 | pc = 0.109 | pc = 1.000 | |||
T. dent.
| 0-1 | 13 | 0 | 30.4 | 13 | 4.3 | 0 |
p = 0.044 |
p = 0.224 | pt = 0.057 | pt = 0.549 |
2 | 4.3 | 4.3 | 8.7 | 17.4 | 8.7 | 0 | |||||
3 4 | 0 82.6 | 17.4 78.3 | 21.7 39.1 | 39.1 30.4 | 26.1 60.9 | 21.7 78.3 | pc = 0.004 | pc = 1.000 | |||
T. fors.
| 0-1 | 8.7 | 4.3 | 26 | 13 | 13 | 4.3 |
p = 0.632 |
p = 0.039 | pt = 0.012 | pt = 0.754 |
2 | 4.3 | 0 | 13 | 4.3 | 0 | 0 | |||||
3 4 | 8.7 78.3 | 0 95.7 | 13 47.8 | 21.7 60.9 | 26.1 60.9 | 4.3 91.3 | pc = 0.008 | pc = xxx | |||
F. nucl.
| 0-1 | 4.3 | 0 | 0 | 4.3 | 4.3 | 0 |
p = 0.029 |
p = 0.179 | pt = 0.344 | pt = 1.000 |
2 | 8.7 | 0 | 13.0 | 4.3 | 4.3 | 0 | |||||
3 4 | 8.7 78.3 | 4.3 95.7 | 26.1 60.9 | 0 91.3 | 17.4 73.9 | 8.7 91.3 | pc = 1.000 | pc = xxx | |||
P. micra
| 0-1 | 34.7 | 4.3 | 52.2 | 39.1 | 26.1 | 13 |
p = 0.127 |
p = 0.155 | pt = 0.035 | pt = 1.000 |
2 | 4.3 | 13.0 | 8.7 | 8.7 | 21.7 | 13 | |||||
3 4 | 30.4 30.4 | 47.8 34.8 | 34.8 4.3 | 52.2 0 | 39.1 13.0 | 65.2 8.7 | pc < 0.001 | pc = 0.210 | |||
C. rectus
| 0-1 | 21.7 | 30.4 | 56.5 | 56.5 | 39.1 | 39.1 | 0.507 | 0.142 | pt = 0.002 | pt = 0.115 |
2 | 8.7 | 4.3 | 21.7 | 4.3 | 30.4 | 13.0 | |||||
3 4 | 56.5 13.0 | 47.8 17.4 | 21.7 0 | 39.1 0 | 26.1 4.3 | 43.5 4.3 | pc = 0.012 | pc = 0.227 | |||
P. interm.
| 0-1 | 65.2 | 39.1 | 78.2 | 56.5 | 65.2 | 34.7 |
p = 0.537 |
p = 0.605 | pt = 0.508 | pt = 1.000 |
2 | 4.3 | 0 | 4.3 | 21.7 | 4.3 | 0 | |||||
3 4 | 8.7 21.7 | 8.7 52.2 | 4.3 13.0 | 4.3 17.4 | 21.7 8.7 | 39.1 26.1 | pc = 0.039 | pc = 0.344 | |||
E. corrod.
| 0-1 | 52.2 | 56.5 | 73.9 | 78.2 | 34.7 | 65.2 |
p = 0.189 |
p = 0.364 | pt = 1.000 | pt = 0.302 |
2 | 13.0 | 13.0 | 4.3 | 8.7 | 21.7 | 4.3 | |||||
3 4 | 21.7 13.0 | 21.7 8.7 | 13.0 8.7 | 13.0 0.0 | 34.8 8.7 | 21.7 8.7 | pc = 0.146 | pc = 0.549 | |||
A. viscosus
| 0-1 | 21.7 | 4.3 | 17.3 | 21.7 | 8.7 | 4.3 |
p = 0.411 |
p = 0.067 | pt = 0.118 | pt = 0.424 |
2 | 17.4 | 8.7 | 8.7 | 8.7 | 13.0 | 30.4 | |||||
3 4 | 47.8 13.0 | 56.5 30.4 | 39.1 34.8 | 52.2 17.4 | 56.5 21.7 | 43.5 21.7 | pc = 0.210 | pc = 0.267 |