Background
Materials and methods
Search strategy
Selection criteria
Inclusion criteria
Exclusion criteria
Data extraction
Methodological quality of the included studies
Statistical analysis
Results
Literature search and study characteristics
Name | Type of literature | Journal | Year Published | Trial sequence | Design | Sample | Pre-infusion conditioning | Dose | Target | Costimulatory domain | AEs criteria |
---|---|---|---|---|---|---|---|---|---|---|---|
Ying Zhita; a | Journal | Molecular Therapy-Oncolytics | 2019 | NCT03528421 | phase 1/2 | 3 | CF | 5*10^5/kg | CD19 | CD28 | CTCAE v5.0 |
Ying Zhita;a | Journal | Molecular Therapy-Oncolytics | 2019 | NCT03528421 | phase 1/2 | 3 | CF | 5*10^5/kg | CD19 | 41BB | Not found |
Yan, Zi-Xun | Journal | Clinical Cancer Research | 2019 | NCT03355859 | phase 1 | 10 | CF | (2.5 or 5 or 10) *10^7 | CD19 | 41BB | CTCTAE v4.03 |
Sang, W | Journal | Cancer Med | 2020 | NCT03207178 | phase 2 | 21 | CF/ifosfamide | CD19: 1.0 (0.2–4.0) *10^6/kg CD20:1.0*(0.1–4.0) *10^6/kg | CD19 + CD22 | CD28 + 41BB | CTCTAE v4.03 |
Tong, C | Journal | Blood | 2020 | NCT03097770 | phase 1/2a | 28 | CF-based | 0.5*10^6–6*10^6/kg | CD19 + CD20 | 41BB | CTCAE v4.0 |
Xu, J | Journal | PNAS | 2019 | NCT03090659 | phase 1 | 17 | CF/Cy-based | 0.7(0.21–1.52) *10^6/kg | LCAR-B38M | 41BB | CTCTAE v4.03 |
Zhao, W. H | Journal | J Hematol Oncol | 2018 | NCT03090659 | phase1 | 57 | Cy | 0.5(0.07–2.1)*10^6/kg | LCAR-B38M | 41BB | CTCTAE v4.03 |
Shah, N. N | Journal | Nature Medicine | 2020 | NCT03019055 | phase 1 | 22 | CF | (2.5 or 7.5 or 25) * 10^5/kg | CD19 + CD20 | 41BB | CTCAE v5.0 |
Wang, Y | Journal | Int J Lab Hematol | 2020 | NCT02782351 | phase 1/2 | 21 | CF | 1*10^6/kg | CD19 | 41BB | CTCTAE v4.03 |
Fried, S. | Journal | Bone Marrow Transplant | 2019 | NCT02772198 | phase1b/2 | 35 | CF | CD19 | CD28 | Not found | |
An, F | Journal | Nature Communications | 2020 | NCT02735291 | phase 2 | 47 | CF/VDCP/ Cy | (1–5)*10^6/kg; ≤2*10^9 | CD19 | 41BB | CTCTAE v4.03 |
Ramos, C. A | Journal | Journal of Clinical Oncology | 2020 | NCT02690545 NCT02917083 | phase 1/2 | 42 | CF/Benda/Benda-Flu | 2*10^7cells/m2; 1*10^8cells/m2; 2*10^8 cells/m2 | CD30 | CD28 | CTCAE v4.0 |
Raje, N | Journal | N Engl J Med | 2019 | NCT02658929 | phase 1 | 33 | CF | 50、150、450、800*10^6 | BCMA | 41BB | CTCTAE v4.03 |
Abramson, J. S | Journal | lancet | 2020 | NCT02631044 | phase 1 | 269 | CF | (50 or 10 or 150) *10^6 | CD19 | 41BB | CTCTAE v4.03 |
Wang, M | Journal | N Engl J Med | 2020 | NCT02601313 | phase 2 | 68 | CF | 2*10^6/kg | CD19 | 41BB | CTCTAE v4.03 |
Cohen, A. D | Journal | J Clin Invest | 2019 | NCT02546167 | phase 1 | 25 | Cy | (1–5)*10^8 | BCMA | 41BB | CTCAE v4.0 |
Goto, H | Journal | Int J Clin Oncol | 2020 | NCT02445248 | phase 2 | 9 | CF or Benda | 2*(1–4.9)*10^8 | CD19 | 41BB | CTCAE v4.03 |
Schuster, S. J | Journal | N EngL J Med | 2018 | NCT02445248 | phase 2a | 111 | CF/Benda | 3(0.1–6)*10^8 cells | CD19 | 41BB | CTCTAE v4.03 |
Ghorashian, S | Journal | Nat Med | 2019 | NCT02443831 | phase1 | 14 | CF/Cy | 10^6/kg or 0.73–0.78*10^6/kg | CD19 | 41BB | CTCAE v4.03 |
Maude, S. L | Journal | N Engl J Med | 2018 | NCT02435849 | phase 1/2a | 75 | CF mainly | 2.9(SD1.2)*10^7/kg | CD19 | 41BB | CTCAE v4.03 |
Strati, Paolo | Journal | Haematologica | 2020 | NCT02348216 NCT03153462 | ZUMA-1 + ZUMA-9 | 31 | CF | 2*10^6/kg | CD19 | CD28 | CTCTAE v4.03 |
Locke, F. L | Journal | Lancet Oncol | 2019 | NCT02348216 | phase 1/2 | 108 | CF | 2*10^6/kg | CD19 | CD28 | CTCTAE v4.03 |
Fry, T. J | Journal | Nature medicine | 2017 | NCT02315612 | phase 1 | 21 | (3 or 10 or 30)*10^5/kg | CD22 | 41BB | Not found | |
Ali, S. A | Journal | Blood | 2016 | NCT02215967 | phase 1 | 12 | CF | (0.3 or 1 or 3 or 9)*10^6/kg | BCMA | CD28 | CTCAE v4.02 |
Enblad, Gunilla | Journal | Clin Cancer Res | 2018 | NCT02132624 | phase 1/2a | 15 | CF | (2–20)*10^7 cells/m2 | CD19 | CD28 + 41BB | Not found |
Schuster, S. J | Journal | N Engl J Med | 2017 | NCT02030834 | case-series | 28 | Cy/EPOCH/Benda/Radio+Cy/etoposide+Cy/CBP + GEM | 5.79(3.08–8.87)*10^6 /Kg | CD19 | 41BB | Not found |
Gardner, R. A | Journal | Blood | 2017 | NCT02028455 | phase 1/2 | 43 | CF/Cy | (1 or 5 or 10)*10^6/kg | CD19 | 41BB | CTCAE v4 |
Curran, K. J | Journal | Blood | 2019 | NCT01860937 | phase 1 | 25 | CF/Cy | (1 or 3)*10^6/kg | CD19 | CD28 | CTCTAE v4.03 |
Ramos, Carlos A | Journal | Molecular Therapy | 2018 | NCT01853631 | phase 1 | 16 | CF | (1 or 5 or 20)*10^6 cells/m2 | CD19 | CD28 + 41BB(2nd + 3st generation) | CTCTAE v4 |
Zhang, W. Y | Journal | Signal Transduct Target Ther | 2016 | NCT01735604 | phase 2a | 11 | Cy-based | (0.41–1.46)*10^7/ kg | CD20 | 41BB | CTCAE v3.0 |
Lee, D. Wb | Journal | Lancet | 2014 | NCT01593696 | phase 1 | 19 | CF | (1 or 3)*10^6/kg | CD19 | CD28 | CTCAE v4.02 |
Geyer, M. B. | Journal | Mol Ther | 2018 | NCT01416974 | phase1 | 8 | Cy | (3 or 10 or 30)*10^7 | CD19 | CD28 | CTCAE v4 |
Geyer, M. B | Journal | JCI Insight | 2019 | NCT00466531 | phase1 | 20 | Cy,or CF or Benda | (0.4–3.0)*10^7/kg | CD19 | CD28 | CTCAE v3.0 |
Sesques, Pc | Journal | American Journal of Hematology | 2020 | commercial CAR T cells | retrospectively | 33 | CF;/Benda | Not found | CD19 | 41BB | CTCAE v5.0 |
Sesques, Pc | Journal | American Journal of Hematology | 2020 | commercial CAR T cells | retrospectively | 28 | CF | Not found | CD19 | CD28 | CTCAE v5.0 |
Wang, Nd | Journal | Blood | 2019 | ChiCTR-OPN-16008526 | a pilot study | 51 | CF | CD19:2.6 ± 1.5*10^6/kg; CD22:2.7 ± 1.2*10^6/kg; | CD19 + CD22 | CD28 + 41BB | CTCTAE v4.03 |
Wang, Nd | Journal | Blood | 2019 | ChiCTR-OPN-16008526 | a pilot study | 38 | CF | CAR19–5.1 ± 2.1*10^6/kg; CAR22–5.3 ± 2.4*10^6/kg | CD19 + CD22 | CD28 + 41BB | CTCTAE v4.03 |
Zhou, X | Journal | Frontiers in Immunology | 2020 | ChiCTR-OOC-16007779) | phase 1 | 21 | CF | 8.9(0.3–48)* 10^5/kg | CD19 | forth generation | CTCTAE v4.03 |
Wang, Jia | Journal | British Journal of Haematology | 2020 | ChiCTR-ONN-16009862+ ChiCTR1800019622 | a pilot study | 23 | CF | 1*10^6/Kg | CD19 | 41BB | CTCAE v4.03 |
Zhiling Yan | Journal | Lancet Haematol | 2019 | ChiCTROIC-17,011,272 | phase 2 | 21 | CF | 1*10^6/kg | CD19 + BCMA | 41BB | CTCAE v4.0 |
Bao, F. | Journal | Zhonghua xueyexue zazhi | 2018 | case-series | 10 | CF | 4.27(0.30–6.93)*10^6/kg | CD19 | 41BB | CTCAE | |
Jain, T | Journal | Blood Advances | 2020 | NCT01044069; NCT03070327; commercial CAR T cells | clinical trials; retrospectively | 83 | CF/Cy/Bendam | Not found | CD19、BCMA | CD28、41BB | CTCAE v5.0 |
Popat, R | Abstract | Blood | 2019 | NCT03287804 | phase 1 | 11 | CF | (15 or 75 or 225 or 600 or 900)*10^6 | BCMA+TACI | CD28 + OX40 | Not found |
Usmani, S. Z | Abstract | HemaSphere | 2020 | NCT03548207 | phase 1b | 29 | CF | 0.73(0.5–0.9)*10^6/kg | BCMA | 41BB | CTCAE v5.0 |
Mailankody, S | Abstract | HemaSphere | 2020 | NCT034330011 | phase1/2 | 51 | CF | (300 or 450 or 600)*10^6 | BCMA | 41BB | Not found |
Hu, Jianda | Abstract | Blood | 2018 | NCT03391726 | phase 2/3 | 8 | CF | (0.7–6) *10^6/kg. | CD19 | 41BB | Not found |
Amrolia, Persis J. | Abstract | Blood | 2018 | NCT03287817 | phase 1; AUTO3 | 8 | CF | (1 or 3 or 5)*10^6/kg | CD19 + CD22 | OX40(CD19); 41BB(CD22) | Not found |
Ardeshna, Kirit | Abstract | Blood | 2019 | NCT03287817 | phase1/2; AUTO3 | 11 | CF | (50 or 150) *10^6 | CD19 + CD22 | OX40(CD19); 41BB(CD22) | Not found |
Yan, Lingzhi | Abstract | Blood | 2019 | NCT03196414 | phase 1/2 | 28 | CF | CD19 1.0*10^7/kg; BCMA(2–6.8) × 10^7/kg | CD19 + BCMA | 41BB | Not found |
Wierda, William G | Abstract | Blood | 2018 | NCT02614066 | phase 1 | 35 | CF | (0.5 or 1 or 2)*10^6/kg | CD19 | 41BB | Not found |
Topp, M. S. | Abstract | Hematological Oncology | 2019 | NCT02348216 | ZUMA-1 updated | 21 | CF | 2*10^6/kg | CD19 | CD28 | Not found |
Jiang, Songfu | Abstract | Blood | 2018 | 16 | CF | (0.5 or 1.8 or 1.5)*10^8 | BCMA | 41BB | Not found | ||
Dourthe, M. E | Abstract | Blood | 2019 | sponsored-clinical trial | 41 | CF | (2–5)*10^6/kg (weight ≤ 50 kg); (1–2.5)*10^8 /kg (weight > 50 kg) | CD19 | 41BB | Not found | |
Jacobson, Caron | Abstract | Blood | 2020 | NCT03105336 | phase 2 | 146 | CF | 2*10^6/kg | CD19 | CD28 | CTCAE v4.03 |
WayneAS | Abstract | HemaSphere | 2019 | NCT02625480 | phase1 | 24 | CF | 1 or 2*10^6/kg | CD19 | 41BB | Not found |
Name | Disease | Sample | Sex (male%) | Age [median(range)] | Prior therapy lines | HSCT% |
---|---|---|---|---|---|---|
Abramson, J. S | lymphoma | 269 | 65% | 63(54–70) | ≥3 lines: 51% | 35% |
Zhiling Yan | MM | 21 | 48% | 58(49.5–61) | mean lines: 6 | 14% |
Ali, S. A | MM | 12 | median lines: 7 | 100% | ||
Cohen, A. D | MM | 25 | 68% | 58(44–75) | median(range) lines: 7(3–13) | 92% |
Curran, K. J | ALL | 25 | 13.5(1–22.5) | Not found | 20% | |
Enblad, Gunilla | lymphoma+ALL | 15 | 47% | 61(24–71) | mean lines: 1.73 | 40% |
Fry, T. J | B-ALL | 21 | 62% | 19(7–30) | Not found | 90% |
Gardner, R. A | B-ALL | 43 | 44% | 12.3(1.3–25.4) | Not found | 62% |
Geyer, M. B. | CLL | 8 | 100% | 58(45–70) | Not found | |
Geyer, M. B | CLL + NHL | 20 | 70% | 63(43–75) | median(range) lines: 4(1–11) | 0 |
Goto, H | DLBCL | 9 | 56% | 61(32–73) | mean lines; 3 | 44.40% |
Fried, S. | ALL+NHL | 35 | 71% | 27(3.5–55) | Not found | 37% |
Lee, D. W | ALL+DLBCL | 19 | 67% | 1 to 30 | mean lines: 2 | 38% |
Locke, F. L | lymphoma | 108 | 68% | Phase 1: 59 (IQR34–69);Phase 2: 58 (IQR51–64) | median lines: 3 | 23% |
Maude, S. L | ALL | 75 | 57% | 11(3–23) | median(range) lines: 3(1–8) | 61% |
Xu, J | MM | 17 | 65% | 55(40–73) | median(range) lines: 5(3–11) | 47% |
Schuster, S. J | DLBCL | 111 | 65% | 56 (22–76) | ≥3 lines: 52% | 49% |
Raje, N | MM | 33 | 64% | 60(37–75) | median(range) lines: 7(3–23) | 97% |
Schuster, S. J | FCL + DLBCL | 28 | 64% | 57.5(25–77) | median(range) lines: 4.5 (1–10) | 39% |
Wang, Na | ALL | 51 | 63% | 27 (9–62) | Not found | 24% |
Wang, Na | NHL | 38 | 58% | 47 (17–71) | Not found | 15.80% |
Zhao, W. H | MM | 57 | 60% | 54 (27–72) | median(range) lines: 3 (1–9) | 18% |
Wang, M | MM | 68 | 84% | 65 (38–79) | ≥3lines 81%; median(range) lines: 3 (1–5) | 43% |
Sang, W | DLBCL | 21 | 62% | 55 (23–72) | median(range) lines: 3(1–6) | 5% |
Wayne AS, | ALL | 24 | 63% | 13(3–20) | ≥3 lines: 42% | 25% |
Ghorashian, S | ALL | 14 | 93% | 9.24 (1.35–19.28) | median(range) lines: 4(2–7) | 71% |
Wang, Jia | ALL | 23 | 61% | 42(10–67) | median(range) lines: 2(2–3) | 22% |
Bao, F. | ALL+NHL | 10 | 40% | 33.5(25–69) | Not found | |
Hu, Jianda | DLBCL | 8 | 52(27–70) | Not found | ||
Jiang, Songfu | MM | 16 | 55 (39–67) | median(range) lines: 4(2–10) | 56% | |
Wierda, William G | ALL | 35 | 51% | 40(18–69) | ≥3 lines: 60% | |
Yan, Lingzhi | MM | 28 | 82% | 57.5 (42–69) | mean(range) lines: 3(2–8) | |
Amrolia, Persis J. | ALL | 8 | 7.5(4–16) | Not found | 63% | |
Ardeshna, Kirit | DLBCL | 11 | 49 | median lines: 3 | 27% | |
Strati, Paolo | lymphoma | 31 | 74% | 52(23–76) | >3lines 45%; median(range) lines: 3(1–11) | 35% |
Yan, Zi-Xun | NHL | 10 | 80% | 47(32–59) | ≥3lines: 100% | |
Ying, Zhitaob | NHL | 3 | 67% | <65 | mean lines: 9.7 | 0 |
Ying, Zhitaob | NHL | 3 | 100% | <65 | mean lines: 8 | 0 |
Topp, M. S. | lymphoma | 21 | 67% | 63 (36–73) | ≥2lines: 76% | 10% |
An, F | ALL | 47 | 49% | 22(3–72) | <10lines: 59.6% | 19.10% |
Dourthe, M. E | ALL | 41 | 18.2(1–29.2) | Not found | 63% | |
Mailankody, S | MM | 51 | 61(33–77) | median(range) lines: 6 (3–18) | ||
Popat, R | MM | 11 | 61 (45–69) | median(range) lines: 5(3–6) | 73% | |
Ramos, C. A | HL | 42 | 67% | 35(17–69) | median(range) lines: 7(2–23) | 100% |
Sesques, Pc | DLBCL | 33 | 72% | 62 (28–75) | ≥4 lines: 64% | 30% |
Sesques, Pc | DLBCL | 28 | 57% | 59 (27–72) | ≥4 lines: 79% | 29% |
Shah, N. N | lymphoma | 22 | 86% | 57 (38–72) | Not found | 50% |
Tong, C | NHL | 28 | 39% | ≥3 lines: 79% | ||
Usmani, S. Z | MM | 29 | median(range) lines: 5(3–18) | |||
Wang, Y | ALL | 21 | 52% | 13 (3–69) | median(range) lines: 4(1–7) | 9.52% |
Zhou, X | NHL + DLBCL | 21 | 62% | 31 to 77 | ≥4 lines: 38% | |
Ramos, Carlos A | NHL | 16 | 67(17–73) | Not found | 31% | |
Zhang, W. Y | NHL | 11 | ≥18 | Not found | 9% | |
Jain, T | NHL + ALL+MM | 83 | 67% | 58(19–85) | Not found | 37% |
Jacobson, Caron | iNHL | 146 | 57% | 61(34–79) | median(range) lines: 3(1–10) |
Study | Selection | Ascertainment | Causality | Reporting | Risk of bias |
---|---|---|---|---|---|
Ying et al | X | Low | |||
Yan et al | X | Low | |||
Sang et al | X | Low | |||
Tong et al | X | Low | |||
Xu et al | X | Low | |||
Zhao et al | X | Low | |||
Shah et al | X | Low | |||
Wang et al | X | X | Moderate | ||
Fried et al | X | Low | |||
An et al | X | X | Moderate | ||
Ramos et al | X | X | Moderate | ||
Raje et al | X | Low | |||
Abramson et al | X | X | Moderate | ||
Wang et al | X | X | Moderate | ||
Cohen et al | X | X | Moderate | ||
Goto et al | X | Low | |||
Schuster et al | X | X | Moderate | ||
Ghorashian et al | X | X | Moderate | ||
Maude et al | X | Low | |||
Strati et al | Low | ||||
Locke et al | X | Low | |||
Fry et al | Low | ||||
Ali et al | X | Low | |||
Enblad et al | Low | ||||
Schuster et al | X | X | Moderate | ||
Gardner et al | X | Low | |||
Curran et al | X | Low | |||
Ramos et al | Low | ||||
Zhang et al | Low | ||||
Lee et al | X | X | Moderate | ||
Geyer et al | Low | ||||
Geyer et al | Low | ||||
Sesques et al | X | Low | |||
Wang et al | X | Low | |||
Zhou et al | X | Low | |||
Wang et al | X | X | Moderate | ||
Yan et al | X | X | Moderate | ||
Bao et al | X | X | Moderate | ||
Jain et al | X | Low |
Hematological toxicity
Overall incidence rate
Pooled results | 95% CI | I2 | |
---|---|---|---|
Any grades AEs | |||
Neutropenia | 80% | 68–89% | 93% |
Thrombocytopenia | 61% | 49–73% | 94% |
Anemia | 68% | 54–80% | 94% |
AST increased | 28% | 18–43% | 92% |
ALT increased | 30% | 26–34% | 39% |
Serum creatine increased | 14% | 8–24% | 82% |
APTT prolonged | 56% | 31–79% | 94% |
Fibrinogen decreased | 13% | 6–22% | 72% |
Serum creatine increased | 14% | 8–24% | 82% |
≥3 grade AEs | |||
Neutropenia | 60% | 49–70% | 94% |
Thrombocytopenia | 33% | 27–40% | 83% |
Anemia | 32% | 25–40% | 88% |
AST increased | 6% | 3–10% | 51% |
ALT increased | 2% | 1–3% | 0% |
Serum creatine increased | 1% | 0–2% | 0% |
APTT prolonged | 4% | 1–8% | 0% |
Subgroup analysis
Any grades of hematological toxicity | ||||||||
Neutropenia | Thrombocytopenia | Anemia | ||||||
Median age (years) | < 45 | ratea | 82% (42–100%) | P > 0.05 | 74% (44–95%) | P > 0.05 | 79% (4–100%) | P > 0.05 |
Nb | 146 | 156 | 65 | |||||
≥45 and < 60 | rate | 82% (64–96%) | 57% (39–75%) | 77% (59–92%) | ||||
N | 565 | 605 | 580 | |||||
> 60 | rate | 72% (56–85%) | 50% (28–71%) | 53% (39–68%) | ||||
N | 428 | 443 | 443 | |||||
Pathological type | leukemia | rate | 62% (17–98%) | P > 0.05 | 60% (22–93%) | P > 0.05 | 69% (17–100%) | P > 0.05 |
N | 244 | 254 | 176 | |||||
lymphoma | rate | 83% (73–90%) | 60% (46–73%) | 68% (54–80%) | ||||
N | 737 | 742 | 721 | |||||
MM | rate | 88% (64–100%) | 57% (36–77%) | 53% (21–84%) | ||||
N | 132 | 182 | 136 | |||||
Targeting antigen | CD19 | rate | 73% (58–86%) | P = 0.0001 | 56% (40–71%) | P > 0.05 | 64% (48–79%) | P > 0.05 |
N | 918 | 933 | 834 | |||||
non-CD19 | rate | 93% (84–99%) | 70% (54–83%) | 74% (46–95%) | ||||
N | 278 | 328 | 282 | |||||
Proportion of previous HSCT | < 50% | rate | 80% (56–97%) | P > 0.05 | 74% (58–87%) | P > 0.05 | 74% (58–87%) | P > 0.05 |
N | 978 | 1071 | 973 | |||||
≥50% | rate | 77% (62–89%) | 52% (34–69%) | 49% (23–74%) | ||||
N | 94 | 94 | 94 | |||||
Median lines of prior therapy | < 4 | rate | 79% (61–93%) | P > 0.05 | 42% (27–58%) | P = 0.0252 | 55% (43–67%) | P > 0.05 |
N | 673 | 707 | 690 | |||||
≥4 | rate | 81% (69–92%) | 67% (53–80%) | 65% (43–84%) | ||||
N | 267 | 288 | 238 | |||||
Co-stimulatory molecule | CD28 | rate | 88% (82–93%) | P > 0.05 | 79% (59–94%) | P = 0.0054 | 79% (64–92%) | P = 0.0274 |
N | 207 | 207 | 207 | |||||
41BB | rate | 65% (41–86%) | 36% (17–57%) | 55% (42–67%) | ||||
N | 463 | 453 | 453 | |||||
Median age in leukemia cases | < 20 | rate | 61% (10–100%) | P > 0.05 | 45% (14–79%) | P = 0.032 | No analysis | |
N | 60 | 60 | ||||||
≥20 | rate | 83% (38–100%) | 87% (66–99%) | |||||
N | 94 | 104 | ||||||
Median age in lymphoma cases | < 60 | rate | 85% (63–99%) | P > 0.05 | 59% (35–81%) | P > 0.05 | 80% (64–93%) | P = 0.0424 |
N | 404 | 394 | 394 | |||||
≥60 | rate | 67% (51–81%) | 47% (23–72%) | 52% (34–69%) | ||||
N | 395 | 410 | 410 | |||||
≥3 grade of hematological toxicity | ||||||||
Neutropenia | Thrombocytopenia | Anemia | ||||||
Median age (years) | < 45 | rate | 57% (28–84%) | P > 0.05 | 33% (20–47%) | P > 0.05 | 38% (22–56%) | P > 0.05 |
N | 314 | 374 | 261 | |||||
≥45 and < 60 | rate | 59% (40–76%) | 32% (22–43%) | 34% (22–46%) | ||||
N | 592 | 662 | 645 | |||||
> 60 | rate | 59% (45–71%) | 32% (23–43%) | 28% (18–40%) | ||||
N | 531 | 514 | 546 | |||||
Pathological type | leukemia | rate | 48% (22–76%) | P > 0.05 | 28% (16–42%) | P > 0.05 | 41% (28–54%) | P > 0.05 |
N | 390 | 450 | 350 | |||||
lymphoma | rate | 60% (49–71%) | 32% (25–40%) | 24% (16–34%) | ||||
N | 985 | 825 | 979 | |||||
MM | rate | 58% (29–84%) | 40% (28–53%) | 31% (15–50%) | ||||
N | 215 | 261 | 350 | |||||
Targeting antigen | CD19 | rate | 52% (40–64%) | P = 0.0088 | 29% (22–36%) | P > 0.05 | 28% (21–35%) | P > 0.05 |
N | 1313 | 1221 | 1267 | |||||
non-CD19 | rate | 75% (57–90%) | 43% (32–54%) | 42% (24–62%) | ||||
N | 339 | 398 | 371 | |||||
Proportion of previous HSCT | < 50% | rate | 58% (44–71%) | P > 0.05 | 33% (26–41%) | P > 0.05 | 36% (26–45%) | P > 0.05 |
N | 1093 | 1180 | 1146 | |||||
≥50% | rate | 59% (34–82%) | 30% (16–46%) | 34% (19–50%) | ||||
N | 258 | 239 | 183 | |||||
Median lines of prior therapy | < 4 | rate | 53% (38–68%) | P > 0.05 | 28% (20–36%) | P > 0.05 | 32% (25–39%) | P > 0.05 |
N | 961 | 924 | 999 | |||||
≥4 | rate | 60% (46–73%) | 34% (24–43%) | 24% (13–36%) | ||||
N | 419 | 440 | 390 | |||||
Co-stimulatory molecule | CD28 | rate | 47% (34–66%) | P > 0.05 | 47% (34–60%) | P = 0.0004 | 29% (18–41%) | P > 0.05 |
N | 405 | 238 | 405 | |||||
41BB | rate | 53% (38–74%) | 18% (10–27%) | 22% (11–34%) | ||||
N | 471 | 463 | 471 | |||||
Median age in leukemia cases | < 20 | rate | 46% (18–75%) | P > 0.05 | 23% (10–40%) | P > 0.05 | 36% (18–70%) | P > 0.05 |
N | 186 | 178 | 65 | |||||
≥20 | rate | 58% (11–97%) | 37% (20–56%) | 42% (28–65%) | ||||
N | 114 | 182 | 174 | |||||
Median age in lymphoma cases | < 60 | rate | 64% (45–82%) | P > 0.05 | 32% (22–44%) | P > 0.05 | 31% (19–43%) | P > 0.05 |
N | 485 | 477 | 485 | |||||
≥60 | rate | 49% (32–67%) | 27% (16–40%) | 22% (12–34%) | ||||
N | 562 | 410 | 577 | |||||
Median age in MM cases | < 60 | rate | 34% (14–57%) | P = 0.0227 | 29% (16–44%) | P = 0.0356 | 26% (9–48%) | P > 0.05 |
N | 58 | 136 | 119 | |||||
≥60 | rate | 73% (47–93%) | 48% (37–58%) | 48% (18–79%) | ||||
N | 95 | 84 | 95 |
Any grades of Coagulation toxicity | ||||||
APTT prolonged | Fibrinogen decreased | |||||
Pathological type | leukemia | rate | 50% (3–97%) | P > 0.05 | 12% (7–41%) | P > 0.05 |
N | 98 | 118 | ||||
MM | rate | 59% (19–94%) | 16% (1–41%) | |||
N | 123 | 103 | ||||
Any grades of Hepatic toxicity | ||||||
AST increased | ALT increased | |||||
Pathological type | leukemia | rate | 25% (18–32%) | P > 0.05 | 34% (24–44%) | P > 0.05 |
N | 154 | 93 | ||||
lymphoma | rate | 24% (16–34%) | 21% (15–27%) | |||
N | 249 | 249 | ||||
MM | rate | 44% (14–77%) | 25% (19–32%) | |||
N | 120 | 188 | ||||
≥3 grade of Hepatic toxicity | ||||||
AST increased | ALT increased | |||||
Pathological type | leukemia | rate | 7% (3–12%) | P = 0.0016 | 4% (1–7%) | P > 0.05 |
N | 236 | 250 | ||||
lymphoma | rate | 1% (0–4%) | 1% (0–3%) | |||
N | 249 | 249 | ||||
MM | rate | 16% (9–25%) | 1% (0–4%) | |||
N | 132 | 200 |