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Affektive Störungen

Neurobiologische Grundlage und Evidenz von Sport bei Depression

verfasst von: Dr. med. Christian Imboden, EMBA, Prof. Dr. med. Martin Hatzinger

Erschienen in: NeuroTransmitter | Ausgabe 10/2016

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Zusammenfassung

Der antidepressive Effekt von Ausdauertraining ist mittlerweile gut belegt, und es gibt Hinweise, dass Sport auch bei Patienten mit therapieresistenter Depression einen Zusatznutzen erbringt. Aufgrund einer positiven Wirkung auf Arbeitsgedächtnis und Aufmerksamkeit könnten Patienten mit ausgeprägten kognitiven Symptomen von Sportinterventionen besonders profitieren.

Warden D, Rush AJ, Trivedi MH, Fava M, Wisniewski SR. The STAR*D Project results: a comprehensive review of findings. Curr Psychiatry Rep 2007 Dec;9(6):449–459.CrossRefPubMed

Reppermund S, Zihl J, Lucae S, Horstmann S, Kloiber S, Holsboer F, et al. Persistent cognitive impairment in depression: the role of psychopathology and altered hypothalamic-pituitary-adrenocortical (HPA) system regulation. Biol Psychiatry 2007 Sep 1;62(5):400–406.CrossRefPubMed

Dunn AL, Trivedi MH, Kampert JB, Clark CG, Chambliss HO. Exercise treatment for depression: efficacy and dose response. Am J Prev Med 2005 Jan;28(1):1–8.CrossRefPubMed

Rethorst CD, Wipfli BM, Landers DM. The antidepressive effects of exercise: a meta-analysis of randomized trials. Sports Med 2009;39(6):491–511.CrossRefPubMed

Mura G, Moro MF, Patten SB, Carta MG. Exercise as an add-on strategy for the treatment of major depressive disorder: a systematic review. CNS Spectr 2014 Mar 3:1–13.

Schuch FB, Vasconcelos-Moreno MP, Borowsky C, Zimmermann AB, Rocha NS, Fleck MP. Exercise and severe major depression: effect on symptom severity and quality of life at discharge in an inpatient cohort. J Psychiatr Res 2015 Feb;61:25–32.CrossRefPubMed

Imboden C, Beck J, Gerber M, Pühse U, Holsboer-Trachsler E, Hatzinger M. P.2.f.008 Aerobic exercise as add-on treatment improves alertness in depressed inpatients: preliminary results from a randomised controlled multicentre-trial. European Neuropsychopharmacology 2015 9;25, Supplement 2:S438.CrossRef

Silveira H, Moraes H, Oliveira N, Coutinho E, Laks J, Deslandes A. Physical Exercise and Clinically Depressed Patients: A Systematic Review and Meta-Analysis. Neuropsychobiology 2013(67):61–68.

Mota-Pereira J, Silverio J, Carvalho S, Ribeiro JC, Fonte D, Ramos J. Moderate exercise improves depression parameters in treatment-resistant patients with major depressive disorder. J Psychiatr Res 2011 Aug;45(8):1005–1011.CrossRefPubMed

10.

Melo MC, Daher EF, Albuquerque SG, de Bruin VM. Exercise in bipolar patients: A systematic review. J Affect Disord 2016 Mar 15;198:32–38.CrossRefPubMed

11.

Rethorst CD, Trivedi MH. Evidence-based recommendations for the prescription of exercise for major depressive disorder. J Psychiatr Pract 2013 May;19(3):204–212.CrossRefPubMed

12.

Beblo T, Sinnamon G, Baune BT. Specifying the neuropsychology of affective disorders: clinical, demographic and neurobiological factors. Neuropsychol Rev 2011 Dec;21(4):337–359.CrossRefPubMed

13.

Knochel C, Oertel-Knochel V, O’Dwyer L, Prvulovic D, Alves G, Kollmann B, et al. Cognitive and behavioural effects of physical exercise in psychiatric patients. Prog Neurobiol 2012 Jan;96(1):46–68.CrossRefPubMed

14.

Greer TL, Grannemann BD, Chansard M, Karim AI, Trivedi MH. Dose-dependent changes in cognitive function with exercise augmentation for major depression: results from the TREAD study. Eur Neuropsychopharmacol 2015 Feb;25(2):248–256.CrossRefPubMed

15.

Krogh J, Videbech P, Thomsen C, Gluud C, Nordentoft M. DEMO-II trial. Aerobic exercise versus stretching exercise in patients with major depression-a randomised clinical trial. PLoS One 2012;7(10):e48316.CrossRefPubMedPubMedCentral

16.

Rotenberg VS, Shami E, Barak Y, Indursky P, Kayumov L, Mark M. REM sleep latency and wakefulness in the first sleep cycle as markers of major depression: a controlled study vs. schizophrenia and normal controls. Prog Neuropsychopharmacol Biol Psychiatry 2002 Oct;26(6):1211–1215.CrossRefPubMed

17.

Hatzinger M, Hemmeter UM, Brand S, Ising M, Holsboer-Trachsler E. Electroencephalographic sleep profiles in treatment course and long-term outcome of major depression: association with DEX/CRH-test response. J Psychiatr Res 2004 Sep-Oct;38(5):453–465.CrossRefPubMed

18.

Kalak N, Gerber M, Kirov R, Mikoteit T, Yordanova J, Puhse U, et al. Daily morning running for 3 weeks improved sleep and psychological functioning in healthy adolescents compared with controls. J Adolesc Health 2012 Dec;51(6):615–622.CrossRefPubMed

19.

Passos GS, Poyares D, Santana MG, D’Aurea CV, Youngstedt SD, Tufik S, et al. Effects of moderate aerobic exercise training on chronic primary insomnia. Sleep Med 2011 Dec;12(10):1018–1027.CrossRefPubMed

20.

Larun L, Brurberg KG, Odgaard-Jensen J, Price JR. Exercise therapy for chronic fatigue syndrome. Cochrane Database Syst Rev 2016 Feb 7;2:CD003200.PubMed

21.

Rethorst CD, Sunderajan P, Greer TL, Grannemann BD, Nakonezny PA, Carmody TJ, et al. Does exercise improve self-reported sleep quality in non-remitted major depressive disorder? Psychol Med 2013 Apr;43(4):699–709.CrossRefPubMed

22.

Hoffman BM, Babyak MA, Craighead WE, Sherwood A, Doraiswamy PM, Coons MJ, et al. Exercise and pharmacotherapy in patients with major depression: one-year follow-up of the SMILE study. Psychosom Med 2011 Feb-Mar;73(2):127–133.CrossRefPubMed

23.

Lindegard A, Jonsdottir IH, Borjesson M, Lindwall M, Gerber M. Changes in mental health in compliers and non-compliers with physical activity recommendations in patients with stress-related exhaustion. BMC Psychiatry 2015 Nov 4;15:272-015-0642-3.

24.

Goldstein BI, Carnethon MR, Matthews KA, McIntyre RS, Miller GE, Raghuveer G, et al. Major Depressive Disorder and Bipolar Disorder Predispose Youth to Accelerated Atherosclerosis and Early Cardiovascular Disease: A Scientific Statement From the American Heart Association. Circulation 2015 Sep 8;132(10):965–986.CrossRefPubMed

25.

Booth FW, Roberts CK, Laye MJ. Lack of exercise is a major cause of chronic diseases. Comprehensive Physiology 2012.

26.

Kerling A, Tegtbur U, Gützlaff E, Kück M, Borchert L, Ates Z, et al. Effects of adjunctive exercise on physiological and psychological parameters in depression: a randomized pilot trial. J Affect Disord 2015;177:1–6.CrossRefPubMed

27.

Lucassen PJ, Meerlo P, Naylor AS, van Dam AM, Dayer AG, Fuchs E, et al. Regulation of adult neurogenesis by stress, sleep disruption, exercise and inflammation: Implications for depression and antidepressant action. Eur Neuropsychopharmacol 2010 Jan;20(1):1–17.CrossRefPubMed

28.

Kobilo T, Liu QR, Gandhi K, Mughal M, Shaham Y, van Praag H. Running is the neurogenic and neurotrophic stimulus in environmental enrichment. Learn Mem 2011 Aug 30;18(9):605–609.CrossRefPubMedPubMedCentral

29.

Schuch FB, Deslandes AC, Stubbs B, Gosmann NP, da Silva, Cristiano Tschiedel Belem, de Almeida Fleck, Marcelo Pio. Neurobiological effects of exercise on major depressive disorder: A systematic review. Neuroscience & Biobehavioral Reviews 2016;61:1–11.CrossRef

30.

Wittert GA, Livesey JH, Espiner EA, Donald RA. Adaptation of the hypothalamopituitary adrenal axis to chronic exercise stress in humans. Med Sci Sports Exerc 1996 Aug;28(8):1015–1019.CrossRefPubMed

31.

Heijnen S, Hommel B, Kibele A, Colzato LS. Neuromodulation of Aerobic Exercise-A Review. Front Psychol 2016 Jan 7;6:1890.CrossRefPubMedPubMedCentral

32.

Foley LS, Prapavessis H, Osuch EA, De Pace JA, Murphy BA, Podolinsky NJ. An examination of potential mechanisms for exercise as a treatment for depression: a pilot study. Mental Health and Physical Activity 2008;1(2):69–73.CrossRef

33.

Krogh J, Nordentoft M, Mohammad-Nezhad M, Westrin Å. Growth hormone, prolactin and cortisol response to exercise in patients with depression. J Affect Disord 2010;125(1):189–197.CrossRefPubMed

34.

Eyre HA, Papps E, Baune BT. Treating depression and depression-like behavior with physical activity: an immune perspective. Front Psychiatry 2013 Feb 4;4:34.CrossRef

35.

Rethorst CD, Toups MS, Greer TL, Nakonezny PA, Carmody TJ, Grannemann BD, et al. Pro-inflammatory cytokines as predictors of antidepressant effects of exercise in major depressive disorder. Mol Psychiatry 2013 Oct;18(10):1119–1124.CrossRefPubMed

36.

Schlittler M, Goiny M, Agudelo LZ, Venckunas T, Brazaitis M, Skurvydas A, et al. Endurance exercise increases skeletal muscle kynurenine aminotransferases and plasma kynurenic acid in humans. Am J Physiol Cell Physiol 2016 Mar 30:ajpcell.00053.2016.

37.

Schuch FB, Vasconcelos-Moreno MP, Borowsky C, Zimmermann AB, Wollenhaupt-Aguiar B, Ferrari P, et al. The effects of exercise on oxidative stress (TBARS) and BDNF in severely depressed inpatients. Eur Arch Psychiatry Clin Neurosci 2014 Oct;264(7):605–613.CrossRefPubMed

38.

Bundesamt für Sport BASPO. Gesundheitswirksame Bewegung bei Erwachsenen - Empfehlungen für die Schweiz. 2013.

39.

Global recommendations on physical activity for health, WHO 2010, ISBN 978 92 4 159 997 9

Titel: Affektive Störungen
Neurobiologische Grundlage und Evidenz von Sport bei Depression
verfasst von: Dr. med. Christian Imboden, EMBA
Prof. Dr. med. Martin Hatzinger
Publikationsdatum: 11.10.2016
Verlag: Springer Medizin
Schlagwörter: Affektive Störungen
Affektive Störungen
Erschienen in: NeuroTransmitter / Ausgabe 10/2016
Print ISSN: 1436-123X
Elektronische ISSN: 2196-6397
DOI: https://doi.org/10.1007/s15016-016-5401-2

Springer Medizin

Zusammenfassung

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