Patients and methods
Patients and data collection
Statistical analysis
Results
Basic characteristics
Overall survival analysis
Validation of AJCC 7th and 8th stages
7th edition | 8th edition | ||||||
---|---|---|---|---|---|---|---|
T1 | Limited to the pancreas, ≤ 2 cm in greatest dimension | T1 | Maximum tumor diameter ≤ 2 cm | ||||
T2 | Limited to the pancreas, > 2 cm in greatest dimension | T2 | Maximum tumor diameter > 2 ≤ 4 cm | ||||
T3 | Beyond the pancreas but without involvement of the celiac axis or the superior mesenteric artery | T3 | Maximum tumor diameter > 4 cm | ||||
T4 | Involvement of celiac axis or the superior mesenteric artery (unresectable tumor) | T4 | Involvement of celiac axis or the superior mesenteric artery (unresectable tumor) | ||||
N0 | No regional lymph node metastasis | N0 | No regional lymph node metastasis | ||||
N1 | Regional lymph node metastasis | N1 | Metastasis in 1–3 regional lymph nodes | ||||
N2 | Metastasis in ≥ 4 regional lymph nodes | ||||||
M0 | No distant metastasis | M0 | No distant metastasis | ||||
M1 | Distant metastasis | M1 | Distant metastasis | ||||
Stage | T | N | M | Stage | T | N | M |
IA | T1 | N0 | M0 | IA | T1 | N0 | M0 |
IB | T2 | N0 | M0 | IB | T2 | N0 | M0 |
IIA | T3 | N0 | M0 | IIA | T3 | N0 | M0 |
IIB | T1–3 | N1 | M0 | IIB | T1–3 | N1 | M0 |
III | T4 | Any N | M0 | III | Any T | N2 | M0 |
T4 | Any N | M0 | |||||
IV | Any T | Any N | M1 | IV | Any T | Any N | M1 |
Edition | 8th | ||||||
IA | IB | IIA | IIB | III | IV | ||
7th | IA | 124 | 0 | 0 | 0 | 0 | 0 |
IB | 0 | 64 | 69 | 0 | 0 | 0 | |
IIA | 31 | 80 | 79 | 0 | 0 | 0 | |
IIB | 0 | 0 | 0 | 207 | 107 | 0 | |
III | 0 | 0 | 0 | 0 | 45 | 0 | |
IV | 0 | 0 | 0 | 0 | 0 | 410 |
Parameter | SEER series (N = 1216) | |
---|---|---|
No. | % | |
Age, years | ||
< 70 | 712 | 58.6 |
≥ 70 | 504 | 41.4 |
Sex | ||
Male | 619 | 50.9 |
Female | 597 | 49.1 |
Race | ||
White | 1014 | 83.4 |
Black | 95 | 7.8 |
Others | 107 | 8.8 |
Location | ||
Head | 646 | 53.1 |
Others | 570 | 46.9 |
Size (cm)a | ||
< 3 cm | 313 | 36.9 |
≥ 3 cm | 535 | 63.1 |
Gradeb | ||
Low, intermediate | 635 | 74.9 |
High | 213 | 25.1 |
AJCC 7th edition | ||
IA | 124 | 10.2 |
IB | 133 | 10.9 |
IIA | 190 | 15.6 |
IIB | 314 | 25.8 |
III | 45 | 3.7 |
IV | 410 | 33.7 |
AJCC 8th edition | ||
IA | 155 | 12.7 |
IB | 144 | 11.8 |
IIA | 148 | 12.2 |
IIB | 207 | 17.0 |
III | 152 | 12.5 |
IV | 410 | 33.7 |
Demographic or characteristic | 7th edition | 8th edition | ||
---|---|---|---|---|
HR (95% CI) |
P
| HR (95% CI) |
P
| |
Age, years | ||||
< 70 | 1 | 1 | ||
≥ 70 | 1.32 (1.14–1.52) | < 0.001 | 1.35 (1.16–1.55) | < 0.001 |
Sex | ||||
Male | 1 | 1 | ||
Female | 1.04 (0.90–1.20) | 0.572 | 1.04 (0.90–1.20) | 0.574 |
Race | ||||
White | 1 | 1 | ||
Black | 0.91 (0.69–1.19) | 0.479 | 0.89 (0.68–1.17) | 0.402 |
Others | 0.80 (0.61–1.04) | 0.094 | 0.79 (0.60–1.03) | 0.083 |
Location | ||||
Head | 1 | 1 | ||
Others | 1.10 (0.94–1.27) | 0.247 | 1.08 (0.93–1.26) | 0.290 |
Grade | ||||
Low, intermediate | 1 | 1 | ||
High | 1.24 (1.03–1.49) | 0.027 | 1.20 (1.00–1.45) | 0.056 |
Unknown | 1.15 (0.97–1.36) | 0.111 | 1.10 (0.93–1.31) | 0.253 |
Stage | ||||
IA | 1 | 1 | ||
IB | 1.48 (0.94–2.31) | 0.087 | 1.48 (1.02–2.15) | 0.040 |
IIA | 2.33 (1.54–3.51) | < 0.001 | 1.26 (0.86–1.85) | 0.232 |
IIB | 4.31 (2.94–6.31) | < 0.001 | 2.91 (2.09–4.05) | < 0.001 |
III | 6.08 (3.76–9.83) | < 0.001 | 4.14 (2.94–5.82) | < 0.001 |
IV | 11.81 (8.13–17.14) | < 0.001 | 8.95 (6.58–12.18) | < 0.001 |
C-index | 0.75 | < 0.001 | 0.75 | < 0.001 |