Skip to main content
main-content

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

BMC Public Health 1/2015

Alcohol intake and associated risk of major cardiovascular outcomes in women compared with men: a systematic review and meta-analysis of prospective observational studies

Zeitschrift:
BMC Public Health > Ausgabe 1/2015
Autoren:
Yan-Ling Zheng, Feng Lian, Qian Shi, Chi Zhang, Yi-Wei Chen, Yu-Hao Zhou, Jia He
Wichtige Hinweise

Electronic supplementary material

The online version of this article (doi:10.​1186/​s12889-015-2081-y) contains supplementary material, which is available to authorized users.
Yan-Ling Zheng Feng Lian and Qian Shi contributed equally to this work.

Competing interests

The authors declare that they have no competing interests.

Authors’ contributions

Z-YH Conceived and designed the experiments. Z-YH, Z-C, L-F and H-J Performed the experiments. Z-YH and C-YW Analyzed the data. Z-YH Contributed reagents/materials/analysis tools. Z-YL, Z-YH and S-Q Wrote and revised the manuscript. All authors contributed to the planning, execution, and interpretation of the submitted manuscript and read and approved the final manuscript.

Abstract

Background

The prevalence of alcohol intake is increasing among women in some populations. Alcohol consumption plays an important role in the risk of major cardiovascular outcomes and total mortality. Here, we conducted a meta-analysis to estimate the association between alcohol intake and major cardiovascular outcomes or total mortality in women compared with men.

Methods

We searched the PubMed, Embase, and the Cochrane Library databases for relevant articles published prior to June 2014. Among these potential included prospective studies, the different dose categories of alcohol intake were compared with the lowest alcohol intake or non-drinkers between women and men for the outcomes of major cardiovascular or total mortality.

Results

We included 23 prospective studies (18 cohorts) reporting data on 489,696 individuals. The summary relative risk ratio (RRR; female to male) for total mortality was significantly increased with moderate alcohol intake compared with the lowest alcohol intake (RRR, 1.10; 95 % confidence interval [CI]: 1.00–1.21; P = 0.047); no such significance was observed with other levels of alcohol intake (low intake: RRR, 1.07; 95 % CI: 0.98–1.17; P = 0.143; heavy intake: RRR, 1.09; 95 % CI: 0.99–1.21; P = 0.084). There was no evidence of a sex difference in the relative risk for coronary disease, cardiac death, stroke, or ischemic stroke between participants with low to heavy alcohol intake compared with those who never consumed alcohol or had the lowest alcohol intake.

Conclusions

Women with moderate to heavy alcohol intake had a significantly increased risk of total mortality compared with men in multiple subpopulations. Control of alcohol intake should be considered for women, particularly for young women who may be susceptible to binge drinking.
Zusatzmaterial
Additional file 1: Search strategy. (DOCX 13 kb)
12889_2015_2081_MOESM1_ESM.docx
Additional file 2: Table S1. Adjustment factors of included studies. Figures S1. RR or RRR (female to male) of low alcohol intake and the risk of coronary disease. Figure S2. RR or RRR (female to male) of moderate alcohol intake and the risk of coronary disease. Figure S3. RR or RRR (female to male) of heavy alcohol intake and the risk of coronary disease. Figure S4. RR or RRR (female to male) of low alcohol intake and the risk of total mortality. Figure S5. RR or RRR (female to male) of moderate alcohol intake and the risk of total mortality. Figure S6. RR or RRR (female to male) of heavy alcohol intake and the risk of total mortality. Figure S7. RR or RRR (female to male) of low alcohol intake and the risk of ischemic stroke. Figure S8. RR or RRR (female to male) of low alcohol intake and the risk of cardiac death. Figure S9. RR or RRR (female to male) of low alcohol intake and the risk of stroke. Figure S10. RR or RRR (female to male) of moderate alcohol intake and the risk of cardiac death. Figure S11. RR or RRR (female to male) of moderate alcohol intake and the risk of stroke. Figure S12. RR or RRR (female to male) of moderate alcohol intake and the risk of ischemic stroke. Figure S13. RR or RRR (female to male) of heavy alcohol intake and the risk of cardiac death. Figure S14. RR or RRR (female to male) of heavy alcohol intake and the risk of stroke. Figure S15. RR or RRR (female to male) of heavy alcohol intake and the risk of ischemic stroke. Figure S16. Funnel plot of RRR (female to male) for low alcohol intake. Figure S17. Funnel plot of RRR (female to male) for moderate alcohol intake. Figure S18. Funnel plot of RRR (female to male) for heavy alcohol intake. (DOC 10344 kb)
12889_2015_2081_MOESM2_ESM.doc
Literatur
Über diesen Artikel

Weitere Artikel der Ausgabe 1/2015

BMC Public Health 1/2015 Zur Ausgabe