nach oben

Erschienen in:

12.09.2016 | Original Article

Alpha-1-Antitrypsin Antagonizes Cisplatin-Induced Cytotoxicity in Prostate Cancer (PC3) and Melanoma Cancer (A375) Cell Lines

verfasst von: Mila Ljujic, Sanja Mijatovic, Mirna Z. Bulatovic, Marija Mojic, Danijela Maksimovic-Ivanic, Dragica Radojkovic, Aleksandra Topic

Erschienen in: Pathology & Oncology Research | Ausgabe 2/2017

Einloggen, um Zugang zu erhalten

Abstract

Increased circulating alpha-1-antitrypsin (AAT) correlates with cancer stage/aggressiveness, but its role in cancer biology is unclear. We revealed antagonistic effect of AAT to cisplatin-induced cytotoxicity in prostate (PC3) and melanoma (A375) cancer cell lines. Moreover, AAT abrogated cytotoxicity of MEK inhibitor U0126 in PC3 cell line. Weaker antagonistic effect of AAT on cytotoxicity of PI3/Akt and NF-kB inhibitors was also observed. In addition, cisplatin increased AAT gene expression in transfected PC3 cells. However, AAT derived from transfected PC3 cells did not antagonize cisplatin-induced cytotoxicity. In conclusion, these results suggest possible association between high circulating AAT and cisplatin resistance.

Crystal RG (1989) The alpha 1-antitrypsin gene and its deficiency states. Trends Genet 5:411–417CrossRefPubMed

Blank CA, Brantly M (1994) Clinical features and molecular characteristics of alpha 1-antitrypsin deficiency. Ann Allergy 72:105–120PubMed

Mason DY, Cramer EM, Massé JM, Crystal R, Bassot JM, Breton-Gorius J (1991) Alpha 1-antitrypsin is present within the primary granules of human polymorphonuclear leukocytes. Am J Pathol 139:623–628PubMedPubMedCentral

Molmenti EP, Perlmutter DH, Rubin DC (1993) Cell-specific expression of alpha 1-antitrypsin in human intestinal epithelium. J Clin Invest 92:2022–2034CrossRefPubMedPubMedCentral

Perlmutter DH, Daniels JD, Auerbach HS, De Schryver-Kecskemeti K, Winter HS, Alpers DH (1989) The alpha 1-antitrypsin gene is expressed in a human intestinal epithelial cell line. J Biol Chem 264:9485–9490PubMed

Sallenave JM, Tremblay GM, Gauldie J, Richards CD (1997) Oncostatin M, but not interleukin-6 or leukemia inhibitory factor, stimulates expression of alpha1-proteinase inhibitor in A549 human alveolar epithelial cells. J Interf Cytokine Res 17:337–346CrossRef

Cichy J, Potempa J, Travis J (1997) Biosynthesis of alpha1-proteinase inhibitor by human lung-derived epithelial cells. J Biol Chem 272:8250–8255CrossRefPubMed

Ikari Y, Mulvihill E, Schwartz SM (2001) Alpha 1-Proteinase inhibitor, alpha 1-antichymotrypsin, and alpha 2-macroglobulin are the antiapoptotic factors of vascular smooth muscle cells. J Biol Chem 276:11798–11803CrossRefPubMed

Daemen MA, Heemskerk VH, van’t Veer C, Denecker G, TG W, Vandenabeele P, WA B (2000) Functional protection by acute phase proteins alpha(1)-acid glycoprotein and alpha(1)-antitrypsin against ischemia/reperfusion injury by preventing apoptosis and inflammation. Circulation 102:1420–1426CrossRefPubMed

10.

Petrache I, Fijalkowska I, Zhen L, Medler TR, Brown E, Cruz P, Choe KH, Taraseviciene-Stewart L, Scerbavicius R, Shapiro L, Zhang B, Song S, Hicklin D, Voelkel NF, Flotte T, Tuder RM (2006) A novel antiapoptotic role for alpha1-antitrypsin in the prevention of pulmonary emphysema. Am J Respir Crit Care Med 173:1222–1228CrossRefPubMedPubMedCentral

11.

Greene CM, Miller SD, Carroll TP, Oglesby IK, Ahmed F, O’Mahony M, Taggart CC, McElvaney NG, O’Neill SJ (2010) Anti-apoptotic effects of Z alpha1-antitrypsin in human bronchial epithelial cells. Eur Respir J 35:1155–1163CrossRefPubMed

12.

Petrache I, Fijalkowska I, Medler TR, Skirball J, Cruz P, Zhen L, Petrache HI, Flotte TR, Tuder RM (2006) Alpha-1 antitrypsin inhibits caspase-3 activity, preventing lung endothelial cell apoptosis. Am J Pathol 169:1155–1166CrossRefPubMedPubMedCentral

13.

Lockett AD, Van Demark M, Gu Y, Schweitzer KS, Sigua N, Kamocki K, Fijalkowska I, Garrison J, Fisher AJ, Serban K, Wise RA, Flotte TR, Mueller C, RG P Jr, Petrache HI, Tuder RM, Petrache I (2012) Effect of cigarette smoke exposure and structural modifications on the α-1 antitrypsin interaction with caspases. Mol Med 18:445–454CrossRefPubMedPubMedCentral

14.

Higashiyama M, Doi O, Kodama K, Yokouchi H, Tateishi R (1992) An evaluation of the prognostic significance of alpha-1-antitrypsin expression in adenocarcinomas of the lung: an immunohistochemical analysis. Br J Cancer 65:300–302CrossRefPubMedPubMedCentral

15.

Kwon CH, Park HJ, Lee JR, Kim HK, Jeon TY, Jo HJ, Kim DH, Kim GH, Park DY (2014) Serpin peptidase inhibitor clade a member 1 is a biomarker of poor prognosis in gastric cancer. Br J Cancer 111:1993–2002CrossRefPubMedPubMedCentral

16.

Chang YH, Lee SH, Liao IC, Huang SH, Cheng HC, Liao PC (2012) Secretomic analysis identifies alpha-1 antitrypsin (A1AT) as a required protein in cancer cell migration, invasion, and pericellular fibronectin assembly for facilitating lung colonization of lung adenocarcinoma cells. Mol Cell Proteomics 11:1320–1339CrossRefPubMedPubMedCentral

17.

Kataoka H, Uchino H, Iwamura T, Seiki M, Nabeshima K, Koono M (1999) Enhanced tumor growth and invasiveness in vivo by a carboxyl-terminal fragment of alpha1-proteinase inhibitor generated by matrix metalloproteinases: a possible modulatory role in natural killer cytotoxicity. Am J Pathol 154:457–468CrossRefPubMedPubMedCentral

18.

Zelvyte I, Lindgren S, Janciauskiene S (2003) Multiple effects of alpha1-antitrypsin on breast carcinoma MDA-MB 468 cell growth and invasiveness. Eur J Cancer Prev 12:117–124CrossRefPubMed

19.

Zhao W, Yang Z, Liu X, Tian Q, Lv Y, Liang Y, Li C, Gao X, Chen L (2013) Identification of α1-antitrypsin as a potential prognostic biomarker for advanced nonsmall cell lung cancer treated with epidermal growth factor receptor tyrosine kinase inhibitors by proteomic analysis. J Int Med Res 41:573–583CrossRefPubMed

20.

Topic A, Ljujic M, Petrovic-Stanojevic N, Dopudja-Pantic V, Radojkovic D (2011) Phenotypes and serum level of alpha-1-antitrypsin in lung cancer. J BUON 16:672–676PubMed

21.

Varela AS, López Sáez JJ (1995) Utility of plasmatic levels of alpha-1-antiprotease (A1AP) as a cancer marker. Cancer Lett 89:15–21CrossRefPubMed

22.

Pérez-Holanda S, Blanco I, Menéndez M, Rodrigo L (2014) Serum concentration of alpha-1 antitrypsin is significantly higher in colorectal cancer patients than in healthy controls. BMC Cancer 14:355CrossRefPubMedPubMedCentral

23.

Mijatovic S, Maksimovic-Ivanic D, Radovic J, Popadic D, Momcilovic M, Harhaji L, Miljkovic D, Trajkovic V (2004) Aloe-emodin prevents cytokine-induced tumor cell death: the inhibition of auto-toxic nitric oxide release as a potential mechanism. Cell Mol Life Sci 61:1805–1815CrossRefPubMed

24.

McCubrey JA, Steelman LS, Abrams SL, Misaghian N, Chappell WH, Basecke J, Nicoletti F, Libra M, Ligresti G, Stivala F, Maksimovic-Ivanic D, Mijatovic S, Montalto G, Cervello M, Laidler P, Bonati A, Evangelisti C, Cocco L, Martelli AM (2012) Targeting the cancer initiating cell: the ultimate target for cancer therapy. Curr Pharm Des 18:1784–1795CrossRefPubMed

25.

EMBL-EBI Expression Atlas, available on: http://www.ebi.ac.uk/gxa/experiments.

26.

Kubisch R, Meissner L, Krebs S, Blum H, Günther M, Roidl A, Wagner EA (2013) Comprehensive gene expression analysis of resistance formation upon metronomic cyclophosphamide therapy. Transl Oncol 6:1–9CrossRefPubMedPubMedCentral

27.

El-Akawi ZJ, Abu-Awad AM, Sharara AM, Khader Y (2010) The importance of alpha-1 antitrypsin (alpha1-AT) and neopterin serum levels in the evaluation of non-small cell lung and prostate cancer patients. Neuroendocrinol Lett 31:113–116PubMed

28.

Zelvyte I, Wallmark A, Piitulainen E, Westin U, Janciauskiene S (2004) Increased plasma levels of serine proteinase inhibitors in lung cancer patients. Anticancer Res 24:241–247PubMed

29.

Li Y, Krowka MJ, Qi Y, Katzmann JA, Song Y, Mandrekar SJ, Yang P (2011) Alpha1-antitrypsin deficiency carriers, serum alpha 1-antitrypsin concentration, and non-small cell lung cancer survival. J Thorac Oncol 6:291–295CrossRefPubMedPubMedCentral

30.

Normandin K, Péant B, Le Page C, de Ladurantaye M, Ouellet V, Tonin PN, Provencher DM, Mes-Masson AM (2010) Protease inhibitor SERPINA1 expression in epithelial ovarian cancer. Clin Exp Metastasis 27:55–69CrossRefPubMed

31.

Zelvyte I, Ohlsson B, Axelson J, Janciauskiene S (2003) Diverse responses between human pancreatic cancer cell lines to native alpha 1-antitrypsin and its C-terminal fragment. Anticancer Res 23(3B):2267–2273PubMed

32.

Zelvyte I, Sjögren HO, Janciauskiene S (2002) Effects of native and cleaved forms of alpha1-antitrypsin on ME 1477 tumor cell functional activity. Cancer Detect Prev 26:256–265CrossRefPubMed

33.

Boulikas T, Vougiouka M (2003) Cisplatin and platinum drugs at the molecular level. Oncol Rep 10:1663–1682PubMed

34.

Fuertes MA, Castilla J, Alonso C, Pérez JM (2003) Cisplatin biochemical mechanism of action: from cytotoxicity to induction of cell death through interconnections between apoptotic and necrotic pathways. Curr Med Chem 10:257–266CrossRefPubMed

35.

Ljujic M, Mijatovic S, Bulatovic MZ, Mojic M, Maksimovic-Ivanic D, Radojkovic D, Topic A (2016) Alpha-1 antitrypsin affects U0126-induced cytotoxicity in colon cancer cell line (HCT116. Mol Biol 50:153–156CrossRef

36.

Pattingre S, Tassa A, Qu X, Garuti R, Liang XH, Mizushima N, Packer M, Schneider MD, Levine B (2005) Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy. Cell 122:927–939CrossRefPubMed

37.

Marquez RT, Xu L (2012) Bcl-2:Beclin 1 complex: multiple, mechanisms regulating autophagy/apoptosis toggle switch. Am J Cancer Res 2:214–221PubMedPubMedCentral

38.

Wei Y, Pattingre S, Sinha S, Bassik M, Levine B (2008) JNK1-mediated phosphorylation of Bcl-2 regulates starvation-induced autophagy. Mol Cell 30:678–688CrossRefPubMedPubMedCentral

39.

Chekhun VF, Kovtonyuk OV, Todor IN, Kulik GI (2005) Total proteolytic activity and levels of the main proteinase inhibitors in blood plasma of mice bearing Lewis lung carcinoma upon development of resistance to cisplatin. Exp Oncol 27:286–289PubMed

40.

Dabbagh K, Laurent GJ, Shock A, Leoni P, Papakrivopoulou J, Chambers RC (2001) Alpha-1-antitrypsin stimulates fibroblast proliferation and procollagen production and activates classical MAP kinase signalling pathways. J Cell Physiol 186:73–81CrossRefPubMed

41.

Gonias SL, Swaim MW, Massey MF, Pizzo SV (1988) cis-dichlorodiammineplatinum (II) as a selective modifier of the oxidation-sensitive reactive-center methionine in alpha 1-antitrypsin. J Biol Chem 263:393–397PubMed

42.

Kloth JN, Gorter A, Fleuren GJ, Oosting J, Uljee S, ter Haar N, Dreef EJ, Kenter GG, Jordanova ES (2008) Elevated expression of SerpinA1 and SerpinA3 in HLA-positive cervical carcinoma. J Pathol 215:222–230CrossRefPubMed

43.

Kwon CH, Park HJ, Choi JH, Lee JR, Kim HK, Jo HJ, Kim HS, Oh N, Song GA, do Y P (2015) Snail and serpinA1 promote tumor progression and predict prognosis in colorectal cancer. Oncotarget 6:20312–20326CrossRefPubMedPubMedCentral

44.

JY W, Cheng CC, Wang JY, DC W, Hsieh JS, Lee SC, Wang WM (2014) Discovery of tumor markers for gastric cancer by proteomics. PLoS One 9:e84158CrossRef

45.

Goodarzi MT, Turner GA (1995) Decreased branching, increased fucosylation and changed sialylation of alpha-1-proteinase inhibitor in breast and ovarian cancer. Clin Chim Acta 236:161–171CrossRefPubMed

46.

Comunale MA, Rodemich-Betesh L, Hafner J, Wang M, Norton P, Di Bisceglie AM, Block T, Mehta A (2010) Linkage specific fucosylation of alpha-1-antitrypsin in liver cirrhosis and cancer patients: implications for a biomarker of hepatocellular carcinoma. PLoS One 5:e12419CrossRefPubMedPubMedCentral

47.

Wang Y, Kuramitsu Y, Yoshino S, Takashima M, Zhang X, Ueno T, Suzuki N, Oka M, Nakamura K (2011) Screening for serological biomarkers of pancreatic cancer by two-dimensional electrophoresis and liquid chromatography-tandem mass spectrometry. Oncol Rep 26:287–292PubMed

48.

Grivennikov SI, Greten FR, Karin M (2010) Immunity, inflammation, and cancer. Cell 140:883–899CrossRefPubMedPubMedCentral

49.

Huang W, Ding X, Li B, Fan M, Zhou T, Sun H, Yi Y, Zhang J (2013) Serum biomarkers analyzed by LC-MS/MS as predictors for short outcome of non-small cell lung cancer patients treated with chemoradiotherapy. Neoplasma 60:11–18CrossRefPubMed

50.

Woźniak B, Mila-Kierzenkowska C, WoŸniak A, Drewa G, Sopońska M, Drewa T, Krzyzyńska-Malinowska E, Makarewicz R, Kowalski T, Szmytkowska K (2008) The effect of combined therapy on activity of cathepsin D and alpha-1-antitrypsin in the blood serum of women with cervical cancer. Eur J Gynaecol Oncol 29:617–619PubMed

Titel: Alpha-1-Antitrypsin Antagonizes Cisplatin-Induced Cytotoxicity in Prostate Cancer (PC3) and Melanoma Cancer (A375) Cell Lines
verfasst von: Mila Ljujic
Sanja Mijatovic
Mirna Z. Bulatovic
Marija Mojic
Danijela Maksimovic-Ivanic
Dragica Radojkovic
Aleksandra Topic
Publikationsdatum: 12.09.2016
Verlag: Springer Netherlands
Erschienen in: Pathology & Oncology Research / Ausgabe 2/2017
Print ISSN: 1219-4956
Elektronische ISSN: 1532-2807
DOI: https://doi.org/10.1007/s12253-016-0104-3

Neu im Fachgebiet Onkologie

25.04.2024 | Nierenkarzinom | Nachrichten

Springer Medizin

Alpha-1-Antitrypsin Antagonizes Cisplatin-Induced Cytotoxicity in Prostate Cancer (PC3) and Melanoma Cancer (A375) Cell Lines

Abstract

Neu im Fachgebiet Onkologie

Adjuvante Immuntherapie verlängert Leben bei RCC

Alectinib verbessert krankheitsfreies Überleben bei ALK-positivem NSCLC

Bei Senioren mit Prostatakarzinom auf Anämie achten!

ICI-Therapie in der Schwangerschaft wird gut toleriert

Update Onkologie

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 2/2017

Relationships between Common and Novel Interleukin-6 Gene Polymorphisms and Risk of Cervical Cancer: a Case-Control Study

17β-hydroxysteroid dehydrogenase type Gene 1937 A > G Polymorphism as a Risk Factor for Cervical Cancer Progression in the Polish Population

Primary Soft Tissue Lymphomas: Description of Seven Cases and Review of the Literature

miRNA-429 Inhibits Astrocytoma Proliferation and Invasion by Targeting BMI1

The Missing Link in the Diagnostic Pathway of Prostate Cancer

Normothermic and Hyperthermic Intraperitoneal Chemoperfusions with Cisplatin to Treat Advanced Ovarian Cancer in Experimental Settings

Neu im Fachgebiet Onkologie

Adjuvante Immuntherapie verlängert Leben bei RCC

Alectinib verbessert krankheitsfreies Überleben bei ALK-positivem NSCLC

Bei Senioren mit Prostatakarzinom auf Anämie achten!

ICI-Therapie in der Schwangerschaft wird gut toleriert

Update Onkologie