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Inflammation
Erschienen in: Inflammation 5/2015

01.10.2015

Alpha-Tomatine Exhibits Anti-inflammatory Activity in Lipopolysaccharide-Activated Macrophages

verfasst von: Ben Zhao, Bing Zhou, Lei Bao, Yuming Yang, Kaijin Guo

Erschienen in: Inflammation | Ausgabe 5/2015

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Abstract

Alpha (α)-tomatine is the major saponin and occurs naturally in tomatoes, which has been confirmed to possess a variety of biological properties including antitumoral, antioxidant, and anti-inflammatory. However, the anti-inflammatory mechanism of α-tomatine is not well understood. This study aims to investigate the anti-inflammatory effects and mechanisms of α-tomatine. Results showed that α-tomatine significantly suppressed the production of pro-inflammatory cytokines in lipopolysaccharide (LPS)-induced macrophages. Moreover, LPS-mediated nuclear translocation of the nuclear factor-kappaB (NF-κB)-p65 and phosphorylation of extracellular signal-regulated kinase (ERK) 1/2 were attenuated after α-tomatine treatment. Still, LPS slightly promoted phosphorylation of Akt, and α-tomatine accelerated the phosphorylation of Akt in macrophages. Our findings indicate that α-tomatine may be a valuable therapeutic agent in the treatment of inflammation-related diseases.
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Metadaten
Titel
Alpha-Tomatine Exhibits Anti-inflammatory Activity in Lipopolysaccharide-Activated Macrophages
verfasst von
Ben Zhao
Bing Zhou
Lei Bao
Yuming Yang
Kaijin Guo
Publikationsdatum
01.10.2015
Verlag
Springer US
Erschienen in
Inflammation / Ausgabe 5/2015
Print ISSN: 0360-3997
Elektronische ISSN: 1573-2576
DOI
https://doi.org/10.1007/s10753-015-0154-9

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