nach oben

Neuroradiology

Erschienen in:

01.11.2015 | Diagnostic Neuroradiology

Alterations in white matter volume and its correlation with clinical characteristics in patients with generalized anxiety disorder

verfasst von: Chung-Man Moon, Gwang-Woo Jeong

Erschienen in: Neuroradiology | Ausgabe 11/2015

Einloggen, um Zugang zu erhalten

Abstract

Introduction

Only a few morphological studies have focused on changes in white matter (WM) volume in patients with generalized anxiety disorder (GAD). We evaluated alterations in WM volume and its correlation with symptom severity and duration of illness in adults with GAD.

Methods

The 44 subjects were comprised of 22 patients with GAD (13 males and nine females) diagnosed using the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision (DSM-IV-TR) and 22 age-matched healthy controls (13 males and nine females). High-resolution magnetic resonance imaging (MRI) data were processed by voxel-based morphometry (VBM) analysis based on diffeomorphic anatomical registration using the exponentiated Lie algebra (DARTEL) algorithm in SPM8.

Results

Patients with GAD showed significantly reduced WM volume, particularly in the dorsolateral prefrontal cortex (DLPFC), anterior limb of the internal capsule (ALIC), and midbrain. In addition, DLPFC volume was negatively correlated with GAD-7 score and illness duration. ALIC volume was negatively correlated with GAD-7 score. Female patients had significantly less orbitofrontal cortex volume compared to that in male patients.

Conclusion

The findings demonstrate localized changes in WM volume associated with cognitive and emotional dysfunction in patients with GAD. The finding will be helpful for understanding the neuropathology in patients with GAD.

American Psychiatric Association (2000) Diagnostic and statistical manual of mental disorders (4th ed., text revision). American Psychiatric Association, Washington, DC

Roemer L, Lee JK, Salters-Pedneault K et al (2009) Mindfulness and emotion regulation difficulties in generalized anxiety disorder: preliminary evidence for independent and overlapping contributions. Behav Ther 40:142–154PubMedCentralCrossRefPubMed

Mantella RC, Butters MA, Dew MA et al (2007) Cognitive impairment in late-life generalized anxiety disorder. Am J Geriatr Psych 15:673–679CrossRef

Bernal M, Haro JM, Bernert S et al (2007) Risk factors for suicidality in Europe: results from the ESEMED study. J Affect Disord 101:27–34CrossRefPubMed

Rickels K, Rynn M, Khalid-Khan S (2002) Diagnosis and evaluation of generalized anxiety disorder patients. In: Nutt D, Rickels K, Stein DJ (eds) Generalized anxiety disorder: symptomatology, pathogenesis and management. Martin Dunitz, London, pp 27–40

Monk CS, Telzer EH, Mogg K et al (2008) Amygdala and ventrolateral prefrontal cortex activation to masked angry faces in children and adolescents with generalized anxiety disorder. Arch Gen Psychiatry 65:568–576PubMedCentralCrossRefPubMed

Price RB, Eldreth DA, Mohlman J (2011) Deficient prefrontal attentional control in late-life generalized anxiety disorder: an fMRI investigation. Transl Psychiatry 1:e46PubMedCentralCrossRefPubMed

Ball TM, Ramsawh HJ, Campbell-Sills L et al (2013) Prefrontal dysfunction during emotion regulation in generalized anxiety and panic disorders. Psychol Med 43:1475–1486CrossRefPubMed

Moon CM, Kim GW, Jeong GW (2014) Whole-brain gray matter volume abnormalities in patients with generalized anxiety disorder: voxel-based morphometry. Neuroreport 25:184–189CrossRefPubMed

10.

Liao M, Yang F, Zhang Y et al (2014) Lack of gender effects on gray matter volumes in adolescent generalized anxiety disorder. J Affect Disord 155:278–282CrossRefPubMed

11.

Schienle A, Ebner F, Schäfer A (2011) Localized gray matter volume abnormalities in generalized anxiety disorder. Eur Arch Psychiatry Clin Neurosci 261:303–307CrossRefPubMed

12.

Strawn JR, Wehry AM, Chu WJ et al (2013) Neuroanatomic abnormalities in adolescents with generalized anxiety disorder: a voxel-based morphometry study. Depress Anxiety 30:842–848CrossRefPubMed

13.

De Bellis MD, Keshavan MS, Shifflett H et al (2002) Superior temporal gyrus volumes in pediatric generalized anxiety disorder. Biol Psychiatry 51:553–562CrossRefPubMed

14.

Liao M, Yang F, Zhang Y et al (2014) White matter abnormalities in adolescents with generalized anxiety disorder: a diffusion tensor imaging study. BMC Psychiatry 14:41PubMedCentralCrossRefPubMed

15.

Zhang Y, Li L, Yu R et al (2013) White matter integrity alterations in first episode, treatment-naive generalized anxiety disorder. J Affect Disord 148:196–201CrossRefPubMed

16.

Fan Q, Yan X, Wang J et al (2012) Abnormalities of white matter microstructure in unmedicated obsessive-compulsive disorder and changes after medication. PLoS One 7:e35889PubMedCentralCrossRefPubMed

17.

Di X, Chan RC, Gong QY (2009) White matter reduction in patients with schizophrenia as revealed by voxel-based morphometry: an activation likelihood estimation meta-analysis. Prog Neuropsychopharmacol Biol Psychiatry 33(8):1390–1394CrossRefPubMed

18.

Duan Y, Liu Y, Liang P et al (2013) White matter atrophy in brain of neuromyelitis optica: a voxel-based morphometry study. Acta Radiol 55(5):589–593CrossRefPubMed

19.

Kessler RC, McGonagle KA, Zhao S et al (1994) Lifetime and 12-month prevalence of DSM-III-R psychiatric disorders in the United States. Results from the National Comorbidity Survey. Arch Gen Psychiatry 51:8–19CrossRefPubMed

20.

Bahrami F, Yousefi N (2011) Females are more anxious than males: a metacognitive perspective. Iran J Psychiatry Behav Sci 5:83–90PubMedCentralPubMed

21.

First MB, Spitzer RL, Gibbon M et al (1995) Structured clinical interview for DSM-IV axis I disorders. Patient Edition (SCIDP), Version 2. Biometrics Research, New York, New York State Psychiatric Institute

22.

Hamilton M (1959) The assessment of anxiety states by rating. Br J Med Psychol 32:50–55CrossRefPubMed

23.

Hamilton M (1960) A rating scale for depression. J Neurol Neurosurg Psychiat 23:56–62PubMedCentralCrossRefPubMed

24.

Spitzer RL, Kroenke K, Williams JB et al (2006) A brief measure for assessing generalized anxiety disorder: the GAD-7. Arch Intern Med 166:1092–1097CrossRefPubMed

25.

Spielberger CD, Gorsuch RL, Lushene RE (1970) Test manual for the State Trait Anxiety Inventory. Consulting Consulting Psychologists Press, Palo Alto, California

26.

Taylor S, Cox BJ (1998) An expanded anxiety sensitivity index: evidence for a hierarchic structure in a clinical sample. J Anxiety Dis 12:463–484CrossRef

27.

Ashburner J (2007) A fast diffeomorphic image registration algorithm. Neuroimage 38:95–113CrossRefPubMed

28.

Bookstein FL (2001) “Voxel-based morphometry” should not be used with imperfectly registered images. Neuroimage 14:1454–1462CrossRefPubMed

29.

Rando K, Tuit K, Hannestad J et al (2013) Sex differences in decreased limbic and cortical grey matter volume in cocaine dependence: a voxel-based morphometric study. Addict Biol 18:147–160PubMedCentralCrossRefPubMed

30.

Luders E, Gaser C, Narr KL et al (2009) Why sex matters: brain size independent differences in gray matter distributions between men and women. J Neurosci 29:14265–14270PubMedCentralCrossRefPubMed

31.

Lancaster JL, Woldorff MG, Parsons LM et al (2000) Automated Talairach atlas labels for functional brain mapping. Hum Brain Mapp 10:120–131CrossRefPubMed

32.

Ke X, Tang T, Hong S et al (2009) White matter impairments in autism, evidence from voxel-based morphometry and diffusion tensor imaging. Brain Res 1265:171–177CrossRefPubMed

33.

Seok JH, Park HJ, Chun JW et al (2007) White matter abnormalities associated with auditory hallucinations in schizophrenia: a combined study of voxel-based analyses of diffusion tensor imaging and structural magnetic resonance imaging. Psychiatry Res 156:93–104CrossRefPubMed

34.

Velakoulis D, Wood SJ, Wong MT et al (2006) Hippocampal and amygdala volumes according to psychosis stage and diagnosis: a magnetic resonance imaging study of chronic schizophrenia, first-episode psychosis, and ultra-high-risk individuals. Arch Gen Psychiatry 63:139–149CrossRefPubMed

35.

Moon CM, Kang HK, Jeong GW (2015) Metabolic change in the right dorsolateral prefrontal cortex and its correlation with symptom severity in patients with generalized anxiety disorder: Proton magnetic resonance spectroscopy at 3 Tesla. Psychiatry Clin Neurosci, in press

36.

Moon CM, Jeong GW (2015) Functional neuroanatomy on the working memory under emotional distraction in patients with generalized anxiety disorder. Psychiatry Clin Neurosci, in press

37.

Shizukuishi T, Abe O, Aoki S (2013) Diffusion tensor imaging analysis for psychiatric disorders. Magn Reson Med Sci 12:153–159CrossRefPubMed

38.

Yang Q, Huang X, Hong N et al (2007) White matter microstructural abnormalities in late-life depression. Int Psychogeriatr 19:757–766CrossRefPubMed

39.

Oh JS, Kubicki M, Rosenberger G et al (2009) Thalamo-frontal white matter alterations in chronic schizophrenia: a quantitative diffusion tractography study. Hum Brain Mapp 30:3812–3825PubMedCentralCrossRefPubMed

40.

Norgren R (1976) Taste pathways to hypothalamus and amygdala. J Comp Neurol 166:17–30CrossRefPubMed

41.

Okun MS, Mann G, Foote KD et al (2007) Deep brain stimulation in the internal capsule and nucleus accumbens region: responses observed during active and sham programming. J Neurol Neurosurg Psychiatry 78:310–314PubMedCentralCrossRefPubMed

42.

Barnden LR, Crouch B, Kwiatek R et al (2011) A brain MRI study of chronic fatigue syndrome: evidence of brainstem dysfunction and altered homeostasis. NMR Biomed 24:1302–1312PubMedCentralCrossRefPubMed

43.

Cotter DR, Pariante CM, Everall IP (2001) Glial cell abnormalities in major psychiatric disorders: the evidence and implications. Brain Res Bull 55:585–595CrossRefPubMed

44.

Neuropsychopharmacology: The fifth generation of progress (2002) Edited by Davis KL, Charney D, Coyle JT, Nemeroff C. Williams and Wilkins, Philadelphia

45.

Coyle JT, Schwarcz R (2000) Mind glue: implications of glial cell biology for psychiatry. Arch Gen Psychiatry 57:90–93CrossRefPubMed

46.

Ongür D, Drevets WC, Price JL (1998) Glial reduction in the subgenual prefrontal cortex in mood disorders. Proc Natl Acad Sci USA 95:13290–13295PubMedCentralCrossRefPubMed

47.

Daubert EA, Condron BG (2010) Serotonin: a regulator of neuronal morphology and circuitry. Trends Neurosci 33:424–434PubMedCentralCrossRefPubMed

48.

Maron E, Kuikka JT, Ulst K et al (2004) SPECT imaging of serotonin transporter binding in patients with generalized anxiety disorder. Eur Arch Psychiatry Clin Neurosci 254:392–396CrossRefPubMed

49.

Konishi J, Asami T, Hayano F et al (2014) Multiple white matter volume reductions in patients with panic disorder: relationships between orbitofrontal gyrus volume and symptom severity and social dysfunction. PLoS One 9:e92862PubMedCentralCrossRefPubMed

Titel: Alterations in white matter volume and its correlation with clinical characteristics in patients with generalized anxiety disorder
verfasst von: Chung-Man Moon
Gwang-Woo Jeong
Publikationsdatum: 01.11.2015
Verlag: Springer Berlin Heidelberg
Erschienen in: Neuroradiology / Ausgabe 11/2015
Print ISSN: 0028-3940
Elektronische ISSN: 1432-1920
DOI: https://doi.org/10.1007/s00234-015-1572-y

Leitlinien kompakt für die Neurologie

Mit medbee Pocketcards sicher entscheiden.

^{Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag}

Kostenlos registrieren

Neu im Fachgebiet Neurologie

Sind Frauen die fähigeren Ärzte?

30.04.2024 Gendermedizin Nachrichten

Patienten, die von Ärztinnen behandelt werden, dürfen offenbar auf bessere Therapieergebnisse hoffen als Patienten von Ärzten. Besonders gilt das offenbar für weibliche Kranke, wie eine Studie zeigt.

Akuter Schwindel: Wann lohnt sich eine MRT?

28.04.2024 Schwindel Nachrichten

Akuter Schwindel stellt oft eine diagnostische Herausforderung dar. Wie nützlich dabei eine MRT ist, hat eine Studie aus Finnland untersucht. Immerhin einer von sechs Patienten wurde mit akutem ischämischem Schlaganfall diagnostiziert.

Niedriger diastolischer Blutdruck erhöht Risiko für schwere kardiovaskuläre Komplikationen

25.04.2024 Hypotonie Nachrichten

Wenn unter einer medikamentösen Hochdrucktherapie der diastolische Blutdruck in den Keller geht, steigt das Risiko für schwere kardiovaskuläre Ereignisse: Darauf deutet eine Sekundäranalyse der SPRINT-Studie hin.

Frühe Alzheimertherapie lohnt sich

25.04.2024 AAN-Jahrestagung 2024 Nachrichten

Ist die Tau-Last noch gering, scheint der Vorteil von Lecanemab besonders groß zu sein. Und beginnen Erkrankte verzögert mit der Behandlung, erreichen sie nicht mehr die kognitive Leistung wie bei einem früheren Start. Darauf deuten neue Analysen der Phase-3-Studie Clarity AD.

Update Neurologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Springer Medizin

Abstract

Introduction

Methods

Results

Conclusion

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 11/2015

Contrast-enhanced angiographic cone-beam computed tomography without pre-diluted contrast medium

Iron deposition influences the measurement of water diffusion tensor in the human brain: a combined analysis of diffusion and iron-induced phase changes

European Society of Neuroradiology (ESNR)

Susceptibility-weighted imaging in stroke-like migraine attacks after radiation therapy syndrome

Functional hemispherectomy: postoperative motor state and correlation to preoperative DTI