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Erschienen in:

08.09.2022 | Original Paper

Altered Resting State Networks Before and After Temporal Lobe Epilepsy Surgery

verfasst von: Wei Li, Yuchao Jiang, Yingjie Qin, Xiuli Li, Du Lei, Heng Zhang, Ding Lei, Dezhong Yao, Cheng Luo, Qiyong Gong, Dong Zhou, Dongmei An

Erschienen in: Brain Topography | Ausgabe 5-6/2022

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Abstract

Objectives

To explore the resting state networks (RSNs) alterations in patients with unilateral mesial temporal lobe epilepsy (mTLE) before and after successful surgery.

Methods

Resting-state functional MRI and T1-weighted structural MRI were obtained in 37 mTLE patients who achieved seizure freedom after anterior temporal lobectomy. Patients were scanned before surgery and at two years after surgery. Twenty-eight age- and sex-matched healthy controls were scanned once. Functional connectivity (FC) changes within and between ten common RSNs before and after surgery, and FC changes between hippocampus and RSNs were explored.

Results

Before surgery, decreased FC was found within visual network and basal ganglia network, while after surgery, FC within basal ganglia network further decreased but FC within sensorimotor network and dorsal attention network increased. Before surgery, between-network FC related to basal ganglia network, visual network and dorsal attention network decreased, while between-network FC related to default mode network increased. After surgery, between-network FC related to visual network and dorsal attention network significantly increased. In addition, before surgery, ipsilateral hippocampus showed decreased FC with visual network, basal ganglia network, sensorimotor network, default mode network and frontoparietal network, while contralateral rostral hippocampus showed increased FC with salience network. After surgery, no obvious FC changes were found between contralateral hippocampus and these RSNs.

Conclusion

MTLE patients showed significant RSNs alterations before and after surgery. Basal ganglia network showed progressive decline in functional connectivity. Successful surgery may lead to RSNs reorganization. These results provide preliminary evidence for postoperative functional remodeling at whole-brain-network level.

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Audrain S, Barnett AJ, McAndrews MP (2018) Language network measures at rest indicate individual differences in naming decline after anterior temporal lobe resection. Hum Brain Mapp 39(11):4404–4419PubMedPubMedCentral

Bauman K, Devinsky O, Liu AA (2019) Temporal lobe surgery and memory: Lessons, risks, and opportunities. Epilepsy Behav 101:106596 (Pt A)PubMedPubMedCentral

Beckung E, Uvebrant P (1993) Motor and sensory impairments in children with intractable epilepsy. Epilepsia 34(5):924–929PubMed

Benuzzi F, Zamboni G, Meletti S et al (2014) Recovery from emotion recognition impairment after temporal lobectomy. Front Neurol 5:92PubMedPubMedCentral

Burianová H, Faizo NL, Gray M et al (2017) Altered functional connectivity in mesial temporal lobe epilepsy. Epilepsy Res 137:45–52PubMed

Caciagli L, Xiao F, Wandschneider B, Koepp MJ (2017) Imaging biomarkers of anti-epileptic drug action: insights from magnetic resonance imaging. Curr Pharm Des 23(37):5727–5739PubMed

Cataldi M, Avoli M, de Villers-Sidani E (2013) Resting state networks in temporal lobe epilepsy. Epilepsia 54(12):2048–2059PubMedPubMedCentral

Corbetta M, Shulman GL (2002) Control of goal-directed and stimulus-driven attention in the brain. Nat Rev Neurosci 3(3):201–215PubMed

Deransart C, Depaulis A (2002) The control of seizures by the basal ganglia? A review of experimental data. Epileptic Disord 4(Suppl 3):S61–72PubMed

de Tisi J, Bell GS, Peacock JL et al (2011) The long-term outcome of adult epilepsy surgery, patterns of seizure remission, and relapse: a cohort study. Lancet 378(9800):1388–1395PubMed

Engel J Jr, International League Against Epilepsy (ILAE) (2001) A proposed diagnostic scheme for people with epileptic seizures and with epilepsy: report of the ILAE Task Force on Classification and Terminology. Epilepsia 42(6):796–803PubMed

Fan L, Li H, Zhuo J et al (2016) The Human Brainnetome Atlas: A New Brain Atlas Based on Connectional Architecture. Cereb Cortex 26(8):3508–3526PubMedPubMedCentral

González HFJ, Chakravorti S, Goodale SE et al (2019) Thalamic arousal network disturbances in temporal lobe epilepsy and improvement after surgery. J Neurol Neurosurg Psychiatry 90(10):1109–1116PubMed

Grant AC, Donnelly KM, Chubb C et al (2008) Temporal lobe epilepsy does not impair visual perception. Epilepsia 49(4):710–713PubMed

Haneef Z, Lenartowicz A, Yeh HJ et al (2014) Functional connectivity of hippocampal networks in temporal lobe epilepsy. Epilepsia 55(1):137–145PubMed

Hetherington HP, Kuzniecky RI, Vives K et al (2007) A subcortical network of dysfunction in TLE measured by magnetic resonance spectroscopy. Neurology 69(24):2256–2265PubMed

He X, Chaitanya G, Asma B et al (2020) Disrupted basal ganglia-thalamocortical loops in focal to bilateral tonic-clonic seizures. Brain 143(1):175–190PubMed

Jin SH, Jeong W, Chung CK (2015) Mesial temporal lobe epilepsy with hippocampal sclerosis is a network disorder with altered cortical hubs. Epilepsia 56:772–779PubMed

Kreitzer AC, Malenka RC (2008) Striatal plasticity and basal ganglia circuit function. Neuron 60(4):543–554PubMedPubMedCentral

Kwan P, Schachter SC, Brodie MJ (2011) Drug-resistant epilepsy. N Engl J Med 365(10):919–926PubMed

Lanciego JL, Luquin N, Obeso JA (2012) Functional neuroanatomy of the basal ganglia. Cold Spring Harb Perspect Med 2(12):a009621PubMedPubMedCentral

Laufs H, Hamandi K, Salek-Haddadi A et al (2007) Temporal lobe interictal epileptic discharges affect cerebral activity in ‘‘default mode’’ brain regions. Hum Brain Mapp 28(10):1023–1032PubMed

Liao W, Zhang Z, Pan Z et al (2011) Default mode network abnormalities in mesial temporal lobe epilepsy: a study combining fMRI and DTI. Hum Brain Mapp 32(6):883–895PubMed

Li W, An D, Tong X et al (2019) Different patterns of white matter changes after successful surgery of mesial temporal lobe epilepsy. Neuroimage Clin 21:101631PubMed

Li W, Jiang Y, Qin Y et al (2021a) Dynamic gray matter and intrinsic activity changes after epilepsy surgery. Acta Neurol Scand 143(3):261–270PubMed

Li W, Jiang Y, Qin Y et al (2021b) Structural and functional reorganization of contralateral hippocampus after temporal lobe epilepsy surgery. Neuroimage Clin 31:102714PubMedPubMedCentral

Maccotta L, Lopez MA, Adeyemo B et al (2017) Postoperative seizure freedom does not normalize altered connectivity in temporal lobe epilepsy. Epilepsia 58(11):1842–1851PubMedPubMedCentral

Majerus S, Péters F, Bouffier M et al (2018) The Dorsal Attention Network Reflects Both Encoding Load and Top-down Control during Working Memory. J Cogn Neurosci 30(2):144–159PubMed

McCormick C, Quraan M, Cohn M et al (2013) Default mode network connectivity indicates episodic memory capacity in mesial temporal lobe epilepsy. Epilepsia 54(5):809–818PubMed

Morgan VL, Rogers BP, González HFJ et al (2019) Characterization of postsurgical functional connectivity changes in temporal lobe epilepsy. J Neurosurg 14:1–11

Negishi M, Martuzzi R, Novotny EJ et al (2011) Functional MRI connectivity as a predictor of the surgical outcome of epilepsy. Epilepsia 52(9):1733–1740PubMedPubMedCentral

Pittau F, Grova C, Moeller F et al (2012) Patterns of altered functional connectivity in mesial temporal lobe epilepsy. Epilepsia 53(6):1013–1023PubMedPubMedCentral

Power JD, Plitt M, Laumann TO et al (2017) Sources and implications of whole-brain fMRI signals in humans. NeuroImage 146:609–625PubMed

Shamshiri EA, Tierney TM, Centeno M et al (2017) Interictal activity is an important contributor to abnormal intrinsic network connectivity in paediatric focal epilepsy. Hum Brain Mapp 38(1):221–236PubMed

Taylor KS, Seminowicz DA, Davis KD (2009) Two systems of resting state connectivity between the insula and cingulate cortex. Hum Brain Mapp 30(9):2731–2745PubMed

Tong X, An D, Xiao F et al (2019) Real-time effects of interictal spikes on hippocampus and amygdala functional connectivity in unilateral temporal lobe epilepsy: An EEG-fMRI study. Epilepsia 60(2):246–254PubMed

van Rooyen F, Young NA, Larson SE et al (2006) Hippocampal kindling leads to motor map expansion. Epilepsia 47(8):1383–1391PubMed

Vuong J, Devergnas A (2018) The role of the basal ganglia in the control of seizure. J Neural Transm (Vienna) 125(3):531–545PubMed

Weniger G, Boucsein K, Irle E (2004) Impaired associative memory in temporal lobe epilepsy subjects after lesions of hippocampus, parahippocampal gyrus and amygdala. Hippocampus 14(6):785–796PubMed

Wieser HG, Blume WT, Fish D et al (2001) ILAE Commission Report. Proposal for a new classification of outcome with respect to epileptic seizures following epilepsy surgery. Epilepsia 42(2):282–286PubMed

Xifra-Porxas A, Kassinopoulos M, Mitsis GD (2021) Physiological and motion signatures in static and time-varying functional connectivity and their subject identifiability. Elife 10:e62324PubMedPubMedCentral

Zhang Z, Lu G, Zhong Y et al (2009a) Impaired attention network in temporal lobe epilepsy: a resting FMRI study. Neurosci Lett 458(3):97–101PubMed

Zhang Z, Lu G, Zhong Y et al (2009b) Impaired perceptual networks in temporal lobe epilepsy revealed by resting fMRI. J Neurol 256(10):1705–1713PubMed

Zhang Z, Liao W, Xu Q et al (2017) Hippocampus-associated causal network of structural covariance measuring structural damage progression in temporal lobe epilepsy. Hum Brain Mapp 38(2):753–766PubMed

Zhang Z, Lu G, Zhong Y et al (2010) Altered spontaneous neuronal activity of the default-mode network in mesial temporal lobe epilepsy. Brain Res 1323:152–160PubMed

Titel: Altered Resting State Networks Before and After Temporal Lobe Epilepsy Surgery
verfasst von: Wei Li
Yuchao Jiang
Yingjie Qin
Xiuli Li
Du Lei
Heng Zhang
Ding Lei
Dezhong Yao
Cheng Luo
Qiyong Gong
Dong Zhou
Dongmei An
Publikationsdatum: 08.09.2022
Verlag: Springer US
Erschienen in: Brain Topography / Ausgabe 5-6/2022
Print ISSN: 0896-0267
Elektronische ISSN: 1573-6792
DOI: https://doi.org/10.1007/s10548-022-00912-1

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