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Arthritis Research & Therapy

Erschienen in:

01.12.2005 | Review

Amplification of autoimmune disease by infection

verfasst von: David N Posnett, Dmitry Yarilin

Erschienen in: Arthritis Research & Therapy | Ausgabe 2/2005

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Abstract

Reports of infection with certain chronic persistent microbes (herpesviruses or Chlamydiae) in human autoimmune diseases are consistent with the hypothesis that these microbes are reactivated in the setting of immunodeficiency and often target the site of autoimmune inflammation. New experimental animal models demonstrate the principle. A herpesvirus or Chlamydia species can be used to infect mice with induced transient autoimmune diseases. This results in increased disease severity and even relapse. The evidence suggests that the organisms are specifically imported to the inflammatory sites and cause further tissue destruction, especially when the host is immunosuppressed. We review the evidence for the amplification of autoimmune inflammatory disease by microbial infection, which may be a general mechanism applicable to many human diseases. We suggest that patients with autoimmune disorders receiving immunosuppressing drugs should benefit from preventive antiviral therapy.

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Titel: Amplification of autoimmune disease by infection
verfasst von: David N Posnett
Dmitry Yarilin
Publikationsdatum: 01.12.2005
Verlag: BioMed Central
Erschienen in: Arthritis Research & Therapy / Ausgabe 2/2005
Elektronische ISSN: 1478-6362
DOI: https://doi.org/10.1186/ar1691

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