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Arthritis Research & Therapy

Erschienen in:

01.12.2005 | Review

Transforming growth factor-β-induced regulatory T cells referee inflammatory and autoimmune diseases

verfasst von: Sharon M Wahl, Wanjun Chen

Erschienen in: Arthritis Research & Therapy | Ausgabe 2/2005

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Abstract

Naturally occurring CD4⁺CD25⁺ regulatory T cells mediate immune suppression to limit immunopathogenesis associated with chronic inflammation, persistent infections and autoimmune diseases. Their mode of suppression is contact-dependent, antigen-nonspecific and involves a nonredundant contribution from the cytokine transforming growth factor (TGF)-β. Not only can TGF-β mediate cell–cell suppression between the regulatory T cells and CD4⁺CD25^- or CD8⁺ T cells, but new evidence also reveals its role in the conversion of CD4⁺CD25^- T cells, together with TCR antigen stimulation, into the regulatory phenotype. Elemental to this conversion process is induction of expression of the forkhead transcription factor, Foxp3. This context-dependent coercion of naive CD4⁺ T cells into a powerful subset of regulatory cells provides a window into potential manipulation of these cells to orchestrate therapeutic intervention in diseases characterized by inadequate suppression, as well as a promising means of controlling pathologic situations in which excessive suppression dominates.

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Titel: Transforming growth factor-β-induced regulatory T cells referee inflammatory and autoimmune diseases
verfasst von: Sharon M Wahl
Wanjun Chen
Publikationsdatum: 01.12.2005
Verlag: BioMed Central
Erschienen in: Arthritis Research & Therapy / Ausgabe 2/2005
Elektronische ISSN: 1478-6362
DOI: https://doi.org/10.1186/ar1504

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