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Journal of Clinical Immunology

Erschienen in:

01.03.2009

An Association Study of 13 SNPs from Seven Candidate Genes with Pediatric Asthma and a Preliminary Study for Genetic Testing by Multiple Variants in Taiwanese Population

verfasst von: Jiu-Yao Wang, Ya-Huei Liou, Ying-Jye Wu, Ya-Hsin Hsiao, Lawrence Shih-Hsin Wu

Erschienen in: Journal of Clinical Immunology | Ausgabe 2/2009

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Abstract

Introduction

Asthma is one of the most common chronic diseases in children. It is caused by complex interactions between various genetic factors and exposures to environmental allergens and irritants. Because of the heterogeneity of the disease and the genetic and cultural differences among different populations, a proper association study and genetic testing for asthma and susceptibility genes is difficult to perform.

Materials and Methods

We assessed 13 single-nucleotide polymorphisms (SNPs) in seven well-known asthma susceptibility genes and looked for association with pediatric asthma using 449 asthmatic subjects and 512 non-asthma subjects in Taiwanese population.

Results

CD14-159 C/T and MS4A2 Glu237Gly were identified to have difference in genotype/allele frequencies between the control group and asthma patients. Moreover, the genotype synergistic analysis showed that the co-contribution of two functional SNPs was riskier or more protective from asthma attack. Our study provided a genotype synergistic method for studying gene–gene interaction on polymorphism basis and genetic testing using multiple polymorphisms.

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Titel: An Association Study of 13 SNPs from Seven Candidate Genes with Pediatric Asthma and a Preliminary Study for Genetic Testing by Multiple Variants in Taiwanese Population
verfasst von: Jiu-Yao Wang
Ya-Huei Liou
Ying-Jye Wu
Ya-Hsin Hsiao
Lawrence Shih-Hsin Wu
Publikationsdatum: 01.03.2009
Verlag: Springer US
Erschienen in: Journal of Clinical Immunology / Ausgabe 2/2009
Print ISSN: 0271-9142
Elektronische ISSN: 1573-2592
DOI: https://doi.org/10.1007/s10875-008-9256-6

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An Association Study of 13 SNPs from Seven Candidate Genes with Pediatric Asthma and a Preliminary Study for Genetic Testing by Multiple Variants in Taiwanese Population

Abstract

Introduction

Materials and Methods

Results

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Abstract

Introduction

Materials and Methods

Results

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