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European Journal of Clinical Microbiology & Infectious Diseases

Erschienen in:

09.02.2016 | Editorial

An infectious disease and pharmacokinetic perspective on oral antibiotic treatment of uncomplicated urinary tract infections due to multidrug-resistant Gram-negative uropathogens: the importance of urinary antibiotic concentrations and urinary pH

verfasst von: B. A. Cunha

Erschienen in: European Journal of Clinical Microbiology & Infectious Diseases | Ausgabe 4/2016

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Excerpt

One of the most common reasons for infectious disease consultation for urinary tract infections (UTIs) from urologists is regarding the selection of antibiotic therapy for acute uncomplicated cystitis (AUC) or catheter-associated bacteriuria (CAB) due to multidrug-resistant (MDR) Gram-negative bacillary (GNB) uropathogens in hospitalized and ambulatory patients. The important therapeutic decisions for AUC or CAB due to MDR uropathogens are regarding the interpretation of susceptibility testing, i.e., in vitro susceptibility versus in vivo effectiveness, and the choice of oral versus intravenous antibiotic therapy. This commentary is based on my experience and pharmacokinetic (PK) principles. The importance of urinary antibiotic concentrations in determining the urinary spectrum of oral antibiotics and the effect of urinary pH are discussed as determinants of therapeutic efficacy. …

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Titel: An infectious disease and pharmacokinetic perspective on oral antibiotic treatment of uncomplicated urinary tract infections due to multidrug-resistant Gram-negative uropathogens: the importance of urinary antibiotic concentrations and urinary pH
verfasst von: B. A. Cunha
Publikationsdatum: 09.02.2016
Verlag: Springer Berlin Heidelberg
Erschienen in: European Journal of Clinical Microbiology & Infectious Diseases / Ausgabe 4/2016
Print ISSN: 0934-9723
Elektronische ISSN: 1435-4373
DOI: https://doi.org/10.1007/s10096-016-2577-0

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