Background
Methods
Statistical analysis
Results
Medication Name | Formulation | Manufacturer |
---|---|---|
2.5 ml | ||
Travatan | travaprost 0.004% | Alcon Laboratories, Inc. Fort Worth, TX 76134 |
Travaprost | travaprost 0.004% | Par Pharmaceutical Cos. Inc. Spring Valley, NY 10977 |
Xalatan | latanoprost 0.005% | Pharmacia&Upjohn Co, Division of Pfizer, Inc. NY, NY 10017 |
Latanoprost | latanoprost 0.005% | Akorn, Inc. Lake Forest, IL 60045 |
Lumigan | bimatoprost 0.001% | Allergan, Inc. Irvine, CA 92612 |
5 ml | ||
Lumigan | bimatoprost 0.001% | Allergan, Inc. Irvine, CA 92612 |
Travaprost | travaprost 0.004% | Par Pharmaceutical Cos. Inc. Spring Valley, NY 10977 |
Travatan | travaprost 0.004% | Alcon Laboratories, Inc. Fort Worth, TX 76134 |
Alphagan P 0.1% | brimonidine tartrate 0.1% | Allergan, Inc. Irvine, CA 92612 |
Combigan | brimonidine tartrate 0.2%, timolol maleate 0.5% | Allergan, Inc. Irvine, CA 92612 |
Timolol Pacific | timolol maleate 0.5% | Pacific Pharma, Irvine CA, 92,612 |
Timolol Hi-Tech | timolol maleate 0.5% | Hi-Tech Pharmacal Co, Inc. Amityville, NY 11701 |
Timolol Sandoz | timolol maleate 0.5% | Alcon Laboratories, Inc. Fort Worth, TX 76134 for Sandoz Inc. Pricenton, NJ 08540 |
Betimol | timolol maleate 0.5% | Akorn, Inc. Lake Forest, IL 60045 for Oak Pharmaceuticals, Inc. |
Timoptic XE | timolol maleate 0.5% | Merck Sharp & Dohme-Chibret 63,963 Clermont-Ferrand Cedex 9, France; Distributed by Valeant Ophthalmics, a division of Valeant Pharmaceuticals North America LLC, Bridgewater, NJ 08807 |
Timoptic | timolol maleate 0.5% | Merck Sharp & Dohme-Chibret 63,963 Clermont-Ferrand Cedex 9, France; Distributed by Valeant Ophthalmics, a division of Valeant Pharmaceuticals North America LLC, Bridgewater, NJ 08807 |
Istalol | timolol maleate 0.5% | Bausch&Lomb Incorporated Tampa, FL 33637 under License from Senju Pharmaceutical Co, Ltd. Osaka, Japan 541–0046 |
7.5 ml | ||
Lumigan | bimatoprost 0.001% | Allergan, Inc. Irvine, CA 92612 |
8 ml | ||
Simbrinza | brinzolamide 1%, brimonidine tartrate 0.2% | Alcon Laboratories, INC 6201 South Freeway, Fort Worth, TX 76134 |
10 ml | ||
Cosopt | dorzolamide HCL 22.3 mg/ml, timolol maleate 6.8 mg/ml | Akorn, Inc. Lake Forest, IL 60045 |
Dorz/Tim Hi-Tech | dorzolamide HCL 22.3 mg/ml, timolol maleate 6.8 mg/ml | Hi-Tech Pharmacal Co, Inc. Amityville, NY 11701 |
Dorz/Tim Bausch | dorzolamide HCL 22.3 mg/ml, timolol maleate 6.8 mg/ml | Bausch & Lomb Incorporated Tampl, FL 33637 |
Dorz/Tim Sandoz | dorzolamide HCL 22.3 mg/ml, timolol maleate 6.8 mg/ml | Alcon Laboratories Inc. Fort Worth Tx 76,134 for Sandoz Inc. Princeton, NJ 08540 |
Trusopt | dorzolamide HCL 2% | Merck Sharp & Dohme Corp.,a subsidiary of Merck & Co, Inc. Whitehouse Station, NJ 08889 |
Dorz Hi Tech | dorzolamide HCL 2% | Hi-Tech Pharmacal Co, Inc. Amityville, NY 11701 |
Dorz Bausch | dorzolamide HCL 2% | Bausch & Lomb Incorporated Tampa, FL 33637 |
Dorz Teva | dorzolamide HCL 2% | Teva Pharmaceutical Ind, Ltd. Jerusalem, 91,010, Israel for Teva Pharmaceuticals USA Sellersville, PA 18960 |
Dorz Sandoz | dorzolamide HCL 2% | Alcon Laboratires, Inc. Fort Worth, TX 76134 for Sandoz Inc. Princeton, NJ 08540 |
Azopt | brinzolamide 1% | Alcon Laboratories, Inc. Fort Worth, TX 76134 |
Combigan | brimonidine tartrate 0.2%, timolol maleate 0.5% | Allergan, Inc. Irvine, CA 92612 |
Alphagan P 0.15% | brimonidine tartrate 0.15% | Allergan, Inc. Irvine, CA 92612 |
Alphagan P 0.1% | brimonidine tartrate 0.1% | Allergan, Inc. Irvine, CA 92612 |
Drop | Mean # Drops | Mean Bottle Volume | Mean Drop Volume | Mean Drops/mL | |||||||
---|---|---|---|---|---|---|---|---|---|---|---|
vert | horz |
p value | vert | horz |
p value | vert | horz | vert | horz |
p value | |
2.5 ml | |||||||||||
Travatan | 76.3 ± 4.2 | 102.3 ± 1.5 |
<0.01
| 2.57 ± 0.07 | 2.53 ± 0.04 | 0.032 | 0.025 | 29.66 ± 1.35 | 40.4 ± 1.07 |
0.0004
| |
Travaprost | 75.3 ± 5.1 | 72 ± 1 | 2.46 ± 0.04 | 2.36 ± 0.07 | 0.032 | 0.032 | 30.6 ± 2.51 | 30.47 ± 1.14 | 0.9445 | ||
Xalatan | 101.3 ± 0.6 | 83.3 ± 3.1 | 2.69 ± 0.05 | 2.70 ± 0.05 | 0.027 | 0.032 | 37.68 ± 0.73 | 30.90 ± 0.60 |
0.0002
| ||
Latanoprost | 86.7 ± 9.3 | 76.7 ± 5.0 | 2.37 ± 0.26 | 2.42 ± 0.13 | 0.027 | 0.032 | 36.59 ± 0.98 | 31.63 ± 0.76 |
0.0023
| ||
Lumigan | 101.7 ± 2.3 | 81.7 ± 4.0 |
<0.01
| 2.50 ± 0.05 | 2.38 ± 0.08 | 0.024 | 0.029 | 40.61 ± 0.18 | 34.25 ± 0.63 |
<0.0001
| |
overall mean | 88.3 | 83.2 | 2.52 | 2.48 | 0.029 | 0.03 | |||||
overall median | 91 | 81 | 2.53 | 2.46 | 0.027 | 0.031 | |||||
overall ST DEV | 12.7 | 11.08 | 0.15 | 0.15 | 0.004 | 0.003 | |||||
5 ml | |||||||||||
Lumigan | 195.6 ± 4.2 | 155 ± 1 |
<0.01
| 4.97 ± 0.06 | 4.73 ± 0.06 | 0.025 | 0.03 | 39.4 ± 0.69 | 32.75 ± 0.22 |
<0.001
| |
Travaprost | 150.3 ± 6.5 | 139.7 ± 13.7 | 4.91 ± 0.02 | 4.78 ± 0.24 | 0.032 | 0.035 | 30.62 ± 1.42 | 29.15 ± 1.50 | 0.2859 | ||
Travatan | 146.3 ± 0.6 | 189 ± 1 |
<0.01
| 4.8 ± 0.04 | 4.78 ± 0.07 | 0.033 | 0.026 | 30.49 ± 0.82 | 29.66 ± 1.35 |
0.0004
| |
Alphagan P | 111 ± 1 | 117 ± 2.6 | 4.89 ± 0.05 | 4.72 ± 0.18 | 0.044 | 0.04 | 22.7 ± 0.16 | 24.82 ± 0.78 |
0.0102
| ||
Combigan | 148 ± 2 | 161.3 ± 3.8 | 5.02 ± 0.16 | 4.67 ± 0.07 |
0.01
| 0.033 | 0.029 | 25.26 ± 1.53 | 34.57 ± 0.50 |
0.0003
| |
Timolol Pacific | 123 ± 1 | 147.7 ± 9.6 |
<0.01
| 4.88 ± 0.04 | 4.69 ± 0.10 | 0.04 | 0.031 | 25.21 ± 0.09 | 25.21 ± 0.09 | 0.0206 | |
Timolol Hi-Tech | 126.7 ± 6.7 | 149.3 ± 4.0 |
<0.01
| 5.09 ± 0.15 | 5.04 ± 0.13 | 0.041 | 0.034 | 24.89 ± 0.56 | 29.61 ± 0.633 |
0.0006
| |
Timolol Sandoz | 161.3 ± 3.5 | 156.3 ± 2.5 | 4.89 ± 0.04 | 4.84 ± 0.08 | 0.03 | 0.031 | 33.02 ± 0.92 | 32.28 ± 0.21 | 0.2459 | ||
Betimol | 165.3 ± 0.6 | 160.7 ± 1.2 | 5.17 ± 0.035 | 5.08 ± 0.06 | 0.031 | 0.031 | 32.00 ± 0.14 | 31.63 ± 0.56 | 0.3282 | ||
Timoptic XE | 130.7 ± 7.5 | 115 ± 9.8 |
0.004
| 5.53 ± 0.24 | 4.9 ± 0.24 | 0.042 | 0.043 | 23.71 ± 2.41 | 23.45 ± 1.16 | 0.8734 | |
Timoptic | 209.3 ± 5.7 | 155.3 ± 7.1 |
<0.01
| 5.93 ± 0.03 | 5.66 ± 0.03 |
0.0003
| 0.089 | 0.036 | 35.28 ± 0.82 | 27.6 ± 1.21 |
0.0008
|
Istalol | 154.6 ± 2.1 | 165.6 ± 2.5 | 4.72 ± 0.03 | 4.74 ± 0.09 | 0.03 | 0.029 | 32.77 ± 0.22 | 34.95 ± 0.32 |
0.0006
| ||
overall mean | 151.9 | 151 | 5.06 | 4.89 | 0.039 | 0.033 | |||||
overall median | 149 | 155.2 | 4.93 | 4.78 | 0.033 | 0.031 | |||||
overall ST DEV | 28.2 | 20.26 | 0.34 | 0.28 | 0.03 | 0.005 | |||||
7.5 ml | |||||||||||
Lumigan | 294 ± 2.6 | 236 ± 2 |
<0.01
| 7.21 ± 0.06 | 7.18 ± 0.03 | 0.024 | 0.03 | 40.76 ± 0.56 | 32.85 ± 0.18 |
<0.001
| |
8 ml | |||||||||||
Simbrinza | 180.7 ± 3.1 | 219.7 ± 6.7 |
<0.01
| 7.51 ± 0.03 | 6.74 ± 0.12 |
0.0004
| 0.167 | 0.031 | 24.07 ± 0.47 | 32.58 ± 1.22 |
0.0003
|
10 ml | |||||||||||
Cosopt | 301.7 ± 39.6 | 242 ± 12.5 |
<0.01
| 10.2 ± 0.17 | 9.58 ± 0.18 |
0.01
| 0.033 | 0.039 | 29.56 ± 3.66 | 25.26 ± 1.53 | 0.1341 |
Dorz/Tim Hi-Tech | 303 ± 1 | 251.7 ± 10.0 |
<0.01
| 9.23 ± 0.34 | 9.19 ± 0.26 | 0.031 | 0.038 | 32.85 ± 1.22 | 27.39 ± 0.39 |
0.0018
| |
Dorz/Tim Bausch | 313.3 ± 1.5 | 293.7 ± 1.5 |
<0.01
| 9.22 ± 0.23 | 8.91 ± 0.21 | 0.03 | 0.031 | 34.01 ± 0.92 | 32.96 ± 0.65 | 0.1804 | |
Dorz/Tim Sandoz | 315 ± 4.6 | 271.3 ± 5.8 |
<0.01
| 8.93 ± 0.15 | 8.39 ± 0.29 | 0.115 | 0.031 | 35.27 ± 1.09 | 32.37 ± 1.03 | 0.0288 | |
Trusopt | 313.3 ± 20.0 | 236 ± 5.6 |
<0.01
| 10.18 ± 0.20 | 9.60 ± 0.33 | 0.221 | 0.051 | 30.77 ± 1.86 | 24.59 ± 0.94 |
0.0068
| |
Dorz Hi Tech | 292.7 ± 10.3 | 261.7 ± 12.9 |
<0.01
| 9.54 ± 0.19 | 9.13 ± 0.29 | 0.033 | 0.035 | 20.92 ± 17.91 | 28.70 ± 2.21 | 0.5313 | |
Dorz Bausch | 289.7 ± 4.2 | 289 ± 4.6 | 9.18 ± 0.26 | 8.78 ± 0.15 | 0.032 | 0.03 | 31.55 ± 0.61 | 32.91 ± 0.06 | 0.0594 | ||
Dorz Teva | 282 ± 11.5 | 260 ± 1 |
<0.01
| 9.31 ± 0.58 | 8.69 ± 0.12 | 0.033 | 0.034 | 30.33 ± 0.79 | 29.91 ± 0.31 | 0.4423 | |
Dorz Sandoz | 193.7 ± 3.79 | 253.7 ± 15.3 |
<0.01
| 9.19 ± 0.12 | 8.38 ± 0.08 |
0.0006
| 0.332 | 0.034 | 21.06 ± 0.16 | 30.26 ± 1.94 | 0.014 |
Azopt | 254.3 ± 2.1 | 322 ± 8.9 |
<0.01
| 9.42 ± 0.08 | 8.59 ± 0.04 |
<0.0001
| 0.037 | 0.027 | 27.01 ± 0.38 | 37.5 ± 1.08 |
<0.001
|
Combigan | 270.3 ± 28.4 | 323.7 ± 17.8 |
<0.01
| 9.86 ± 0.21 | 9.79 ± 0.07 | 0.034 | 0.03 | 27.4 ± 2.50 | 33.07 ± 1.64 | 0.0303 | |
Alphagan 0.15% | 212.7 ± 3.1 | 234 ± 3.6 |
<0.01
| 9.78 ± 0 | 9.53 ± 0.09 | 0.046 | 0.041 | 21.75 ± 0.31 | 24.56 ± 0.16 |
0.0002
| |
Alphagan 0.1% | 216 ± 4 | 283.3 ± 5.5 |
<0.01
| 9.93 ± 0.19 | 9.61 ± 0.07 | 0.046 | 0.037 | 21.75 ± 0.11 | 24.80 ± 0.41 |
0.0002
| |
overall mean | 273.7 | 267.5 | 9.54 | 9.09 | 0.079 | 0.034 | |||||
overall median | 290 | 261 | 9.51 | 9.02 | 0.034 | 0.033 | |||||
overall ST DEV | 42.69 | 31.07 | 0.45 | 0.51 | 0.119 | 0.005 |