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05.05.2018

An online randomized controlled trial, with or without problem-solving treatment, for long-term cancer survivors after hematopoietic cell transplantation

verfasst von: Karen L. Syrjala, Jean C. Yi, Samantha B. Artherholt, Joan M. Romano, Marie-Laure Crouch, Allison S. Fiscalini, Mark T. Hegel, Mary E. D. Flowers, Paul J. Martin, Wendy M. Leisenring

Erschienen in: Journal of Cancer Survivorship | Ausgabe 4/2018

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Abstract

Purpose

This randomized controlled trial examines the efficacy of INSPIRE, an INternet-based Survivorship Program with Information and REsources, with or without problem-solving treatment (PST) telehealth calls, for survivors after hematopoietic cell transplantation (HCT).

Methods

All adult survivors who met eligibility criteria were approached for consent. Participants completed patient-reported outcomes at baseline and 6 months. Those with baseline impaired scores on one or more of the outcomes were randomized to INSPIRE, INSPIRE + PST, or control with delayed INSPIRE access. Outcomes included Cancer and Treatment Distress, Symptom Checklist-90-R Depression, and Fatigue Symptom Inventory. Planned analyses compared arms for mean change in aggregated impaired outcomes and for proportion of participants improved on each outcome.

Results

Of 1306 eligible HCT recipients, 755 (58%) participated, and 344 (45%) had one or more impaired scores at baseline. We found no reduction in aggregated outcomes for either intervention (P > 0.3). In analyses of individual outcomes, participants randomized to INSPIRE + PST were more likely to improve in distress than controls (45 vs. 20%, RR 2.3, CI 1.0, 5.1); those randomized to INSPIRE alone were marginally more likely to improve in distress (40 vs. 20%, RR 2.0, CI 0.9, 4.5).

Conclusions

The INSPIRE online intervention demonstrated a marginal benefit for distress that improved with the addition of telehealth PST, particularly for those who viewed the website or were age 40 or older.

Implications for Cancer Survivors

Online and telehealth programs such as INSPIRE offer opportunities to enhance HCT survivorship outcomes, particularly for mood, though methods would benefit from strategies to improve efficacy.

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Titel: An online randomized controlled trial, with or without problem-solving treatment, for long-term cancer survivors after hematopoietic cell transplantation
verfasst von: Karen L. Syrjala
Jean C. Yi
Samantha B. Artherholt
Joan M. Romano
Marie-Laure Crouch
Allison S. Fiscalini
Mark T. Hegel
Mary E. D. Flowers
Paul J. Martin
Wendy M. Leisenring
Publikationsdatum: 05.05.2018
Verlag: Springer US
Erschienen in: Journal of Cancer Survivorship / Ausgabe 4/2018
Print ISSN: 1932-2259
Elektronische ISSN: 1932-2267
DOI: https://doi.org/10.1007/s11764-018-0693-9

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25.04.2024 | Nierenkarzinom | Nachrichten

Springer Medizin

An online randomized controlled trial, with or without problem-solving treatment, for long-term cancer survivors after hematopoietic cell transplantation

Abstract

Purpose

Methods

Results

Conclusions

Implications for Cancer Survivors

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Abstract

Purpose

Methods

Results

Conclusions

Implications for Cancer Survivors

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