nach oben

Archives of Virology

Erschienen in:

01.11.2012 | Brief Review

An overview of infectious bursal disease

verfasst von: Hebata Allah Mahgoub

Erschienen in: Archives of Virology | Ausgabe 11/2012

Einloggen, um Zugang zu erhalten

Abstract

Infectious bursal disease (IBD) is a viral immunosuppressive disease of chickens attacking mainly an important lymphoid organ in birds [the bursa of Fabricius (BF)]. The emergence of new variant strains of the causative agent [infectious bursal disease virus (IBDV)] has made it more urgent to develop new vaccination strategies against IBD. One of these strategies is the use of recombinant vaccines (DNA and viral-vectored vaccines). Several studies have investigated the host immune response towards IBDV. This review will present a detailed background on the disease and its causative agent, accompanied by a summary of the most recent findings regarding the host immune response to IBDV infection and the use of recombinant vaccines against IBD.

Afonso CL, Tulman ER, Lu Z, Zsak L, Kutish GF, Rock DL (2000) The genome of fowlpox virus. J Virol 74:3815–3831PubMedCrossRef

Azad AA, Jagadish MN, Brown MA, Hudson PJ (1987) Deletion mapping and expression in Escherichia coli of the large genomic segment of a birnavirus. Virology 161:145–152PubMedCrossRef

Bayliss CD, Spies U, Shaw K, Peters RW, Papageorgiou A, Muller H, Boursnell ME (1990) A comparison of the sequences of segment A of four infectious bursal disease virus strains and identification of a variable region in VP2. J Gen Virol 71(6):1303–1312PubMedCrossRef

Bayliss CD, Peters RW, Cook JK, Reece RL, Howes K, Binns MM, Boursnell ME (1991) A recombinant fowlpox virus that expresses the VP2 antigen of infectious bursal disease virus induces protection against mortality caused by the virus. Arch Virol 120:193–205PubMedCrossRef

Biet F (2002) Results of recent IBD field survey in France using bursal imaging analysis, RT-PCR-RFLP and serology. In: Annual Report and Proceedings of immunosuppressive viral disease in poultry, COST Action 839

Birghan C, Mundt E, Gorbalenya AE (2000) A non-canonical lon proteinase lacking the ATPase domain employs the ser-Lys catalytic dyad to exercise broad control over the life cycle of a double-stranded RNA virus. Embo J 19:114–123PubMedCrossRef

Boot HJ, ter Huurne AA, Hoekman AJ, Peeters BP, Gielkens AL (2000) Rescue of very virulent and mosaic infectious bursal disease virus from cloned cDNA: VP2 is not the sole determinant of the very virulent phenotype. J Virol 74:6701–6711PubMedCrossRef

Bottcher B, Kiselev NA, Stel’Mashchuk VY, Perevozchikova NA, Borisov AV, Crowther RA (1997) Three-dimensional structure of infectious bursal disease virus determined by electron cryomicroscopy. J Virol 71:325–330PubMed

Boursnell ME, Green PF, Campbell JI, Deuter A, Peters RW, Tomley FM, Samson AC, Chambers P, Emmerson PT, Binns MM (1990) Insertion of the fusion gene from Newcastle disease virus into a non-essential region in the terminal repeats of fowlpox virus and demonstration of protective immunity induced by the recombinant. J Gen Virol 71(3):621–628PubMedCrossRef

10.

Boyle DB, Heine HG (1993) Recombinant fowlpox virus-vaccines for poultry. Immunol Cell Biol 71:391–397PubMedCrossRef

11.

Boyle DB, Heine HG (1994) Influence of dose and route of inoculation on responses of chickens to recombinant fowlpox virus vaccines. Vet Microbiol 41:173–181PubMedCrossRef

12.

Brandt M, Yao K, Liu M, Heckert RA, Vakharia VN (2001) Molecular determinants of virulence, cell tropism, and pathogenic phenotype of infectious bursal disease virus. J Virol 75:11974–11982PubMedCrossRef

13.

Brown MD, Skinner MA (1996) Coding sequences of both genome segments of a European ‘very virulent’ infectious bursal disease virus. Virus Res 40:1–15PubMedCrossRef

14.

Bublot M, Pritchard N, Le Gros FX, Goutebroze S (2007) Use of a vectored vaccine against infectious bursal disease of chickens in the face of high-titred maternally derived antibody. J Comp Pathol 137(Suppl 1):S81–S84PubMedCrossRef

15.

Buckley MF, Loveland KA, Mckinstry WJ, Garson OM, Goding JW (1990) Plasma-cell membrane glycoprotein Pc-1-Cdna cloning of the human molecule, amino-acid-sequence, and chromosomal location. J Biol Chem 265:17506–17511PubMed

16.

Butter C, Sturman TD, Baaten BJ, Davison TF (2003) Protection from infectious bursal disease virus (IBDV)-induced immunosuppression by immunization with a fowlpox recombinant containing IBDV-VP2. Avian Pathol 32:597–604PubMedCrossRef

17.

Chang HC, Lin TL, Wu CC (2001) DNA-mediated vaccination against infectious bursal disease in chickens. Vaccine 20:328–335PubMedCrossRef

18.

Chang HC, Lin TL, Wu CC (2003) DNA vaccination with plasmids containing various fragments of large segment genome of infectious bursal disease virus. Vaccine 21:507–513PubMedCrossRef

19.

Cohen JJ (1991) Programmed cell death in the immune system. Adv Immunol 50:55–85PubMedCrossRef

20.

Coulibaly F, Chevalier C, Gutsche I, Pous J, Navaza J, Bressanelli S, Delmas B, Rey FA (2005) The birnavirus crystal structure reveals structural relationships among icosahedral viruses. Cell 120:761–772PubMedCrossRef

21.

Degen WG, van Zuilekom HI, Scholtes NC, van Daal N, Schijns VE (2005) Potentiation of humoral immune responses to vaccine antigens by recombinant chicken IL-18 (rChIL-18). Vaccine 23:4212–4218PubMedCrossRef

22.

Delgui L, Ona A, Gutierrez S, Luque D, Navarro A, Caston JR, Rodriguez JF (2009) The capsid protein of infectious bursal disease virus contains a functional alpha 4 beta 1 integrin ligand motif. Virology 386:360–372PubMedCrossRef

23.

Dong P, Brunn C, Ho RJY (1995) Cytokines as vaccine adjuvants. Current status and potential applications. In: Powell MF, Newman MJ, Burdman JR (eds) Vaccine design: the subunit and adjuvant approach. Pharmaceutical Biotechnology; Plenum Press, New York, pp 625–643

24.

Eldaghayes I, Rothwell L, Williams A, Withers D, Balu S, Davison F, Kaiser P (2006) Infectious bursal disease virus: strains that differ in virulence differentially modulate the innate immune response to infection in the chicken bursa. Viral Immunol 19:83–91PubMedCrossRef

25.

Eldaghayes IM (2005) Use of chicken interleukin-18 as a vaccine adjuvant with a recombinant fowlpox virus fpIBD1, a subunit vaccine giving partial protection against IBDV. University of Bristol, Bristol

26.

Fahey KJ, Erny K, Crooks J (1989) A conformational immunogen on VP-2 of infectious bursal disease virus that induces virus-neutralizing antibodies that passively protect chickens. J Gen Virol 70(6):1473–1481PubMedCrossRef

27.

Fodor I, Horvath E, Fodor N, Nagy E, Rencendorsh A, Vakharia VN, Dube SK (1999) Induction of protective immunity in chickens immunised with plasmid DNA encoding infectious bursal disease virus antigens. Acta Vet Hung 47:481–492PubMedCrossRef

28.

Francois A, Chevalier C, Delmas B, Eterradossi N, Toquin D, Rivallan G, Langlois P (2004) Avian adenovirus CELO recombinants expressing VP2 of infectious bursal disease virus induce protection against bursal disease in chickens. Vaccine 22:2351–2360PubMedCrossRef

29.

Gao Y, Liu W, Gao H, Qi X, Lin H, Wang X, Shen R (2008) Effective inhibition of infectious bursal disease virus replication in vitro by DNA vector-based RNA interference. Antiviral Res 79:87–94PubMedCrossRef

30.

Gurrala R, Dastjerdi A, Johnson N, Nunez-Garcia J, Grierson S, Steinbach F, Banks M (2009) Development of a DNA microarray for simultaneous detection and genotyping of lyssaviruses. Virus Res 144:202–208PubMedCrossRef

31.

Haygreen EA, Kaiser P, Burgess SC, Davison TF (2006) In ovo DNA immunisation followed by a recombinant fowlpox boost is fully protective to challenge with virulent IBDV. Vaccine 24:4951–4961PubMedCrossRef

32.

Haygreen L, Davison F, Kaiser P (2005) DNA vaccines for poultry: the jump from theory to practice. Expert Rev Vaccines 4:51–62PubMedCrossRef

33.

Heath AW (1995) Cytokines as immunological adjuvants. Pharm Biotechnol 6:645–658PubMedCrossRef

34.

Heckert RA, Elankumaran S, Oshop GL, Vakharia VN (2002) A novel transcutaneous plasmid-dimethylsulfoxide delivery technique for avian nucleic acid immunization. Vet Immunol Immunopathol 89:67–81PubMedCrossRef

35.

Hulse DJ, Romero CH (2002) Fate of plasmid DNA encoding infectious bursal disease virus VP2 capsid protein gene after injection into the pectoralis muscle of the chicken. Poult Sci 81:213–216PubMed

36.

Jackwood DJ (2002) Molecular diagnosis of infectious bursal disease viruses using conventional and real-time RT-PCR. In: Annual Report and Proceedings of immunosuppressive viral disease in poultry, COST Action 839, pp 136–143

37.

Jensen FC, Savary JR, Diveley JP, Chang JC (1998) Adjuvant activity of incomplete Freund’s adjuvant. Adv Drug Deliv Rev 32:173–186PubMedCrossRef

38.

Kim I-J, Sharma JM (2000) IBDV-induced bursal T lymphocytes inhibit mitogenic response of normal splenocytes. Vet Immunol Immunop 74:47–57CrossRef

39.

Kim IJ, You SK, Kim H, Yeh HY, Sharma JM (2000) Characteristics of bursal T lymphocytes induced by infectious bursal disease virus. J Virol 74:8884–8892PubMedCrossRef

40.

Kim JJ, Yang JS, VanCott TC, Lee DJ, Manson KH, Wyand MS, Boyer JD, Ugen KE, Weiner DB (2000) Modulation of antigen-specific humoral responses in rhesus macaques by using cytokine cDNAs as DNA vaccine adjuvants. J Virol 74:3427–3429PubMedCrossRef

41.

Kim SJ, Sung HW, Han JH, Jackwood D, Kwon HM (2004) Protection against very virulent infectious bursal disease virus in chickens immunized with DNA vaccines. Vet Microbiol 101:39–51PubMedCrossRef

42.

Kumar S, Ahi YS, Salunkhe SS, Koul M, Tiwari AK, Gupta PK, Rai A (2009) Effective protection by high efficiency bicistronic DNA vaccine against infectious bursal disease virus expressing VP2 protein and chicken IL-2. Vaccine 27:864–869PubMedCrossRef

43.

Laidlaw SM, Anwar MA, Thomas W, Green P, Shaw K, Skinner MA (1998) Fowlpox virus encodes nonessential homologs of cellular alpha-SNAP, PC-1, and an orphan human homolog of a secreted nematode protein. J Virol 72:6742–6751PubMed

44.

Laidlaw SM, Skinner MA (2004) Comparison of the genome sequence of FP9, an attenuated, tissue culture-adapted European strain of Fowlpox virus, with those of virulent American and European viruses. J Gen Virol 85:305–322PubMedCrossRef

45.

Lejal N, Da Costa B, Huet JC, Delmas B (2000) Role of Ser-652 and Lys-692 in the protease activity of infectious bursal disease virus VP4 and identification of its substrate cleavage sites. J Gen Virol 81:983–992PubMed

46.

Letzel T, Coulibaly F, Rey FA, Delmas B, Jagt E, van Loon AA, Mundt E (2007) Molecular and structural bases for the antigenicity of VP2 of infectious bursal disease virus. J Virol 81:12827–12835PubMedCrossRef

47.

Li J, Huang Y, Liang X, Lu M, Li L, Yu L, Deng R (2003) Plasmid DNA encoding antigens of infectious bursal disease viruses induce protective immune responses in chickens: factors influencing efficacy. Virus Res 98:63–74PubMedCrossRef

48.

Li J, Liang X, Huang Y, Meng S, Xie R, Deng R, Yu L (2004) Enhancement of the immunogenicity of DNA vaccine against infectious bursal disease virus by co-delivery with plasmid encoding chicken interleukin 2. Virology 329:89–100PubMedCrossRef

49.

Lin TW, Lo CW, Lai SY, Fan RJ, Lo CJ, Chou YM, Thiruvengadam R, Wang AH, Wang MY (2007) Chicken heat shock protein 90 is a component of the putative cellular receptor complex of infectious bursal disease virus. J Virol 81:8730–8741PubMedCrossRef

50.

Lombardo E, Maraver A, Espinosa I, Fernandez-Arias A, Rodriguez JF (2000) VP5, the nonstructural polypeptide of infectious bursal disease virus, accumulates within the host plasma membrane and induces cell lysis. Virology 277:345–357PubMedCrossRef

51.

Lowenthal JW, O’Neil TE, Broadway M, Strom AD, Digby MR, Andrew M, York JJ (1998) Coadministration of IFN-gamma enhances antibody responses in chickens. J Interferon Cytokine Res 18:617–622PubMedCrossRef

52.

Lukert PD, Saif YM (1997) Infectious bursal disease. In: Calnek BW, Barnes HJ, Beard CW, Mcdougald LR, Saif YM (eds) Diseases of poultry. Iowa State University Press, Iowa, pp 721–738

53.

Luque D, Saugar I, Rodriguez JF, Verdaguer N, Garriga D, Martin CS, Velazquez-Muriel JA, Trus BL, Carrascosa JL, Caston JR (2007) Infectious bursal disease virus capsid assembly and maturation by structural rearrangements of a transient molecular switch. J Virol 81:6869–6878PubMedCrossRef

54.

Mahgoub HA (2010) Improved vaccination strategies for IBDV: cytokines as vaccine adjuvants. University of Bristol, Bristol

55.

Mahmood MS, Siddique M, Hussain I, Khan A, Mansoor MK (2006) Protection capability of recombinant plasmid DNA vaccine containing VP2 gene of very virulent infectious bursal disease virus in chickens adjuvanted with CpG oligodeoxynucleotide. Vaccine 24:4838–4846PubMedCrossRef

56.

Mahmood MS, Hussain I, Siddique M, Akhtar M, Ali S (2007) DNA vaccination with VP2 gene of very virulent infectious bursal disease virus (vvIBDV) delivered by transgenic E-coli DH5 alpha given orally confers protective immune responses in chickens. Vaccine 25:7629–7635PubMedCrossRef

57.

Martinez-Torrecuadrada JL, Saubi N, Pages-Mante A, Caston JR, Espuna E, Casal JI (2003) Structure-dependent efficacy of infectious bursal disease virus (IBDV) recombinant vaccines. Vaccine 21:3342–3350PubMedCrossRef

58.

Mast J, Gilson D, Morales D, Muelemans G, TP vdB (2001) Transfer of maternal antibodies from the yolk sac to the chicken. In: Annual Report and Proceedings of immunosuppressive viral disease in poultry, COST Action 839

59.

McFerran JB, McNulty MS, McKillop ER, Connor TJ, McCracken RM, Collins DS, Allan GM (1980) Isolation and serological studies with infectious bursal disease viruses from fowl, turkeys and ducks: demonstration of a second serotype. Avian Pathol 9:395–404PubMedCrossRef

60.

Mundt E, Beyer J, Muller H (1995) Identification of a novel viral protein in infectious bursal disease virus-infected cells. J Gen Virol 76(2):437–443PubMedCrossRef

61.

Murphy FA, Gibbs EPJ, Horzinek MC, Studdert MJ (1999) Veterinary virology, 3rd edn. Academic Press, London, pp 405–409

62.

Ogawa M, Yamaguchi T, Setiyono A, Ho T, Matsuda H, Furusawa S, Fukushi H, Hirai K (1998) Some characteristics of a cellular receptor for virulent infectious bursal disease virus by using flow cytometry. Arch Virol 143:2327–2341PubMedCrossRef

63.

Palmquist JM, Khatri M, Cha RM, Goddeeris BM, Walcheck B, Sharma JM (2006) In vivo activation of chicken macrophages by infectious bursal disease virus. Viral Immunol 19:305–315PubMedCrossRef

64.

Phenix KV, Wark K, Luke CJ, Skinner MA, Smyth JA, Mawhinney KA, Todd D (2001) Recombinant Semliki Forest virus vector exhibits potential for avian virus vaccine development. Vaccine 19:3116–3123PubMedCrossRef

65.

Pous J, Chevalier C, Ouldali M, Navaza J, Delmas B, Lepault J (2005) Structure of birnavirus-like particles determined by combined electron cryomicroscopy and X-ray crystallography. J Gen Virol 86:2339–2346PubMedCrossRef

66.

Ramm HC, Wilson TJ, Boyd RL, Ward HA, Mitrangas K, Fahey KJ (1991) The effect of infectious bursal disease virus on B lymphocytes and bursal stromal components in specific pathogen-free (SPF) white leghorn chickens. Dev Comp Immunol 15:369–381PubMedCrossRef

67.

Rautenschlein S, Yeh HY, Njenga MK, Sharma JM (2002) Role of intrabursal T cells in infectious bursal disease virus (IBDV) infection: T cells promote viral clearance but delay follicular recovery. Arch Virol 147:285–304PubMedCrossRef

68.

Rautenschlein S, Yeh HY, Sharma JM (2002) The role of T cells in protection by an inactivated infectious bursal disease virus vaccine. Vet Immunol Immunopathol 89:159–167PubMedCrossRef

69.

Rautenschlein S, von Samson-Himmelstjerna G, Haase C (2007) A comparison of immune responses to infection with virulent infectious bursal disease virus (IBDV) between specific-pathogen-free chickens infected at 12 and 28 days of age. Vet Immunol Immunop 115:251–260CrossRef

70.

Rodriguez-Lecompte JC, Nino-Fong R, Lopez A, Frederick Markham RJ, Kibenge FS (2005) Infectious bursal disease virus (IBDV) induces apoptosis in chicken B cells. Comp Immunol Microbiol Infect Dis 28:321–337PubMedCrossRef

71.

Rong J, Cheng T, Liu X, Jiang T, Gu H, Zou G (2005) Development of recombinant VP2 vaccine for the prevention of infectious bursal disease of chickens. Vaccine 23:4844–4851PubMedCrossRef

72.

Rong J, Jiang TZ, Cheng TP, Shen MH, Du YZ, Li SL, Wang SM, Xu BJ, Fan GC (2007) Large-scale manufacture and use of recombinant VP2 vaccine against infectious bursal disease in chickens. Vaccine 25:7900–7908PubMedCrossRef

73.

Schat KA, Skinner MA (2008) Avian immunosuppressive diseases and immune evasion. In: Davison TF, Kaspers B, Schat KA (eds) Avian immunology. Academic press and Elsevier Ltd, Amsterdam; London, pp 299–322CrossRef

74.

Schijns VEJC, Sharma J, Tarpey I (2008) Practical aspects of poultry vaccination. In: Davison F, Kaspers B, Schat KA (eds) Avian immunology. Academic Press and Elsevier Ltd, Amsterdam; London, pp 373–393

75.

Schneider J, Gilbert SC, Hannan CM, Degano P, Prieur E, Sheu EG, Plebanski M, Hill AV (1999) Induction of CD8+ T cells using heterologous prime-boost immunisation strategies. Immunol Rev 170:29–38PubMedCrossRef

76.

Sharma JM, Kim IJ, Rautenschlein S, Yeh HY (2000) Infectious bursal disease virus of chickens: pathogenesis and immunosuppression. Dev Comp Immunol 24:223–235PubMedCrossRef

77.

Shaw I, Davison TF (2000) Protection from IBDV-induced bursal damage by a recombinant fowlpox vaccine, fpIBD1, is dependent on the titre of challenge virus and chicken genotype. Vaccine 18:3230–3241PubMedCrossRef

78.

Sheppard M, Fahey KJ (1989) Herpesviruses and adenoviruses as potential vectors for vaccines in poultry. Aust Vet J 66:421–423PubMedCrossRef

79.

Skinner MA, Laidlaw SM, Eldaghayes I, Kaiser P, Cottingham MG (2005) Fowlpox virus as a recombinant vaccine vector for use in mammals and poultry. Expert Rev Vaccines 4:63–76PubMedCrossRef

80.

Sun JH, Yan YX, Jiang J, Lu P (2005) DNA immunization against very virulent infectious bursal disease virus with VP2-4-3 gene and chicken IL-6 gene. J Vet Med B Infect Dis Vet Public Health 52:1–7PubMedCrossRef

81.

Tao Q, Wang X, Bao H, Wu J, Shi L, Li Y, Qiao C, Yakovlevich SA, Mikhaylovna PN, Chen H (2009) Detection and differentiation of four poultry diseases using asymmetric reverse transcription polymerase chain reaction in combination with oligonucleotide microarrays. J Vet Diagn Invest 21:623–632PubMedCrossRef

82.

Tsukamoto K, Tanimura N, Mase M, Imai K (1995) Comparison of virus replication efficiency in lymphoid tissues among three infectious bursal disease virus strains. Avian Dis 39:844–852PubMedCrossRef

83.

Tsukamoto K, Sato T, Saito S, Tanimura N, Hamazaki N, Mase M, Yamaguchi S (2000) Dual-viral vector approach induced strong and long-lasting protective immunity against very virulent infectious bursal disease virus. Virology 269:257–267PubMedCrossRef

84.

Tsukamoto K, Saito S, Saeki S, Sato T, Tanimura N, Isobe T, Mase M, Imada T, Yuasa N, Yamaguchi S (2002) Complete, long-lasting protection against lethal infectious bursal disease virus challenge by a single vaccination with an avian herpesvirus vector expressing VP2 antigens. J Virol 76:5637–5645PubMedCrossRef

85.

Vasconcelos AC, Lam KM (1994) Apoptosis induced by infectious bursal disease virus. J Gen Virol 75(7):1803–1806PubMedCrossRef

86.

Vazquez Blomquist D, Green P, Laidlaw SM, Skinner MA, Borrow P, Duarte CA (2002) Induction of a strong HIV-specific CD8+ T cell response in mice using a fowlpox virus vector expressing an HIV-1 multi-CTL-epitope polypeptide. Viral Immunol 15:337–356PubMedCrossRef

87.

Villinger F (2003) Cytokines as clinical adjuvants: how far are we? Expert Rev Vaccines 2:317–326PubMedCrossRef

88.

Williams AE (2002) The pathogenesis of very virulent Infectious Bursal Disease virus and its modulation by DNA vaccination. Royal Veterinary College, London

89.

Williams AE, Davison TF (2005) Enhanced immunopathology induced by very virulent infectious bursal disease virus. Avian Pathol 34:4–14PubMedCrossRef

90.

Withers DR, Young JR, Davison TF (2005) Infectious bursal disease virus-induced immunosuppression in the chick is associated with the presence of undifferentiated follicles in the recovering bursa. Viral Immunol 18:127–137PubMedCrossRef

91.

Xiang Y, Moss B (1999) IL-18 binding and inhibition of interferon gamma induction by human poxvirus-encoded proteins. Proc Natl Acad Sci USA 96:11537–11542PubMedCrossRef

92.

Yao K, Goodwin MA, Vakharia VN (1998) Generation of a mutant infectious bursal disease virus that does not cause bursal lesions. J Virol 72:2647–2654PubMed

Titel: An overview of infectious bursal disease
verfasst von: Hebata Allah Mahgoub
Publikationsdatum: 01.11.2012
Verlag: Springer Vienna
Erschienen in: Archives of Virology / Ausgabe 11/2012
Print ISSN: 0304-8608
Elektronische ISSN: 1432-8798
DOI: https://doi.org/10.1007/s00705-012-1377-9

Leitlinien kompakt für die Innere Medizin

Mit medbee Pocketcards sicher entscheiden.

^{Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag}

Kostenlos registrieren

Neu im Fachgebiet Innere Medizin

Notfall-TEP der Hüfte ist auch bei 90-Jährigen machbar

26.04.2024 Hüft-TEP Nachrichten

Ob bei einer Notfalloperation nach Schenkelhalsfraktur eine Hemiarthroplastik oder eine totale Endoprothese (TEP) eingebaut wird, sollte nicht allein vom Alter der Patientinnen und Patienten abhängen. Auch über 90-Jährige können von der TEP profitieren.

Niedriger diastolischer Blutdruck erhöht Risiko für schwere kardiovaskuläre Komplikationen

25.04.2024 Hypotonie Nachrichten

Wenn unter einer medikamentösen Hochdrucktherapie der diastolische Blutdruck in den Keller geht, steigt das Risiko für schwere kardiovaskuläre Ereignisse: Darauf deutet eine Sekundäranalyse der SPRINT-Studie hin.

Bei schweren Reaktionen auf Insektenstiche empfiehlt sich eine spezifische Immuntherapie

25.04.2024 Allergien und Intoleranzreaktionen Nachrichten

Insektenstiche sind bei Erwachsenen die häufigsten Auslöser einer Anaphylaxie. Einen wirksamen Schutz vor schweren anaphylaktischen Reaktionen bietet die allergenspezifische Immuntherapie. Jedoch kommt sie noch viel zu selten zum Einsatz.

Therapiestart mit Blutdrucksenkern erhöht Frakturrisiko

25.04.2024 Hypertonie Nachrichten

Beginnen ältere Männer im Pflegeheim eine Antihypertensiva-Therapie, dann ist die Frakturrate in den folgenden 30 Tagen mehr als verdoppelt. Besonders häufig stürzen Demenzkranke und Männer, die erstmals Blutdrucksenker nehmen. Dafür spricht eine Analyse unter US-Veteranen.

Update Innere Medizin

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 11/2012

Full-length genome analysis of vesicular stomatitis New Jersey virus strains representing the phylogenetic and geographic diversity of the virus

Development of a nested PCR assay to detect equine infectious anemia proviral DNA from peripheral blood of naturally infected horses

Establishment and maintenance of persistent infection by picobirnavirus in greater rhea (Rhea Americana)

Detection of cucumber mosaic virus isolates from banana by one-step reverse transcription loop-mediated isothermal amplification

Quantitative comparison of the RNA bacteriophage Qβ infection cycle in rich and minimal media