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Osteoporosis International

Erschienen in:

07.04.2018 | Review

Anabolic agents: what is beyond osteoporosis?

verfasst von: Y. Liu, A. E. Levack, E. Marty, O. Or, B. P. Samuels, M. Redko, J. M. Lane

Erschienen in: Osteoporosis International | Ausgabe 5/2018

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Abstract

Osteoporosis is a common skeletal disorder characterized by low bone mass, which leads to reduced bone strength and an increased risk of fractures. Anabolic agents have been shown to improve bone mass and decrease fracture risk in osteoporosis patients by directly stimulating osteoblasts to produce new bone. Currently, two anabolic agents are available in the USA: recombinantly produced teriparatide (TPTD), which is the fully active (1–34) amino active sequence of human parathyroid hormone (PTH), and abaloparatide (APTD), a synthetic analog of parathyroid hormone-related peptide (PTHrP). At present, both agents are approved only for treatment of patients with osteoporosis at high risk of fracture. Nonetheless, their anabolic properties have led to off-label application in additional settings which include spine fusion, osteonecrosis of the jaw, arthroplasty, and fracture healing. In this article, we summarize available scientific literature regarding the efficacy, effectiveness, and safety of TPTD in these off-label settings.

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Titel: Anabolic agents: what is beyond osteoporosis?
verfasst von: Y. Liu
A. E. Levack
E. Marty
O. Or
B. P. Samuels
M. Redko
J. M. Lane
Publikationsdatum: 07.04.2018
Verlag: Springer London
Erschienen in: Osteoporosis International / Ausgabe 5/2018
Print ISSN: 0937-941X
Elektronische ISSN: 1433-2965
DOI: https://doi.org/10.1007/s00198-018-4507-8

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