Skip to main content
Erschienen in: Osteoporosis International 5/2020

10.12.2019 | Original Article

Analysis of mortality after hip fracture on patient, hospital, and regional level in Germany

verfasst von: C. Schulz, H.-H. König, K. Rapp, C. Becker, D. Rothenbacher, G. Büchele

Erschienen in: Osteoporosis International | Ausgabe 5/2020

Einloggen, um Zugang zu erhalten

Abstract

Summary

Knowledge about risk factors of mortality after hip fracture might encourage prevention and further improvements in care. This study identified patient risk factors as well as hospital and regional characteristics associated with a decreased risk. Variation of mortality was largest on patient level and modest on hospital and regional level.

Introduction

Among numerous studies analyzing mortality as worst consequence after hip fracture, the majority focused on patient level and fewer on hospital and regional level. Comprehensive knowledge about contributing factors on all levels might help to reveal relevant inequalities, which would encourage prevention and further improvements in care. This study aimed at investigating variation of mortality after hip fracture on patient, hospital, and regional level in Germany.

Methods

We performed a retrospective cohort study on hip fracture patients aged 65 and older using statutory health insurance claims data from Jan 2009 through Dec. 2012 and additional information from the Federal Statistical Office Germany. Regions were classified based on two-digit postal code. We applied a multilevel Cox proportional hazard model with random intercepts on hospital and regional level to investigate the risk factors for mortality within 6 and 12 months after hip fracture.

Results

The dataset contained information on 123,119 hip fracture patients in 1014 hospitals in 95 German regions. Within 6/12 months, 20.9%/27.6% of the patients died. On patient level, male sex, increasing age, increased pre-fracture care level, and increasing comorbidity were associated with an increased hazard of mortality. Hospitals with increasing hip fracture volume or with orthogeriatric co-management and regions with increased population density were associated with a decreased hazard. Variation was largest on patient level and rather modest on hospital and regional level.

Conclusions

The identification of patient-related risk factors enables prognosticating mortality after hip fracture. After adjusting for those, variation seemed to be attributable rather to hospitals than to regions.
Literatur
1.
Zurück zum Zitat Kanis JA, Odén A, McCloskey E, Johansson H, Wahl DA, Cooper C (2012) A systematic review of hip fracture incidence and probability of fracture worldwide. Osteoporos Int 23:2239–2256CrossRef Kanis JA, Odén A, McCloskey E, Johansson H, Wahl DA, Cooper C (2012) A systematic review of hip fracture incidence and probability of fracture worldwide. Osteoporos Int 23:2239–2256CrossRef
2.
Zurück zum Zitat Gullberg B, Johnell O, Kanis JA (1997) World-wide projections for hip fracture. Osteoporos Int 7:407–413CrossRef Gullberg B, Johnell O, Kanis JA (1997) World-wide projections for hip fracture. Osteoporos Int 7:407–413CrossRef
3.
Zurück zum Zitat Weller I, Wai EK, Jaglal S, Kreder HJ (2005) The effect of hospital type and surgical delay on mortality after surgery for hip fracture. J Bone Joint Surg 87:361–366CrossRef Weller I, Wai EK, Jaglal S, Kreder HJ (2005) The effect of hospital type and surgical delay on mortality after surgery for hip fracture. J Bone Joint Surg 87:361–366CrossRef
4.
Zurück zum Zitat Bottle A, Aylin P (2006) Mortality associated with delay in operation after hip fracture: observational study. Br Med J 332:947–951CrossRef Bottle A, Aylin P (2006) Mortality associated with delay in operation after hip fracture: observational study. Br Med J 332:947–951CrossRef
5.
Zurück zum Zitat Abrahamsen B, van Staa T, Ariely R, Olson M, Cooper C (2009) Excess mortality following hip fracture: a systematic epidemiological review. Osteoporos Int 20:1633–1650CrossRef Abrahamsen B, van Staa T, Ariely R, Olson M, Cooper C (2009) Excess mortality following hip fracture: a systematic epidemiological review. Osteoporos Int 20:1633–1650CrossRef
6.
Zurück zum Zitat Hu F, Jiang C, Shen J, Tang P, Wang Y (2012) Preoperative predictors for mortality following hip fracture surgery: a systematic review and meta-analysis. Injury 43:676–685CrossRef Hu F, Jiang C, Shen J, Tang P, Wang Y (2012) Preoperative predictors for mortality following hip fracture surgery: a systematic review and meta-analysis. Injury 43:676–685CrossRef
7.
Zurück zum Zitat Smith T, Pelpola K, Ball M, Ong A, Myint PK (2014) Pre-operative indicators for mortality following hip fracture surgery: a systematic review and meta-analysis. Age Ageing 43:464–471CrossRef Smith T, Pelpola K, Ball M, Ong A, Myint PK (2014) Pre-operative indicators for mortality following hip fracture surgery: a systematic review and meta-analysis. Age Ageing 43:464–471CrossRef
8.
Zurück zum Zitat Sheehan K, Sobolev B, Chudyk A, Stephens T, Guy P (2016) Patient and system factors of mortality after hip fracture: a scoping review. BMC Musculoskelet Disord 17:166CrossRef Sheehan K, Sobolev B, Chudyk A, Stephens T, Guy P (2016) Patient and system factors of mortality after hip fracture: a scoping review. BMC Musculoskelet Disord 17:166CrossRef
9.
Zurück zum Zitat Malik AT, Panni UY, Masri BA, Noordin S (2018) The impact of surgeon volume and hospital volume on postoperative mortality and morbidity after hip fractures: a systematic review. Int J Surg 54:316–327CrossRef Malik AT, Panni UY, Masri BA, Noordin S (2018) The impact of surgeon volume and hospital volume on postoperative mortality and morbidity after hip fractures: a systematic review. Int J Surg 54:316–327CrossRef
10.
Zurück zum Zitat Augurzky B, Hentschker C, Pilny A, Wübker A (2017) Krankenhausreport 2017. In Barmer (ed) Schriftenreihe zur Gesundheitsanalyse. Barmer, Siegburg Augurzky B, Hentschker C, Pilny A, Wübker A (2017) Krankenhausreport 2017. In Barmer (ed) Schriftenreihe zur Gesundheitsanalyse. Barmer, Siegburg
11.
Zurück zum Zitat Zeltzer J, Mitchell RJ, Toson B, Harris IA, Ahmad L, Close J (2014) Orthogeriatric services associated with lower 30-day mortality for older patients who undergo surgery for hip fracture. Med J Aust 201:409–411CrossRef Zeltzer J, Mitchell RJ, Toson B, Harris IA, Ahmad L, Close J (2014) Orthogeriatric services associated with lower 30-day mortality for older patients who undergo surgery for hip fracture. Med J Aust 201:409–411CrossRef
12.
Zurück zum Zitat Forni S, Pieralli F, Sergi A, Lorini C, Bonaccorsi G, Vannucci A (2016) Mortality after hip fracture in the elderly: the role of a multidisciplinary approach and time to surgery in a retrospective observational study on 23,973 patients. Arch Gerontol Geriatr 66:13–17CrossRef Forni S, Pieralli F, Sergi A, Lorini C, Bonaccorsi G, Vannucci A (2016) Mortality after hip fracture in the elderly: the role of a multidisciplinary approach and time to surgery in a retrospective observational study on 23,973 patients. Arch Gerontol Geriatr 66:13–17CrossRef
13.
Zurück zum Zitat Kristensen PK, Thillemann TM, Søballe K, Johnsen SP (2015) Can improved quality of care explain the success of orthogeriatric units? A population-based cohort study. Age Ageing 45:66–71CrossRef Kristensen PK, Thillemann TM, Søballe K, Johnsen SP (2015) Can improved quality of care explain the success of orthogeriatric units? A population-based cohort study. Age Ageing 45:66–71CrossRef
14.
Zurück zum Zitat Haleem S, Lutchman L, Mayahi R, Grice JE, Parker MJ (2008) Mortality following hip fracture: trends and geographical variations over the last 40 years. Injury 39:1157–1163CrossRef Haleem S, Lutchman L, Mayahi R, Grice JE, Parker MJ (2008) Mortality following hip fracture: trends and geographical variations over the last 40 years. Injury 39:1157–1163CrossRef
15.
Zurück zum Zitat Romley JA, Jena AB, Goldman DP (2011) Hospital spending and inpatient mortality: evidence from California: an observational study. Ann Intern Med 154:160–167CrossRef Romley JA, Jena AB, Goldman DP (2011) Hospital spending and inpatient mortality: evidence from California: an observational study. Ann Intern Med 154:160–167CrossRef
16.
Zurück zum Zitat Fisher ES, Wennberg DE, Stukel TA, Gottlieb DJ, Lucas FL, Pinder EL (2003) The implications of regional variations in Medicare spending. Part 2: health outcomes and satisfaction with care. Ann Intern Med 138:288–298CrossRef Fisher ES, Wennberg DE, Stukel TA, Gottlieb DJ, Lucas FL, Pinder EL (2003) The implications of regional variations in Medicare spending. Part 2: health outcomes and satisfaction with care. Ann Intern Med 138:288–298CrossRef
17.
Zurück zum Zitat Medin E, Goude F, Melberg HO, Tediosi F, Belicza E, Peltola M (2015) European regional differences in all-cause mortality and length of stay for patients with hip fracture. Health Econ 24(Suppl 2):53–64CrossRef Medin E, Goude F, Melberg HO, Tediosi F, Belicza E, Peltola M (2015) European regional differences in all-cause mortality and length of stay for patients with hip fracture. Health Econ 24(Suppl 2):53–64CrossRef
18.
Zurück zum Zitat Rogowski J, Jain AK, Escarce JJ (2007) Hospital competition, managed care, and mortality after hospitalization for medical conditions in California. Health Serv Res 42:682–705CrossRef Rogowski J, Jain AK, Escarce JJ (2007) Hospital competition, managed care, and mortality after hospitalization for medical conditions in California. Health Serv Res 42:682–705CrossRef
19.
Zurück zum Zitat Hakkinen U, Rosenqvist G, Iversen T, Rehnberg C, Seppala TT (2015) Outcome, use of resources and their relationship in the treatment of AMI. Stroke and Hip Fracture at European Hospitals Health Economics 24(Suppl 2):116–139PubMed Hakkinen U, Rosenqvist G, Iversen T, Rehnberg C, Seppala TT (2015) Outcome, use of resources and their relationship in the treatment of AMI. Stroke and Hip Fracture at European Hospitals Health Economics 24(Suppl 2):116–139PubMed
20.
Zurück zum Zitat Federal Statistical Office Germany (2011) Verzeichnis der Krankenhäuser und Vorsorge- oder Rehabilitationseinrichtungen in Deutschland. Krankenhausverzeichnis. Statistische Ämter des Bundes und der Länder, Wiesbaden Federal Statistical Office Germany (2011) Verzeichnis der Krankenhäuser und Vorsorge- oder Rehabilitationseinrichtungen in Deutschland. Krankenhausverzeichnis. Statistische Ämter des Bundes und der Länder, Wiesbaden
21.
Zurück zum Zitat Federal Statistical Office Germany (2012) Daten aus dem Gemeindeverzeichnis. Postleitregionen mit regionaler Zugehörigkeit nach Fläche und Bevölkerung. Gebietsstand: 31.12.2011. Statistische Ämter des Bundes und der Länder, Wiesbaden Federal Statistical Office Germany (2012) Daten aus dem Gemeindeverzeichnis. Postleitregionen mit regionaler Zugehörigkeit nach Fläche und Bevölkerung. Gebietsstand: 31.12.2011. Statistische Ämter des Bundes und der Länder, Wiesbaden
22.
Zurück zum Zitat Deutsches Institut für Medizinische Dokumentation und Information (2017) Internationale statistische Klassifikation der Krankheiten und verwandter Gesundheitsprobleme. 10. Revision. German Modification. Deutschen Institut für Medizinische Dokumentation und Information (DIMDI) im Auftrag des Bundesministeriums für Gesundheit (BMG), Köln Deutsches Institut für Medizinische Dokumentation und Information (2017) Internationale statistische Klassifikation der Krankheiten und verwandter Gesundheitsprobleme. 10. Revision. German Modification. Deutschen Institut für Medizinische Dokumentation und Information (DIMDI) im Auftrag des Bundesministeriums für Gesundheit (BMG), Köln
23.
Zurück zum Zitat Elixhauser A, Steiner C, Harris DR, Coffey RM (1998) Comorbidity measures for use with administrative data. Med Care 36:8–27CrossRef Elixhauser A, Steiner C, Harris DR, Coffey RM (1998) Comorbidity measures for use with administrative data. Med Care 36:8–27CrossRef
24.
Zurück zum Zitat van Walraven C, Austin PC, Jennings A, Quan H, Forster AJ (2009) A modification of the Elixhauser comorbidity measures into a point system for hospital death using administrative data. Med Care 47:626–633CrossRef van Walraven C, Austin PC, Jennings A, Quan H, Forster AJ (2009) A modification of the Elixhauser comorbidity measures into a point system for hospital death using administrative data. Med Care 47:626–633CrossRef
25.
Zurück zum Zitat Cox D (1972) Regression models and life-tables (with discussion). J R Stat Soc 34:187–220 Cox D (1972) Regression models and life-tables (with discussion). J R Stat Soc 34:187–220
26.
Zurück zum Zitat Hess KR (1995) Graphical methods for assessing violations of the proportional hazards assumption in Cox regression. Stat Med 14:1707–1723CrossRef Hess KR (1995) Graphical methods for assessing violations of the proportional hazards assumption in Cox regression. Stat Med 14:1707–1723CrossRef
27.
Zurück zum Zitat Schoenfeld D (1980) Chi-squared goodness-of-fit tests for the proportional hazards regression model. Biometrika 67:145–153CrossRef Schoenfeld D (1980) Chi-squared goodness-of-fit tests for the proportional hazards regression model. Biometrika 67:145–153CrossRef
28.
Zurück zum Zitat Therneau TM, Grambsch PM (2013) Modeling survival data: extending the Cox model. Springer Science & Business Media, New York Therneau TM, Grambsch PM (2013) Modeling survival data: extending the Cox model. Springer Science & Business Media, New York
29.
Zurück zum Zitat Neuhaus JM, Kalbfleisch JD (1998) Between-and within-cluster covariate effects in the analysis of clustered data Biometrics 638-645 Neuhaus JM, Kalbfleisch JD (1998) Between-and within-cluster covariate effects in the analysis of clustered data Biometrics 638-645
30.
Zurück zum Zitat Sjölander A, Lichtenstein P, Larsson H, Pawitan Y (2013) Between–within models for survival analysis. Stat Med 32:3067–3076CrossRef Sjölander A, Lichtenstein P, Larsson H, Pawitan Y (2013) Between–within models for survival analysis. Stat Med 32:3067–3076CrossRef
31.
Zurück zum Zitat Austin PC, Wagner P, Merlo J (2017) The median hazard ratio: a useful measure of variance and general contextual effects in multilevel survival analysis. Stat Med 36:928–938CrossRef Austin PC, Wagner P, Merlo J (2017) The median hazard ratio: a useful measure of variance and general contextual effects in multilevel survival analysis. Stat Med 36:928–938CrossRef
32.
Zurück zum Zitat Hox JJ, Moerbeek M, van de Schoot R (2010) Multilevel analysis: techniques and applications. Routledge Hox JJ, Moerbeek M, van de Schoot R (2010) Multilevel analysis: techniques and applications. Routledge
33.
Zurück zum Zitat Sundmacher L, Gaskins MD, Hofmann K, Busse R (2012) Spatial distribution of avoidable cancer deaths in Germany. J Public Health 20:279–288CrossRef Sundmacher L, Gaskins MD, Hofmann K, Busse R (2012) Spatial distribution of avoidable cancer deaths in Germany. J Public Health 20:279–288CrossRef
35.
Zurück zum Zitat Lagerros YT, Hantikainen E, Michaëlsson K, Ye W, Adami H-O, Bellocco R (2017) Physical activity and the risk of hip fracture in the elderly: a prospective cohort study. Eur J Epidemiol 32:983–991CrossRef Lagerros YT, Hantikainen E, Michaëlsson K, Ye W, Adami H-O, Bellocco R (2017) Physical activity and the risk of hip fracture in the elderly: a prospective cohort study. Eur J Epidemiol 32:983–991CrossRef
Metadaten
Titel
Analysis of mortality after hip fracture on patient, hospital, and regional level in Germany
verfasst von
C. Schulz
H.-H. König
K. Rapp
C. Becker
D. Rothenbacher
G. Büchele
Publikationsdatum
10.12.2019
Verlag
Springer London
Erschienen in
Osteoporosis International / Ausgabe 5/2020
Print ISSN: 0937-941X
Elektronische ISSN: 1433-2965
DOI
https://doi.org/10.1007/s00198-019-05250-w

Weitere Artikel der Ausgabe 5/2020

Osteoporosis International 5/2020 Zur Ausgabe

Letter to the Editor

Osteocrinology

Arthropedia

Grundlagenwissen der Arthroskopie und Gelenkchirurgie. Erweitert durch Fallbeispiele, Videos und Abbildungen. 
» Jetzt entdecken

Notfall-TEP der Hüfte ist auch bei 90-Jährigen machbar

26.04.2024 Hüft-TEP Nachrichten

Ob bei einer Notfalloperation nach Schenkelhalsfraktur eine Hemiarthroplastik oder eine totale Endoprothese (TEP) eingebaut wird, sollte nicht allein vom Alter der Patientinnen und Patienten abhängen. Auch über 90-Jährige können von der TEP profitieren.

Arthroskopie kann Knieprothese nicht hinauszögern

25.04.2024 Gonarthrose Nachrichten

Ein arthroskopischer Eingriff bei Kniearthrose macht im Hinblick darauf, ob und wann ein Gelenkersatz fällig wird, offenbar keinen Unterschied.

Therapiestart mit Blutdrucksenkern erhöht Frakturrisiko

25.04.2024 Hypertonie Nachrichten

Beginnen ältere Männer im Pflegeheim eine Antihypertensiva-Therapie, dann ist die Frakturrate in den folgenden 30 Tagen mehr als verdoppelt. Besonders häufig stürzen Demenzkranke und Männer, die erstmals Blutdrucksenker nehmen. Dafür spricht eine Analyse unter US-Veteranen.

Ärztliche Empathie hilft gegen Rückenschmerzen

23.04.2024 Leitsymptom Rückenschmerzen Nachrichten

Personen mit chronischen Rückenschmerzen, die von einfühlsamen Ärzten und Ärztinnen betreut werden, berichten über weniger Beschwerden und eine bessere Lebensqualität.

Update Orthopädie und Unfallchirurgie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.