Overview of the Hippo pathway
Hippo signaling pathway
YAP proteins
TAZ protein
Signals of regulation of Hippo signaling
Wnt pathway
AMPK pathway
TGF-β pathways
KRAS signaling
MAPK/ERK signaling
Role of microRNAs on Hippo pathway in cancer
microRNAs
microRNAs | Function | Cancer | Mechanism | References |
---|---|---|---|---|
miR-550a-3-5p | Suppressed cell proliferation, metastasis, and tumor sphere formation | Colon, esophageal,melanoma | Inhibiting YAP | [45] |
miR-665 | Promoted cell proliferation, migration, invasion, and the epithelial–mesenchymal transition | Hepotacellular | Inhibiting hippo pathway | [47] |
miR-195 | Inhibited the migration, invasion and epithelial–mesenchymal transition | Gastric, breast, thyroid and hepotacellular | Suppressing YAP | [50] |
miR-3910 | Inhibited apoptosis induced the tumor formation | Hepotacellular | Suppressing MST1 | |
miR-874-3p | Increased the apoptosis ratio and decreased the mitochondrial potential | Colorectal | Inhibited YAP and TAZ | [55] |
microRNAs and Hippo pathway
miR-550a-3-5p
miR-665
miR-195
miR-3910
miR-874-3p
Role of circular RNAs on Hippo pathway in cancer
circRNAs
Circular RNAs | Function | Cancer | Mechanism | References |
---|---|---|---|---|
circ_104075 | Promoted cancer growth | Hepatocellular | Up-regulate YAP expression | [59] |
hsa_circ_0023404 | Promoted the proliferation and promoted the cell-cycle progression suppressed cell migration and invasion | Colorectal | Activated YAP pathway in CC via promoting TFCP2 expression by sponging miR-136 | [60] |
circPVT1 | An increase of the malignant phenotype | Head and neck squamous cell carcinoma | Binding to YAP | |
circLARP4 | Inhibits cancer cell migration and invasion | Gastric | Regulation of miR-424/LATS1/YAP signaling pathway |