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Erschienen in: Journal of Natural Medicines 1/2008

01.01.2008 | Note

Anti-diabetic, anti-hyperlipidemic and spermatogenic effects of Amaranthus spinosus Linn. on streptozotocin-induced diabetic rats

verfasst von: B. Sangameswaran, B. Jayakar

Erschienen in: Journal of Natural Medicines | Ausgabe 1/2008

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Abstract

Anti-diabetic, anti-hyperlipidemic and spermatogenic effects were studies with methanolic extract of stem of Amaranthus spinosus Linn (Family: Amaranthaceae) in diabetic rats. In streptozotocin (STZ)-induced diabetic rats, it was observed that both the standard drug (Glibenclamide) and methanolic extract of Amaranthus spinosus Linn. significantly exhibited control of blood glucose level on a 15day model. Further, the methanolic extract also showed significant anti-hyperlipidemic and spermatogenic effects in STZ-induced diabetic rats. The methanolic extract has also accelerated the process of spermatogenesis by increasing the sperm count and accessory sex organ weights. The present investigation of the plant established some pharmacological evidence to support the folklore claim that it is used as an anti-diabetic.
Literatur
1.
Zurück zum Zitat Kirtikar KR, Basu BD (1993) Indian medicinal plants, vol III. International Book Publisher, Dehradun, pp 2057–2058 Kirtikar KR, Basu BD (1993) Indian medicinal plants, vol III. International Book Publisher, Dehradun, pp 2057–2058
2.
Zurück zum Zitat Hilou A, Nacoulma OG, Guiguemde TR (2006) In vivo antimalarial activity of extracts from Amaranthus spinosus L., and Boerhaavia erecta L. in mice. J Ethnopharmacol 103:236–40PubMedCrossRef Hilou A, Nacoulma OG, Guiguemde TR (2006) In vivo antimalarial activity of extracts from Amaranthus spinosus L., and Boerhaavia erecta L. in mice. J Ethnopharmacol 103:236–40PubMedCrossRef
3.
Zurück zum Zitat Sawangjaroen N, Sawangjaroen K (2005) The effects of extract from anti-diarrheic Thai medicinal plants on the in vitro growth of the intestinal protozoa parasite Blastocystis hominis. J Ethnopharmacol 98:67–72PubMedCrossRef Sawangjaroen N, Sawangjaroen K (2005) The effects of extract from anti-diarrheic Thai medicinal plants on the in vitro growth of the intestinal protozoa parasite Blastocystis hominis. J Ethnopharmacol 98:67–72PubMedCrossRef
4.
Zurück zum Zitat Bi-Fong Lin, Bor-Luen Chiang, Jin-Yuarn Lin (2005) Amaranthus spinosus water extract directly stimulates proliferation of B-lymphocytes in vitro. Int Immunopharmacol 4:711–722 Bi-Fong Lin, Bor-Luen Chiang, Jin-Yuarn Lin (2005) Amaranthus spinosus water extract directly stimulates proliferation of B-lymphocytes in vitro. Int Immunopharmacol 4:711–722
5.
Zurück zum Zitat Olufemi BE, Assiak IE, Ayoade GO, Onigemo MA (2003) Studies on the effects of Amaranthus spinosus leaf extract on the haematology of growing pigs. Afr J Biomed Res 6:149–150 Olufemi BE, Assiak IE, Ayoade GO, Onigemo MA (2003) Studies on the effects of Amaranthus spinosus leaf extract on the haematology of growing pigs. Afr J Biomed Res 6:149–150
6.
Zurück zum Zitat Harold Varley, Gowenlock AH, Masvice B (1983) Practical clinical biochemistry, 5th edn. Heinemann Medical Book, London pp 625–85 Harold Varley, Gowenlock AH, Masvice B (1983) Practical clinical biochemistry, 5th edn. Heinemann Medical Book, London pp 625–85
7.
Zurück zum Zitat MacDonald RP (1970) Standard methods of clinical chemistry. Academic, New York, pp 215–22 MacDonald RP (1970) Standard methods of clinical chemistry. Academic, New York, pp 215–22
8.
Zurück zum Zitat Abercrombie M (1946) Estimation of nuclear population from microtome section. Anat Rec 94:239–47CrossRef Abercrombie M (1946) Estimation of nuclear population from microtome section. Anat Rec 94:239–47CrossRef
9.
Zurück zum Zitat Kempinas WG, Lamano-Carvolho TL (1987) A method for estimation of the concentration of spermatozoa in the cauda epididymis. Lab Anim 154–56 Kempinas WG, Lamano-Carvolho TL (1987) A method for estimation of the concentration of spermatozoa in the cauda epididymis. Lab Anim 154–56
10.
Zurück zum Zitat Snedecor CW, Cochran WG (1974) Statistical methods. Iowa State University Press, Ames, IA, pp 100–104 Snedecor CW, Cochran WG (1974) Statistical methods. Iowa State University Press, Ames, IA, pp 100–104
Metadaten
Titel
Anti-diabetic, anti-hyperlipidemic and spermatogenic effects of Amaranthus spinosus Linn. on streptozotocin-induced diabetic rats
verfasst von
B. Sangameswaran
B. Jayakar
Publikationsdatum
01.01.2008
Verlag
Springer-Verlag
Erschienen in
Journal of Natural Medicines / Ausgabe 1/2008
Print ISSN: 1340-3443
Elektronische ISSN: 1861-0293
DOI
https://doi.org/10.1007/s11418-007-0189-9

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