Erschienen in:
01.05.2008 | Poster presentation
Anti-oestrogen therapy switches off tumour suppressors and proapoptotic genes in breast cancer and reveals a new therapeutic opportunity
verfasst von:
A Stone, H Jones, M Giles, J Gee, R Nicholson
Erschienen in:
Breast Cancer Research
|
Sonderheft 2/2008
Einloggen, um Zugang zu erhalten
Excerpt
Previous studies in the Tenovus Centre have demonstrated that the development of antioestrogen resistance in vitro is accompanied by unfavourable changes in the breast cancer phenotype leading to increase tumour cell growth rate. Here evidence is presented to suggest that this is in part due to antihormones causing the epigenetic silencing of oestrogen-induced genes involved in the negative regulation of cell growth. Importantly, we show that reversal of this process using the demethylation agent 5-azacytidine (5AZA) allows oestrogen-induced cell kill by a previously unrecognised mechanism. …