Ausgabe Sonderheft 2/2008
Breast Cancer Research 2008
Inhalt (104 Artikel)
Molecular diversity of human breast cancer: clinical and therapeutic implications
D Slamon
Chromosomal instability in the pathogenesis and treatment of breast cancer
A Venkitaraman
Use of BRCA1 protein:protein interactions to classify cancer risk
JR Morris, SV Tavtigian
Activation of TGF-beta signalling in breast cancer metastatic cells
S Giampieri, E Sahai
Development of breast cancer immunotherapy using MUC1-retargeted T lymphocytes
S Wilkie, G Picco, J Foster, D Davies, S Julien, L Cooper, S Arif, S Mather, J Taylor-Papadimitriou, J Burchell, J Maher
Dietary patterns across the life course, mammographic density and implications for breast cancer: results from a British prospective cohort
G Mishra, I dos Santos Silva, S McNaughton, V McCormack, R Hardy, A Stephen, D Kuh
Loss of oestrogen receptor alpha in long-term antioestrogen-resistant cells: reversal by a c-src inhibitor
A Bensmail, I Hutcheson, M Giles, J Gee, R Nicholson
Suppression of the NF-κB cofactor Bcl3 inhibits mammary epithelial cell apoptosis and, in breast tumours, correlates with poor prognosis
A Wakefield, L Piggott, D Croston, WG Jiang, R Clarkson
Role of the Hsp90 cochaperone, FKBPL, in oestrogen receptor signalling and breast cancer growth and survival
H McKeen, C Byrne, A Valentine, M O'Rourke, A Yakkundi, K McClelland, K McAlpine, DG Hirst, T Robson
Two functionally distinct epithelial progenitors exist within the luminal cell compartment of the mouse mammary gland
J Stingl, CJ Eaves, CJ Watson
Interactions between BRCA2 protein and the meiosis-specific recombinase DMC1
T Thorslund, F Esashi, SC West
Lineage commitment in mammary epithelium is regulated by type 2 cytokines and Stat6
WT Khaled, SE Nicholson, FO Baxter, N Sprigg, JP Stingl, ANJ McKenzie, CJ Watson
Topoisomerase II expression as a determinant of chromosomal radiosensitivity and possible susceptibility in breast cancer
PE Bryant, AC Riches, S Terry, O Shovman, D Adamson
Chromosome translocations in breast cancer
K Howarth, K Blood, B Ng, J Beavis, Y Chua, S Cooke, J Pole, S Chin, K Ichimura, VP Collins, I Ellis, C Caldas, N Carter, PAW Edwards
ZNF366 is a novel corepressor for estrogen receptor alpha that mediates its effects through interaction with CtBP
S Ali, M Periyasamy, J Lopez-Garcia, RS Thomas, M Christian, MG Parker, L Buluwela
A novel role for C-terminal binding proteins in the regulation of mitotic fidelity in breast cancer cells
LM Bergman, CN Birts, M Darley, B Gabrielli, JP Blaydes
RASSF2 can suppress the growth of breast cancer cell lines and is epigenetically inactivated in breast tumours
WN Cooper, RE Dickinson, A Dallol, LB Hesson, I Bieche, GJ Clark, ER Maher, ER Zabarovsky, F Latif
Role of poly(ADPribosyl)ation of CTCF in cancer and normal breast cells
F Docquier, G Kita, D Farrar, I Chernukhin, E Klenova
NRG1is frequently silenced by methylation in breast cancers and is a strong candidate for the 8p tumour suppressor gene
Y-L Chua, Y Ito, JCM Pole, S-F Chin, IO Ellis, C Caldas, MJ O'Hare, AM Murrell, PAW Edwards
p53β isoform modulates differentially p53 transcriptional activity in response to stress
K Fernandes, JC Bourdon
Inhibitor of apoptosis proteins as a therapeutic target in breast cancer
FM Foster, NJ Bundred, CH Streuli
Cellular localization of the proto-oncogenic p53 inhibitor AGR2 protein in breast cancer
A Fourtouna, T Hupp
Investigating h-Prune activation of Wnt signalling in breast cancer
J Freeman, M Zollo, T Dale
Coactivation of estrogen receptor alpha by the DEAD-box RNA helicases p68 and p72 and its role in breast cancer
FV Fuller-Pace, E Ahamed, NC Wortham, S Ali
TSC22 in mammary gland development and breast cancer
C Huser, V Heath, M-A Pringle, AK Bell, D Crighton, K Ryan, G Inman, T Stein, B Gusterson
Accurate prediction of BRCA1 and BRCA2 heterozygous genotypes using expression profiling of lymphocytes after irradiation-induced DNA damage
Z Kote-Jarai, S Jugurnauth, L Matthews, I Giddings, E Bancroft, R Williams, M Girolami, C Campbell, RA Eeles
Investigation into the molecular mechanism of the antiapoptotic functions of CTCF in breast cancer cells using a proteomics approach
CF Méndez-Catalá, I Cherhukhin, F Docquier, D Farrar, E Pugacheva, A Vostrov, E Klenova
Inhibition of apoptosis by Notch signalling in breast epithelial cells
O Meurette, S Stylianou, GM Collu, AP Gilmore, K Brennan
TopBP1 contains transcriptional regulatory domains and regulates gene pathways involved in breast cancer
RHG Wright, ES Dornan, MM Donaldson, M MacFarlane, P Herzyk, IM Morgan
Modelling estrogen receptor alpha-positive breast cancer by transformation of normal human mammary epithelial cells
X Schmidt, S Duss, RD Iggo
Regulation of estrogen receptor beta by 5' untranslated regions in breast carcinogenesis
L Smith, TA Hughes
Reelin expression in breast tumours is associated with increased survival and is controlled by promoter methylation
T Stein, E Cosimo, P Smith, R Simon, K Price, L Baird, AK Bell, G Sauter, T Crook, BA Gusterson
Investigation of the roles of novel apoptosis-controlling genes in breast cancer
GT Williams, M Mourtada-Maarabouni, MR Pickard, VL Hedge, A Sutherland
D133p53 isoform is a direct p53 target gene that modulates p53 tumour suppressor activity
M Aoubala
De novo expression of αvβ6 integrin by myoepithelial cells in ductal carcinoma in situ may be an important marker of disease progression
M Allen, K Mulligan, S Clark, I Hart, JF Marshall, JL Jones
Understanding and exploiting changes in O-linked glycosylation in breast cancer
S Julien, J Coleman, G Picco, R Beatson, J Taylor-Papadimitriou, J Burchell
Downregulation of 15-hydroxyprostaglandin dehydrogenase in hormone-resistant breast cancer
M Cummings, L Maraqa, MB Peter, AM Shaaban, AM Hanby, MA Hull, V Speirs
Plasma MMP1, MMP8 and MMP13 expression in breast cancer: protective role of MMP8 against lymph node metastasis
J Decock, W Hendrickx, U Vanleeuw, MR Christiaens, S Ye, R Paridaens
Association of MMP8 gene variation with breast cancer prognosis
J Decock, JR Long, RC Laxton, XO Shu, C Hodgkinson, W Hendrickx, EG Pearce, YT Gao, AC Pereira, R Paridaens, W Zheng, S Ye
CD44 signalling increases cathepsin K and MT1MMP expression to potentiate breast cancer cell invasion through collagen I
A Hill, S McFarlane, PG Johnston, DJJ Waugh
Overexpression of CD44 in acquired tamoxifen-resistant breast cancer cells augments their migratory response to heregulin beta 1
S Hiscox, L Goddard, N Jordan, C Smith, M Harper, RI Nicholson, J Gee
Role of CLEVER-1 in breast cancer metastasis
A Ammar, R Mohammed, M Salmi, M Pepper, EC Paish, I Ellis, P Patel, SG Martin
Characterization of a cytoskeletal signaling pathway underpinning CD44-initiated, integrin-mediated adhesion of breast cancer cells to bone marrow endothelium
S McFarlane, A Hill, PG Johnston, DJJ Waugh
Identification of genes involved in the formation of lymph node metastasis from human tumour xenograft models of breast cancer
L Paon, SA Eccles
Matrix metalloproteinase-8 is a regulator of the clinical aggressiveness of mammary tumours
CJ Pennington, S Pilgrim, A Gutiérrez-Fernández, XS Puente, C López-Otín, JL Jones, D Holliday, PN Span, F Sweep, DR Edwards
Actions of IGF-I are differentially regulated by fatty acids in normal and breast cancer epithelial cells
CM Perks, AA Morrison, L Zeng, C Jarrett, J Shield, ZE Winters, JMP Holly
Insulin-like growth factor binding protein 3 modulates epidermal growth factor (EGF)-induced growth of breast epithelial cells by altering EGF receptor internalization
GJ Dennison, JMP Holly, J McIntosh, ZE Winters, CM Perks
Anti-oestrogen therapy switches off tumour suppressors and proapoptotic genes in breast cancer and reveals a new therapeutic opportunity
A Stone, H Jones, M Giles, J Gee, R Nicholson
Zinc transporter HKE4 as a new target in antihormone resistance of breast cancer
KM Taylor, N Jordan, S Hiscox, JM Gee, RI Nicholson
Stromal fibroblasts with nuclear β-catenin are present within breast tumours and increase proliferation and invasion of epithelial breast cancer cells
E Verghese, HG Shenoy, AM Shaaban, A Waterworth, MB Peter, K Horgan, V Speirs, AM Hanby, TA Hughes
Proapoptotic protein Bid is regulated by phosphorylation during anoikis and the cell cycle
J Lindsay, AP Gilmore
Breast cancer and environmental risk factors: an appraisal of the scientific evidence
A Kortenkamp
Assessment of angiogenesis in the hyperplasia preinvasive, invasive breast carcinoma sequence
JE Bluff, SS Cross, NJ Brown, MW Reed, CA Staton
Altered myoepithelial cell expression and function in cancer-containing breasts
V Modes, CM Rodrigues, N Nyquist, JA Shaw, JL Jones, RA Walker
Association of gene variants in the TGF-beta signalling pathways with invasive breast cancer risk
S Scollen, AM Dunning, AC Bradshaw, R Hesketh, JC Metcalfe
From association to cause: fine mapping of the TNRC9gene region, a novel susceptibility locus identified in the first genome-wide association study for breast cancer
S Ahmed, M Maranian, CS Gregory, M Udler, HI Field, J Tyrer, R Hesketh, JC Metcalfe, S Scollen, JP Stuewing, BAJ Ponder, PDP Pharoah, DF Easton, AM Dunning
Cytochrome P450 modulates the therapeutic actions of tamoxifen, as evidenced in novel breast cancer models
E Polson, S Weidlich, A Stenhouse, T Friedberg
Multicentre study of CASP8 polymorphisms in breast cancer
N Shephard, I Brock, N Camp, L Canon-Albright, B Frank, B Burwinkel, A Cox
Abnormal expression of p53 isoforms can be associated with poor survival in primary breast tumours
J-C Bourdon
The effect of intermittent versus chronic energy restriction on breast cancer risk biomarkers in premenopausal women: a randomised pilot trial
M Harvie, M Chapman, J Cuzick, A Flyvbjerg, P Hopwood, S Jebb, G Parfitt, A Howell
Urinary and serum biomarkers of phytoestrogen exposure are not associated with breast cancer risk in the European Prospective into Cancer Norfolk study
H Ward, G Chapelais, GGC Kuhnle, R Luben, KT Khaw, S Bingham
Adherence to hormone therapy in a chemoprevention randomised trial
L Atkins, V Jenkins, L Fallowfield, A Howell
MCPH1, a potential predictor for response to cancer chemotherapy
SM Bell, V Speirs, EE Morrison
Quantitative proteomics reveals proteins associated with radiotherapy resistance in breast cancer cells
L Smith, D Potts, O Qutob, MB Watson, AW Beavis, MJ Lind, PJ Drew, L Cawkwell
Identification of proteins associated with radiotherapy resistance in breast cancer cells: a combined proteomic and microarray screening approach
L Smith, O Qutob, MB Watson, AW Beavis, JKA Jameel, KJ Welham, PJ Drew, MJ Lind, L Cawkwell
Proteomic screening of 725 antibodies simultaneously using antibody microarray technology to identify proteins associated with radiotherapy resistance in breast cancer cells
L Smith, O Qutob, MB Watson, AW Beavis, MJ Lind, PJ Drew, L Cawkwell
Development of anti-MUC1 DNA aptamers for the imaging and radiotherapy of breast cancer
C Da Pieve, JN Iley, A Perkins, S Missailidis
Prognostic significance of steroid receptor co-regulators in breast cancer: co-repressor NCOR2/SMRT is an independent indicator of poor outcome
AR Green, C Burney, CJ Granger, EC Paish, S El-Sheikh, EA Rakha, DG Powe, RD Macmillan, IO Ellis, E Stylianou
High-throughput optical proteomics and breast cancer patient profiling: novel applications to individualise prognosis and treatment
MT Kelleher, F Festy, C Gillett, SE Pinder, S Ameer-Beg, EO Fo, PA Ellis, T Ng
Expression analysis of novel biomarkers for breast cancer
SA Laversin, AK Miles, GR Ball, AD Gritzapis, S Perez, C Baxevanis, G Li, RC Rees
Identification and role of migration stimulating factor isoforms in breast carcinomas
AM Schor, IR Ellis, SJ Jones, S Perrier, MM Florence, J Cox, G Ohe, K Kankova, B Vojtesek, AM Thompson, C Purdie, S Kazmi, S Foo, AM Woolston, SL Schor
Development of functional assays for BRCA1 missense mutations
A Sturdy, D Finch, R Naseem, D Trump, G Evens, M Webb
Chemotherapy-induced modulation of [18F]Fluoro-2-deoxy-D-glucose incorporation at the tumour cell level
RI Sharma, RW Cheyne, SA Suttie, TAD Smith
Identification and definition of novel clinical phenotypes of breast cancer through consensus derived from automated clustering methods
AR Green, JM Garibaldi, D Soria, F Ambrogi, G Ball, PJG Lisboa, TA Etchells, P Boracchi, E Biganzoli, RD Macmillan, RW Blamey, DG Powe, EA Rakha, IO Ellis
Detection of gene amplification in matched tumour and plasma DNA from breast cancer patients by quantitative PCR
K Page, N Hava, MJ Slade, RA Walker, RC Coombes, JA Shaw
Prospective Study of Outcome in Sporadic versus Hereditary Breast Cancer: pros and cons of running a cohort study
SM Gerty, PD Simmonds, L Durcan, DM Eccles
Lymphovascular invasion in breast cancer: improved methods of detection and clinical significance
RAA Mohammed, SG Martin, MS Gill, AR Green, EC Paish, IO Ellis
TARGIT: an international trial of intraoperative versus external beam radiotherapy
M Baum, N Williams, J Vaidya, M Keshtgar, J Tobias
Cambridge Breast Intensity Modulated Radiotherapy Trial: dosimetry results for 1,139 patients
CE Coles, JS Wilkinson, CB Wilson, NG Burnet, GC Wishart, N Twyman, ACF Hoole, AM Moody
Bevacizumab resistance in breast cancer: are neuropilins the key?
CA Staton, Z Yang, MWR Reed, NJ Brown
Brk expression may affect the differentiation status of breast cancer cells
AJ Harvey, CJ Pennington, DR Edwards, SA Eccles, MR Crompton
C35 overexpression defines subsets of human breast cancer and its immunoreceptor tyrosine-based activation motif represents a novel treatment target
E Katz, D Faratian, JMS Bartlett, K MacLeod, H Pedersen, A Larionov, EM Smith, AP Howell, JM Dixon, EE Evans, SP Langdon, DJ Harrison
Why do most c-erbB-2/HER-2-positive breast cancer patients fail to respond to Herceptin?
ML Murphy, SKW Chan, WJ Gullick
Identification of components of the ubiquitin system as targets for therapeutic intervention
MK Saville
Pretreatment of breast cancer cells with doxorubicin facilitates the subsequent uptake of zoledronic acid
DV Lefley, I Holen, RE Coleman, PD Ottewell
Mechanisms of apoptosis and cell-cycle arrest in subcutaneous breast tumours treated sequentially with doxorubicin followed by zoledronic acid
PD Ottewell, DV Lefley, RE Coleman, I Holen
An exploration of the management of menopausal symptoms for women with a diagnosis of breast cancer: lay and professional experiences and expectations
S Cruickshank, A Hume, EM Alder
Investigation of immunoregulatory mechanisms relating to poor surgical wound healing and breast cancer recurrence
BV Hogan, HG Shenoy, MB Peter, NM Orsi, C Carter, K Horgan, TA Hughes
Discrepancies and challenge of ductal carcinoma in situfor health professionals
F Kennedy, D Harcourt, N Rumsey
Exploring the breast cancer experiences, needs and preferences of women aged 70 years and over: a study in progress
J Moffat, C Foster, D Fenlon, J Addington-Hall
Exploring the acceptability of, and preferences for, an ongoing support network for known BRCA1 and BRCA2 mutation carriers
L Hughes, C Phelps, M Rogers
The QUEST study: a multicentre randomised trial to assess the impact of the type and timing of breast reconstruction on quality of life following mastectomy
S Potter, ZE Winters
'The sooner the better' or 'too much too soon'? A pilot prospective longitudinal study to evaluate quality of life and body image following immediate latissimus dorsi breast reconstruction
S Potter, HJ Thomson, LJ Fallowfield, ZE Winters
Diagnosed with breast cancer whilst on a family history screening programme: an exploratory qualitative study
A Clements, B Henderson, S Tyndel, G Evans, K Brain, E Watson, J Austoker
'More positive about mammography' – reactions of women to a false positive recall: a qualitative study of women at risk of familial breast cancer
A Clements, S Tyndel, B Henderson, K Brain, E Watson, J Austoker
What is the psychological impact of mammographic screening on younger women with a family history of breast cancer? Findings from a prospective cohort study (PIMMS)
S Tyndel, J Austoker, BJ Henderson, K Brain, C Bankhead, A Clements, E Watson
Food choice and phytoestrogen consumption in women previously treated for postmenopausal breast cancer
BM Parry, JM Lawrence, L Storey, JE Brown, DB Clarke, M Raats, SM Horton, JM Stilwell, RM Rainsbury
Homeopathy service in an NHS hospital breast cancer clinic: outcome study
SL Hughes, AC Smith, C Relton
Primary ductal carcinoma in situmammosphere formation: importance of the epidermal growth factor and Notch receptor signalling pathways
G Farnie, K Spence, K Brennan, NJ Bundred, RB Clarke
PARP-1 inhibitor monotherapy and combination therapy in a preclinical mouse model of Brca2 mutant breast cancer
T Hay, J Matthews, L Pietzka, A Lau, A Cranston, R Boulter, A Nygren, A Douglas-Jones, G Smith, N Martin, M O'Connor, A Clarke