nach oben

Erschienen in:

01.04.2008 | Original Paper

Anticarcinogenic compounds in the Uzbek medicinal plant, Helichrysum maracandicum

verfasst von: Toru Yagura, Tomoko Motomiya, Michiho Ito, Gisho Honda, Akira Iida, Fumiyuki Kiuchi, Harukuni Tokuda, Hoyoku Nishino

Erschienen in: Journal of Natural Medicines | Ausgabe 2/2008

Einloggen, um Zugang zu erhalten

Abstract

An ethanol extract of Helichrysum maracandicum showed antiproliferative activity against cultured cells of SENCAR mouse in an in vitro assay, and activity-guided fractionation of the extract resulted in the isolation of isosalipurposide as an active substance. Naringenin chalcone, the aglycone of isosalipurposide, also showed strong antiproliferative activity. An in vivo assay of two-stage carcinogenesis on mouse skin revealed that epidermal application of isosalipurposide resulted in delayed formation of papillomas. Western blot analysis showed that the expression of p38 mitogen-activated protein kinase was suppressed by the administration of naringenin chalcone or isosalipurposide, which might be related to the anticarcinogenic activity.

Murakami A, Ohigashi H, Koshimizu K (1996) Anti-tumor promotion with food phytochemicals: a strategy for cancer chemoprevention. Biosci Biotechnol Biochem 60:1–8PubMedCrossRef

Digiovanni J (1992) Multistage carcinogenesis in mouse skin. Pharmacol Ther 54:63–128PubMedCrossRef

Bode AM, Dong Z (2000) Signal transduction pathways: targets for chemoprevention of skin cancer. Lancet Oncol 1:181–188PubMedCrossRef

Suzgec S, Mericli AH, Houghton PJ, Cubukcu B (2005) Flavonoids of Helichrysum compactum and their antioxidant and antibacterial activity. Fitoterapia 76:269–272PubMedCrossRef

Delapuerta R, Saenz MT, Garcia MD (1993) Choleretic effect of the essential oil from Helichrysum picardii Boiss and Reuter in rats. Phytother Res 7:376–377CrossRef

Drewes SE, Mudau KE, Van Vuuren SF, Viljoen AM (2006) Antimicrobial monomeric and dimeric diterpenes from the leaves of Helichrysum tenax var tenax. Phytochemistry 67:716–722PubMedCrossRef

Jakupovic J, Kuhnke J, Schuster A, Metwally MA, Bohlmann F (1986) Phloroglucinol derivatives and other constituents from South African Helichrysum species. Phytochemistry 25:1133–1142CrossRef

Randriaminahy M, Proksch P, Witte L, Wray V (1992) Lipophilic phenolic constituents from Helichrysum species endemic to Madagascar. Z Naturforsch C 47:10–16

Meyer JJM, Afolayan AJ (1995) Antibacterial activity of Helichrysum aureonitens (Asteraceae). J Ethnopharmacol 47:109–111PubMedCrossRef

10.

Tepe B, Sokmen M, Akpulat HA, Sokmen A (2005) In vitro antioxidant activities of the methanol extracts of four Helichrysum species from Turkey. Food Chem 90:685–689CrossRef

11.

Jager AK, Hutchings A, vanStaden J (1996) Screening of Zulu medicinal plants for prostaglandin-synthesis inhibitors. J Ethnopharmacol 52:95–100PubMedCrossRef

12.

Musabayane CT, Munjeri O, Mdege ND (2003) Effects of Helichrysum ceres extracts on renal function and blood pressure in the rat. Ren Fail 25:5–14PubMedCrossRef

13.

Tokuda H, Ichiishi E, Onozuka M, Yamaguchi S, Konoshima T, Takasaki M, Nishino H (1998) The tumor initiating activity of NO donor. In: Moncada S, Tada N, Maeda H (eds) Biology of nitric oxide, part 6. Portland Press, London, pp 185–186

14.

Zapesochnaya GG, Kurkin VA, Braslavskii VB, Filatova NV (2002) Phenolic compounds of Salix acutifolia bark. Chem Nat Comp 38:314–318CrossRef

15.

Le Bail JC, Pouget C, Fagnere C, Basly JP, Chulia AJ, Habrioux G (2001) Chalcones are potent inhibitors of aromatase and 17β-hydroxysteroid dehydrogenase activities. Life Sci 68:751–761PubMedCrossRef

16.

Kato R, Nakadate T, Yamamoto S, Sugimura T (1983) Inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced tumor promotion and ornithine decarboxylase activity by quercetin: possible involvement of lipoxygenase inhibition. Carcinogenesis 4:1301–1305PubMedCrossRef

17.

Facino RM, Carini M, Franzoi L, Pirola O, Bosisio E (1990) Phytochemical characterization and radical scavenger activity of flavonoids from Helichrysum italicum G. Don (Compositae). Pharmacol Res 22:709–721PubMedCrossRef

18.

Calliste CA, Le Bail JC, Trouillas P, Pouget C, Habrioux G, Chulia AJ, Duroux JL (2001) Chalcones: structural requirements for antioxidant, estrogenic and antiproliferative activities. Anticancer Res 21:3949–3956PubMed

19.

Mantena SK, Katiyar SK (2006) Grape seed proanthocyanidins inhibit UV-radiation-induced oxidative stress and activation of MAPK and NF-κB signaling in human epidermal keratinocytes. Free Radic Biol Med 40:1603–1614PubMedCrossRef

20.

Katiyar SK, Afaq F, Azizuddin K, Mukhtar H (2001) Inhibition of UVB-induced oxidative stress-mediated phosphorylation of mitogen-activated protein kinase signaling pathways in cultured human epidermal keratinocytes by green tea polyphenol (−)-epigallocatechin-3-gallate. Toxicol Appl Pharmacol 176:110–117PubMedCrossRef

21.

Chen WX, Tang QB, Gonzales MS, Bowden GT (2001) Role of p38 MAP kinases and ERK in mediating ultraviolet-B induced cyclooxygenase-2 gene expression in human keratinocytes. Oncogene 20:3921–3926PubMedCrossRef

22.

Subbaramaiah K, Dannenberg AJ (2003) Cyclooxygenase 2: a molecular target for cancer prevention and treatment. Trends Pharmacol Sci 24:96–102PubMedCrossRef

Titel: Anticarcinogenic compounds in the Uzbek medicinal plant, Helichrysum maracandicum
verfasst von: Toru Yagura
Tomoko Motomiya
Michiho Ito
Gisho Honda
Akira Iida
Fumiyuki Kiuchi
Harukuni Tokuda
Hoyoku Nishino
Publikationsdatum: 01.04.2008
Verlag: Springer Japan
Erschienen in: Journal of Natural Medicines / Ausgabe 2/2008
Print ISSN: 1340-3443
Elektronische ISSN: 1861-0293
DOI: https://doi.org/10.1007/s11418-007-0223-y

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 2/2008

Cesdiurins I–III, steroidal saponins from Cestrum diurnum L.

Antinociceptive and anti-inflammatory activities of the aqueous extract of Kaempferia galanga leaves in animal models

Message from the chief editor

Cyclooxygenase-2 inhibitory effects and composition of the volatile oil from the dried roots of Lithospermum erythrorhizon

New alkaloid from the aerial parts of Codonopsis clematidea

Phyllanthus maderaspatensis, a dietary supplement for the amelioration of adriamycin-induced toxicity and oxidative stress in mice