nach oben

Erschienen in:

01.12.2008 | Basic Neurosciences, Genetics and Immunology - Original Article

Antidepressant-like activity of zinc: further behavioral and molecular evidence

verfasst von: Magdalena Sowa-Kućma, Beata Legutko, Bernadeta Szewczyk, Kinga Novak, Paweł Znojek, Ewa Poleszak, Mariusz Papp, Andrzej Pilc, Gabriel Nowak

Erschienen in: Journal of Neural Transmission | Ausgabe 12/2008

Einloggen, um Zugang zu erhalten

Abstract

Zinc exhibits antidepressant-like activity in preclinical tests (the forced swim test and tail suspension test) and in olfactory bulbectomy and chronic unpredictable stress; two models of depression. Zinc also enhances the treatment of depression in humans. In the present study we evaluated the antidepressant activity of zinc in another model of depression—chronic mild stress (CMS) and the effect of zinc treatment on BDNF protein and the mRNA level. In CMS zinc hydroaspartate (10 mg/kg) exhibited a rapid (after 1 week of treatment) antidepressant-like effect. Chronic treatment with zinc induced a 17–39% increase in the BDNF mRNA and protein level in the hippocampus. These data indicate a rapidly acting antidepressant-like activity of zinc in CMS and the involvement of zinc in the regulation of BDNF.

Adachi M, Barrot M, Autry AE, Theobald D, Monteggia ML (2008) Selective loss of brain-derived neurotrophic factor in the dentate gyrus attenuates antidepressant efficacy. Biol Psychiatry 63:642–649PubMedCrossRef

Brandoli C, Sanna A, De Bernardi M, Follesa P, Brooker G, Mocchetti I (1998) Brain-derived neurotrophic factor and basic fibroblast growth factor downregulate NMDA receptor function in cerebellar granule cells. J Neurosci 18:7953–7961PubMed

Caldeira M, Melo C, Pereira D, Carvalho R, Carvalho A, Duarte C (2007) BDNF regulates the expression and traffic of NMDA receptors in cultured hippocampal neurons. Mol Cell Neurosci 35:208–219PubMedCrossRef

Castren E (2004) Neurotrophic effects of antidepressant drugs. Curr Opin Pharmacol 4:58–64PubMedCrossRef

Castren E, da Penha Berzaghi M, Lindholm D, Thoenen H (1993) Differential effects of MK-801 on brain-derived neurotrophic factor mRNA level in different regions of the rat brain. Exp Neurol 122:244–252PubMedCrossRef

Chen B, Dowlatshahi D, MacQueen GM, wang JF, Young LT (2001) Increased hippocampal BDNFimmunoreactivity in subjects treated with antidepressant medication. Biol Psychiatry 50:260–265PubMedCrossRef

Cieślik K, Klenk-Majewska B, Danilczuk Z, Wróbel A, Łupina T, Ossowska G (2007) Influence of zinc supplementation on imipramine effect in a chronic unpredictable stress (CUS) model in rats. Pharmacol Rep 59:46–52PubMed

Duman RS, Monteggia LM (2006) A neurotrophic model for stress related mood disorders. Biol Psychiatry 59:1116–1127PubMedCrossRef

Duman RS, Heninger GR, Nestler EJ (1997a) A molecular and cellular theory of depression. Arch Gen Psychiatry 54:597–606PubMed

Duman RS, Nibuya M, Vaidya VA (1997b) A role of CREB in antidepressant action. In: Skolnick P (ed) Antidepressants: new pharmacological strategies. Human Press, Totowa, pp 173–194

Franco JL, Posser T, Brocardo SP, Trevisan R, Uliano-Silva M, Gabilan NH, santos ARS, Leal RB, Rodrigues ALS, Farina M, Dafre AL (2008) Involvement of glutathione, ERK ½ phosphorylation and BDNF expression in the antidepressant-like effect of zinc in rats. Behav Brain Res 188:316–323PubMedCrossRef

Glazner GW, Mattson M (2000) Differential effects of BDNF, ADNF9, and TNF alpha on levels of NMDA receptor subunits, calcium homeostasis, and neuronal vulnerability to excitotoxicity. Exp Neurol 161:442–452PubMedCrossRef

Harrison NL, Gibbsons SJ (1994) Zn: an endogenous modulator of ligand- and voltage-gated ion channels. Neuropharmacology 33:935–952PubMedCrossRef

Karege F, Perret G, Bondolfi G, Schwald M, Bertschy G, Aubry JM (2002) Decreased serum brain-derived neurotrophic factor levels in major depressed patients. Psych Res 109:143–148CrossRef

Knusel B, Gao H, Okazaki T, Yoshida T, Mori N, Hefti F, Kaplan D (1997) Ligand-induced down-regulation of Trk messenger RNA, protein and tyrosine phosphorylation in rat cortical neurons. Neuroscience 78:851–862PubMedCrossRef

Kroczka B, Zięba A, Dudek D, Pilc A, Nowak G (2000) Zinc exhibits an antidepressant-like effect in the forced swimming test in mice. Pol J Pharmacol 52:403–406PubMed

Kroczka B, Brański P, Pałucha A, Pilc A, Nowak G (2001) Antidepressant-like properties of zinc in rodent forced swim test. Brain Res Bull 55:297–300PubMedCrossRef

Legutko B, Szewczyk B, Pomierny-Chamioło L, Nowak G, Pilc A (2006) Effect of MPEP treatment on brain-derived neurotrophic factor gene expression. Pharmacol Rep 58:427–430PubMed

Maes M, D’Haese PC, Scharpe S, D’Hondt PD, Cosyns P, De Broe ME (1994) Hypozincemia in depression. J Affect Disord 31:135–140PubMedCrossRef

Marvanova M, Lakso M, Pirhonen J, Nawa H, Wong G, Castren E (2001) The neuroprotective agent memantine induces brain-derived neurotrophic factor and trkB receptor expression in rat brain. Mol Cell Neurosci 18:247–258PubMedCrossRef

McLoughlin IJ, Hodge SJ (1990) Zinc in depressive disorder. Acta Psychiatr Scand 82:451–453PubMedCrossRef

Nibuya M, Morinobu S, Duman RS (1995) Regulation of BDNF and trkB mRNA in rat brain by chronic electroconvulsive seizure and antidepressant drug treatments. J Neurosci 15:7539–7547PubMed

Nowak G, Siwek M, Dudek D, Zięba A, Pilc A (2003a) Effect of zinc supplementation on antidepressant therapy in unipolar depression: a preliminary placebo-controlled study. Pol J Pharmacol 55:1143–1147PubMed

Nowak G, Szewczyk B, Wieronska JM, Brański P, Pałucha A, Pilc A, Sadlik K, Piekoszewski W (2003b) Antidepressant-like effects of acute and chronic treatment with zinc in forced swim test and olfactory bulbectomy model in rats. Brain Res Bull 61:159–164PubMedCrossRef

Nowak G, Legutko B, Szewczyk B, Papp M, Sanak M, Pilc A (2004) Zinc treatment induces cortical brain-derived neurotrophic factor gene expression. Eur J Pharmacol 492:57–59PubMedCrossRef

Nowak G, Szewczyk B, Pilc A (2005) Zinc and depression. An update. Pharmacol Rep 57:713–718PubMed

Papp M, Moryl E, Willner P (1996) Pharmacological validation of the chronic mild stress model of depression. Eur J Pharmacol 296:129–136PubMedCrossRef

Rosa AO, Lin J, Calixto JB, Santos ARS, Rodrigues AL (2003) Involvement of NMDA receptors and L-arginine-nitric oxide pathway in the antidepressant-like effects of zinc in mice. Behav Brain Res 144:87–93PubMedCrossRef

Saarelainen T, Hendolin P, Lucas G, Koponen E, Sairanen M, MacDonald E, Agerman K, Haapasalo A, Nawa H, Aloyz R, Ernfors P, Castren E (2003) Activation of the TrkB neurotrophin receptor is induced by antidepressant drugs and is required for antidepressant-induced behavioral effects. J Neurosci 23:349–357PubMed

Sánchez C, Gruca P, Papp M (2003) R-citalopram counteracts the antidepressant-like effect of escitalopram in a rat chronic mild stress model. Behav Pharmacol 14:465–470PubMed

Sandoval M, Sandoval R, Thomas U, Spilker CH, Smalla K, Falcon R, Marengo J, Calderon R, Saavedra V, Heumann R, Bronfman F, Garner C, Gundelfinger E, Wyneken U (2007) Antagonistic effects of TrkB and p75^NTR on NMDA receptor currents in post-synaptic transplanted into Xenopus oocytes. J Neurochem 101:1672–1684PubMedCrossRef

Semba J, Wakuta M, Suhara T (2006) Differential effects of chronic phencyclidine on brain-derived beurotrophic factor in neonatal and adult rat brains. Addict Biol 11:126–130PubMedCrossRef

Shimizu E, Hashimoto K, Okamura N, Koike K, Komatsu N, Kumakiri CH, Nakazato M, Watanabe H, Shinoda N, Okada S, Iyo M (2003) Alterations of serum levels of brain-derived neurotrophic factor (BDNF) in depressed patients with or without antidepressant. Biol Psych 54:70–75CrossRef

Shirayama Y, Chen AC, Nakagawa S, Russell DS (2002) Brain-derived neurotrophic factor produces antidepressant effects in behavioral models of depression. J Neurosci 22:3251–3261PubMed

Siuciak JA, Lewis DR, Wiegand SJ, Lindsay RM (1997) Antidepressant-like effect of brain-derived neurotrophic factor (BDNF). Pharmacol Biochem Behav 56:131–137PubMedCrossRef

Skolnick P, Legutko B, Li X, Bymaster FP (2001) Current perspectives on the development of non-biogenic amine-based antidepressants. Pharmacol Res 43:411–422PubMedCrossRef

Szewczyk B, Brański P, Wierońska JM, Pałucha A, Pilc A, Nowak G (2002) Interactions of zinc with antidepressants in the forced swimming test in mice. Pol J Pharmacol 54:681–685PubMed

Takeda A (2000) Movement of zinc and its functional significance in the brain. Brain Res Bull 34:137–148

Toyomoto M, Inoue S, Ohta K, Kuno S, Ohta M, Hayashi K, Ikeda K (2005) Production of NGF, BDNF and GDNF in mouse astrocyte cultures is strongly enhanced by a cerebral vasodilator, ifenprodil. Neurosci Lett 379:185–189PubMedCrossRef

Willner P (2005) Chronic mild stress (CMS) revisited: consistency and behavioural-neurobiological concordance in the effects of CMS. Neuropsychobiology 52:90–110PubMedCrossRef

Xu F, Plummer M, Len G, Nakazawa T, Yamamoto T, Black I, Wu K (2006) Brain-derived neurotrophic factor rapidly increases NMDA recptor channel activity trough Fyn-mediated phosphorylation. Brain Res 1121:22–34PubMedCrossRef

Titel: Antidepressant-like activity of zinc: further behavioral and molecular evidence
verfasst von: Magdalena Sowa-Kućma
Beata Legutko
Bernadeta Szewczyk
Kinga Novak
Paweł Znojek
Ewa Poleszak
Mariusz Papp
Andrzej Pilc
Gabriel Nowak
Publikationsdatum: 01.12.2008
Verlag: Springer Vienna
Erschienen in: Journal of Neural Transmission / Ausgabe 12/2008
Print ISSN: 0300-9564
Elektronische ISSN: 1435-1463
DOI: https://doi.org/10.1007/s00702-008-0115-7

Leitlinien kompakt für die Neurologie

Mit medbee Pocketcards sicher entscheiden.

^{Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag}

Kostenlos registrieren

Update Neurologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Live-Webinar "Chronische Unterbauch- und Viszeralschmerzen in der Praxis managen"

Springer Medizin

Antidepressant-like activity of zinc: further behavioral and molecular evidence

Abstract

Leitlinien kompakt für die Neurologie

Neu im Fachgebiet Neurologie

Stuhltransfusion könnte Fortschreiten von Parkinson-Symptomen bremsen

Frühe Tranexamsäure-Therapie nützt wenig bei Hirnblutungen

Sind Frauen die fähigeren Ärzte?

Akuter Schwindel: Wann lohnt sich eine MRT?

Update Neurologie

Live-Webinar "Chronische Unterbauch- und Viszeralschmerzen in der Praxis managen"

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 12/2008

Differential effects of the antidepressants tranylcypromine and fluoxetine on limbic cannabinoid receptor binding and endocannabinoid contents

Intracortical motor inhibition and facilitation in adults with attention deficit/hyperactivity disorder

Fine structural analysis of the neuronal inclusions of frontotemporal lobar degeneration with TDP-43 proteinopathy

Investigation on tolerance development to subchronic blockade of mGluR5 in models of learning, anxiety, and levodopa-induced dyskinesia in rats

The exercise redox paradigm in the Down’s syndrome: improvements in motor function and increases in blood oxidative status in young adults

BrainNet Europe 2nd International Conference on Human Brain Tissue Research Munich, Germany 10–12 December 2008

Leitlinien kompakt für die Neurologie

Neu im Fachgebiet Neurologie

Stuhltransfusion könnte Fortschreiten von Parkinson-Symptomen bremsen

Frühe Tranexamsäure-Therapie nützt wenig bei Hirnblutungen

Sind Frauen die fähigeren Ärzte?

Akuter Schwindel: Wann lohnt sich eine MRT?

Update Neurologie