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Journal of Natural Medicines

Erschienen in:

01.10.2009 | Original Paper

Antihyperlipidaemic activity of swertiamarin, a secoiridoid glycoside in poloxamer-407-induced hyperlipidaemic rats

verfasst von: Hitesh Vaidya, Mandapati Rajani, Vasudevan Sudarsanam, Harish Padh, Ramesh Goyal

Erschienen in: Journal of Natural Medicines | Ausgabe 4/2009

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Abstract

We have investigated antihyperlipidaemic effect of swertiamarin (50 mg/kg, oral once) isolated from the perennial herb Enicostemma littorale Blume in poloxamer 407 (P-407)-induced hyperlipidaemic rats. Rats were made hyperlipidaemic by intraperitoneal administration of P-407 (400 mg/kg). Serum lipid levels such as total cholesterol, triglycerides and low-density lipoprotein cholesterol increased significantly (P < 0.001) compared with normal control rats. All these changes were significantly prevented in the rats treated with swertiamarin. Serum high-density lipoprotein (HDL) cholesterol was found to be reduced in the P-407 control rats. However, administration of swertiamarin significantly (P < 0.01) increased HDL levels and it showed a significant lipid-lowering effect, as well as a high antiatherogenic potential. Overall swertiamarin is an effective lipid-lowering lead compound and can be useful for preventing atherosclerosis.

Lovegrove JA, Jackson KG (2000) Coronary heart disease. In: Gibson GR, Williams CM (eds) Functional foods. Woodhead, Cambridge, pp 97–139

Castelli WB, Garrison RJ, Wilson PWF, Abbott RD, Kalousdian S, Kannel WB (1986) Incidence of coronary heart disease and lipoprotein cholesterol levels—the Framingham study. JAMA 256:2835–2838PubMedCrossRef

Kannel WB, Castelli WP, Gordon T (1979) Cholesterol in prediction of atherosclerotic disease. New perspectives based on the Framingham study. Ann Intern Med 90:85–91PubMed

Gordon DJ, Rifkind BM (1989) High-density lipoprotein—the clinical implications of recent studies. N Engl J Med 321:1311–1316PubMed

Anderson KM, Wilson PW, Odell PM, Kannel WB (1991) An updated coronary risk profile—a statement for health professionals. Circulation 83:356–362PubMed

Berliner JA, Navab M, Fogelma A, Frank JS, Demer LL, Edwards PA, Watson AD, Lusis AJ (1995) Atherosclerosis: basic mechanisms: oxidation, inflammation, and genetics. Circulation 91:2488–2496PubMed

Levine GN, Keaney JF Jr, Vita JA (1995) Medical progress: cholesterol reduction in cardiovascular disease—clinical benefits and possible mechanisms. N Engl J Med 332:512–521PubMedCrossRef

Ghule BV, Ghante MH, Saoji AN, Yeole PG (2006) Hypolipidemic and antihyperlipidemic effects of Lagenaria siceraria (Mol) fruit extracts. Indian J Exp Biol 44:905–909PubMed

Lemhadri A, Hajji L, Michel JB, Eddouks M (2006) Cholesterol and triglycerides lowering activities of caraway fruits in normal and streptozotocin diabetic rats. J Ethnopharmacol 106:321–326PubMedCrossRef

10.

Kirtikar KR, Basu BD (1935) Indian medicinal plants. 2nd edn, vol 3. Alluhadad, pp 1655–1656

11.

Sadique J, Chandra T, Thenmozhi V, Elango V (1987) The anti-inflammatory activity of Enicostemma littorale and Mollugo cerviana. Biochem Med Metab Biol 37:167–176PubMedCrossRef

12.

Kavimani S, Manisenthlkumar KT (2000) Effect of methanolic extract of Enicostemma littorale on Dalton’s ascitic lymphoma. J Ethnopharmacol 71:349–352PubMedCrossRef

13.

Vishwakarma SL, Goyal RK (2004) Hepatoprotective activity of Enicostemma littorale in CCl₄-induced liver damage. J Nat Rem 4:120–126

14.

Vijayvargia R, Kumar M, Gupta S (2000) Hypoglycemic effect of aqueous extract of Enicostemma littorale Blume (chhota chirayata) on alloxan induced diabetes mellitus in rats. Indian J Exp Biol 38:781–784PubMed

15.

Maroo J, Ghosh A, Mathur R, Vasu VT, Gupta S (2003) Antidiabetic efficacy of Enicostemma littorale methanol extract in alloxan induced diabetic rats. Pharm Biol 41:388–391CrossRef

16.

Maroo J, Vasu VT, Aalinkeel R, Gupta S (2002) Glucose lowering effect of aqueous extract of Enicostemma littorale Blume in diabetes: a possible mechanism of action. J Ethnopharmacol 81:317–320PubMedCrossRef

17.

Maroo J, Vasu VT, Gupta S (2003) Dose dependent hypoglycemic effect of Enicostemma littorale Blume in alloxan induced diabetic rats. Phytomedicine 10:196–199PubMedCrossRef

18.

Vasu VT, Ashwinikumar C, Maroo J, Gupta S (2003) Antidiabetic effect of Enicostemma littorale Blume aqueous extract in newly diagnosed non-insulin-dependent diabetes mellitus patients (NIDDM): a preliminary investigation. OPEM 3:84–89

19.

Upadhyay UM, Goyal RK (2004) Efficacy of Enicostemma littorale in type 2 diabetic patients. Phytother Res 18:233–235PubMedCrossRef

20.

Babu PS, Prince PSM (2004) Antihyperglycaemic and antioxidant effect of hyponidd, an ayurvedic herbomineral formulation in streptozotocin-induced diabetic rats. J Pharm Pharmcol 56:1435–1442CrossRef

21.

Natarajan PN, Prasad S (1972) Chemical investigation of Enicotemma littorale. Planta Med 22:42–46PubMedCrossRef

22.

Retnam KR, DeBritto AJ (1988) Preliminary phytochemical screening of three medicinal plants of Tirunelveli hills. J Econ Tax Bot 22:677–681

23.

Rai J, Thakar KA (1966) Chemical investigation of Enicostemma littorale Blume. Curr Sci 35:148–149

24.

Desai PD, Ganguly AK, Govindachari TR, Joshi BS, Kamat VN, Manmade AH, Mohamed PA, Nagle SK, Nayak RH, Saksena AK, Sathe SS, Vishwanathan N (1966) Chemical investigation of some Indian medicinal plants: part II. Indian J Chem 4:457–459

25.

Vishwakarma SL, Rajani M, Bagul MS, Goyal RK (2004) A rapid method for the isolation of swertiamarin from Enicostemma littorale. Pharm Biol 42:400–403CrossRef

26.

Gopal R, Gnanamani A, Udayakumar R, Sadulla S (2004) Enicostemma littorale Blume. A potential hypolipidemic plant. Nat Prod Rad 3:401–405

27.

Vasu VT, Modi H, Thaikoottathil JV, Gupta S (2005) Hypolipidaemic and antioxidant effect of Enicostemma littorale Blume aqueous extract in cholesterol fed rats. J Ethnopharmacol 101:277–282PubMedCrossRef

28.

Murali B, Upadhyaya UM, Goyal RK (2002) Effect of chronic treatment with Enicostemma littorale in non-insulin-dependent diabetic (NIDDM) rats. J Ethnopharmacol 81:199–204PubMedCrossRef

29.

Vishwakarma SL, Rajani M, Goyal RK (2003) Comparative antidiabetic activity of different fractions of Enicostemma littorale Blume in STZ induced NIDDM rats. OPEM 3:196–204

30.

Schmolka IR (1991) In: Tarch PJ (ed) Polymers for controlled drug delivery. CRC, Boca Raton, pp 189–215

31.

Allian C, Poon LS, Chan CSG, Richmond Fu WPC (1974) Enzymatic determination of total serum cholesterol. J Clin Chem 20:470

32.

Friedewald WT, Levy RI, Fredrickson DS (1972) Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 18:499–502PubMed

33.

Woodson RF (1987) Statistical methods for the analysis of biochemical data. Wiley, Chichester, p 315

34.

Genest J, McNamara JR, Ordow JM, Siberman SR, Anderson KM, Wilson PW, Salem DM, Schaefer EJ (1992) Lipoprotein cholesterol, apolipoprotein A–I and B and lipoprotein (a) abnormalities in men with premature coronary artery disease. J Am Coll Cardiol 19:792–802PubMedCrossRef

35.

Bhandari U, Sharma JN, Zafar R (1998) The protective action of ethanolic ginger (Zingiber officinale) extract in cholesterol fed rabbits. J Ethnopharmacol 61:167–171PubMedCrossRef

36.

Ghasi S, Nwobodo E, Ofili JO (2000) Hypocholesterolemic effects of crude extract of leaf of Moringa oleifera Lam in high-fat diet fed Wistar rats. J Ethnopharmacol 69:21–25PubMedCrossRef

37.

Nimenibo-Uadia R (2003) Control of hyperlipidemia, hypercholesterolaemia and hyperketonaemia by aqueous extract of Discorea dumetorum tuber. Trop J Pharm Res 2:183–189

38.

Choudhary MI, Naheed S, Jalil S, Alam JM, Rahman A (2005) Effects of ethanolic extract of Iris germanica on lipid profile of rats fed on a high-fat diet. J Ethnopharmacol 98:217–220PubMedCrossRef

39.

Eliot LA, Foster RT, Jamali F (1999) Effects of hyperlipidemia on the pharmacokinetics of nifedipine in the rat. Pharm Res 16:309–313PubMedCrossRef

40.

Wout ZG, Pec EA, Maggiore JA, Williams RH, Palicharla P, Johnston TP (1992) Poloxamer-407 mediated changes in plasma cholesterol and triglycerides following intraperitoneal injection to rats. J Parenter Sci Technol 46:192–200PubMed

41.

Johnston TP, Palmer WK (1997) Effect of poloxamer 407 on the activity of microsomal 3-hydroxy-3-methylglutaryl CoA reductase in rats. J Cardiovas Pharmacol 29:580–585CrossRef

42.

Wasan KM, Ramaswamy S, Kwong M (2003) Poloxamer 407-mediated alterations in the activities of enzymes regulating lipid metabolism in rats. J Pharm Pharmaceut Sci 6:189–197

43.

Jones JD, Chambliss ML (2000) Hypertriglyceridemia and coronary heart disease. Arch Fam Med 9:189–190PubMedCrossRef

44.

Hopkins PN, Wu LL, Hunt SC, Brinton EA (2005) Plasma triglycerides and type III hyperlipidemia is independently associated with premature familial coronary artery disease. J Am Coll Cardiol 45:1003–1012PubMedCrossRef

45.

Smith SC Jr, Jackson Rod, Thomas AP, Valentin F, Salim Y, Faergeman O, Wood DA, Alderman M, Horgan J, Home P, Hunn M, Grundy SM (2004) Principles for national and regional guidelines on cardiovascular disease prevention: a scientific statement from the World Heart and Stroke Forum. Circulation 109:3112–3121PubMedCrossRef

46.

Steinberg D, Parthasarathy S, Carew T, Khoo J, Witztum J (1989) Beyond cholesterol: modifications of low-density lipoprotein that increase its atherogenicity. N Engl J Med 320:915–924PubMed

47.

Aviram M (1993) Modified forms of low density lipoprotein and atherosclerosis. Atherosclerosis 98:1–9PubMedCrossRef

48.

Nenseter MS, Gudmundsen O, Malterud KE, Berg T, Drevon CA (1994) Effect of cholesterol feeding on the susceptibility of lipoproteins to oxidative modification. Biochim Biophys Acta 1213:207–214PubMed

49.

Steinberg D (1993) Antioxidant vitamins and coronary heart disease. N Engl J Med 328:1487–1489PubMedCrossRef

50.

The Expert Panel (1993) Summary of the second report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel II). JAMA 269:3015–3023CrossRef

51.

Schaefer EJ, Lichtenstein AH, Lamon-Fava S, McNamara JR, Ordovas JM (1995) Lipoproteins, nutrition, aging, and atherosclerosis. Am J Clin Nutr 61:726S–740SPubMed

52.

Stein O, Stein Y (1999) Atheroprotective mechanisms of HDL. Atherosclerosis 144:285–301PubMedCrossRef

53.

Young CE, Karas RH, Kuvin JT (2004) High-density lipoprotein cholesterol and coronary heart disease. Cardiol Rev 12:107–119PubMedCrossRef

Titel: Antihyperlipidaemic activity of swertiamarin, a secoiridoid glycoside in poloxamer-407-induced hyperlipidaemic rats
verfasst von: Hitesh Vaidya
Mandapati Rajani
Vasudevan Sudarsanam
Harish Padh
Ramesh Goyal
Publikationsdatum: 01.10.2009
Verlag: Springer Japan
Erschienen in: Journal of Natural Medicines / Ausgabe 4/2009
Print ISSN: 1340-3443
Elektronische ISSN: 1861-0293
DOI: https://doi.org/10.1007/s11418-009-0350-8

Springer Medizin

Abstract

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