Background
Results and Discussion
Antimicrobial agent* | S. flexneri(n = 31) | S. sonnei(n = 21) | Breakpoint values (μg/ml)|| | ||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Resistant isolates | MIC†(μg/ml) | Resistant isolates | MIC (μg/ml) | ||||||||
No (%) | Range | MIC50‡ | MIC90§ | No (%) | Range | MIC50 | MIC90 | R | I | S | |
Am | 28(90.4) | 2-512 | 256 | 512 | 1(4.8) | 4-512 | 4 | 8 | ≥32 | 16 | ≤8 |
Cl | 28(90.4) | 4-256 | 128 | 256 | 1(4.8) | 2-256 | 8 | 8 | ≥32 | 16 | ≤8 |
Te | 29(93.5) | 1-256 | 128 | 128 | 7(66.7) | 1-256 | 128 | 256 | ≥16 | 8 | ≤4 |
Sxt | 10(32.3) | 0.5-128 | 2/38 | 128/2432 | 6(62) | 0.5-128 | 128/2432 | 128/2432 | ≥4/76 | N/A | ≤2/38 |
Km | 2(6.5) | 4-128 | 8 | 16 | 1(4.8) | 4-64 | 8 | 8 | ≥64 | 32 | ≤16 |
Str | 31(100) | 64-256 | 256 | 256 | 21(100) | 256 | 256 | 256 | ≥64 | 32 | ≤16 |
Gm | 1(3.2) | 2-32 | 4 | 4 | 2(9.5) | 1-64 | 2 | 2 | ≥16 | 8 | ≤4 |
Czn | 1(3.2) | 0.5-32 | 2 | 4 | 0(0.0) | 1-4 | 2 | 2 | ≥32 | 16 | ≤8 |
Cpr | 1(3.2) | 0.03-64 | 0.25 | 0.5 | 0(0.0) | 0.12-0.5 | 0.12 | 0.25 | ≥64 | 32 | ≤16 |
Cur | 1(3.2) | 1-64 | 4 | 4 | 0(0.0) | 1-4 | 4 | 4 | ≥32 | 16 | ≤8 |
Ctz | 1(3.2) | 0.06-64 | 0.12 | 0.25 | 0(0.0) | 0.06-0.5 | 0.12 | 0.25 | ≥32 | 16 | ≤8 |
NA | 0(0.0) | 0.12-0.5 | 0.12 | 0.5 | 1(4.8) | 0.12-32 | 0.12 | 0.25 | ≥32 | N/A | ≤16 |
Cip | 0(0.0) | 0.008-0.016 | 0.008 | 0.016 | 1(4.8) | 0.004-4 | 0.008 | 0.016 | ≥4 | 2 | ≤1 |
Antimicrobial resistance pattern* | S. flexneri(n = 31) No (%) | S. sonnei(n = 21) No (%) |
---|---|---|
Am/Cl/Str/Te | 19 (61.3) | 0 (0.0) |
Am/Cl/Str/Sxt/Te | 8 (25.8) | 0 (0.0) |
Am/Cl/Str/Sxt/Te/Czn/Cpr/Cur/Ctz/Gm/Km | 1 (3.2) | 0 (0.0) |
Km/Str/Sxt | 1 (3.2) | 0 (0.0) |
Str/Sxt | 2 (6.4) | 0 (0.0) |
Str/Sxt/Te | 0 (0.0) | 10 (47.6) |
Str | 0 (0.0) | 6 (28.6) |
Str/Te | 0 (0.0) | 2 (9.5) |
Am/Cl/Str/Sxt/Gm/Km | 0 (0.0) | 1 (4.8) |
Gm/Str/Sxt/Te | 0 (0.0) | 1 (4.8) |
NA/Cip/Str/Sxt/Te | 0 (0.0) | 1 (4.8) |
Isolate no. | Species | Antimicrobial agent* | Integron class | |||||||
---|---|---|---|---|---|---|---|---|---|---|
Am | Cl | Gm | Km | Sxt | Te | Str | 1 | 2 | ||
1410 | S. flexneri 1a | R | R | S | S | S | R | R | + | - |
1806 | S. flexneri 1b | R | R | S | S | S | R | R | + | + |
2316 | S. flexneri 1c | R | R | S | S | S | R | R | + | - |
1461/542 | S. flexneri 2a | R | R | S | S | S | R | R | + | - |
2125/947 | S. flexneri 2a | R | R | S | S | S | R | R | + | - |
2864/574 | S. flexneri 2a | R | R | S | S | R | R | R | + | + |
3104/355 | S. flexneri 2a | R | R | S | S | R | R | R | + | + |
3116/944 | S. flexneri 2a | R | R | S | S | R | R | R | + | + |
3160/383 | S. flexneri 2a | R | R | S | S | R | R | R | + | - |
4036/750 | S. flexneri 2a | R | R | S | S | S | R | R | + | + |
33 | S. flexneri 2a | R | R | S | S | S | R | R | + | + |
430 | S. flexneri 2a | R | R | S | S | S | R | R | + | - |
525 | S. flexneri 2a | R | R | S | S | R | R | R | + | + |
842 | S. flexneri 2a | R | R | S | S | R | R | R | + | + |
1773 | S. flexneri 2a | R | R | S | S | S | R | R | + | + |
1771 | S. flexneri 2a | R | R | S | S | S | R | R | + | + |
1807 | S. flexneri 2a | R | R | S | S | S | R | R | + | + |
1832 | S. flexneri 2a | R | R | S | S | R | R | R | + | + |
2011 | S. flexneri 2a | R | R | S | S | S | R | R | + | + |
2344 | S. flexneri 2a | R | R | S | S | S | R | R | + | + |
2215/278 | S. flexneri 2a | S | S | S | R | R | S | R | - | + |
737 | S. flexneri 2a | S | S | S | S | S | R | R | - | - |
1875 | S. flexneri 2b | R | R | S | S | R | R | R | + | + |
4297/499 | S. flexneri 2b | R | R | S | S | S | R | R | + | + |
1874 | S. flexneri 3a | R | R | S | S | S | R | R | + | + |
769 | S. flexneri 3b | R | R | S | S | S | R | R | + | - |
1544 | S. flexneri 4 | R | R | R | R | R | R | R | + | + |
2376 | S. flexneri 4 | R | R | S | S | S | R | R | + | - |
3049/4396 | S. flexneri 6 | R | R | S | S | S | R | R | + | + |
2078 | S. flexneri 6 | R | R | S | S | S | R | R | + | - |
2126/4720 | S. flexneri 6 | S | S | S | S | S | S | R | - | - |
344/1899 |
S. sonnei
| S | S | S | S | S | S | R | - | - |
346/459 |
S. sonnei
| S | S | S | S | R | R | R | + | + |
358/477 |
S. sonnei
| S | S | S | S | S | S | R | - | + |
333/1755 |
S. sonnei
| S | S | S | S | S | R | R | + | + |
359/400 |
S. sonnei
| S | S | S | S | S | S | R | - | + |
353/1950 |
S. sonnei
| S | S | S | S | R | R | R | - | + |
766/601 |
S. sonnei
| S | S | S | S | S | R | R | - | - |
1159/107 |
S. sonnei
| S | S | S | S | R | R | R | - | - |
1201/1982 |
S. sonnei
| S | S | S | S | R | R | R | - | + |
1316/152 |
S. sonnei
| S | S | S | S | S | S | R | - | + |
1805/146 |
S. sonnei
| S | S | S | S | R | R | R | + | + |
1849/760 |
S. sonnei
| S | S | S | S | S | S | R | - | + |
2939/5116 |
S. sonnei
| S | S | S | S | S | S | R | - | - |
1553/3 |
S. sonnei
| R | R | R | R | R | S | R | + | + |
1711/2 |
S. sonnei
| S | S | S | S | R | R | R | - | + |
1745/3 |
S. sonnei
| S | S | S | S | R | R | R | - | + |
4166/149 |
S. sonnei
| S | S | S | S | R | R | R | - | + |
4336/671 |
S. sonnei
| S | S | S | S | R | R | R | - | + |
4340/966 |
S. sonnei
| S | S | S | S | R | R | R | - | + |
4342/1199 |
S. sonnei
| S | S | S | S | R | R | R | - | + |
4345/199 |
S. sonnei
| S | S | R | S | R | R | R | - | + |